n. a localized collection of thin-walled blood vessels covered by a cap of warty material. It is most often seen as angiokeratoma of Fordyce, purple papules on the scrotum or vulva of the elderly, which should not be treated unless they bleed easily. Angiokeratomas can also occur on the hands and feet of children. The condition is not malignant and its cause is unknown. Angiokeratomas may be removed surgically. See also Fabry disease.
(Anderson–Fabry disease) an inherited disorder – an X-linked recessive condition (see sex-linked) – characterized by deficiency of the enzyme ?-galactosidase. It causes accumulation of glycosphingolipid (see cerebroside) in the body, leading to prominent and progressive involvement of the skin (with the formation of *angiokeratomas), heart, kidneys, and nervous system. The disease is treated with genetically engineered enzyme replacement therapy. [J. Fabry (1860–1930), German dermatologist]... fabry disease
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