Anti Health Dictionary

Immunologic proteins, usually made from immunoglobulins, that are capable of binding to, and rendering inactive, foreign substances that have entered the skin envelope and have been deemed dangerous. They may be synthesized anew in the presence of a previously encountered substance (antigen); they may be present in small amounts at all times in the bloodstream; or they may be present in the tissues in a more primitive form designed to react to a broad spectrum of potential antigens. The latter may be responsible for some allergies.... antibody

An agent which neutralizes or opposes the action of a poison... antidote

A substance, usually a protein, that induces the formation of defending antibodies. Example: bacterial toxins, Juniper pollen (in allergies). Auto-immune disorders can occur when antibodies are formed against normal proteins created within the body.... antigen

A substance that prevents oxidation or slows a redox reaction. More generally, an agent that slows the formation of lipid peroxides and other free-radical oxygen forms, preventing the rancidity of oils or blocking damage from peroxides to the mitochondria of cells or cell membranes. (Examples : Vitamin E, Larrea (Chaparral), Gum Benzoin.)... antioxidant

Killing disease causing microorganisms ... antibiotic

Antibiotic is the term used to describe any antibacterial agent derived from micro-organisms, although most of them are now prepared synthetically. Such agents destroy or inhibit the growth of other micro-organisms: examples are penicillin, cephalosporin, amino-glycosides, streptomycin, and tetracycline.

Penicillin was the ?rst antibiotic to be discovered and used in the 1940s. The discovery and isolation in 1958 of the penicillin nucleus, 6-amino penicillanic acid (6-PNA), allowed many new penicillins to be synthesised. These are now the largest single group of antibiotics used in clinical medicine. Most staphylococci (see STAPHYLOCOCCUS) have now developed resistance to benzylpenicillin, the early form of the drug, because they produce penicillinases – enzymes which break down the drug. Other types of penicillin such as cloxacillin and ?ucoxacillin are not affected and are used against penicillin-resistant staphylococci.

The cephalosporins are derived from the compound cephalosporin C, which is obtained by fermentation of the mould cephalosporium.

The cephalosporin nucleus 7 amino cephalosporanic (7-ICA) acid has been the basis for the production of the semi-synthetic compounds of the cephalosporin nucleus. The ?rst semi-synthetic cephalosporin, cephalothin, appeared in 1962; it was followed by cephaloridine in 1964. The original cephalosporins had to be given by injection, but more recent preparations can be given by mouth. The newer preparations are less readily destroyed by betalactamases and so they have a much broader spectrum of antibacterial activity. The newer cephalosporins include cephalexin, cefazolin, cephacetrile, cephapirin, cefamandole, cefuroxine, cephrodine, cefodroxil and cefotaxine. Inactivation of beta-lactamase is the basis of bacterial resistance both to the penicillins and to the cephalosporins, so that attempts to prepare these antibiotics with resistance to betalactamase is of great importance. A synthetic inhibitor of beta-lactamase called clavulanic acid has been synthesised; this is used in combination with the penicillins and cephalosporins to prevent resistance. The cephamycins are a new addition to the beta-lactam antibiotics. They are similar in structure to the cephalosporins but are produced, not by fungi, but by actinomycetes.

Overuse and misuse of antibiotics have resulted in many bacteria becoming resistant to them. Hospitals, in particular, have problems with METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA). Combinations of antibiotics are needed to combat resistant strains of bacteria, another example being Mycobacterium tuberculosis.... antibiotics

An agent that impedes the impulses or actions of the nerves or fibers of the parasympathetic ganglia, competing with, and blocking the release of acetycholine at what are called the muscarinic sites. Cholinergic functions affected are those that induce spasms and cramps of the intestinal tracts and allied ducts. Examples: Atropine, Datura, Garrya.... anticholinergic

Inhibiting the clotting of blood ... anticoagulant

Literally, substances meant to oppose depressions or sadness, and generally heterocyclic types such as Elavil, MAO inhibitors like phenelzine, or lithium carbonate. This category of substances formerly included stuff like amphetamines and other stimulants. Our only plants that could fit the current definition would be Hypericum, Peganum and perhaps Oplopanax.... antidepressant

Stopping emesis or vomiting ... antiemetic

An exogenous agent that inhibits the release of histamine, the amino acid derivative that stimulates vasodilation and permeability under many circumstances, particularly tissue irritation. The most common type of antihistamine, the H1 receptor antagonist, produces many moderate side effects, and the H2 receptor antagonist cimetidine is even more problematic. That they are so commonly used can lull both physician and patient into trivializing their iatrogenic potential. Histamines, which are most abundant in the skin, respiratory, and GI tract mucus membranes, help heal; using antihistamines to inhibit the healing response for the whole body simply in order to lessen the acute but physiologically superficial symptoms of something like hay fever is to risk many subtle side effects.... antihistamine

A group of drugs used to treat high blood pressure (HYPERTENSION). Untreated hypertension leads to STROKE, heart attacks and heart failure. The high incidence of hypertension in western countries has led to intensive research to discover antihypertensive drugs, and many have been marketed. The drugs may work by reducing the power of the heartbeat, by dilating the blood vessels or by increasing the excretion of salts and water in the urine (diuresis). Antihypertensive treatment has greatly improved the prognosis of patients with high blood pressure by cutting the frequency of heart and renal failure (see KIDNEYS, DISEASES OF), stroke, and coronary thrombosis (see HEART, DISEASES OF). Drugs used for treatment can be classi?ed as follows: diuretics; vasodilator antihypertensives; centrally acting antihypertensives; adrenergic neurone-blocking drugs; alpha-adrenoreceptorblocking drugs; drugs affecting the renin-angiotensin system; ganglion-blocking drugs; and tyrosine hydroxylase inhibitors. The drugs prescribed depend on many factors, including the type of hypertension being treated. Treatment can be di?cult because of the need to balance the e?ectiveness of a drug in reducing blood pressure against its side-effects.... antihypertensive drugs

Preventing or relieving itching... antipruritic

Counteracting fever... antipyretic

A chemical sterilising substance to kill or control pathogenic microbes... antiseptic

Antiseptics prevent the growth of disease-causing micro-organisms without damaging living tissues. Among chemicals used are boric acid, carbolic acid, hydrogen peroxide and products based on coal tar, such as cresol. Chlorhexidines, iodine, formaldehyde, ?avines, alcohol and hexachlorophane are also used. Antiseptics are applied to prevent infection – for example, in preparing the skin before operation. They are also used externally to treat infected wounds.... antiseptics

A substance used to relieve or prevent spasms of the smooth muscles of the intestinal tract, bronchi, or uterus.(Examples: barbiturates, Garrya.)... antispasmodic

Any one of various preparations that contain ANTIBODIES which combine and neutralise the effects of a particular toxin (see TOXINS) released into the bloodstream by BACTERIA. Examples are the toxins produced by DIPHTHERIA and TETANUS. Antitoxins are produced from the blood of humans or animals that have been exposed to a particular toxin – whether by INFECTION or by INOCULATION – and thus have produced antibodies against it. They are usually given by intramuscular injection.... antitoxin

Controlling or preventing cough... antitussive

Antibody mixtures produced by an animal after exposure to small doses of an injected venom that may be harmful to man. As the doses are small, the injection is not lethal and antibodies are formed. This resultant antibodymixture is then collected from the animal’s blood, purified, concentrated, and thus becomes an antivenom. It can then be injected into humans to counteract symptoms (or death) produced by the venom of the animal potentially lethal to humans. An antivenom is specific for the venom against which it is prepared, and does not neutralise other antivenoms. A rare exception to this is Tiger snake (Notechis scutatus) antivenom which can be used to effectivelycounteract the venom of the sea snakes if specific sea snake antivenom is not available.... antivenom

ARRHYTHMIA is a variation in the normal rhythm of the heartbeat. Management of the condition requires accurate diagnosis of the type, and ELECTROCARDIOGRAPHY is vital in this process (see HEART, DISEASES OF). Drug treatment is usually part of the management, and antiarrhythmic drugs can be divided clinically into those that act on supraventricular arrhythmias, those that act on both supraventricular and ventricular arrythmias, and those that act on ventricular arrythmias. Respective examples are VERAPAMIL, DISOPYRAMIDE and LIDOCAINE. This large group of drugs can also be classi?ed according to their effects on the electrical reactions of active myocardial cells. The many drugs available are described in the British National Formulary.... antiarrhythmic drugs

A group of drugs, which include ANTIBIOTICS, used to treat infections caused by BACTERIA. Drugs include CEPHALOSPORINS and cephamycins, TETRACYCLINES, AMINOGLYCOSIDES, MACROLIDES, and antituberculous compounds.... antibacterial drugs

Any compound that inhibits the activity of CHOLINESTERASE, thus permitting ACETYLCHOLINE to continue its function of transmitting nerve impulses. Drugs with anticholinesterase properties include distigmine, NEOSTIGMINE and PHYSOSTIGMINE.... anticholinesterase

An agent that kills or inhibits fungi, and, in my usage here, an herb that inhibits either a dermatomycosis like ringworm or athlete’s foot, or one that inhibits Candida albicans either externally as a douche or internally as a systemic antifungal. (Examples: Nystatin, griseofulvin, Tabebuia.)... antifungal

These widely used drugs include a range of different preparations which relieve DEPRESSION. All the antidepressants available at the time of writing are more or less equally e?ective. In studies where patients agree to take either antidepressants or identical dummy PLACEBO pills (without knowing which), at least two-thirds of those who receive antidepressants feel much better within three months, while fewer than one-third of those on placebos recover naturally in the same period. In general these drugs are useful for severe and moderate depression including postnatal illness; they are not e?ective in milder forms of depression although they may be tried for a short time if other therapies have failed.

The most widely prescribed type of antidepressants are the tricyclics, so-called because their molecular structure includes three rings. The other commonly used types are named after the actions they have on chemicals in the brain: the SELECTIVE SEROTONIN-REUPTAKE INHIBITORS (SSRIS) and the MONOAMINE OXIDASE INHIBITORS (MAOIS) – see also below. All types of antidepressant work in similar ways. Tricyclic antidepressants have cured depression in millions of people, but they can cause unpleasant side-effects, particularly in the ?rst couple of weeks. These include SEDATION, dry mouth, excessive sweating, CONSTIPATION, urinary problems, and impotence (inability to get an erection). Up to half of all people prescribed tricyclic drugs cannot tolerate the side-effects and stop treatment before their depression is properly treated. More seriously, tricyclics can upset the rhythm of the heart in susceptible people and should never be given in the presence of heart disease.

The SSRIs are newer, coming into wide use in the late 1980s. They increase the levels in the brain of the chemical messenger SEROTONIN, which is thought to be depleted in depression. Indeed, the SSRIs are as e?ective as tricyclics and, although they can cause nausea and excessive sweating at ?rst, they generally have fewer side-effects. Their main disadvantage, however, is that they cost much more than the most commonly used tricyclic, amitriptyline. On the other hand, they are more acceptable to many patients and they cause fewer drop-outs from treatment – up to a quarter rather than a half. The money saved by completed, successful treatment may outweigh the prescribing costs. SSRIs have been reported as associated with an increased risk of suicide.

