Atrial septal defect Health Dictionary

The atria (see ATRIUM) of the heart contain peptides with potent diuretic and vasodilating properties. It has been known since 1980 that extracts of human atria have potent diuretic and natriuretic effects in animals (see DIURETICS). In 1984 three polypeptide species were isolated from human atria and were called alpha, beta and gamma human atrial natriuretic peptides. Plasma concentration of immunoreactive atrial natriuretic peptide can now be measured: the levels are low in healthy subjects and are increased in patients with congestive heart failure. Infusion of the peptides reduces blood pressure and causes a natriuresis and diuresis.... atrial natriuretic peptide

A congenital abnormality of the HEART affecting about 260 babies in every 100,000, in which there is a hole in the septum – the dividing wall – between the left and right sides of the heart. The effects of the defect depend upon its size and position. A defect in the wall between the atria (upper chambers of the heart) is called an atrial septal defect, and that between the ventricles, a ventricular septal defect – the most common form (25 per cent of all defects). Both defects allow blood to circulate from the left side of the heart, where pressures are highest, to the right. This abnormal ?ow of blood is described as a ‘shunt’ and the result is that too much blood ?ows into the lungs. PULMONARY HYPERTENSION occurs and, if the shunt is large, heart failure may develop. A small septal defect may not need treatment but a large one will need to be repaired surgically.... septal defect

An inherited defect of the HEART. The septum (partition) separating the two ventricles is pierced by a hole which, if large, results in blood being diverted to the LUNGS at a greater pressure than normal. This may lead to irreversible PULMONARY HYPERTENSION, which early surgical intervention (repair of the septal defect) should prevent. A quarter of patients with VSD have other cardiac defects. Half of the defects seal themselves spontaneously.... ventricular septal defect

Arrhythmia. Heart flutter. Disorderly uncoordinated contraction of atrial muscle wall, the ventricles responding irregularly.

Causes: thyrotoxicosis, valvular or coronary disease. Present in mitral stenosis and myocarditis. Precursor of heart failure. Carrying a bucket of coal upstairs may be sufficient to precipitate an attack. Symptoms. Pulse irregular in time and force, breathlessness, visible pulse in neck, excessive heart beats of sudden onset or permanent, with breathlessness often from emotional excitement.

Treatment. Patient should avoid excessive physical exercise or give way to anxiety and depression. Alternatives:– Tea. Equal parts: Hawthorn (berries or blossoms), Broom, Valerian. 1-2 teaspoons in each cup boiling water; infuse 5-15 minutes; dose – half-1 cup thrice daily.

Tablets/capsules. Hawthorn, Valerian, Motherwort.

Formula. Hawthorn 2; Passion flower 2; Broom 3. Mix. Dose: Powders: 750mg (three 00 capsules or half a teaspoon). Liquid extracts: 1 teaspoon. Tinctures: 2 teaspoons. In water or honey thrice daily. Practitioner. Tincture Gelsemium (BPC 1973): 2-5 drops. Tincture Lily of the Valley: 0.5-1ml.

Undue violence. Tincture Gelsemium 1; Tincture Cactus 2. Mix. Dose: 5-10 drops. Where heart muscle is damaged, add 1 part Liquid Extract Black Cohosh.

Broom. Spartiol Drops, 20 drops thrice daily. (Klein)

Diet. See: DIET – HEART AND CIRCULATION. ... atrial fibrillation

See CONGENITAL.... birth defects

Congenital abnormalities resulting from the failure of the NEURAL TUBE to form normally. The resulting conditions include SPINA BIFIDA, MENINGOCELE and defects in the bones of the SKULL.... neural tube defects

This is the main cause of anaemia in infections. The micro-organism responsible for the infection has a deleterious e?ect upon the blood-forming organs, just as it does upon other parts of the body.

Toxins. In conditions such as chronic glomerulonephritis (see KIDNEYS, DISEASES OF) and URAEMIA there is a severe anaemia due to the e?ect of the disease upon blood formation.

Drugs. Certain drugs, such as aspirin and the non-steroidal anti-in?ammatory drugs, may cause occult gastrointestinal bleeding.... defective blood formation

A type of abnormality of the heartbeat (see arrhythmia, cardiac)

in which the atria beat regularly and very rapidly. Symptoms and treatment are the same as for atrial fibrillation.... atrial flutter

Incomplete development of one or more limbs at birth.

Limb defects are rare and may be inherited or form part of a syndrome.

In a condition called phocomelia, hands, feet, or tiny finger- or toe-buds are attached to limb stumps or grow directly from the trunk.

The sedative drug thalidomide, when taken by pregnant women, is known to have caused phocomelia in fetuses.... limb defects

(ASH) see hypertrophic cardiomyopathy.... asymmetric septal hypertrophy

A developmental failure affecting the spinal cord or brain of the embryo. The most serious defect is anencephaly (total lack of a brain), which is fatal. More common is spina bifida, in which the vertebrae do not form a complete ring around the spinal cord. Spina bifida can occur anywhere on the spine, but it is most common in the lower back.

There are different forms of spina bifida. In spina bifida occulta, the only defect is a failure of the fusion of the bony arches behind the spinal cord, which may not cause any problems. When the bone defect is more extensive, there may be a meningocele, a protrusion of the meninges, or a myelomeningocele, a malformation of the spinal cord. Myelomeningocele is likely to cause severe handicap, with paralysis of the legs, loss of sensation in the lower body, hydrocephalus, and paralysis of the anus and bladder, causing incontinence. Associated problems include cerebral palsy, epilepsy, and mental handicap.

Surgery is usually performed a few days after birth. In mild cases, the defect can usually be corrected, but in myelomeningocele, some handicap will remain.

Genetic factors play a part in neural tube defects, which show multifactorial inheritance. Couples who have had an affected child or who have a family history of neural tube defects should seek genetic counselling. The risk of a neural tube defect occurring can be substantially reduced if the mother takes folic acid supplements for a month before conception and during the early part of the pregnancy.

Ultrasound scanning and amniocentesis allow accurate antenatal testing for neural tube defects.... neural tube defect