Carbon Health Dictionary

A drug that curbs the action of an ENZYME in the blood controlling the production of carbonic acid or bicarbonate from CARBON DIOXIDE (CO2). Called carbonic anhydrase, the enzyme is present in ERYTHROCYTES and it has a key part in maintaining the acid-base balance in the blood. Inhibiting drugs include ACETAZOLAMIDE and DORZOLAMIDE, and these are used as weak DIURETICS to reduce the increased intraocular pressure in ocular hypertension or open-angle GLAUCOMA (see EYE, DISORDERS OF).... carbonic anhydrase inhibitor

(CO) A colourless, odourless gas. Carbon dioxide is present in small amounts in the air and is an important by-product of metabolism in cells. It is produced by the breakdown of substances such as carbohydrates and fats to produce energy, and is carried in the blood to the lungs and exhaled. Carbon dioxide helps to control the rate of respiration: when a person exercises, CO2 levels in the blood rise, causing the person to breathe more rapidly in order to expel carbon dioxide and to take in more oxygen.

When it is compressed and cooled to -75ºC, carbon dioxide becomes solid dry ice, which is used in cryosurgery.... carbon dioxide

(CO) A colourless, odourless, poisonous gas present in motor exhaust fumes and produced by inefficient burning of coal, gas, or oil.

Carbon monoxide binds with haemoglobin and prevents the transportation of oxygen to body tissues.

The initial symptoms of acute high-level carbon monoxide poisoning are dizziness, headache, nausea, and faintness.

Continued inhalation of the gas may lead to loss of consciousness, permanent brain damage, and even death.

Low-level exposure to carbon monoxide over a period of time may cause fatigue, nausea, diarrhoea, abdominal pain, and general malaise.... carbon monoxide

(CCl) A colourless, poisonous, volatile chemical with a characteristic odour that is present in some home dry-cleaning fluids and industrial solvents. It can cause dizziness, confusion, and liver and kidney damage if it is inhaled or swallowed.... carbon tetrachloride

Formed by the body during metabolism and exhaled by the lungs. Seen in sparkling waters and wines, it is also used in baths as a stimulant to the skin. Combined with oxygen in cylinders, it is used to control breathing in ANAESTHESIA and in the treatment of victims of CARBON MONOXIDE (CO) poisoning.

Measuring the partial pressure of the gas by taking blood for blood gas estimation provides information on the adequacy of breathing. A high partial pressure may indicate impending or actual respiratory failure.... carbon dioxide (co2)

This is a colourless, odourless, tasteless, nonirritating gas formed on incomplete combustion of organic fuels. Exposure to CO is frequently due to defective gas, oil or solid-fuel heating appliances. CO is a component of car exhaust fumes and deliberate exposure to these is a common method of suicide. Victims of ?res often suffer from CO poisoning. CO combines reversibly with oxygen-carrying sites of HAEMOGLOBIN (Hb) molecules with an a?nity 200 to 300 times greater than oxygen itself. The carboxyhaemoglobin (COHb) formed becomes unavailable for oxygen transportation. In addition the partial saturation of the Hb molecule results in tighter oxygen binding, impairing delivery to the tissues. CO also binds to MYOGLOBIN and respiratory cytochrome enzymes. Exposure to CO at levels of 500 parts per million (ppm) would be expected to cause mild symptoms only and exposure to levels of 4,000 ppm would be rapidly fatal.

Each year around 50 people in the United Kingdom are reported as dying from carbon monoxide poisoning, and experts have suggested that as many as 25,000 people a year are exposed to its effects within the home, but most cases are unrecognised, unreported and untreated, even though victims may suffer from long-term effects. This is regrettable, given that Napoleon’s surgeon, Larrey, recognised in the 18th century that soldiers were being poisoned by carbon monoxide when billeted in huts heated by woodburning stoves. In the USA it is estimated that 40,000 people a year attend emergency departments suffering from carbon monoxide poisoning. So prevention is clearly an important element in dealing with what is sometimes termed the ‘silent killer’. Safer designs of houses and heating systems, as well as wider public education on the dangers of carbon monoxide and its sources, are important.

Clinical effects of acute exposure resemble those of atmospheric HYPOXIA. Tissues and organs with high oxygen consumption are affected to a great extent. Common effects include headaches, weakness, fatigue, ?ushing, nausea, vomiting, irritability, dizziness, drowsiness, disorientation, incoordination, visual disturbances, TACHYCARDIA and HYPERVENTILATION. In severe cases drowsiness may progress rapidly to COMA. There may also be metabolic ACIDOSIS, HYPOKALAEMIA, CONVULSIONS, HYPOTENSION, respiratory depression, ECG changes and cardiovascular collapse. Cerebral OEDEMA is common and will lead to severe brain damage and focal neurological signs. Signi?cant abnormalities on physical examination include impaired short-term memory, abnormal Rhomberg’s test (standing unsupported with eyes closed) and unsteadiness of gait including heel-toe walking. Any one of these signs would classify the episode as severe. Victims’ skin may be coloured pink, though this is very rarely seen even in severe incidents. The venous blood may look ‘arterial’. Patients recovering from acute CO poisoning may suffer neurological sequelae including TREMOR, personality changes, memory impairment, visual loss, inability to concentrate and PARKINSONISM. Chronic low-level exposures may result in nausea, fatigue, headache, confusion, VOMITING, DIARRHOEA, abdominal pain and general malaise. They are often misdiagnosed as in?uenza or food poisoning.

First-aid treatment is to remove the victim from the source of exposure, ensure an e?ective airway and give 100-per-cent oxygen by tight-?tting mask. In hospital, management is largely suppportive, with oxygen administration. A blood sample for COHb level determination should be taken as soon as practicable and, if possible, before oxygen is given. Ideally, oxygen therapy should continue until the COHb level falls below 5 per cent. Patients with any history of unconsciousness, a COHb level greater than 20 per cent on arrival, any neurological signs, any cardiac arrhythmias or anyone who is pregnant should be referred for an expert opinion about possible treatment with hyperbaric oxygen, though this remains a controversial therapy. Hyperbaric oxygen therapy shortens the half-life of COHb, increases plasma oxygen transport and reverses the clinical effects resulting from acute exposures. Carbon monoxide is also an environmental poison and a component of cigarette smoke. Normal body COHb levels due to ENDOGENOUS CO production are 0.4 to

0.7 per cent. Non-smokers in urban areas may have level of 1–2 per cent as a result of environmental exposure. Smokers may have a COHb level of 5 to 6 per cent.... carbon monoxide (co)

A drug widely used in the PROPHYLAXIS treatment of certain forms of MENTAL ILLNESS. The drug should be given only on specialist advice. The major indication for its use is acute MANIA; it induces improvement or remission in over 70 per cent of such patients. In addition, it is e?ective in the treatment of manic-depressive patients (see MANIC DEPRESSION), preventing both the manic and the depressive episodes. There is also evidence that it lessens aggression in prisoners who behave antisocially and in patients with learning diffculties who mutilate themselves and have temper tantrums.

Because of its possible toxic effects – including kidney damage – lithium must only be administered under medical supervision and with monitoring of the blood levels, as the gap between therapeutic and toxic concentrations is narrow. Due to the risk of its damaging the unborn child, it should not be prescribed, unless absolutely necessary, during pregnancy – particularly not in the ?rst three months. Mothers should not take it while breast feeding, as it is excreted in the milk in high concentrations. The drug should not be taken with DIURETICS.... lithium carbonate

a weak *antacid used to relieve indigestion. It is taken alone or combined with other compounds in mixtures, powders, and tablets.... magnesium carbonate