Another group of antidepressants, the MAOIs, have been in use since the late 1950s.

They are stimulants, rather than sedatives, and are particularly helpful for people who are physically and mentally slowed by depression. They work well but have one big disadvantage – a dangerous interaction with certain foods and other drugs, causing a sudden and very dangerous increase in blood pressure. People taking them must carry an information card explaining the risk and listing the things that they should avoid. Because of this risk, MAOIs are not used much now, except when other treatments have failed. A new MAOI, moclobemide, which is less likely to interact and so cause high blood pressure, is now available.

LITHIUM CARBONATE is a powerful antidepressant used for intractable depression. It should be used under specialist supervision as the gap between an e?ective dose and a toxic one is narrow.

St John’s Wort is a popular herbal remedy which may be e?ective, but which is handicapped by di?erences of strength between di?erent preparations or batches. It can interact with a number of conventional drugs and so needs to be used cautiously and with advice.

In general, antidepressants work by restoring the balance of chemicals in the brain. Improved sleep and reduced anxiety are usually the ?rst signs of improvement, particularly among people taking the more sedative tricyclic drugs. Improvement in other symptoms follow, with the mood starting to lift after about two weeks of treatment. Most people feel well by three months, although a few residual symptoms, such as slowness in the mornings, may take longer to clear up. People taking antidepressants usually want to stop them as soon as they feel better; however, the risk of relapse is high for up to a year and most doctors recommend continuing the drugs for around 4–6 months after recovery, with gradual reduction of the dose after that.

Withdrawal reactions may occur including nausea, vomiting, headache, giddiness, panic or anxiety and restlessness. The drugs should be withdrawn gradually over about a month or longer (up to six months in those who have been on maintenance treatment).

A wide range of antidepressant drugs is described in the British National Formulary. Examples include:

Tricyclics: amitryptyline, imipramine, doxepin.

MAOIs: phenelzine, isocarboxazid.

SSRIs: citalopram, ?uoxetine, paraxtene. (Antidepressant drugs not in these three

groups include ?upenthixol, mertazapine and venlafaxine.)... antidepressant drugs

Antihistamine drugs antagonise the action of HISTAMINE and are therefore of value in the treatment of certain allergic conditions (see ALLERGY). They may be divided into those with a central action (e.g. ?upheniramine and cyclizine) and those such as loratidine and terfenadine with almost no central action. Antihistamines are also of some value in the treatment of vasomotor RHINITIS (see also under NOSE, DISORDERS OF); they reduce rhinorrhoea and sneezing but are usually less e?ective in relieving nasal congestion. All antihistamines are useful in the treatment of URTICARIA and certain allergic skin rashes, insect bites and stings, as well as in the treatment of drug allergies. Chlorpheniramine or promethazine injections are useful in the emergency treatment of angio-oedema (see under URTICARIA) and ANAPHYLAXIS.

There is little evidence that any one antihistamine is superior to another, and patients vary considerably in their response to them. The antihistamines di?er in their duration of action and in the incidence of side-effects such as drowsiness. Most are short-acting, but some (such as promethazine) work for up to 12 hours. They all cause sedation but promethazine, trimeprazine and dimenhydrinate tend to be more sedating while chlorpheniramine and cyclizine are less so, as are astemizole, oxatomide and terfenadine. Patients should be warned that their ability to drive or operate machinery may be impaired when taking these drugs, and that the effects of ALCOHOL may be increased.... antihistamine drugs

Acting against heat or inflammation... antiphlogistic

An agent that limits or decreases inflammation; an anti­inflammatory or antihistamine.... antiphlogistine

See NEUROLEPTICS.... antipsychotic drugs

A condition that causes inflammation and pain in the joints and muscles... antirheumatic

Acting against scurvy... antiscorbutic

An agent that experimentally inhibits the proliferation and viability of infectious viruses. In our domain of herbal medicines, some plants will slow or inhibit the adsorption or random initial attachment of viruses, extend the lifespan of infected target cells, or speed up several aspects of immunity, including complement, antibody, and phagocytosis responses. Herbal antivirals work best on respiratory viruses such as influenza, adenoviruses, rhinoviruses, and the enteric echoviruses. Touted as useful in the alphabet group of slow viruses (HIV, EBV, CMV, etc.), they really help to limit secondary concurrent respiratory infections that often accompany immunosuppression.... antiviral

A rare genetic disorder in which a person is missing the enzyme alpha1-antitrypsin, which protects the body from damage by other enzymes.

The disease mainly affects tissues in the lungs, resulting in emphysema, and the liver, causing cirrhosis.

The effects of alpha1-antitrypsin deficiency may not become apparent until after the age of 30.

There is no cure, but symptoms can be relieved by drug treatment.

In severe cases, a liver transplant may be a possibility.... alpha-antitrypsin deficiency

See ADH.... antidiuretic hormone

A group of drugs used to treat diabetes mellitus, in which a lack of insulin, or resistance to its actions, results in raised blood glucose levels. A wide range of antidiabetics are used to keep the blood glucose level as close to normal as possible, and consequently reduce the risk of complications such as vascular (blood vessel) disease.

Antidiabetic drugs include insulin, which must be administered by injection, and oral hypoglycaemics such as glibenclamide and metformin. Acarbose and guar gum reduce or slow absorption of carbohydrate from the intestines after meals. Repaglinide stimulates insulin release from the pancreas for a short time and may be taken directly before meals. Rosiglitazone reduces resistance to the effects of insulin in the tissues and may be used together with other hypoglycaemics.... antidiabetic drugs

A preparation containing antibodies (also known as immunoglobulins) that combine with specific antigens (foreign proteins), usually components of microorganisms, leading to deactivation or destruction of the microorganisms.

Antiserum is usually used, along with immunization, as an emergency treatment when someone has been exposed to a dangerous infection such as rabies and has not previously been immunized.... antiserum

Impulsive, destructive behaviour that often disregards the feelings and rights of others.

People who have an antisocial personality lack a sense of guilt and cannot tolerate frustration.

They may have problems with relationships and are frequently in trouble with the law.

Behaviour therapy, and various forms of psychotherapy, may help to improve integration.

In general, the effects of this disorder decrease with age.... antisocial personality disorder

Drugs used to treat hyperthyroidism, in which the thyroid gland is overactive. They may be used as the sole treatment or before thyroid surgery. Carbimazole and propylthiouracil interfere with the production of thyroid hormone by the gland.... antithyroid drugs

See antibody, monoclonal.... monoclonal antibody

A type of antidepressant drug.

Tricyclic antidepressants prevent neurotransmitters in the brain from being reabsorbed, thereby increasing their level.

Examples are amitriptyline, clomipramine, and imipramine.... tricyclic antidepressants

n. a drug that prevents or reduces the severity and frequency of seizures in various types of epilepsy; the term antiepileptic drug is now preferred since not all epileptic seizures involve convulsions. The choice of drug is dictated by the type of seizure and the patient’s response, and the dosage must be adjusted carefully as individuals vary in their response to these drugs and side-effects may be troublesome. Commonly used antiepileptic drugs include *carbamazepine, *lamotrigine, *phenytoin, *sodium valproate, levetiracetem, topiramate, *gabapentin, pregabalin, and oxcarbazepine. Phenobarbital is no longer commonly prescribed.

Certain anticonvulsants have shown efficacy in treating bipolar disorder and chronic pain, as in postherpetic neuralgia or *peripheral neuropathy, and can be used to prevent migraine and other primary headache syndromes.... anticonvulsant

1. adj. describing a drug that reduces *inflammation. The various groups of anti-inflammatory drugs act against one or more of the mediators that initiate or maintain inflammation. Some groups suppress only certain aspects of the inflammatory response. The main groups of anti-inflammatory drugs are the *antihistamines, the glucocorticoids (see corticosteroid), and the nonsteroidal anti-inflammatory drugs (see NSAID). 2. n. an anti-inflammatory drug.... anti-inflammatory

See ANALGESICS; NON-STEROIDAL ANTIINFLAMMATORY DRUGS (NSAIDS).... anti-inflammatory drugs

Lesch.

Anthocephalus cadamba Miq.

Synonym: A. indicus A. Rich. A. chinensis (Lam.) A. Rich. ex Walp.

Family: Rubiaceae.

Habitat: Assam, Bengal, southwards to Andhra Pradesh and western Ghats.

English: Kadam.

Ayurvedic: Kadamba, Priyaka, Vrtta-pushpa, Nipa, Halipriya. Kadambaka is equated with Adina cordifolia.

Siddha/Tamil: Venkadambu, Vellai Kadambam.

Action: Stembark—febrifugal, antidiuretic, anthelmintic, hypo- glycaemic. Fruit—cooling; anti- catarrhal, blood purifier, analgesic.

Family: Moraceae.

Habitat: Western Ghats from Konkan southwards to Trivandrum, up to 600 m.

English: Sacking tree, Upas tree.

Ayurvedic: Valkala vrksha.

Siddha/Tamil: Aranthelli, Mara-uri, Nettavil.

Folk: Jangali Lakuch, Jasund, Chaandakudaa.

Action: Seed—febrifuge, antidysen- teric (in minute doses). Latex— circulatory stimulant (in minute doses.)

The latex contains a series of poisonous cardenolides, of which alpha- and/or beta-antiarin are the main components. The total amount of crystalline cardiac glycosides in the latex ranges from 0.1 to 2.5%; alpha-antiarin from 0.0 to 1.38% and beta-antiarin from 0.075 to 1.44%. Antiarins are said to act on the heart more powerfully than digitalin. Beta-antiarin is more potent than alpha-antiarin.

Latex, in small quantities, is a mild cardiac and circulatory stimulant, whereas in large quantities it acts as a myocardial poison. It stimulates intestinal and uterine contractions.

As many as 34 Kedde-positive substances were reported in the seed sample from Indonesia. The latex sample showed the presence of 29 Kedde- positive substances.... antiaris toxicaria

Relieving asthma... antiasthmatic

Antibodies are substances in the blood which destroy or neutralise various toxins or ‘bodies’

(e.g. bacteria), known generally as antigens (see ANTIGEN). The antibodies are formed, usually, as a result of the introduction into the body of the antigens to which they are antagonistic, as in all infectious diseases (see ALLERGY; IMMUNITY).... antibodies

(Greek) In mythology, the mother of Odysseus Antiklea, Antiklia... anticlea

Anticoagulants are drugs which inhibit COAGULATION of the blood. They are used to prevent and treat abnormal clotting of the blood, to treat THROMBOSIS, and sometimes to prevent or treat STROKE or TRANSIENT ISCHAEMIC ATTACKS OR EPISODES (TIA, TIE). Anticoagulant drugs are also prescribed preventively in major surgery to stop abnormal clotting from occurring; HAEMODIALYSIS is another procedure during which these drugs are used. Anticoagulants are also prescribed to prevent thrombi (clots) forming on prosthetic heart valves after heart surgery.

The drugs are much more e?ective in the treatment and prevention of venous clotting – for example, deep vein thrombosis (DVT), see under VEINS, DISEASES OF – than in preventing thrombosis formation in arteries with their fast-?owing blood in which thrombi contain little ?brin (against which the anticoagulants work) and many PLATELETS.

