Antimitotic Health Dictionary

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Antimitotic: From 1 Different Sources

n. any one of a group of drugs that inhibit cell division and growth, e.g. *doxorubicin. The drugs used to treat cancer are mainly antimitotics. See also antimetabolite; cytotoxic drug.
Health Source: Oxford | Concise Colour Medical Dictionary
Author: Jonathan Law, Elizabeth Martin

Cucurbita Maxima

Duchesne.

Habitat: Cultivated throughout India.

English: Red Gourd, Red Pumpkin.

Ayurvedic: Peeta Kuushmaanda, Kuushmaandaka, Kuusmaandi, Karkaaruka, Seetaaphal.

Unani: Kaddu-e-Sheerin, Aqteen.

Siddha/Tamil: Parangikayi.

Action: Fruit pulp—sedative, emollient and refrigerant; used as poultice, applied to burns, inflammations, boils, and burns. Seeds—diuretic, anthelmintic (for tapeworm). Because of their zinc content and antimitotic effect, seeds are used to arrest enlargement of prostate gland. Also used in cystitis and minor kidney dyfunction.

Pumpkin (Cucurbita maxima and C. pepo) seeds contain B vitamins, Vitamin A; minerals—calcium, iron, phosphorus, zinc; cucurbitacins; linonelic acid. An infusion of seeds (2-3 teaspoons) is taken as a diuretic and in hypertrophy of prostate.

Seeds of C. maxima contain sterol glycosides and sterol fatty acid esters which showed antitumour activity in mice.

The leaves contain calcium 36.38; magnesium 38.80; iron 2.04; zinc 0.76; and copper 0.42 (mg/100 g).

The seed oil contains sterols and tri- terpenoids. The oil is used in migraine and neuralgia.... cucurbita maxima

Solanum Trilobatum

Linn.

Family: Solanaceae.

Habitat: Deccan Peninsula.

English: Climbing Brinjal.

Ayurvedic: Alarka, Valli- kantakaarikaa, Kantakaari-lataa.

Siddha/Tamil: Toothuvilai.

Action: Berries and flowers—a decoction is used for cough and chronic bronchitis.

The steroidal alkaloid, solasodine, is present in fruit and leaf of the plant (air-dried fruits and leaves from Coim- batore gave 0.96 and 0.36% respectively). A crude glycoalkaloid mixture, isolated from the plant material, contained about 20% beta-solamarine. The plant exhibited antimitotic, antitu- mour, antibacterial and antifungal activities and showed promising results in two cancer test systems—KB cell and sarcoma 180 in mice.... solanum trilobatum

Taxus Baccata

Linn.

Family: Taxaceae.

Habitat: Temperate Himalayas, Khasi Hills and Manipur.

English: European Yew. Himalayan Yew is equated with Taxus wal- lichiana Zucc., synonym T. baccata Linn. subspecies wallichiana (Zucc.) Pilgoe, T. baccata Hook. f.

Ayurvedic: Thunera, Sthauneya, Sthauneyaka, Shukapushpa, Dhaatri-patra, Vikarna. (Not a substitute for Taalisapatra.)

Unani: Zarnab.

Siddha/Tamil: Taaleespatri Bhedam.

Folk: Birmi, Thuno.

Action: Herb—CNS depressant; reduces motor activity; analgesic, anticonvulsant. Leaf used in nervousness, epilepsy, hysteria, asthma, chronic bronchitis. Leaf and fruit—antispasmodic, sedative, emmenagogue.

Berry—used in chronic bronchitis. Taxol—antimitotic; also being tried for the treatment of severe drug-resistant human malaria. (Chem Abstr, 1994, 21, 124674 j.) (The taxol content in Himalayan Yew varied with season and location from 0.045-0.130%.)

The needles contain diterpene esters of taxane-type (mixture is known as taxine 0.6-2.0%). Taxine consists of 11 compounds of which only tax- ine A and B have been characterized. Taxol, the diterpene amide, is found active against ovarian cancer in humans. (clinical results showed 24-30% response). The ester alkaloids in higher doses are cardiotoxic.

Dried needles contain biflavonoids, including sotetsuflavone, sequoifla- vone, sciadopitysin, ginkgetin, kayafla- vone, amentoflavone, beta-sitosterol, heptacosanol and surcose.

The needles gave several phenolics. Betuloside (rhododendron) exhibited hepatoprotective activity against hepa- totoxins in rats.

The seeds are poisonous and contain taxine.

The aqueous extract of leaves showed a depressant effect on the central nervous system in rats.

The Ayurvedic Pharmacopoeia ofIn- dia attributed antirheumatic, anticatar- rhal, insecticidal and wound-healing properties to the dried needles of Himalayan Yew and indicated the use of the drug in powder form (1-3 g) in disorders due to vitiated blood, tumours, dermatosis and helminthiasis.

Dosage: Leaf—1-3 g powder. (API, Vol. III.) Leaf, bark—3-5 g powder. (CCRAS.)... taxus baccata

Vinca Alkaloid

one of a group of *antimitotic drugs (see also cytotoxic drug) derived from the periwinkle (Vinca rosea). Vinca alkaloids are used especially to treat leukaemias and lymphomas; they include vinblastine, vincristine, and vindesine. Vinorelbine is used in the treatment of advanced breast cancer and *non-small-cell lung cancer. Vinflunine is given by intravenous infusion to treat *transitional cell carcinoma. Vinca alkaloids are highly toxic; side-effects include *myelosuppression, peripheral neuropathy, and severe irritation at the injection site.... vinca alkaloid

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