Anasarca Health Dictionary

Baliospermum montanum

Euphorbiaceae

San: Danti;

Hin: Danti;

Mal: Danti, Nagadanti;

Tam: Nakatanti;

Tel: Nelajidi

Importance: Danti or Nagadanti is a stout undershrub with numerous flowers. Root, which is the officinal part, is used in abdominal pain, constipation, calculus, general anasarca, piles, helminthic manifestations, scabies, skin disorders, suppurative ulcers and diseases caused by the morbidity of kapha and pitta. Root paste is applied to painful swellings and piles. Leaves cure asthma and seeds are used in snakebite (Kurup et al, 1979; Sharma, 1983). The drug forms an important constituent of preparations like Dantyarishta, Dantiharitakileham, Kaisoraguggulu gulika, etc.(Sivarajan et al, 1994).

Distribution: The plant is found throughout the sub-Himalayan tracts from Kashmir to Khasi Hills. It is common in West Bengal, Bihar and Central and Peninsular India.

Botany: Baliospermum montanum (Willd.) Muell-Arg. syn. B. axillare Bl., B. polyandrum Wt. belongs to the family Euphrobiaceae. It is a stout under-shrub 0.9-1.8m in height with herbaceous branches from the roots. Leaves are simple, sinuate-toothed, upper ones small, lower ones large and sometimes palmately 3-5 lobed. Flowers are numerous, arranged in axillary racemes with male flowers above and a few females below. Fruits are capsules, 8-13mm long and obovoid. Seeds are ellipsoid smooth and mottled (Warrier et al,1993).

Agrotechnology: The tropical plant is suited to almost all soils. It can be cultivated either as pure crop or intercrop. It is propagated vegetatively by cuttings. About 15-20cm long rooted cuttings are used for planting. Pits of size 50cm cube are to be taken at 3m spacing and filled with dried cowdung, sand and top soil and formed into a mound. On these mounds, rooted cuttings are to be planted at 2 cuttings/mound. Cuttings establish within one month. Weeding is to be carried out at this time. Application of organic manure after every 6 months is beneficial. Irrigation during summer months is preferable. The plant is not attacked by any serious pests or diseases. Roots can be collected at the end of second year. The roots are to be cut and dried in sun before marketing. The yield is about one tonne root/ha (Prasad et al,1997).

Properties and activity: Roots contain diterpenes, baliospermin, montanin, phorbol-12-deoxy-13-O-palmitate, phorbol-12-deoxy-16-hydroxy-13-O-palmitate and phorbol-12-deoxy-5 -hydroxy-13 – myristate (Ogura et al, 1978). Alcoholic extract of plant showed hypotensive activity in experimental animals (Bhakuni et al, 1971). Antilukaemic and cytotoxic activities have been demonstrated in the esters of both 12-deoxyphorbol and 12-deoxy-16-hydroxyphorbol, isolated from B. montanum (King-horn, 1979). The roots are acrid, thermogenic, purgative, antiinflammatory, anodyne, digestive, anthelmintic, diuretic, diaphoretic, rubefacient, febrifuge and tonic. Seed is purgative, stimulant, rubefacient and antidote for snakebite. Seed oil is antirheumatic. Leaf is antiasthmatic and wound healing. Root and seed oil is cathartic and antidropsical. Stem is anti-dontalgic.... nagadanti

Croton tiglium

Euphorbiaceae

San: Jepalah, Dantibijah

Hin: Jamalgota

Ben: Jaypal Mal: Nirvalam

Tam: Nervalam, Sevalamkottai

Tel: Nepala

Importance: Purging croton or croton oil plant, a small evergreen tree with separate male and female flowers, is one among the seven poisons described in Ayurveda. The drug is well known for its drastic purgative property. The drug is found to be useful in ascites, anasarca, cold, cough, asthma, constipation, calculus, dropsy, fever and enlargement of the abdominal viscera. The seed paste is a good application for skin diseases, painful swellings and alopacia. The seed-oil is useful in chronic bronchitis, laryngeal affections, arthritis and lock jaw. Misraka-sneham is an important preparation using the drug (Nadkarni, 1954; Dey, 1980; Sharma, 1983).

Distribution: It is distributed throughout North India. It is cultivated in Assam, West Bengal and South India.

