Cashew (Anacardium occidentale).Plant Part Used: Seed case, dried bark.Dominican Medicinal Uses: Traditionally the dried bark or seed case is prepared as a decoction by boiling in water and taken orally for diarrhea in both children and adults.Safety: The fresh seed case is a potent skin irritant and is considered poisonous although roasting neutralizes this toxin. The juice of the fruit-stem is widely consumed as a beverage and generally considered safe. The seeds are commonly eaten and considered safe as long as they are properly roasted and processed. No information on the safety of the dried seed case or bark has been identified in the available literature.Laboratory & Preclinical Data: In animal studies, the nut extract in milk has demonstrated antiarthritic and antioxidant effects, and the aqueous plant extract has shown antidiabetic activity. Extracts of the bark have shown anti-inflammatory and hypoglycemic activity, and the nut shell oil and fruit stem juice have demonstrated antioxidant effects in vivo. In vitro, extracts of the plant or bark have exhibited antibacterial, antifungal, antileishmaniasis, tyrosinase inhibition and vasorelaxant activity.* See entry for Cajuil in “Part 3: Dominican Medicinal Plant Profiles” of this book for more information, including references.