Cake bush (Piper marginatum).Plant Part Used: Leaf.Dominican Medicinal Uses: The leaf is traditionally prepared as a decoction and taken orally for flatulence, indigestion and stomach pain.Safety: No data on the safety of this plant in humans or animals has been identified in the available literature.Contraindications: Insufficient information has been identified in the available literature.Drug Interactions: Insufficient information has been identified in the available literature.Clinical Data: No human clinical trials of this plant have been identified in the available literature.Laboratory & Preclinical Data: The following biological activities of the essential oil or plant extracts have been demonstrated in laboratory studies using in vitro assays: antibacterial, antifungal and antiparasitic.* See entry for Aniseto in “Part 3: Dominican Medicinal Plant Profiles” of this book for more information, including references.