Botany: Croton tiglium Linn. belongs to the family Euphorbiaceae. It is a small evergreen tree, 4.5-6.0m in height with ash coloured smooth bark and young shoots sprinkled with stellate hairs. Leaves are oblong to ovate-lanceolate, obtuse or rounded at the 2-glanded box, acuminate, membraneous, yellowish green and minutely toothed. Flowers are small, unisexual, males on slender pedicels, females larger and on short thick pedicels. Fruits are ovoid or oblong trigonous capsules. Seeds are smooth, testa black and enclosing reddish brown oily endosperm (Warrier et al,1994). Other species belonging to the genus Croton are as follows:

C. aromaticus Linn. C. caudatus Geisel C. jouera Roxb.

C. malabaricus Bedd.

C. oblongifolius Roxb.

C. polyandrus Roxb. syn. Baliospermum montanum Muell-Arg.

C. reticulatus(Chopra et al, 1980)

Agrotechnology: The plant is propagated by seeds. Seeds are to be sown on seedbeds and about 2 months old seedlings are used for transplanting. Pits of size 50cm cube are to be taken at 3m spacing and filled with dried cowdung, sand and topsoil and formed into a mound. The seedlings are to be planted on these mounds. Irrigation during summer months is beneficial. Application of organic manure after every 6 months is desirable. Weeding is to be carried out one month after transplanting. The plant is not attacked by any serious pests or diseases. Fruits are formed at the end of first year. Fruits when ripen and start to crack are to be collected, dried in sun, then the outer shell is removed and again dried for one day before marketing (Prasad et al,1997).

Properties and activity: Oil contains phorbol myristate acetate (Husain et al, 1992). Seeds contain upto 20% protein and 30-50% lipids. Iso-guanine-D-ribose (crotoniside) and saccharose were isolated from the seeds. In fractionation of croton oil, liquid-liquid distribution procedures proved to be the separation tools of choice. The per hydrogenated parent hydrocarbon of phorbol is a perhydrocyclopropabenzulene called tigliane and phorbol is 1, 1a , 1b , 4, 4a, 7a , 7b, 8, 9, 9a-decahydro-4a , 7 , 9 , 9a - tetrahydroxy-3-(hydroxymethyl)-1, 1, 6, 8 tetramethyl-5-H-cyclopropa[3,4] benz [1.2-e]azulen-5- one. Phorbol, a tetracylic diterpene with a 5, 7, 6 and 3- membered ring has 6 oxygen functions. Phorbol accounts for 3.4% and 4- deoxy- 4 - phorbol for 0.29% of the weight of croton oil. Twenty- five phorbol-12, 13-diesters have been detected (Hecker et al, 1974). A toxin croton 1, mol. wt 72,000 has been isolated from the seeds (Lin et al, 1978).

Phorbol myristate acetate activates nitroblue tetrazolium reduction in human polymorphs. Seed and oil is purgative, rubefacient and anti-dote for snakebite. The seeds and oil are acrid, bitter, thermogenic, emollient, drastic purgative, digestive, carminative, anthelmintic, antiinflammatory, vermifuge, deterent, diaphoretic, expectorant, vesicant, irritant and rubefacient.... purging croton

(Lour.) Spach.

Synonym: A. macrorrhiza (Linn.) G. Don

Family: Araceae.

Habitat: A genus of topical Asia, Malayasia and the Pacific. Found wild and cultivated all over India.

English: Giant Taro.

Ayurvedic: Maanaka, Maana, Maankanda, Kasaalu, Hastikarni.

Siddha/Tamil: Merukan kizhangu.

Action: Rootstock—mild laxative, diuretic (in anasarca); used in inflammations and diseases of abdomen and spleen. Leaf—astringent, styptic, antitumour. Root and leaf—rubefacient. Tubers—used as vegetable after eliminating oxalate content.

All parts of the plant, except tubers, contain cyanogenic principle, a mixture of triglochinin and iso- triglochinin. The tubers contain sterols and high concentration of soluble oxa- lates (prolonged use may lead to calcium deficiency and oxaluria.) The tubers contain a trypsin/chymotrypsin inhibitor. The plant contains HCN (0.0027%). It is found to be mitogenic to human peripheral blood lymphocytes.

Dosage: Tuber—5-10 g powder. (CCRAS.)... alocasia indica

Linn.