The main anticoagulants now in use are the natural agent HEPARIN (a quick-acting variety and a low-molecular-weight long-acting type); synthetic oral anticoagulants such as WARFARIN and the less-often-used acenocoumarol and PHENINDIONE; and antiplatelet compounds such as ASPIRIN, clopidogrel dipyridamole and ticlopidines. Fondaparinux is an extract of heparin which can be given once daily by injection; ximelagatran, an inhibitor of thrombin, is being trialled as the ?rst new oral anticoagulant since heparin.

Patients taking anticoagulants need careful medical monitoring and they should carry an Anticoagulant Card with instructions about the use of whatever drug they may be receiving – essential information should the individual require treatment for other medical conditions as well as for thrombosis.... anticoagulants

Drugs that reduce or prevent the severity of an epileptic convulsion or seizure (see EPILEPSY). The nature of the ?t, and the patient’s reaction to it, in?uences the type of anticonvulsant used. Anticonvulsants inhibit the high level of electrical activity in the brain that causes the ?t. Among regularly used anticonvulsants are carbamazepine, sodium valproate, clonazopam, lamotrigine, gabapentin, vigabatrin, and topiramate. Older drugs such as phenytoin and primidone remain useful in some patients. Intravenous anticonvulsants, such as diazepam, are used for rapid control of epileptic status.... anticonvulsants

Initial treatment of acute DIARRHOEA is to prevent or correct the loss of ?uid and ELECTROLYTES from the body. This is a priority especially in infants and elderly people. Rehydration can be achieved orally or, in severe cases, by urgent admission to hospital for the replacement of ?uid and electrolytes.

For adults with acute diarrhoea, short-term symptomatic treatment can be achieved with antimotility drugs such as codeine phosphate, co-phenotrope or loperamide hydrochloride. Adsorbent drugs, for example, KAOLIN, should not be used in acute diarrhoea, but bulk-forming drugs – ispaghula or methylcellulose

– can help to control the consistency of faeces in patients with ileostomies and colostomies (see ILEOSTOMY; COLOSTOMY), or those with diarrhoea caused by DIVERTICULAR DISEASE.

Irritable bowel syndrome, malabsorption syndrom, ulcerative colitis, Crohn’s disease and diverticular disease are often accompanied by diarrhoea; for more information on these conditions, see under separate entries.

ANTIBIOTICS may sometimes cause diarrhoea and this side-e?ect should be borne in mind when the cause of the condition is being investigated.... antidiarrhoeal treatments

See VASOPRESSIN.... antidiuretic hormone (adh)

An antidote is a therapeutic substance used to counteract the toxic action(s) of a speci?c substance. Very few substances have an antidote.... antidotes

Relieving dyspepsia or indigestion... antidyspeptic

Preventing or controlling diarrhea... antidiarrheal

(Greek) In mythology, the daughter of Oedipus

Antigoni, Antigonie, Antigony, Antigoney, Antigonea, Antygone, Antygoni, Antygonie, Antygonee... antigone

See ANTHELMINTICS.... antihelminthic

Controlling bleeding ... antihemorrhagic

Reducing high blood pressure... antihypertensive

Controlling inflammation... antiinflammatory

An agent which prevents the formation of calculi or promotes their dilution... antilithich

A group of drugs used in the treatment of certain forms of malignant disease. Chemically, they closely resemble substances (or METABOLITES) which are essential for the life and growth of CELLS. Antimetabolites are incorporated into new nuclear material in the cell or combine irreversibly with essential cellular enzymes, thus disrupting normal cellular division (see MITOSIS and MEIOSIS) and causing death of the cell. There is now a range of antimetabolites including CYTARABINE, METHOTREXATE, FLUOROURACIL and MERCAPTOPURINE.... antimetabolites

An agent that kills or inhibits microorganisms.... antimicroblal

A pharmacological e?ect where the action of ACETYLCHOLINE, a chemical neurotransmitter released at the junctions (synapses) of parasympathetic and ganglionic nerves, is inhibited. The junctions between nerves and skeletal muscles have nicotinic receptors. A wide range of drugs with antimuscarinic effects are in use for various disorders including PSYCHOSIS, BRONCHOSPASM, disorders of the eye (see EYE, DISORDERS OF), PARKINSONISM, and problems of the GASTROINTESTINAL TRACT and URINARY TRACT. (See also ANTISPASMODICS.)... antimuscarine

(Greek) In mythology, a queen of the Amazons... antiope

Preventing the regular recurrence of a disease... antiperiodic

A movement in the bowels and stomach by which the food and other contents are passed upwards, instead of in the proper direction. (See PERISTALSIS.)... antiperistalsis

Measures used to reduce temperature in FEVER. Varieties include cold-sponging, wet-packs, baths and diaphoretic (sweat-reducing) drugs such as QUININE, salicylates and ASPIRIN.... antipyretics

Preventing or curing rickets... antirachitic

Treating scrofula or tubercular swellings of the lymph glands... antiscrofulous

These are antimuscarinic drugs (see ANTIMUSCARINE) which have the property of relaxing smooth muscle. Along with other antimuscarinic drugs, antispasmodics may be helpful supportive treatment for patients with non-ulcer DYSPEPSIA, IRRITABLE BOWEL SYNDROME (IBS) and DIVERTICULAR DISEASE. Examples of antispasmodic drugs are ATROPINE sulphate, dicyclomine bromide and propantheline (a synthetic antimuscarinic drug used as a treatment adjunct in gastrointestinal disorders and also for controlling urinary frequency), bromide, alverine, mebervine and peppermint oil. With the arrival of more powerful and speci?c antisecretory drugs, such as the histamine H2-receptor antagonists – examples are CIMETIDINE and RANITIDINE – the use of antispasmodics has declined.... antispasmodics

Opposing spasms or convulsions... antispsmodic

Counteracting excessive acidity in the urine... antiuric

Antibody which reacts with an antigen which has not stimulated its production (i.e. a crossreacting antibody).... heterophil antibody

See HLA SYSTEM.... human leucocyte antigen (hla)

An arti?cially prepared antibody (see ANTIBODIES) obtained from cell clones – a genetically identical group of cells – and comprising a single type of immunoglobulin. It neutralises only one speci?c ANTIGEN. The antibodies are prepared by linking antibody-forming lymphocytes (see LYMPHOCYTE) from the spleen of mice with myeloma cells from mice. Monoclonal antibodies are used in the development of new vaccines and in the study of human cells, hormones, and micro-organisms. Research is under way for their use in the treatment of some forms of cancer. (See IMMUNOLOGY.)... monoclonal antibodies

As used by immunologists, this term refers to IgE antibodies. As used by microbiologists, it refers to antibodies produced in syphilis – probably in response to the tissue damage caused by Treponema pallidum. Production of these antibodies in patients with syphilis has been utilised in the development of the non-treponemal serological tests for syphilis such as the VDRL Test, the RPR Test and the now superceded Wasserman Complement Fixation Test. These tests are useful in that they are only positive in active syphilis but they have many biological false positive reactions, including pregnancy.... reaginic antibody

Herbs that check any tendency to miscarriage. They should be prescribed by a practitioner and may include: Raspberry leaves, Cramp bark, Lobelia, etc. See: ABORTION. ... anti-abortives

Herbs that relieve the symptoms of asthma. According to the case the remedy may be an expectorant, antispasmodic, bronchodilator or a combination of each. A large group including:– Belladonna, Black Haw bark, Comfrey, Ephedra, Elecampane, Euphorbia, Evening Primrose, Gelsemium, Irish Moss, Lobelia, Mullein, Senega, Storax, Stramonium, Wild Cherry bark and Wild Yam are all of practitioner use. ... anti-asthmatics

Basil tea is an Ayurvedic natural remedy used to treat a wide variety of diseases such as asthma, diabetes and high cholesterol. Hindus worship the plant for its religious significance as well. Basil Tea description Basil, a plant from the mint family, is original from India and Asia. It is an aromatic herb with a strong fragrance being largely used in spaghetti sauces, stews and tomato recipes. Basil is a source of vitamins and other nutrients.  Studies showed that this herb has anti-bacterial and anti-inflammatory health properties, fighting against intestinal problems, headaches and ulcers, as well. In aromatherapy, basil is used to alleviate mental fatigue. Basil tea is the resulting beverage from brewing the abovementioned plant. Basil Tea brewing To prepare Basil tea:

• bring the water and the basil leaves to boil (in a small tea pan)
• lower the heat and allow it to brew for 3-4 minutes
• add the tea leaves or tea bags and sugar according to taste
• bring to boil
• turn off the heat
• strain it into cups and add milk according to taste

Basil Tea benefits Studies claimed that Basil Tea is successesfully used to:

• treat intestinal colics, gastric ulcers and bloating/swelling of the abdomen
• treat anorexia
• fight urinary tract infections
• help against diarrhea
• help fight insomnia
• help treat lesions and inflammations in the mouth
• enhance the body’s ability to resist stress
• help to relieve pain

Basil Tea side effects Basil tea side effects are generally associated to large intakes. There have been thus noticed:shallow breathing, blood in the urine or sputum, mouth and throat burns, nausea, racing heartbeat, seizures, dizziness and coma. Pregnant or breastfeeding women, as well as women trying to become pregnant should not use Basil tea. Basil tea has anti-inflammatory and anti-microbial properties, proving itself to be an important adjuvant in treating arthritis, fevers and other ailments. It is also constantly used to add savor to several dishes.... basil tea has anti-inflammatory properties

Calendula tea can be consumed for its healing properties as well as for its taste. It is efficient in treating a large array of diseases, being an important ingredient in the pharmaceutical industry. Calendula Tea description Calendula, or ‘marigold’, is an orange or yellow flower, originating from the northern Mediterranean countries. In Roman Catholic Church, calendulas are used in the events honoring the Virgin Mary. In households, marigold flavors and colors cereals, rice and soups. Nowadays, calendula is appreciated for its ornamental features.   Calendula tea is the resulting beverage from brewing the abovementioned plant. Calendula Tea brewing Calendula Tea is prepared by steeping dried calendula flowers in boiling water for about 5 minutes. After taking it out of the heat, strain it and drink it slowly. Calendula Tea benefits Calendula tea is successfully used as:

• an anti-inflammation and anti-bacterial adjuvant
• an immuno-stimulator
• an ear infections aid
• a conjunctivitis treatment
• a collagen production stimulator
• a sore throat and a mouth inflammation adjuvant
• a gastrointestinal disorders treatment
• a menstruation cycle regulator
• a body detoxifier (after an operation)
• a soothing skin treatment
• a minor burns healer
• a toothache mitigator
• a flu adjuvant

Calendula Tea side effects As a topical treatment, Calendula tea should not be applied on open wounds. Also, allergic responses were noticed by people allergic to ragweed, chrysanthemums and other plants from the daisy or aster family. Calendula tea is best known for its anti-inflammatory and anti-bacterial properties, but also for its healing properties for gastrointestinal disorders.... calendula tea is anti-bacterial

Chaga tea is a medicinal beverage with anti-inflammatory and anti-cancer properties. It is also an adjuvant in the liver treatment. Chaga Tea description Chaga is an irregularly-shaped polypore fungus (a mushroom), mainly found on the wounds of birch trees, on elm trees, alder trees and ironwood trees. This mushroom has a brown color, its veins being white or cream. It is acknowledged to hold less water than other types of mushrooms. In North Europe and Russia, the chaga mushroom has been used for a long period of time as a popular medicine remedy. Scientists have demonstrated that chaga has anti-cancer, anti-inflammatory, antiviral and immune-stimulating actions. It could also be used to relieve pain. Changa tea is the resulting beverage from brewing the abovementioned mushroom. Chaga Tea brewing Chaga tea is prepared in the following way:

• shred the Chaga mushrooms
• soften the pieces in cold water for about five hours
• get the softened mushrooms out
• save the liquid
• add heated water to the softened mushrooms
• let the mixture stand for about 2 days
• mix the resultant Chaga tea with the saved liquid from the softening process
• drink it slowly

Chaga tea may be consumed three times a day. Chaga Tea benefits Chaga tea has been successfully used to:

• boost and strengthen the immune system
• help in the treatment of various stomach diseases
• help in expelling intestinal worms
• help in the treatment of liver problems
• help in the treatment of certain heart ailments, including hypertension
• help in fighting tumors and lowering the risk of certain cancers (like breast, liver, uterus and stomach cancers)
• help in the treatment of diabetes
• act against HIV
• treat inflammations

Chaga Tea side effects Before drinking Chaga tea, consult a health care provider. Chaga tea is a natural beverage used as a treatment for diabetes, several heart ailments as well as for inflammations.... chaga tea has anti-cancer properties

Herbs with an affinity for the liver and gallbladder, prescribed for inflammation of those organs and promotion of bile.

