Cefaclor Health Dictionary

These are broad-spectrum antibiotics. Most are semi-synthetic derivatives of cephalosporin C, an antibiotic originally derived from a sewage outfall in Sardinia.

First-generation examples still in use include cephalexin and cefadroxil. They are orally active and, along with second-generation cefaclor, have a similar antimicrobial spectrum. They are used for ‘resistant’ urinary infections and urinary infections in pregnancy. Cephalosporins have a similar pharmacology to that of penicillin, and about 10 per cent of patients allergic to penicillin will also be hypersensitive to cephalosporins. They are e?ective in treating SEPTICAEMIA, PNEUMONIA, MENINGITIS, biliary-tract infections and PERITONITIS.

Second-generation cefuroxime and cefamandole are less vulnerable to penicillinases and are useful for treating ‘resistant’ bacteria and Haemophilus in?uenzae and Neisseria gonorrhoea. Third-generation cephalosporins include cefotaxime, ceftazidime and others; these are more e?ective than the second-generation in treating some gram-negative infections, especially those causing septicaemia.... cephalosporins

n. any one of a group of semisynthetic *beta-lactam antibiotics, derived from the mould Cephalosporium, which are effective against a wide range of microorganisms and are therefore used in a variety of infections. The older (first-generation) cephalosporins include *cefadroxil and *cefalexin; more recent (second-generation) drugs include *cefaclor and *cefuroxime. Third-generation cephalosporins, such as *ceftazidime, cefotaxime, and ceftriaxone, have greater activity against Gram-negative bacteria. Cross-sensitivity with penicillin may occur and the principal side-effects are allergic reactions and irritation of the digestive tract.... cephalosporin