Family: Amaranthaceae.

Habitat: Grown as vegetable in northern India.

English: Love-Lies-Bleeding, Tassel Flower.

Ayurvedic: Raam-daanaa (grain).

Siddha/Tamil: Pungikeerai, Siru- keerai.

Folk: Chuko.

Action: Blood-purifier, diuretic; used in piles, strangury, dropsy and anasarca; tea has been used for relieving pulmonary conditions; also given in scrofula and applied to scrofulous sores. Antimicrobial peptides have been isolated from seeds.

In Western herbal medicine, LoveLies-Bleeding is equated with Amaranthus hypochondriacus, and is used for ulcers, diarrhoea, as well as inflammation of the mouth and throat.

Preliminary evidence suggests that Amaranth seed can reduce total cholesterol and LDL, while increasing HDL, but Amaranth muffins failed to reduce cholesterol levels in hypercholes- terolemic adults beyond the reduction achieved by low-fat diet. (Natural Medicines Comprehensive Database, 2007.)... amaranthus caudatus

(L.) Benth.

Family: Papilionaceae; Fabaceae.

Habitat: Throughout India; up to 1,800 m in the western Himalayas.

Ayurvedic: Vana-kulattha.

Folk: Jangli Tur, Kulthi.

Action: Antidysenteric, anticholerin, febrifuge; also used in anaemia, anasarca and hemiplegia. Seeds— taeniafuge.

A flavone glucoside, atyloside, has been isolated from the leaves.... atylosia scarabaeoides

Linn.

Family: Lauraceae

Habitat: Throughout the greater parts of India.

English: Doddar-Laurel, Love-Vine.

Ayurvedic: Amarvalli, Aakaashbel. (Cuscuta reflexa is also known as Amarvalli.)

Siddha/Tamil: Erumaikkottan.

Action: Astringent, diuretic (given in dropsy and anasarca, also in biliousness, chronic dysentery, haemoptysis and for supressing lactation after still-birth); piscicidal and insecticidal (used as a hair-wash for killing vermin).

The plant contains aporphine alkaloids. calcium, phosphorus, thiamine, riboflavin and niacin; also tocopherols. Nuts, crushed with vinegar and barley flour, are used against indurations of breast. The extract of nuts exhibits possibility of its use as a platelet inhibitor in thrombosis and atherosclerosis. Leaves are inhibitors of pectinolytic enzymes.

American chestnut and European chestnut are equated with Castanea dentata and C. sativa,respectively. Both are used for respiratory ailments.... cassytha filiformis

Linn.

Family: Euphorbiaceae.

Habitat: Native to South-East Asia. Now cultivated in Assam, Bengal and South India.

English: Purging Croton.

Ayurvedic: Jayapaala, Dravanti, Dantibija, Tintidiphala.

Unani: Habb-us-Salaateen, Jamaal- gotaa, Hubb-ul-Malook.

Siddha/Tamil: Nervaalam.

Action: Cathartic, rubefacient, irritant. Used in ascites, anasarca, dropsy and enlargement of abdominal viscera.

The seed oil is purgative. It produces severe symptoms of toxicity when taken internally or applied externally to the skin.

Croton oil showed tumour-promoting activity on mouse skin. The skin irritant and tumour promoting diterpene esters of the tigliane type (phorbol esters) and toxins have been isolated from the seeds. (In China, where the herb is employed for the treatment of gastro-intestinal disturbances, the highest incidence of naso- pharyngeal cancer has been reported.) 1 ml oil is usually fatal. Phorbols (terpenoids) from nonvolatile oil are toxic. Crotin, a toxic albuminous substance, is not extracted in the oil. The plant caused haematuria and swelling of lymph glands in animals.

Dosage: Seed—6-12 mg powder. (API Vol. IV.)... croton tiglium

Linn.

Family: Euphorbiaceae.

Habitat: The warmer regions of India; often cultivated for hedges.

English: Triangular Spurge.

Ayurvedic: Snuhi (Substitute), Vajra-kantaka, Vajratundi

Siddha/Tamil: Chathurakkali.

Folk: Tridhaari, Tidhaaraa Sehunda.