Balmony, Barberry, Betony, Bitter root, Black root, Centuary, Chamomile, Dandelion, Fringe Tree, Fumitory, Goldenseal, Holy Thistle, Hops, Mountain Grape, Mugwort, Pomegranate bark, Vervain, Wahoo, Wild Yam, Wormwood. ... anti-bilious

Linn.

Family: Euphorbiaceae.

Habitat: The warmer regions of India; often cultivated for hedges.

English: Triangular Spurge.

Ayurvedic: Snuhi (Substitute), Vajra-kantaka, Vajratundi

Siddha/Tamil: Chathurakkali.

Folk: Tridhaari, Tidhaaraa Sehunda.

Action: Latex—purgative. Applied on burns. Plant—used in dropsy, anasarca, sores, venereal sores, syphilis; also in dysentery, bronchitis, asthma. Root—anthelmintic. Fresh stems—used for skin sores and scabies. A decoction of stems is given in gout.

The stems yielded friedelan-3 alpha- ol and 3 beta-ol, taraxerol and taraxe- rone. The roots yielded taraxerol. Latex gave beta-amyrin, cycloartenol, euphol (70%) and alpha-euphorbol.... euphorbia antiquorum

(Linn.) Wall.

Synonym: H. pubescens (Buch.- Ham.) Wall. ex G. Don.

Family: Apocynaceae.

Habitat: The tropical Himalayas, going up to an altitude of 1,100 m. Also found throughout many forests of India, in Travancore, Assam and Uttar Pradesh.

English: Easter tree, Ivory tree, Tellicherry Bark.

Ayurvedic: Kutaja, Girimallikaa, Kaalinga, Kalingaka, Indravrik- sha, Shakra, Vatsa, Vatsaka, Shakraahvya. Indrayava, Indrabija, Vatsabija (seed). Kurchi (bark).

Unani: Inderjo talkh, Teewaaj-e- Khataai.

Siddha/Tamil: Kudasappaalai-pattai, -vidai (bark, seed).

Action: Root and bark—used in amoebic dysentery. Bark—astringent, anthelmintic, amoebicidal, diuretic. Used in colic, dyspepsia, piles, diseases of the skin and spleen. Seed—antibilious. Used for promoting conception, also for toning up vaginal tissues after delivery.

The bark contains the alkaloids, regholarrhenine-A, -B, -C, -D, -E and -F; pubescine, norholadiene, pubes- cimine, kurchinin, kurchinine, kur- chinidine, holarrifine, holadiene, kurchilidine, kurchamide, kurcholes- sine, kurchessine, conessine, cones- simine and isoconessimine, and the steroidal compounds kurchinicin and holadyson.

The alkaloid conessine is used as a therapeutic drug for the treatment of dysentery and helminthic disorders. Conessine and conimine inhibited the growth of Shigella sonnei, S. flexneri and Salmonella enteritidis strains in vitro. In chronic amoebiasis, Bi-iodide compound of total alkaloids, given orally, compare favourably with emetine Bi-iodide.

The plant possesses potent immuno- stimulant property.

The Kurchi seeds are sold as a substitute for Strophanthus sp. seeds in Indian market. (Seeds of Strophanthus sp. contain a toxic glucoside, strophan- thin, and are poisonous.)

Dosage: Stem bark—20-30 g for decoction. (API Vol. I); seed—3- 6 g powder; 20-30 g for decoction. (API Vol. III.)... holarrhena antidysenterica

These act by inhibiting the formation of PROSTAGLANDINS which are mediators of INFLAMMATION. They act both as ANALGESICS to relieve pain, and as inhibitors of in?ammation. Aspirin is a classic example of such a compound. Newer compounds have been synthesised with the aim of producing fewer and less severe side-effects. They are sometimes preferred to aspirin for the treatment of conditions such as RHEUMATOID ARTHRITIS, OSTEOARTHRITIS, sprains, strains and sports injuries. Their main side-effects are gastrointestinal: gastric ulcers and gastric haemorrhage may result (see STOMACH, DISEASES OF). This is because prostaglandins are necessary for the production of the mucous protective coat in the stomach and, when the production of prostaglandin is inhibited, the protection of the stomach is compromised. NSAIDs should therefore be used with caution in patients with DYSPEPSIA and gastric ulceration. The various nonsteroidal anti-in?ammatory drugs di?er little from each other in e?cacy, although there is considerable variation in patient response. Ibuprofen is one of the ?rst choices in this group of drugs as it combines good e?cacy with a low incidence of side-effects and administration is only required twice daily. Other drugs in this series include diclofenac, fenbufen, fenclofenac, fenoprofen, feprazone, ?urbiprofen, indomethacin, indoprofen, ketoprofen, ketorolac, naproxen, piroxicam, sulindac, tiaprofenic acid and tolmetin.... non-steroidal anti-inflammatory drugs (nsaids)

Remedies that inhibit release of acetylcholine as a neuro-transmitter. Given for anti-depressant therapy. May have side-effects of dry mouth, drowsiness, blurred vision. Administered by a qualified practitioner. Two chief remedies: Belladonna (atropa) and Henbane (hyoscyamus). They reduce acid secretion but are sometimes given with Comfrey and other tissue builders to promote healing. Anti-cholinergics decrease secretion of gastric juices by their control of the vagus nerve. ... anti-cholingergics

Herbs that keep the blood ‘flowing’ by preventing clotting or clumping of the platelets. Anti-coagulants are justified after myocardial infarction, may prevent cardiac death, and are not outweighed by adverse reactions. Of value in thrombosis.

Bayberry, Cowslip root (Biostrath), Garlic, Ginseng, Lime flowers. ... anti-coagulants

Usually refers to children with fevers. Herbs for a febrile seizure, or for prevention and reduction of epileptic fits. Usually given orally, but where this is not possible a rectal injection or a suppository (such as Valerian) may be used. Another term for ‘antispasmodics’. ... anti-convulsants

Anti-diabetics have an ability to counter hyperglycaemia and are of value for diabetes mellitus.

1st degree. Goat’s Rue, Fenugreek Seeds, Garlic, Jambul.

2nd degree. Damiana, Nettles, Pipsissewa, Olive leaves, Karela, White Horehound, Sweet Sumach, Mountain Grape, Fennel. ... anti-diabetics

An ENZYME produced by glandular tissue in the PROSTATE GLAND. When the gland enlarges (see PROSTATE, DISEASES OF), greater amounts of PSA are secreted, raising the concentration of the enzyme in the blood. This is especially so in cancer of the prostate, and testing the level of PSA is an indicator that the disease may be present. There is much controversy about the use of PSA as a screening test. Its proponents claim that its use reduces deaths from prostate cancer; its opponents suggest that it does this only by bringing to light many cases that needed no treatment and would not have caused death in any case. Further, if the level of PSA is very high, the disease is already advanced; where the result is equivocal it is uncertain whether the bene?ts of treatment outweigh the risks.... prostate specific antigen (psa)

This group of drugs is one of three main types of drugs used to treat DEPRESSION, and was the ?rst to be introduced (in the 1950s). Tricyclic drugs work by blocking the re-uptake of the neurotransmitters SEROTONIN and NORADRENALINE (see NEUROTRANSMITTER), thus increasing the amount of the neurotransmitters at the nerve cell’s receptors. In people with depression, fewer neurotransmitters than normal are released, resulting in a slowing of neural activities. The drugs have a sedative e?ect, which can be useful for depressives with sleep problems, and an antimuscarinic action which can cause dry mouth and constipation (see ANTIMUSCARINE). Overdosage can produce COMA, ?ts (see SEIZURE) and irregular heart rhythm (ARRHYTHMIA). They are sometimes used for treating bed-wetting. (See also ANTIDEPRESSANT DRUGS.)... tricyclic antidepressant drugs

Agents that reduce the production of mucus. Angelica, Avens, Bayberry, Bistort, Blood root, Cayenne, Chamomile (German), Coltsfoot, Comfrey, Elderflowers, Elecampane, Eyebright, Fenugreek, Garlic, Ginger, Goldenseal, Gotu Kola, Ground Ivy, Hyssop, Iceland Moss, Irish Moss, Juniper, Liquorice, Marsh Cudweed, Marshmallow, Mountain Grape, Mouse Ear, Mullein, Myrrh, Parsley, Plantain, Poke root, Senega, Skunk Cabbage, White Horehound, Wild Cherry bark, Wild Indigo, Witch Hazel, Yarrow. Successful treatment of catarrh is often dependent upon efficient kidney, skin and bowel function which may require also, diuretics, alteratives and laxatives. ... anti-catarrhals

Agents that lift depression without sedation. Thymoleptics. Mood raisers. They may exert an antagonising action or specifically influence any particular organ that might be responsible i.e., Dandelion for depression caused by a congested liver; Hawthorn for circulatory stasis and Skullcap for cerebral congestion.

As indicated: Oats, Kola nuts, Balmony, Ginseng, Damiana, Lavender, Ladyslipper, Rosemary, Vervain. Yerbe Mate tea is used in Paraguay for this purpose.

For neurotic depression with obsessive and phobic states: Black Cohosh, Damiana, Kola, Betony and Oats.

No behavioural changes in children have been observed. Impressive safety record. Little effect upon the cardiovascular system. ... antidepressants

Herbs with an ability to arrest diarrhoea or soothe an irritable bowel. According to degree, an astringent may have a similar effect. A large group including:– Avens, Bistort, Catnep, Cinnamon, Hemlock Spruce, Holy Thistle, Kola nuts, Matico, Orris root, Rhatany root. ... anti-diarrhoeals

Remedies that allay a sense of nausea and prevent vomiting. Three most popular: Chamomile, Black Horehound, Meadowsweet. Others: Balm, Balmony, Barberry, Cayenne, Cinnamon, Cloves, Dill, Fennel, Fringe Tree bark, Iceland Moss, Lavender, Mountain Grape, Nutmeg, Peppermint.

