Linn.Family: Bixaceae.
Habitat: Native to Central America, often cultivated in Madhya Pradesh and South India.
English: Annatto.Ayurvedic: Sinduri, Sinduriyaa.Siddha/Tamil: Jabara, Manjitti.Action: Plant—astringent, antibil- ious, antiemetic, blood purifier. Leaves—infusion is given in jaundice, also in dysentery. Externally, scar-preventive. Root bark— febrifuge, antiperiodic. Seed pulp— haemostatic, antidysenteric, diuretic, laxative. Fruit—antidysenteric.
An antimicrobial constituent, mas- linic acid, alongwith gallic acid and pyrogallol, has been isolated from the leaves. Alcoholic extract of the leaves completely inhibited Micrococcus pyo- genes, but was inactive against E. coli. The aqueous extract, however, showed partial inhibition against E. coli. The aqueous extract also showed potent inhibitory activity towards lens aldose re- ductase, which plays an important role in the management of diabetic complications. The activity is attributed to a flavonoid, isoscutelarein.Bixin, the main constituent of seed coat, shows cytostatic effect on the growth of human lymphoma cells. Bixin also has a hyperglycaemic effect and may disturb blood glucose control.