n. the start of secretion of *androgens by the adrenal glands, occurring at around 6–7 years of age in girls and 7–8 in boys. It is usually determined by the measurement of urinary 17-ketosteroids rather than direct assay of the androgens themselves. Adrenal androgens are *dehydroepiandrosterone (DHEA), DHEA sulphate, and androstenedione. The age of adrenarche is unrelated to the age of *gonadarche. Premature adrenarche is usually manifested as the early appearance of pubic hair due to levels of the adrenal androgens equivalent to those found in puberty. It does not proceed to full puberty as the gonads do not become active.... adrenarche
(DHEA) n. a weak androgen produced and secreted by the adrenal glands after the stage of adrenal maturation known as *adrenarche. It is produced from 17-hydroxypregnenolone and itself is largely converted to dehydroepiandrosterone sulphate and androstenedione. All three of these molecules can cause a degree of mild *androgenization but can also be converted in the circulation to the more potent androgens *testosterone and *dihydrotestosterone.... dehydroepiandrosterone
n. the principal male sex hormone (see androgen). Formed from androstenedione within the interstitial cells of the *testis, it is converted in target cells to *dihydrotestosterone, which mediates most of its actions. Preparations of testosterone are used for replacement therapy in males with testosterone deficiency; they can be administered orally, by intramuscular depot injection, or topically (in the form of skin patches or gels).... testosterone
Health Encyclopedia