Action: Latex—purgative. Applied on burns. Plant—used in dropsy, anasarca, sores, venereal sores, syphilis; also in dysentery, bronchitis, asthma. Root—anthelmintic. Fresh stems—used for skin sores and scabies. A decoction of stems is given in gout.

The stems yielded friedelan-3 alpha- ol and 3 beta-ol, taraxerol and taraxe- rone. The roots yielded taraxerol. Latex gave beta-amyrin, cycloartenol, euphol (70%) and alpha-euphorbol.... euphorbia antiquorum

Auct. Non Linn.

Synonym: E. ligularia Roxb.

Family: Euphorbiaceae.

Habitat: Grown as a field and boundary fence and as curious on rockeries in gardens.

English: Holy Milk Hedge, Dog's Tongue.

Ayurvedic: Snuhi, Samant-dugdhaa, Sehunda, Singhtunda, Snuk, Gudaa, Sudhaa, Vajra, Vajjri, Vajjradram, Thuuhar.

Siddha/Tamil: Ielaikkali, Perumbu- kalli.

Action: Latex—purgative, diuretic, antiasthmatic, expectorant, rube- facient. Used in ascites, polyuria, anasarca, chlorosis, tympanitis; externally on warts, cutaneous eruptions, scabies, unhealthy ulcers.

A succus compounded of equal parts of the juice and simple syrup is said to be used for giving relief in asthma.

The triterpenoids, euphol, 24-meth- ylenecycloartenol, euphorbol hexa- cosonate, glut-5 (10)-en-1-one, glut-5- en-3 beta-yet-acetate, taraxerol, friede- lan-3 alpha-ol and -3 beta-ol have been reported from the plant.... euphorbia neriifolia

Plumbago spp.

Plumbaginaceae

The genus Plumbago belonging to the family Plumbaginaceae is a popular and medicinally very important group of medicinal plants. Three species, namely P. rosea, P. zeylanica and P. auriculata have been identified. Among these P. rosea and P. zeylanica are important ones.

Plumbago, in general is an esteemed remedy for leucoderma and other skin diseases. The synonyms of fire like agnih, vahnih, etc. are attributed to this drug to indicate the very burning action of the root, causing blisters on the skin (daranah). The drug is used only after adequate curing and purification. Root is the officinal part and it enters into the composition of preparations like Citrakasavam, Dasamularista, Gulgulutiktaka kasaya, Yogarajachurna, etc.

1. P. rosea Linn. syn. P. indica Linn.

Eng: Rosy-flowered Leadwort; San: Citrakah, Dhahanah;

Hin: Lalcitra, Raktacitra;

Ben: Lalchita;

Mal: Kotuveli, Chettikkoduveli, Chuvannakotuveli;

Tam: Chenkotuveli, Cittiramulam;

Kan: Kempacitramula;

Tel: Yerracitramulam

Rosy-flowered leadwort or Fire plant is a native of Coromandel Coast. It is found throughout India, in moist situations as well as cultivated. The roots are useful in dyspepsia, colic, inflammations, cough, bronchitis, helmenthiasis, haemorrhoids, elephantiasis, chronic and intermittent fever, leprosy, leucoderma, ringworm, scabies, hepatosplenomegaly, amenorrhoea, odontalgia, vitiated conditions of vata, kapha and anaemia. It is a pretty subscandent perennial shrub with semi -woody striate stems and flexible branches. Leaves are simple, alternate oblong, short cuneate at the base passing into a very short amplexicaul, exauriculate, and reddish petiole. Flowers are bright red, arranged in long terminal spikes. The calyx ribs are covered with stipitate, bifarious and subsessile gland. Corolla tube is slender and four times as long as the calyx. The stout roots are cylindrical, irregularly bent, light yellowish brown with smooth surface having short transverse shallow fissures at the regions of the bents. A light yellowish juice excudes from the cut surface. A healthy plant may produce 18-20 stout roots (Warrier et al, 1995).

The chemical constituents include plumbagin and sitosterol glucoside. Clinical trials have demonstrated that plumbagin oil from P. indica is useful in common wart (Satyavati et al, 1987). The roots are acrid, astringent, thermogenic, anthelmintic, constipating, expectorant, antiinflammmatory, abortifacient, alterant, anti-periodic, carminative, digestive, sudorific, narcotic, gastric, nervous stimulant and rejuvenating. Root is a powerful sialogogue and vesicant.

