Bradykinin Health Dictionary

Bradykinin: From 3 Different Sources


Bradykinin is a substance derived from plasma proteins; it plays an important role in many of the reactions of the body, including INFLAMMATION. Its prime action is in producing dilatation of arteries and veins. It has also been described as ‘the most powerful pain-producing agent known’.
Health Source: Herbal Medical
Author: Health Dictionary
A plasma polypeptide that tends to lower blood pressure and increase capillary permeability.
Health Source: Medical Dictionary
Author: Health Dictionary
n. a naturally occurring polypeptide consisting of nine amino acids. Bradykinin is a very powerful vasodilator and causes contraction of smooth muscle; it is formed in the blood under certain conditions and is thought to play an important role as a mediator of inflammation. See kinin.
Health Source: Oxford | Concise Colour Medical Dictionary
Author: Jonathan Law, Elizabeth Martin

Aesculus Hippocastanum

Linn.

Family: Hippocastanaceae; Sapinda- ceae.

Habitat: Endemic to the mountains of Balkan Peninsula and western Asia. Introduced into India; occasionally grown as an ornamental tree.

English: Horse Chestnut tree.

Unani: Baloot. (Quercus incana and Q. infectoria have also been equated with Baloot in National Formulary in Unani Medicine.)

Folk: Pu.

Action: Anti-inflammatory, vasodilator, astringent (used for rheumatism, venous congestion, haemorrhoids), febrifuge. Leaf— used in whooping cough.

Key application: In chronic venous insufficiency, varicosis, nocturnal systremma (cramps in the calves) and swelling of the legs. (Non- invasive treatment measures should also be followed.) (German Commission E, ESCOP, The British Herbal Pharmacopoeia.)

Horse Chestnut contains triterpe- noid saponins (especially aescin, a complex mixture composed of acylat- ed glycosides of protoaesigenin and barringtogenol-C, including hippo- caesculin), coumarins and flavonoids. Aescin has been shown to eliminate oedema and reduce exudation. It antagonizes the effect of bradykinin, although it is not a direct bradykinin antagonist. It causes an increase in plasma levels of ACTH, corticosterone and glucose in rats. Hippocaescu- lin and barringtogenol-C-21-angelate show antitumour activity in vitro.

The hydroxycoumarin aesculin leads to increased bleeding time. (Roasting seems to destroy the toxins.) A few fruits can cause severe toxic symptoms. (Francis Brinker.) In some countries, an intravenous mixture containing aescin is used after surgery. (Natural Medicines Comprehensive Database, 2007.)... aesculus hippocastanum

Aloe Barbadensis

Mill.

Synonym: A. Vera Tourn. Ex Linn. A. indica Royle A. littoralis Koening

Family: Liliaceae; Agavaceae.

Habitat: Cultivated throughout India, wild on coasts of Maharashtra, Gujarat and South India.

English: Curacao Aloe, Barbados Aloe, Indian Aloe, Jaffarabad Aloe.

Ayurvedic: Kanyaasaara, Eleyaka (dried juice of the leaves). Kumaari, Kumaarikaa, Kanyaa, Grihkanyaa, Ghritkumaarika (plant).

Unani: Gheekwaar, Sibr.

Siddha/Tamil: Sotru Kattraazhai, Kumaari. Moosaambaram (dried juice).

Folk: Elwaa, Musabbar (dried juice of leaves).

Action: Purgative (causes griping), emmenagogue. Gel—topically emollient, anti-inflammatory, antimicrobial (used for wound healing, sunburn).

Key application: In occasional constipation; contraindicated in intestinal obstruction and acutely inflamed intestinal diseases, ulcerative colitis, appendicitis. (German Commission E, ESCOP, WHO.)

The Ayurvedic Pharmacopoeia of India recommends the use of dried juice of leaves in dysmenorrhoea and diseases of the liver.

Aloe vera improved the hypoglycaemic effect of glyburide (gliben- clamide) when one tablespoonful aloe juice was given orally in the morning and at bedtime to 36 diabetic patients for 42 days. The juice (same dose) showed antihyperglycaemic activity (independently). (Francis Brinker.)