A cup of Chamomile tea may sometimes alleviate the vomiting of cancer chemotherapy and radiation. ANTI-FATIGUE HERBS. Ginseng, Gotu Kola, Saw Palmetto, Kola. ... anti-emetics

Formula: Garlic 30mg; Garlic oil 1mg; dry extract Echinacea 100=22 13.2mg. Traditional remedy for the symptomatic relief of catarrh, rhinitis and nasal congestion. (Potters) ... antifect

See: CARMINATIVES. ... anti-flatulents

Fungicides. Herbs that destroy fungi, as in the treatment of thrush, candida, etc. Internal or external use: Aloe Vera, Tea Tree oil, Caprycin, Bitter-Sweet, Daisy, Blood root (skin), Castor oil, Common Ivy, Ground Ivy, Marigold, Eucalyptus oil, Scarlet Pimpernel, Echinacea, Life root, Myrrh, Witch Hazel, White Pond Lily, Wild Indigo, Poke root. Thuja and Garlic are perhaps the most widely used. Externally, used as dusting powders, creams, ointments.

Administration of anti-fungals should be accompanied by a sugarless diet. ... anti-fungals

Substances, usually harmful, that when entering the body stimulate the immune system to produce antibodies. Invaders may be polio virus, typhoid bacillus, or chain-like streptococcal bacteria – the usual pus-forming type found in infected wounds, or toxins they release into the blood stream. ... antigens

Herbs that reduce milk production. Sage.

ANTI-LITHICS. Agents used for elimination or dissolution of stone or gravel. Stone root, Parsley root, Hydrangea, Pellitory of the Wall, Gravel root. ... anti-lacteals

Remedies that arrest fungal growth on the skin or mucous membrane. See: ANTI- FUNGAL. ... anti-mycotics

Herbs that arrest or inhibit vomiting and nausea. Black Horehound. ... anti-nauseants

Herbs that prevent formation or destroy tumour cells. Some reported in the literature to arrest the spread of malignancy. A neoplasm is a new growth and may be malignant or non- malignant. Bayberry (intestinal), Bryonia (lung), Clivers (Genito-urinary tract), Comfrey (general), Condurango (gastric), Dandelion (liver), Echinacea, Greater Celandine (epithelial), Mandrake (face and skin), Mistletoe, Myrrh, Plantain (throat), Poke root (breast), Queen’s Delight, Red Clover (epithelial and breast), Rosebay Willowherb (gastric), Vinca rosea (leukaemia), Thuja (womb), Wild Violet (breast and womb), Yellow Dock. ... anti-neoplastics

A group of powerful astringents clinical experience has shown to be effective in arresting mild to moderate internal bleeding.

Digestive tract: Marigold, Comfrey, Bur-Marigold, Matico, Shepherd’s Purse, Holy Thistle, American Cranesbill, Goldenseal.

Anal/Rectal: Pilewort, Plantain, Matico, Rhatany root, Witch Hazel.

Mouth: Tormentil.

Nose-bleeds: Nettles.

Uterus. Shepherd’s Purse, Ladies Mantle, Greater Periwinkle, Beth root, Avens, Goldenseal. Urinary system. Bistort, Plantain, Marigold, Stone root, Horsetail, Bur-Marigold.

Lungs. Bugleweed, Elecampane, Lungwort.

Colon. Greater Burnet, Matico, Comfrey, Bistort, Wild Yam, Holy Thistle, Avens, Tormentil. Capillary haemorrhage. Buckwheat. ... anti-haemorrhagics

Agents that arrest production of histamine and which are useful in allergic conditions.

Herbal antihistamines may lessen severity of symptoms. Not limited by sedative, anticholinergic or central nervous system side effects. Nor do they impair psychomotor skills or potentiate the effect of alcohol. Non-sedating antihistamines are available for perennial allergic rhinitis, conjunctivitis and other conditions normally responsive to antihistamines including allergic skin reactions.

Garlic has powerful antihistamine properties. It is a vaso-constrictor and thus reduces swelling of mucosa of the nose and conjunctiva of the eye. It is of special value for purulent discharge. According to the individual case it works well with Hyssop, Angelica and Peppermint. Herbal antihistamines include: Juniper, Marshmallow root, Burdock, Parsley root, Cudweed, Elder, Ephedra, Eyebright, Echinacea, Goldenseal, Peppermint, Sage, Lobelia, Chaparral. One in common use among herbalists is Marigold (calendula), directed particularly against staphylococcus.

Ayurvedic Medicine, specific: equal parts Ginger root, Black Pepper and Aniseed. ... antihistamines

Herbs that stimulate the body’s immune system to withstand infection. Alternatives to anti-bacterial substances obtained from micro-organisms as penicillin, streptomycin etc. Those from herbs do not destroy beneficial bacteria normally present in the intestines, neither does the body get used to them.

Some essential oils are natural antibiotics. Others: Blue Flag root, Buchu, Chaparral, Butterbur, Echinacea, Feverfew, Garlic, Goldenseal, Holy Thistle, Horse Radish (Vogel), Juniper berries, Myrrh, Nasturtium, Poke root, Red Clover, Watercress (Vogel), Wild Indigo, Wild Thyme.

Vitamin C is a powerful antibiotic (1-2g daily).

ANTI-INFLAMMATORIES. A group of agents known to reduce inflammation. Action is not to suppress but to enable tissue to return to normal on the strength of its own resources. Some members of the group are helpful for chronic conditions such as polyarthritis and rheumatism caused by a sub-acute inflammation going on quietly over a long time. Others work by blocking prostaglandin synthesis. General. Chamomile (German, Roman), Cowslip root, Fennel, Feverfew, Heartsease, Mistletoe, Turmeric, Yellow Dock.

Specific. Bistort (bowel). Comfrey (bones). Devil’s Claw (muscles). St John’s Wort (nerve tissue). Lignum vitae (rheumatic joints). Poke root (lymph vessels). Eyebright (conjunctivitis: topical as an eye lotion). Horsechestnut (anus). Bogbean (liver and gall bladder).

Steroid-like action. Ginseng, Black Cohosh, Black Haw, Liquorice, Wild Yam.

Aspirin-like action. Birch, Black Willow bark, Meadowsweet, White Poplar bark, White Willow bark, Wintergreen.

Some types of inflammation may be reduced by herbs that stimulate the eliminatory organs – lungs, bowel, skin and kidneys. A timely enema may reduce a high temperature with inflammation, to expel toxins and unload an over-loaded bowel; (Dandelion root, Parsley root, Sarsaparilla).

ANTI-INFLAMMATION FORMULA. (Biostrath). Drops containing cultures combined with extracts derived from medicinal plants possessing known therapeutic properties: Arnica, Bryony, Balm, Chamomile, Horseradish, Marigold, Hypericum, Echinacea.

Indications: colic, inflammation of the alimentary tract. ... anti-infectives

Plant medicines that destroy or inhibit growth of disease-causing bacteria or other micro-organisms. Aniseed, Barberry, Bayberry, Bearberry, Benzoin, Blood root, Buchu, Camphor, Caraway oil, Catechu, Cayenne, Cinnamon, Clove, Cornsilk, Coriander, Echinacea, Elecampane, Eucalyptus, Fennel seed, Garlic, Gentian, Goldenseal, Guaiacum, Heather flowers (Calluna), Hemlock Spruce bark, Juniper, Kava Kava, Kino, Labrador tea, Lavender, Liquorice, Lovage root, Mandrake, Marigold, Marjoram, Meadowsweet, Mountain Grape, Myrrh, Nasturtium, Olive, Orthosiphon, Parsley root, Peppermint, Peruvian balsam, Plantain, Propolis, Rosemary, Rue, Sage, St John’s Wort, Southernwood, Thuja, Thyme, Turmeric, White Pond Lily, Wild Indigo, Wood Sage, Wormwood, Yarrow. ... anti-microbials

Another term for ANTHELMINTICS.

ANTI-PERIODICS. Remedies that prevent the return of a disease that tends to recur (malaria). Peruvian bark, Ash Tree (Fraxinus excelsior). ... anti-parasitics

Herbs that reduce sweating; anti-hidrotics.

Internal: White Willow bark, Red Sage.

External: Essential oils of Sage, Pine, Rosemary, Lavender. Blended with fresh lemon juice are marketed as a gentle spray without aerosol (Weleda). Zinc and Castor oil cream or ointment.

Bath preparations made from these oils; herbal soaps, massage oils. ... anti-perspirants

Remedies that inhibit the action of protozoa, a class of single-celled microscopic animals. Ipecacuanha, Peruvian bark. ... anti-protozoals

Agents to relieve intense itching. Chamomile, Chickweed, Clivers, Cucumber, Goldenseal, Marigold, Sarsaparilla, Peppermint, St John’s Wort. ... anti-pruritics

Another term for FEBRIFUGE. ... anti-pyretic

Herbs that may relieve discomforts of rheumatism and arthritis. Bearberry, Black Cohosh, Blue Cohosh, Black Willow, Bladderwrack, Blue Flag root, Bogbean, Boneset, Burdock, Calluna (Heather flowers), Cayenne, Celery seed, Chickweed, Couchgrass, Cowslip (Biostrath), Dandelion, Devil’s Claw, Guaiacum, Juniper, Lavender, Meadowsweet, Mountain Grape, Nettles, Parsley root, Poke root, Prickly Ash, Sarsaparilla, Pipsissewa, White Poplar, Wild Yam, Wintergreen, Wood Sage, Willow (Biostrath), Wormwood, Yarrow, Yellow Dock. ... anti-rheumatics

Compounds that protect the body against free radical activity and lipid peroxidation. Free-radical scavengers. Low levels in the tissues reduce the span of human life. High levels enable humans to live longer. The greater the oxidation damage to the DNA, the shorter the lifespan.

Vitamins A, C and E inhibit production of free radicals. Especially effective is beta-carotene, the precursor of Vitamin A, found in carrots, spinach, yams and some green leafy vegetables. Vitamin E and Selenium work together to prevent free radical damage to cell membrane. Antioxidants act favourably on glaucoma, Parkinson’s disease and rheumatoid arthritis.

This group claims to have an anti-tumour effect. Epithelial cancers may invade the respiratory and gastro-intestinal tracts, lungs, skin and cervix of the womb. The higher the level of antioxidants in the cells, the lesser the risk of epithelial cell cancer, and blindness in the aged. vChief antioxidants: Alfalfa, Comfrey, Asparagus (fresh), Beet tops, Dandelion leaves, Ginseng, Gotu Kola, Goldenseal, Irish Moss, Parsley, Walnuts, Watercress, Wheat sprouts. Perhaps the cheapest and most effective is Garlic.

Diet. Highly coloured fruits and vegetables: oranges, red and green peppers, carrots, apricots, mangoes, liver and spinach.