2. P. zeylanica Linn.

Eng:White flowered Leadwort; San:Chitraka;

Hin, Ben:Chitarak, Chitra; Mal:Vellakotuveli

Tam: Sittragam, Chittiramoolam;

Kan: Vahini; Mar: Chitraka;

Tel: Chitramulam

White flowered Leadwort or Chitarak is found wild in peninsular India and mostly in West Bengal. Root is used externally in leprosy and other skin diseases or obstinate character, aphthae, abscesses, influenza, piles and anasarca. Juice is used externally in scabies and ulcers. One of the important preparations of Chitrak is “Yograjguggal”, prescribed for arthritis, rheumatism, etc. The other well known preparations are “Chitrak Adivati” and “ Chitraka Haritaki”. In Unani system it is an ingredient of “Aqaruva-i- Kabir”, “Hab Ashkhar”, “Ma’jun Baladur”, “Ma’jun Raig Mahi”, etc. It is a branched undershrub. Roots are long and tuberous. Stem is striate. Leaves are simple, alternate, short petioled, ovate or ovate-oblong, acute with entire or wavy margin, 7x3.8cm and glabrous. Flowers are white, arranged in terminal spikes. Calyx is tubular, glandular-hairy. Corolla tube is slender; limb rotate and 5 lobbed. Stamens are 5 on a disc. Style is slender with 5 stigmatic branches. Fruit is membranous capsule enclosed within the persistent calyx.

The roots of P. zeylanica have been exhaustively studied and naphthaquinones have been isolated, namely, plumbagin, 3-chlroplumbagin, droserone (Sidhu et al, 1971; Padhye et al, 1973), 3,3’-biplumbagin(Chitranone), zeylanone and iso-zeylanone and a coumarin, elliptinone (Sankaram et al, 1976, 1979). It also contains 1,2(3)-tetrahydro-3,3’-biplumbagin and plumbazeylanone. The leaf is antirheumatic. Root is appetiser, sudorific, relieves pain, vasicant, diuretic, caustic, antidiarrhoeal and expellent of phlegmatic tumours. Root is uterine stimulant. Root and fruits have antiimplantation activity. Plumbagin induces antiimplantation, has abortifacient and antiovulatory activity and causes selective testicular lesions in dogs. It is also a mitotic inhibitor. In lower concentration it behaves like a spindle, poison but in higher concentration it exhibits radiomimetic, nucleotoxic and cyclotoxic effects. It also has antibacterial, antifungal and anticoagulant activities and shows antagonism to amphetamine hyperactivity in mice.

3. P. auriculata Lam. syn. P. capensis

Eng: Blue flowered Leadwort;

Mal: Neelakotuveli

The blue flowered Leadwort is often grown in gardens throughout India (Moos, 1976; Chunekar, 1982; Sharma, 1983). It is a native of Cape Province in South Africa. It is a constituent of many Ayurvedic drugs (KAU, 1991). The plant is a subshrub growing to a height of 1-1.5m. Leaves are elliptic to obovate, 3-4 x 1.5-2cm. Inflorescence is a raceme of length 3-4cm. Corolla is blue to violet. Stamens are 5 in number. Flowers and fruits may be upto 12 in number (Matthew, 1995).

Agrotechnology: The plant is grown in tropical to subtropical ecosystems. Warm humid tropical climate is most suited. They come up well in almost all types of deep and well drained soils. It is propagated vegetatively by stem cuttings. Three stem cuttings of size 15cm long are planted in polybags of size 14x10cm. IAA and IBA treatments will improve rooting of cuttings. The land is to be ploughed well. About 4 tonnes of FYM are to be applied, mixed thoroughly and seed bed of size 50cm breadth, 1.5cm height and convenient length are to be prepared. On these beds pits are taken at a distance of 25cm and the rooted plants are transplanted from the polybags. Regular irrigation and weeding are to be carried out. In the second year with the onset of monsoon, seedbeds are again refreshed after adding about 4 tonnes of FYM. At the end of second year tubers are collected. Care should be taken to wear gloves, else the chemical plumbagin present in the roots will cause burning sensation. The collected tubers are washed, tied into bundles and marketed. Plumbago yields about 7-10t tubers/ha with good management (Prasad et al, 1997).... leadwort