Burkholderia Health Dictionary

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Burkholderia: From 1 Different Sources

A genus of Gram negative rods including Burkholderia pseudomallei which can cause a severe infection of humans, called melioidosis in tropical regions including Australia and S.E.Asia.
Health Source: Dictionary of Tropical Medicine
Author: Health Dictionary

Ashdown’s Medium

A differential selective culture medium for Burkholderia pseudomallei, devised by Dr LesleyRichard Ashdown (1943-93), Townsville, Australia. B. pseudomallei grows as distinctive purple rugose colonies on this medium.... ashdown’s medium

Melioidosis

An infectious disease caused by a soil bacterium, Burkholderia pseudomallei, seen in many areas of the tropics and is particularly prevalent during the wet season. The illness may present in a number of ways including life threatening acute septicaemia as well as pneumonia and chronic suppuration, which has a lower mortality.... melioidosis

Cystic Fibrosis

(fibrocystic disease of the pancreas, mucoviscidosis) a hereditary disease affecting cells of the exocrine glands (including mucus-secreting glands, sweat glands, and others). The faulty gene responsible for the most common form of the disease has been identified as lying on chromosome no. 7 and is recessive, i.e. both parents of the patient can be *carriers without being affected by the disease. Affected individuals have abnormalities in a protein, cystic fibrosis transmembrane conductance regulator (CFTR), that enables the transport of chloride ions across cell membranes: this results in the production of thick mucus, which obstructs the intestinal glands (causing meconium *ileus in newborn babies), pancreas (causing deficiency of pancreatic enzymes resulting in *malabsorption and *failure to thrive), and bronchi (causing *bronchiectasis). Respiratory infections, which may be severe, are a common complication. Common agents include *Haemophilus, *Pseudomonas, *Staphylococcus, and Burkholderia cepacia. The sweat contains excessive amounts of sodium and chloride, which is an aid to diagnosis.

Treatment consists of minimizing the effects of the disease by administration of pancreatic enzymes and physiotherapy for the lungs and by preventing and combating secondary infection. Sputum viscosity can be reduced by nebulized recombinant human *DNAse. *Genetic counselling is essential, as each subsequent child of carrier parents has a one in four chance of being affected (see also mouthwash test; preimplantation genetic diagnosis). Some patients are benefiting from revolutionary new treatments, including transplantation of heart and lungs and treatment aimed at altering the genetic content of the faulty cells (see gene therapy).... cystic fibrosis


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