Supplements. Beta carotene (Vitamin A), Vitamin C, Vitamin E, Selenium, Zinc. See: SOD, FREE RADICALS. ... antioxidants

Agents that relieve or cure scurvy. Bogbean, Burdock, Chickweed, Clivers, Cubebs, Blue Flag root, Lemon juice, Sorrel, Nettles, Sarsaparilla, Yellow Parilla, Yellow Dock, Watercress. ... anti-scorbutics

An agent that tends to reduce glandular inflammation and swelling, and inhibits onset of tuberculosis of the lymphatics. See: LYMPHATICS. ... anti-scrofulous

Agents for relief of muscular cramp, spasm or mild pain. To reduce spasm of smooth muscle. The key remedy is Cramp bark but all have their specific uses.

They may be general (Black Haw, Cramp bark), or those that exert their influence upon specific structures: Hyssop (lungs), Cloves (mucous membranes), Wild Thyme (bronchi), Figwort (anus).

Others in common use: Asafoetida, Balm, Betony, Black Haw (muscles generally, also womb), Black Cohosh, Blue Cohosh, Butterburr, Blood root (externally), Cayenne, German Chamomile (stomach), Dong Quai (ovaries), Eucalyptus, Hops (stomach), Ladyslipper, Liquorice, Lime Blossom, Lobelia, Mistletoe, Motherwort (heart), Nutmeg (angina), Passion Flower, Skullcap, Skunk Cabbage, Thyme, Valerian, Vervain, Wild Cherry (respiratory), Wild Carrot (kidneys and bladder), Wild Lettuce, Wild Yam. Devil’s Claw (muscles).

Anti-Spasmodic Drops (Heath and Heather). Cramp, neuralgia, etc. Tincture Myrrh 6 per cent; Tincture Capsic 15 per cent; with 45 per cent ethanol extractive from Scutellaria (Skullcap) 10 per cent; Lobelia 1.25 per cent; Fennel 2.5 per cent; American Valerian 5 per cent. Dose: 10-30 drops according to age.

John Christopher: 2oz crushed Lobelia seeds; half an ounce Lobelia herb; 1 teaspoon Cayenne; macerated in 1 pint cider 8 days. 1-2 teaspoon when necessary.

Combination: powders. Equal parts: Skullcap, Valerian, Lobelia, Black Cohosh. Myrrh quarter part. Mix. Sift. Quarter of a teaspoon in water, honey etc as necessary.

Formula. Powders. Cramp Bark 2; Skullcap 1; Cloves half; Cayenne Pepper quarter. Mix. Dose: 500mg (two 00 capsules or one-third teaspoon thrice daily. (Indian Herbology of North America, Alma R. Hutchens) ... anti-spasmodics

Agents that have anti-bacterial action on most strains of staphylococcus. For treatment of pus-forming lesions, necrotic tissue and for after-surgery infections.

Angostura, Balm, Barberry, Bayberry, Bearberry, Benzoin, Bistort, Blood root, Black Cohosh, Black Currant, Buchu, Bugleweed (Lycopus virginicus and Lycopus europaeus), Butternut (Juglans cinerea), Camphor, Catechu, Cola, Cornsilk, Elecampane, Eucalyptus, Fringe Tree, Goldenseal, Guaiacum, Holy Thistle, Hops, Jaborandi, Jalap, Jambul, Juniper, Kino, Ladysmantle, Labrador tea, Lavender, Liquorice, Male fern, Mandrake, Marjoram, Meadowsweet, Mountain Grape, Myrtle (common), Oleander, Olive, Orthosiphon, Pennyroyal, Peony (common), Pine (Hemlock spruce), Pulsatilla, Rhus toxicodendron, Sage, St John’s Wort, Senna, Sumach, Sumbul, Sundew, Thuja, Turmeric, Unicorn root true, Walnut (juglans regia), Wild Indigo. Propolis, a resin foraged by bees for the exclusion of draughts in the hive has proved to be an effective anti-staphylococcal. ... anti-staphylococcals

Formula: Buchu leaf 60mg; Dry extract Buchu 100=39 23.4mg. Dry extract Clivers 100=28 16.8mg; Dry extract Couchgrass 5=1 12mg; Dry extract Equisetum 5=1 12mg; Dry extract Shepherd’s Purse 5=1 12mg; Dry extract Uva Ursi 5=2 80mg. A traditional remedy for the symptomatic relief of urinary or bladder discomfort. (Potter’s) ... antitis

See: ANTI-NEOPLASTICS. ... anti-tumours

To reduce cough severity, ease expectoration and clear the lungs. Over a hundred medicinal plants are listed from which the following are a small selection: Angelica, Balm of Gilead, Coltsfoot, Comfrey, Cowslip, Elecampane, Fenugreek, Garlic, Grindelia Hyssop, Linseed, Liquorice, Marshmallow, Irish Moss, Mousear, Mullein, Pleurisy root, Senega, Sweet Chestnut leaves, Sundew, Violet leaves, Thyme (Garden or Wild), White Horehound, Slippery Elm bark, Marsh Cudweed,. ... anti-tussives

Herbs that contain Vitamin C or stimulate its metabolism in the body. Vitamin C has a broad spectrum viricidal action which is often overlooked for acute infectious diseases.

Aloe Vera, Balm, Boneset, Burdock, Echinacea, Elderflowers, Elecampane, Eucalyptus, Garlic, Goldenseal, Liquorice, Marjoram, Pulsatilla, Queen’s Delight, St John’s Wort, Thuja, Wild Indigo, Yarrow. ... anti-virals

Drugs that are used to treat or prevent allergic reactions (see allergy). There are several groups, including corticosteroids, antihistamines, leukotriene receptor antagonists, and sodium cromoglicate.... antiallergy drugs

A group of drugs used to relieve the symptoms of anxiety. Benzodiazepine drugs and beta-blocker drugs are the 2 main types, although antidepressant drugs may occasionally be used. Benzodiazepine drugs promote mental and physical relaxation; they can also be used to treat insomnia, but their use for this purpose is avoided because they are addictive. Beta-blockers reduce only the physical symptoms of anxiety, such as shaking and palpitations, and are not addictive.... antianxiety drugs

A group of drugs used to treat infections caused by bacteria and to prevent bacterial infection in cases of immune system impairment.

Most of the commonly used antibiotic drugs belong to one of the following classes: penicillins, quinolones, aminoglycosides, cephalosporins, macrolides, and tetracyclines. Some antibiotics are effective against only certain types of bacteria; others, which are known as broad-spectrum antibiotics, are effective against a wide range.

Some bacteria develop resistance to a previously effective antibiotic drug. This is most likely to occur during long-term treatment. Some alternative antibiotics are available to treat bacteria that have become resistant to the more commonly prescribed drugs.

Most antibiotic drugs can cause nausea, diarrhoea, or a rash. Antibiotics may disturb the normal balance between certain types of bacteria and fungi in the body, leading to proliferation of the fungi that cause candidiasis (thrush). Some people experience a severe allergic reaction to the drugs, resulting in facial swelling, itching, or breathing difficulty.... antibiotic drugs

An artificially produced antibody that neutralizes only one specific antigen (foreign protein).

Monoclonal antibodies are produced in a laboratory by stimulating the growth of a large number of antibody-producing cells that are genetically identical. In effect, this process enables antibodies to be tailor-made so that they will react with a particular antigen.

Monoclonal antibodies are used in the study of human cells, hormones, microorganisms, and in the development of vaccines. They are also being used in the diagnosis and treatment of some forms of cancer.... antibody, monoclonal

Drugs that are used to treat many forms of cancer. They are particularly useful in the treatment of lymphomas, leukaemias, breast cancer, cancer of the testis (see testis, cancer of), and prostate cancer and are often used together with surgery or radiotherapy.

Most anticancer drugs are cytotoxic (kill or damage rapidly dividing cells), but some act by slowing the growth of hormone-sensitive tumours. Anticancer drugs are often prescribed in combination to maximize their effects.

Treatment with cytotoxic drugs is often given by injection in short courses repeated at intervals. Some drugs cause nausea and vomiting and may result in hair loss and increased susceptibility to infection. Others, such as tamoxifen, which is used for breast cancer, are given continuously by mouth for months or years and cause few side effects.... anticancer drugs

A group of drugs that block the effects of acetylcholine, a chemical released from nerve endings in the parasympathetic autonomic nervous system. Acetylcholine stimulates muscle contraction, increases secretions in the mouth and lungs, and slows the heartbeat.

Anticholinergic drugs are used in the treatment of irritable bowel syndrome, urinary incontinence, Parkinson’s disease, asthma, and bradycardia (abnormally slow heartbeat).

They are also used to dilate the pupil before eye examination or surgery.

Anticholinergic drugs are used as a premedication before general anaesthesia and to treat motion sickness.

They may cause dry mouth, blurred vision, urinary retention, and confusion.... anticholinergic drugs

A group of drugs used to treat and prevent abnormal blood clotting, to treat thrombosis, and to prevent and treat stroke and transient ischaemic attack. Anticoagulant drugs are also given to prevent abnormal blood clotting after major surgery (especially heart-valve replacement) or during haemodialysis (see dialysis). The most common anticoagulants are heparin and the newer heparin-derived drugs, such as tinzaparin, all of which have to be given by injection, and warfarin, which is taken orally.

Excessive doses of anticoagulant drugs increase the risk of unwanted bleeding, and regular monitoring is needed.... anticoagulant drugs

A group of drugs used to treat or prevent seizures. They are used mainly in the treatment of epilepsy but are also given to prevent seizures following serious head injury or some types of brain surgery. They may be needed to control seizures in children with a high fever (see convulsions, febrile).

Anticonvulsants may produce various side effects, including impaired memory, reduced concentration, poor coordination, and fatigue. If the side effects are severe, they can often be minimized by use of an alternative anticonvulsant.... anticonvulsant drugs

Drugs used to reduce or stop diarrhoea and to help regulate bowel action in people with a colostomy or ileostomy.

In most acute cases of diarrhoea, the only treatment recommended is oral rehydration therapy.

Antidiarrhoeal drugs include adsorbents, bulk-forming agents such as kaolin, and antimotility drugs (including the opioid drugs, morphine and codeine, and loperamide), which slow movement through the intestine.

None of these drugs are suitable for children.... antidiarrhoeal drugs

An antiserum that contains antibodies against Rhesus (Rh) D factor (a substance present on the red blood cells of people with Rh-positive blood).

Anti-D(Rh0) immunoglobulin is given routinely at intervals during normal pregnancy and at delivery.

An additional dose is also given after an amniocentesis, miscarriage, or any event in which the baby’s blood may enter the mother’s circulation.

The injected antibodies prevent the woman from forming her own antibodies against Rh-positive blood, which might adversely affect a subsequent pregnancy.

(See also haemolytic disease of the newborn; Rhesus incompatibility.)... anti-d(rh0) immunoglobulin

A group of drugs used to treat nausea and vomiting.

Antihistamine drugs and anticholinergic drugs reduce vomiting in motion sickness, vertigo, and Ménière’s disease.

The most powerful antiemetics are used to control nausea and vomiting associated with radiotherapy or anticancer drugs.

These drugs include serotonin antagonists such as ondansetron and nabilone.

Antiemetics are not normally used in the treatment of food poisoning because the body needs to rid itself of harmful substances.

