n. a drug that inhibits the action of vascular endothelial growth factor A (VEGF-A) and thereby prevents the development of new blood vessels (see angiogenesis inhibitor). It is injected into the vitreous humour to stop abnormal blood vessel growth and leakage in the eye(s) in treating wet age-related *macular degeneration and is given by intravenous infusion, in combination with chemotherapy drugs, to treat metastatic colorectal cancer.
an agent that prevents the development of new blood vessels (*angiogenesis) by inhibiting the action of *vascular endothelial growth factor (it is also known as anti-VEGF). Angiogenesis inhibitors are used as anticancer drugs, since growing cancers have a greater need for blood supply than normal tissue and must develop new blood vessels before progressing beyond a very small size. They include *aflibercept, *bevacizumab, and *thalidomide. Because of their action, some of these drugs are used in the treatment of wet age-related *macular degeneration.... angiogenesis inhibitor
n. a recombinant *monoclonal antibody fragment used for the treatment of wet age-related *macular degeneration. It inhibits *vascular endothelial growth factor and therefore choroidal *neovascularization. Common side-effects are conjunctival haemorrhage, eye pain, *floaters, increased intraocular pressure, and intraocular inflammation. *Aflibercept and pegaptanib have similar uses and effects.... ranibizumab
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