Anthraquinone glycosides, known as aloin, in small doses act as a tonic to the digestive system, and at higher doses become a strong purgative, as well as increase colonic secretions and peristaltic contractions. Resin fraction is also as important as aloin in cathartic action. In A. barbadensis the highest percentage of aloin is 21.8%.

Aloe produces pelvic congestion and is used for uterine disorders, generally with Fe and carminatives. The pulp is used in menstrual suppressions.

A molecule in the Aloe vera gel, ace- mannan, stimulates macrophages and releases immune system potentiators; enhances function of T cells and interferon production. Animal studies have shown promising results in sarcoma.

The carboxypeptidase and salicylate components of Aloe gel can inhibit bradykinin, a pain-producing agent; C-glycosyl chromone appears to reduce topical inflammation. Aloe gel also slows or inhibits the synthesis of thromboxane, which may accelerate the healing of burns. (Natural Medicines Comprehensive Database, 2007.)

Dosage: Leaf pulp juice—10-20 ml. (CCRAS.) Dried leaf pulp juice— 125-500 mg powder. (API Vol. I.)... aloe barbadensis

Kallikrein

n. one of a group of enzymes found in the blood and body fluids that act on certain plasma globulins to produce bradykinin and kallidin. See kinin.... kallikrein

Kinin

n. one of a group of naturally occurring polypeptides that are powerful *vasodilators, which lower blood pressure, and cause contraction of smooth muscle. The kinins bradykinin and kallidin are formed in the blood by the action of proteolytic enzymes (kallikreins) on certain plasma globulins (kininogens). Kinins are not normally present in the blood, but are formed under certain conditions; for example when tissue is damaged or when there are changes in the pH and temperature of the blood. They are thought to play a role in inflammatory response.... kinin

Blumea Fastulosa

(Roxb.) Kurz.

Synonym: B. glomerata DC.

Family: Compositae; Asteraceae.

Habitat: Tropical Himalayas, and throughout the plains of Assam and Penninsular India.

Ayurvedic: Kukundara (var.).

Unani: Kakarondaa.

Action: Plant—diuretic. Essential oil—CNS depressant.

The steam non-volatile fraction of plant extract contained a mixture of n-alkanes.

Blumea lacera.

Family: Compositae; Asteraceae.

Habitat: Throughout the plains of India, ascending to 700 m.

Ayurvedic: Kukundara, Kukuradru, Taamrachuuda.

Unani: Kakarondaa.

Siddha/Tamil: Narakkarandai, Kaatu Mullangi.

Folk: Kakranda.

Action: Plant—antipyretic. Leaf— astringent, febrifuge, diuretic, deobstruent, anthelmintic (particularly in case of thread worm). Root—anticholerin. Essential oil— antibacterial, antifungal.

The leaves on steam distillation yield 0.5% essential oil from which camphor is isolated.

The oil contains cineol 66, d-fen- chone 10 and citral about 6%. The plant gave a diester of coniferyl alcohol, acetylenic compounds, a thiophene derivative; aerial parts gave campes- terol, hentriacontane, hentriacontanol, alpha-amyrin and its acetate, lupeol and its acetate and beta-sitosterol.

The alcoholic extract of the plant showed marked anti-inflammatory activity in carrageenin and bradykinin- induced inflammation in rats.

Dosage: Root—5-10 g paste. (CCRAS.)... blumea fastulosa

Corchorus Fascicularis

Lam.

Family: Tiliaceae.

Habitat: Throughout warmer parts of India.

Ayurvedic: Chanchuka, Chanchu.

Folk: Chanchu shaaka, Baaphali.

Action: Astringent, spasmolytic, restorative, mucilaginous.

The plant contains betulinic acid and beta-sitosterol. Seeds yield cardeno- lides including trilocularin. The glyco- sides of the plant were found to be devoid of any effect of its own on smooth muscle of guinea pig ileum, but produced spasmolytic effect against acetyl- choline, histamine and bradykinin. Direct action of the drug was observed on rabbit intestines. Slight cardiac depressant effect was found on isolated amphibian heart preparation.

Corchorus depressus (L.) Christensen, found in drier parts of North India, is known as Bhauphali (Delhi).

The Plant is used as a cooling medicine in fevers; its mucilage is prescribed in gonorrhoea, also for increasing the viscosity of seminal fluid. An extract of the plant is applied as a paste to wounds.