Only certain antiemetics can be used to treat vomiting in early pregnancy because damage to the developing fetus may occur.

Many antiemetics cause drowsiness.... antiemetic drugs

Most antifreeze in the contains ethylene glycol, which is poisonous.

Drinking antifreeze initially produces effects similar to alcohol intoxication, but vomiting, stupor, seizures, and coma may follow; acute kidney failure may occur within 24–36 hours.

Antifreeze poisoning requires immediate medical attention.... antifreeze poisoning

A group of drugs used to treat infections caused by fungi. Antifungal drugs are commonly used to treat different types of tinea, including athlete’s foot and scalp ringworm. They are also used for candidiasis (thrush) and rare fungal infections, such as cryptococcosis, that affect internal organs.

Antifungal preparations are available in various forms including tablets, injection, creams, and pessaries. Prolonged treatment of serious fungal infections can result in side effects that include liver or kidney damage.... antifungal drugs

Drugs that reduce inflammation. The main groups of these drugs are nonsteroidal antiinflammatory drugs and corticosteroid drugs. (See also analgesic drugs.)... anti-inflammatory drugs

Drugs used to treat malaria. One antimalarial drug, chloroquine, is also used to treat arthritis.... antimalarial drugs

A substance applied to the skin in the form of a lotion, cream, or spray to reduce sweating. High concentrations are sometimes used to treat hyperhidrosis (abnormally heavy sweating). Antiperspirants may cause skin irritation, particularly if they are used on broken skin. (See also deodorants.)... antiperspirant

Drugs that reduce the tendency of platelets to stick together to form blood clots when blood flow in the arteries is disrupted. This action reduces the risk of thromboembolism, which can cause potentially fatal disorders such as a myocardial infarction or stroke. Aspirin and dipyridamole are commonly used antiplatelet drugs. Others, such as ticlopidine, are used specifically to protect against clots forming in the coronary arteries of people with angina.... antiplatelet drugs

Drugs that are used to relieve persistent itching (pruritus).

Antipruritics may be applied as creams and emollients and may contain corticosteroid drugs, antihistamine drugs, or local anaesthetics.

Oral antihistamines may also be used to relieve itching.... antipruritic drugs

Drugs that reduce fever. Examples of antipyretic drugs include paracetamol, aspirin, and other non-steroidal anti-inflammatory drugs.... antipyretic drugs

Drugs that are used to slow or halt the spread of viruses in people with HIV infection and AIDS. There are 3 main groups: reverse transcriptase inhibitors, protease inhibitors, and non-nucleoside reverse transcriptase inhibitors. Drugs from different groups are often used in combination. Antiretroviral drugs can have a range of side effects, including nausea, vomiting, diarrhoea, tiredness, and a range of effects on blood chemistry, particularly involving fats.... antiretroviral drugs

A group of drugs used to treat rheumatoid arthritis and types of arthritis that are caused by other autoimmune disorders such as systemic lupus erythematosus.

Antirheumatic drugs affect the disease process and may limit joint damage, unlike nonsteroidal anti-inflammatory drugs, which only relieve pain and stiffness.

The main antirheumatic drugs are corticosteroid drugs, immunosuppressant drugs, chloroquine, gold, penicillamine, and sulfasalazine.

Many of these drugs can have serious side effects, and treatment must be under specialist supervision.... antirheumatic drugs

A group of drugs that relax spasm in smooth muscle in the wall of the intestine or bladder. These drugs are used to treat irritable bowel syndrome and irritable bladder. Possible side effects include dry mouth, blurred vision, and difficulty in passing urine. (See also anticholinergic drugs.)... antispasmodic drugs

Drugs that suppress or relieve a cough (see cough remedies).... antitussive drugs

Drugs used in the treatment of infection by viruses. No drugs have been developed that can eradicate viruses, and at present immunization is the most effective way of preventing serious viral infections.

However, antiviral drugs can reduce the severity of some viral infections (most notably herpes, influenza, viral hepatitis, and cytomegalovirus infections), particularly in people who have reduced immunity.

Advances have also been made in the treatment of infection (see antiretroviral drugs).... antiviral drugs

A group of proteins that have a role in the immune system. Certain types of histocompatibility antigens are essential for the immunological function of killer T cells (see lymphocytes). The antigens act as a guide for killer T cells to recognize and kill abnormal or foreign cells.

The main group of histocompatibility antigens is the human leukocyte antigen (HLA) system, which consists of several series of antigens. A person’s tissue type (the particular set of HLAs in the body tissues) is unique, except for identical twins, who have the same set.

HLA analysis has some useful applications. Comparison of HLA types may show that 2 people are related, and it has been used in paternity testing. The HLA system is also used in tissue-typing to help match recipient and donor tissues before transplant surgery. Certain HLA types occur more frequently in people with particular diseases, such as multiple sclerosis, coeliac disease, and ankylosing spondylitis. HLA testing can help to confirm the presence of such diseases and identify people at risk of developing them.... histocompatibility antigens

(HLA) A type of protein belonging to the group known as histocompatibility antigens, which play a role in the immune system.... human leukocyte antigen

A group of drugs, also known as NSAIDs that produce analgesia (pain relief) and reduce inflammation in joints and soft tissues such as muscles and ligaments.

Nonsteroidal anti-inflammatory drugs are widely used to relieve symptoms caused by types of arthritis, such as rheumatoid arthritis, osteoarthritis, and gout. They do not cure or halt the progress of disease. NSAIDs are also used in the treatment of back pain, menstrual pain, headaches, pain after minor surgery, and soft tissue injuries.

The drugs reduce pain and inflammation by blocking the production of prostaglandins (chemicals that cause inflammation and trigger transmission of pain signals to the brain).

NSAIDs may cause a wide range of side effects, the most important of which are nausea, indigestion, bleeding from the stomach, and, sometimes, peptic ulcer.... nonsteroidal anti-inflammatory drugs

A substance secreted by a specific type of tumour that can be detected in the blood and may be used to help monitor a patient’s response to therapy.

Alpha-fetoprotein is an example of a tumour-specific antigen.... tumour-specific antigen

n. any one of a group of drugs that inhibit the action of testosterone on the prostate gland by blocking androgen receptors, competing for binding sites, or decreasing androgen production. They are therefore used in the treatment of prostate cancer, which is an androgen-dependent tumour. Anti-androgens include *abiraterone acetate, *bicalutamide, *cyproterone, *finasteride, and *flutamide.... anti-androgen

adj. describing a group of drugs used to correct irregularities in the heartbeat (see arrhythmia). They include *adenosine, *amiodarone, *verapamil, *disopyramide, *flecainide, and *lidocaine.... anti-arrhythmic

adj. describing an antibiotic that is active against bacteria.... antibacterial

autoantibodies that are directed against phospholipid-binding plasma proteins found in *antiphospholipid antibody syndrome, which is characterized by venous and arterial thrombosis and recurrent miscarriages.... anticardiolipin antibodies

adj. describing impulses travelling ‘the wrong way’ in a nerve fibre. This is rare but may happen in shingles, when the irritation caused by the virus in the spinal canal initiates impulses that travel outwards in normally afferent nerves. The area of skin that the sensory nerves supply (usually a strip on the trunk) becomes painfully blistered. Antidromic impulses cannot pass *synapses, which work in one direction only.... antidromic

(anti-D Ig) a preparation of anti-D, a *rhesus factor antibody formed by Rh-negative individuals following exposure to Rh-positive blood (usually by exchange between fetal and maternal blood in Rh-negative women who carry a Rh-positive fetus). Anti-D Ig is administered (by intramuscular injection) to Rh-negative women within 72 hours of giving birth to a Rh-positive child (or following miscarriage or abortion) to prevent the risk of *haemolytic disease of the newborn in a subsequent child. It rapidly destroys any remaining Rh-positive cells, which could otherwise stimulate antibody production affecting the next pregnancy. Anti-D is also available as antenatal prophylaxis to all Rh-negative pregnant women.... anti-d immunoglobulin

see anticonvulsant.... antiepileptic drug

adj. describing an agent that inhibits the dissolution of blood clots (see fibrinolysis). Antifibrinolytic drugs include *tranexamic acid.... antifibrinolytic

(APC) a cell, such as a *dendritic cell or a *macrophage, that processes antigen for presentation to a T lymphocytes (see helper T cell).... antigen-presenting cell

(anthelix) n. the curved inner ridge of the *pinna of the ear.... antihelix

n. an agent that prevents formation of *ketones in the body.... antiketogenic

(antilymphocyte globulin, ALS, ALG) an *antiserum, containing antibodies that suppress lymphocytic activity, prepared by injecting an animal with lymphocytes. ALS may be given to a patient to prevent the immune reaction that causes tissue rejection following transplantation of such organs as kidneys or of bone marrow. Administration naturally also impairs other immunity mechanisms, making infection a serious hazard.... antilymphocyte serum

n. any one of a group of drugs that interfere with the normal metabolic processes within cells by combining with the enzymes responsible for them. Some drugs used in the treatment of cancer, e.g. *cytarabine *fluorouracil, *methotrexate, and *mercaptopurine, are antimetabolites that prevent cell growth by interfering with enzyme reactions essential for nucleic acid synthesis. For example, fluorouracil inhibits the enzyme thymidylate synthetase. Side-effects of antimetabolites can include blood cell disorders and digestive disturbances. See also chemotherapy; cytotoxic drug.... antimetabolite

n. any one of a group of drugs that inhibit cell division and growth, e.g. *doxorubicin. The drugs used to treat cancer are mainly antimitotics. See also antimetabolite; cytotoxic drug.... antimitotic

see Müllerian duct.... anti-müllerian hormone

n. a substance that can either reduce the spontaneous production of mutations or prevent or reverse the action of a *mutagen.... antimutagen

adj. see antifungal.... antimycotic

(ANA) an autoantibody directed against nuclear membranes, found in systemic *lupus erythematosus and other autoimmune rheumatic diseases, such as *Sjögren’s syndrome, *scleroderma, and inflammatory *myositis.

