adisintegrin and metalloproteinase with athrombospondin type 1 motif, member 13, also known as von Willebrand factor-cleaving protease: an enzyme that cleaves and degrades large von Willebrand factor multimers and decreases their activity, thereby disrupting *platelet activation. Most cases of *thrombotic thrombocytopenic purpura are as a result of inhibition or deficiency of ADAMTS13.
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