The plant contains alpha-amyrin derivatives, together with apigenin, luteolin, sitosterol and its glucoside. Presence of quercetin and kaempferol has been reported in leaves and flowers.

The plant exhibits antimicrobial and antipyretic activities.... corchorus fascicularis

Ficus Carica

Linn.

Family: Moraceae.

Habitat: Native to the Mediterranean region; now cultivated in Uttar Pradesh, Rajasthan, Punjab, Andhra Pradesh and Maharashtra.

English: Common Fig.

Ayurvedic: Phalgu, Manjul, Raajodumbara, Bhadrodumbara.

Unani: Anjeer, Teen.

Siddha/Tamil: Semaiatti.

Action: Fruit—gentle laxative and expectorant. Syrup of figs— a remedy for mild constipation. Fruit pulp-analgesic and anti- inflammatory, used for treating tumours, swellings and gum abscesses. Latex—analgesic and toxic. Used for treating warts, insect bites and stings. Leaf—used in lucoderma. Bark—used for eczema and other skin diseases.

Key application: As a laxative. (Included among unapproved herbs by German Commission E.)

The leaves gave bergapten, psoralen, taraxasterol, beta-sitosterol, rutin and a sapogenin. Calotropenyl acetate, lep- eol acetate and oleanolic acid have been identified in the leaves.

Three peptides which exhibit action against angiotensin I-converting enzyme (ACE) have been isolated from the fresh latex. Their inhibitory activity is similar to that of ACE inhibitors derived from casein. (ACE catalyzes both the production of vasoconstrictor angiotensin II and the inactivation of the vasodilator bradykinin.)

Dosage: Fruit—10-20 ml juice; 510 g paste. (CCRAS.)... ficus carica

Ricinus Communis

Linn.

Family: Euphorbiaceae.

Habitat: Cultivated chiefly in Andhra Pradesh, Maharashtra, Karnataka, and Orissa.

English: Castor seed.

Ayurvedic: Eranda, Chitra- bija, Triputi; Tribija, Vaataari, Chanchu, Manda, Uruvaka, Gandharva-hastaa, Panchaan- gula, Vardhamaana, Uttaanpatraka, Vyaaghrapuchha, Chitraa.

Unani: Bedanjeer, Arand.

Siddha/Tamil: Ammanakku.

Action: Oil from seeds and young leaf—purgative. Oil is used in dermatosis and eczema. Leaves— used as poultice to extract the worm.

Root—a decoction is administered for lumbago and allied complaints.

Bark—purgative.

The Ayurvedic Pharmacopoeia ofIn- dia recommends the decoction of the dried, mature root in rheumatism, pain in the urinary bladder, lumbago, diseases of the abdomen and inflammations; fresh leaf in helminthiasis, dysu- ria, arthritis, pain in the urinary bladder, dysuria, abscesses; dried seed powder in constipation, rheumatism, diseases of the liver and spleen, piles, lumbago, sciatica.

The root extract exhibited significant anti-inflammatory activity against carrageenan-, bradykinin-, 5-HT-and dextran-induced rat hind paw oedema. N-Demethylricinine showed dose-dependent anticholestatic and hepato- protective activities in rats.

Castor oil, derived from the seeds, is a well-known purgative (dose 520 ml).

Castor seed contains toxic components (2.8-3.0% on whole seed; about 10% in the flour) which are highly poisonous to human beings and animals. The principal toxic substance is the albumin, ricin. Allergens and a feebly toxic alkaloid ricinine is also present. An ulcerative factor in the seed is reported. Like other toxalbumins, ricin agglutinizes the mammalian red bleed corpuscles. (Ricin loses its toxicity and antigenic action on treatment with potassium permanganate.)

Castor oil consists principally of ri- cinoleic acid. Stearic, oleic, linoleic and dihydroxystearic acids are present in small amounts. The strong laxative property of castor oil is reported due to the local irritant action caused in the intestines by ricinoleic acid formed by hydrolysis under the influence of lipolytic enzymes. (The oil should not be used with fat-soluble vermifuge, it may increase its absorption and toxic- ity.)

Dosage: Root—20-30 g for decoction. (API, Vol. I.) Leaf—10- 20 ml juice; 2-5 g powder; seed— 0.5-3 g powder. (API, Vol. III.)... ricinus communis



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