autoantibodies that are directed against phospholipid-binding plasma proteins found in *antiphospholipid antibody syndrome, which is characterized by venous and arterial thrombosis and recurrent miscarriages.
An arti?cially prepared antibody (see ANTIBODIES) obtained from cell clones – a genetically identical group of cells – and comprising a single type of immunoglobulin. It neutralises only one speci?c ANTIGEN. The antibodies are prepared by linking antibody-forming lymphocytes (see LYMPHOCYTE) from the spleen of mice with myeloma cells from mice. Monoclonal antibodies are used in the development of new vaccines and in the study of human cells, hormones, and micro-organisms. Research is under way for their use in the treatment of some forms of cancer. (See IMMUNOLOGY.)... monoclonal antibodies
a group of autoantibodies directed against components of the insulin-secreting beta cells of the pancreas. They are usually detectable in the blood of people presenting with type 1 diabetes. Antibodies against *glutamic acid decarboxylase (GAD) in the beta cells have become a more specific test for islet cell antibodies, to help confirm a diagnosis of type 1 diabetes.... islet cell antibodies
autoantibodies directed against the cells of the thyroid gland, which serve as a marker of autoimmune thyroid disease. There are two main types: antibodies directed against the thyroid peroxidise (TPO) enzyme; and anti-thyroglobulin, directed against the thyroid colloid (see thyroid gland). The highest level of thyroid antibodies is found in *Hashimoto’s disease.... thyroid antibodies
autoantibodies targeted against the *thyroid-stimulating hormone (TSH) receptor of the thyroid cells. They can activate the TSH receptor, leading to the hyperthyroidism of *Graves’ disease, or they can block the TSH receptor, causing *hypothyroidism.... tsh receptor antibodies
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