The different types of ANAs are defined by their target antigen and different profiles have been correlated with clinical features.... antinuclear antibody

(oestrogen-receptor antagonist) n. one of a group of drugs that oppose the action of oestrogen by binding to *oestrogen receptors in the body’s tissues. The most important of these drugs is currently *tamoxifen, which is used in the treatment of breast cancers dependent on oestrogen. Because they stimulate the production of pituitary *gonadotrophins, some anti-oestrogens (e.g. *clomifene, tamoxifen) are used to induce or stimulate ovulation in infertility treatment. Side-effects of anti-oestrogens include hot flushes, itching of the vulva, nausea, vomiting, fluid retention, and sometimes vaginal bleeding.... anti-oestrogen

(anticholinergic) adj. inhibiting the action of *acetylcholine, the neurotransmitter that conveys information in the parasympathetic nervous system. Antimuscarinic drugs block the effects of certain (muscarinic) receptors (hence their name). The actions of these drugs include relaxation of smooth muscle, decreased secretion of saliva, sweat, and digestive juices, and dilation of the pupil of the eye. *Atropine and similar drugs have these effects; they are used in the treatment of gut spasms (e.g. *propantheline) and of parkinsonism (e.g. *trihexyphenidyl) as bronchodilators (e.g. *ipratropium), and as *mydriatics. Characteristic side-effects include dry mouth, thirst, blurred vision, dry skin, increased heart rate, and difficulty in urination.... antimuscarinic

(APS, Hughes syndrome) an autoimmune disease in which the presence of antibodies against phospholipid (see anticardiolipin antibodies; lupus anticoagulant) is associated with a tendency to arterial or venous thrombosis and, in women of childbearing age, to recurrent miscarriage. APS may be primary or occur in association with systemic lupus erythematosus (SLE) or other connective-tissue diseases. Treatment is by low-dose aspirin or heparin.... antiphospholipid antibody syndrome

any one of a class of drugs that reduce platelet aggregation (see platelet activation) and therefore the formation of clot (see thrombosis). Examples are *abciximab, *aspirin, *clopidogrel, prasugrel, and ticagrelor.... antiplatelet drug

n. any one of a group of drugs used to treat severe mental disorders (psychoses), including schizophrenia and mania; some are administered in small doses to relieve anxiety and tic disorders or to treat impulsivity in *emotionally unstable personality disorder. Formerly called major tranquillizers, and later typical and atypical antipsychotics, they are now known as first- and second-generation antipsychotics. The first-generation (or typical) antipsychotics include the *phenothiazines (e.g. *chlorpromazine), *butyrophenones (e.g. *haloperidol), and thioxanthenes (e.g. *flupentixol). Side-effects of antipsychotic drugs can include *extrapyramidal effects, sedation, *antimuscarinic effects, weight gain, and *long QT syndrome. The second-generation (or atypical) antipsychotics are a group of more recently developed drugs that are in theory associated with fewer extrapyramidal effects than first-generation antipsychotics: they include *clozapine, *risperidone, amisulpride, aripiprazole, olanzapine, and quetiapine. Antipsychotics act on various neurotransmitter receptors in the brain, including dopamine, histamine, serotonin, and cholinergic receptors. Most of them block neurotransmitter activity, but some have partially agonistic effects. Recent evidence suggests that there are significant differences among the second-generation antipsychotics regarding their efficacy and side-effect profiles. Clozapine, amisulpride, and olanzapine were found to be the most effective antipsychotics. Clozapine, zotepine, and olanzapine caused the most weight gain; haloperidol, zotepine, and chlorpromazine caused the most extrapyramidal side-effects; sertindole, amisulpride, and ziprasidone caused the most QT-prolongation; and clozapine, zotepine, and chlorpromazine caused the most sedation.... antipsychotic

(ARV) any of a group of drugs that inhibit or slow the growth of *retroviruses, specifically HIV, and are used in the treatment of HIV infection and *AIDS. They include the *reverse transcriptase inhibitors and the *protease inhibitors (see also maraviroc; raltegravir). Treatment with a combination of antiretrovirals is known as highly active antiretroviral therapy (HAART).... antiretroviral drug

any drug that reduces the normal rate of secretion of a body fluid, usually one that reduces acid secretion into the stomach. Such drugs include *antimuscarinic drugs, H2-receptor antagonists (see antihistamine), and *proton-pump inhibitors.... antisecretory drug

n. the elimination of bacteria, fungi, viruses, and other microorganisms that cause disease by the use of chemical or physical methods.... antisepsis

n. a drug that relieves spasm of skeletal muscle. See also muscle relaxant. Compare antispasmodic.... antispastic

termination of a *tachycardia by temporarily pacing the heart at a faster rate.... antitachycardia pacing

see cytokine inhibitor.... anti-tnf drugs

n. a small projection of cartilage above the lobe of the ear, opposite the tragus. See pinna.... antitragus

an agent that inhibits the action of *vascular endothelial growth factor (VEGF). See angiogenesis inhibitor.... anti-vegf

(antivenin) n. an *antiserum containing antibodies against specific poisons in the venom of such an animal as a snake, spider, or scorpion.... antivenene

a drug effective against viruses that cause disease. Antiviral drugs include *DNA polymerase inhibitors (e.g. *aciclovir, *foscarnet, *ganciclovir), *ribavirin, and *oseltamivir; they are used for treating herpes, cytomegalovirus and respiratory syncytial virus infections, and influenza. Antiviral drugs are also used for treating HIV infection and AIDS (see antiretroviral drug).... antiviral drug

see antipsychotic.... atypical antipsychotics

another name for the *hepatitis B antigen, which was first discovered in the blood of an Australian aborigine. This disease is caused by a virus of which the Australia antigen forms part.... australia antigen

one of a group of drugs that includes the *penicillins and the *cephalosporins. All have a four-membered beta-lactam ring as part of their molecular structure. Beta-lactam antibiotics function by interfering with the growth of the cell walls of multiplying bacteria. Bacteria become resistant to these antibiotics by producing beta-lactamases, enzymes (such as *penicillinase) that disrupt the beta-lactam ring. To counteract this, beta-lactamase inhibitors (e.g. *clavulanic acid) may be added to beta-lactam antibiotics. For example, co-amoxiclav is a mixture of *amoxicillin and clavulanic acid.... beta-lactam antibiotic

(CEA) a protein produced in the fetus but not in normal adult life. It may be produced by carcinomas, particularly of the colon, and is a rather insensitive marker of malignancy. It is an example of an *oncofetal antigen that is used as a *tumour marker, particularly in the follow-up of colorectal cancer.... carcino-embryonic antigen

(DOAC) a relatively recently introduced class of drugs that reduce coagulation of the blood by inhibition of one of the coagulation factors (Factor Xa). They may be used as an alternative to *warfarin in many (but not all) cases, their advantage being that regular blood tests are not required for dose adjustment. Examples include, apixaban, dabigatran, edoxaban, and rivaroxaban.... direct oral anticoagulant

(DMARD) any of various drugs used in the treatment of rheumatic disease: they affect the progression of the disease by suppressing the disease process. DMARDs include drugs affecting the immune response (immunomodulators), such as *immunosuppressants (e.g. methotrexate) and *cytokine inhibitors; *gold salts; *penicillamine; *sulfasalazine; and *hydroxychloroquine.... disease-modifying antirheumatic drug

(DAPT) aspirin prescribed at the same time as another oral *antiplatelet drug (e.g. clopidogrel, prasugrel, ticagrelor) for patients deemed to be at temporarily increased risk of coronary or stent thrombosis (typically following *acute coronary syndrome or new coronary stent implantation). After a prespecified time (usually 12 months), the aspirin is continued and the other antiplatelet drug is stopped.... dual antiplatelet therapy

see islet cell antibodies.... gad antibodies

see vancomycin.... glycopeptide antibiotics

see HLA system.... human leucocyte antigen system

a group of autoantibodies directed against components of the insulin-secreting beta cells of the pancreas. They are usually detectable in the blood of people presenting with type 1 diabetes. Antibodies against *glutamic acid decarboxylase (GAD) in the beta cells have become a more specific test for islet cell antibodies, to help confirm a diagnosis of type 1 diabetes.... islet cell antibodies

a group of antigens that may or may not be present on the surface of red blood cells, forming the basis of a *blood group. This group is important in blood transfusion reactions. [Mrs Kell (20th century), patient in whom they were first demonstrated]... kell antigens

one of several autoantibodies that can cause *antiphospholipid antibody syndrome (APS). Despite the name, the antibody behaves as a coagulant, increasing the risk of thrombosis. It can be found in 50% of patients with APS.... lupus anticoagulant

see NSAID.... nonsteroidal anti-inflammatory drug

a protein normally produced only by fetal tissue but often produced by certain tumours. An example is *carcino-embryonic antigen (CEA), which has been used as a *tumour marker, especially in colorectal carcinomas.... oncofetal antigen

autoantibodies directed against the cells of the thyroid gland, which serve as a marker of autoimmune thyroid disease. There are two main types: antibodies directed against the thyroid peroxidise (TPO) enzyme; and anti-thyroglobulin, directed against the thyroid colloid (see thyroid gland). The highest level of thyroid antibodies is found in *Hashimoto’s disease.... thyroid antibodies

autoantibodies targeted against the *thyroid-stimulating hormone (TSH) receptor of the thyroid cells. They can activate the TSH receptor, leading to the hyperthyroidism of *Graves’ disease, or they can block the TSH receptor, causing *hypothyroidism.... tsh receptor antibodies

(PSA) a protease enzyme produced by the glandular epithelium of the prostate. Its effect is to liquefy the semen within the ejaculate. Overall PSA has a half-life of 2–3 days. Increased quantities are secreted when the gland becomes enlarged or inflamed, and levels of PSA in the blood are significantly elevated in cancer of the prostate. Although there is no clear ‘cut-off’ level for normality, over 4 ng/ml in the blood is associated with a 20% risk of prostate cancer, even in patients with normal-feeling prostates on rectal examination. Age-specific PSA reference ranges are often used. Newer PSA assays can measure free PSA and compare it to the total PSA in the blood. Low free:total PSA ratios indicate a greater risk of prostate cancer and improve the discrimination between cancer and benign disease in men with a PSA in the range 4–10 ng/ml. PSA levels tend to be much higher in advanced prostate cancer and the rate of fall on treatment (e.g. after radical prostatectomy or radiotherapy) is a good prognostic indicator of response.... prostate specific antigen

(SIADH) a condition of inappropriately high plasma levels of ADH (see vasopressin) with associated water retention, dilutional *hyponatraemia, and the production of highly concentrated urine. Renal, adrenal, thyroid, and hepatic function are normal, as is the volume of circulating blood (euvolaemia). It is caused by a variety of pathological conditions, usually intrathoracic and intracerebral, and also by a number of drugs, including antidepressants, chemotherapy agents, and some of the older antidiabetic agents. The treatment involves fluid restriction, treatment (or removal) of the underlying cause (or drug), and, in severe cases, administration of *demeclocycline to reduce the effects of ADH on the kidney. Very rarely, hypertonic saline is given.... syndrome of inappropriate secretion of antidiuretic hormone

a protein produced by cancer cells. Its presence in the blood can be revealed by means of a simple blood test, aiding the diagnosis of malignant melanoma and other cancers at their earliest – and most treatable – stages of development.... tumour-associated antigen

an agent which combats anaemia. Anti-arthritic: an agent which combats arthritis. Antibilious: an agent which helps remove excess bile from the body.... anti-anaemic

an agent which helps remove excess catarrh from the body.... anticatarrhal

efficacious against diarrhoea.... antidiarrhoeal

an agent which reduces the incidence and severity of nausea or vomiting.... anti-emetic

an agent which prevents or combats haemorrhage or bleeding.... antihaemorrhagic

prevents the formation of a calculus or stone.... antilithic

an agent which resists or destroys pathogenic micro-organisms.... antimicrobial

relieves or reduces nerve pain.... antineuralgic

an agent which prevents and combats decay or putrefaction.... antiputrescent

helps prevent the hardening of tissue.... antisclerotic

combats the development of tuberculosis of lymph nodes (scrofula).... antiscrofula

helps control the production of sebum, the oily secretion from sweat glands.... antiseborrhoeic

an antidote or treatment that counteracts the effects of poison.... antitoxic