Children act Health Dictionary

Children Act: From 1 Different Sources


The Children Act 1989 (Children Act) introduced major reforms of child-care law. It encourages negotiation and cooperation between parents, children and professionals to resolve problems affecting children. The aim is to enable children to stay within their own families with appropriate back-up from local-authority and professional resources. The emphasis is on empowering families rather than paternalistic control. The Act set up a court made up of three tiers – the High Court, county court and magistrates’ court – each with concurrent jurisdiction. The Act has been broadened, clari?ed and interpreted by subsidiary legislation, rules, case law and o?cial guidance. An equivalent act is in force in Scotland.
Health Source: Medical Dictionary
Author: Health Dictionary

Actinomycosis

A chronic infectious condition caused by an anaerobic micro-organism, Actinomyces israelii, that often occurs as a COMMENSAL on the gums, teeth and tonsils. Commonest in adult men, the sites most affected are the jaw, lungs and intestine, though the disease can occur anywhere. Suppurating granulomatous tumours develop which discharge an oily, thick pus containing yellowish (‘sulphur’) granules. A slowly progressive condition, actinomycosis usually responds to antibiotic drugs but improvement may be slow and surgery is sometimes needed to drain infected sites. Early diagnosis is important. Treatment is with antibiotics such as penicillin and tetracyclines. The disease occurs in cattle, where it is known as woody tongue.... actinomycosis

Actinomycin D

See DACTINOMYCIN.... actinomycin d

Acth

The common abbreviation for adrenocorticotrophic hormone (also called corticotrophin). is produced by the anterior pituitary gland and stimulates the adrenal cortex (outer layer of the adrenal glands) to release various corticosteroid hormones, most importantly hydrocortisone (cortisol) but also aldosterone and androgen hormones.

production is controlled by a feedback mechanism involving both the hypothalamus and the level of hydrocortisone in the blood. levels increase in response to stress, emotion, injury, infection, burns, surgery, and decreased blood pressure.

A tumour of the pituitary gland can cause excessive production which leads to overproduction of hydrocortisone by the adrenal cortex, resulting in Cushing’s syndrome. Insufficient production results in decreased production of hydrocortisone, causing low blood pressure. Synthetic is occasionally given by injection to treat arthritis or allergy.... acth

Actin

A protein involved in muscle contraction, in which microscopic filaments of actin and another protein, myosin, slide in between each other.... actin

Actaea Spicata

Linn.

Synonym: A. acuminata Wall. ex Royle

Family: Ranunculaceae.

Habitat: Native to Europe; grows in temperate Himalayas from Hazara to Bhutan.

English: Baneberry Grapewort.

Folk: Visha-phale (Kannada).

Action: Root—antirheumatic, anti-inflammatory, nerve sedative, emetic, purgative; used in the treatment of rheumatic fever, lumbago, scrofula, nervous disorders, chorea.

The plant is reported to contain trans-aconitic acid, which shows a strong cytostatic action. Its Me ether is active against Ehrlich's ascites tumours.

In folk medicine, roots are used in cases of ovarian neuralgia, uterine tenderness and sub-involution. They are adulterant of the roots of Helleborus niger. Berries are poisonous; used topically for skin diseases. The toxic constituent is protoanemonin (lactone). It is irritant to mucous membrane.... actaea spicata

Acth (adrenocorticotrophic Hormone)

ACTH is the commonly used abbreviation for CORTICOTROPIN.... acth (adrenocorticotrophic hormone)

Actiniopteris Dichotoma

Kuhn.

Synonym: A. australis (L. f.) Link. A. radiata (Sw.) Link. A. dichotoma Kuhn.

Family: Adiantaceae.

Habitat: Throughout India, especially common in Kumaon Hills and the Nilgiris, below an altitude of 1,200 m.

English: Peacocks tail.

Ayurvedic: Mayurshikhaa, Madhu- chhadaa, Sahastrahi, Vahrishikhaa.

Action: Styptic, antibacterial, antipyretic.

The stems and leaves contain rutin, a styptic active principle. Anthelmintic activity, attributed to the fern, was not observed in experiments on mice.

Dosage: Root—3-5 g powder. (CCRAS.)... actiniopteris dichotoma

Actinodaphne Hookeri

Meissn.

Synonym: A. angustifolia Nees.

Family: Lauraceae.

Habitat: The western Ghats, Orissa and Sikkim up to 1,500 m.

Siddha/Tamil: Thali, Paratathali.

Folk: Pisaa (Maharashtra).

Action: Infusion of leaves—urinary tract disinfectant, antidiabetic, spasmolytic.

The leaves contain a very small amount of an amorphous alkaloid. They also contain beta-sitosterol, hen- triacontanone, hentriacontanol and quercetin-3-rhamnoside and hydrocarbons.

The bark gives an alkaloid, actino- daphnine.

The roots contain a flavanone glycoside.... actinodaphne hookeri

Action On Smoking And Health

See ASH.... action on smoking and health

Action Research

A family of research methodologies which pursue action (or change) and research (or understanding) at the same time.... action research

Active Ageing

The process of optimizing opportunities for health, participation and security in order to enhance quality of life as people age.... active ageing

Activities Of Daily Living (adl)

A concept of functioning – activities of daily living are basic activities that are necessary to independent living, including eating, bathing and toileting. This concept has several assessment tools to determine an individual’s ability to perform the activity with or without assistance. See related “instrumental activities of daily living (IADL)”.... activities of daily living (adl)

Activity Coordinator

A trained staff member who is responsible for leisure activities in a health care programme. Activity coordinators develop programmes for people based on individual abilities and interests.... activity coordinator

Adrenocorticotrophic Hormone (acth)

See also CORTICOTROPIN. A hormone which is released into the body during stress. Made and stored in the anterior PITUITARY GLAND, ACTH regulates the production of corticosteroid hormones from the ADRENAL GLANDS, and is vital for the growth and maintenance of the adrenal cortical cells. Its production is in part controlled by the amount of HYDROCORTISONE in the blood and also by the HYPOTHALAMUS. ACTH participates in the FEEDBACK MECHANISM of hormone production and actions involving particularly the hypothalamus and pituitary gland. The hormone is used to test adrenal function and treat conditions such as ASTHMA. (See also CUSHING’S SYNDROME.)... adrenocorticotrophic hormone (acth)

Community Action For Health

Collective efforts by communities which are directed towards increasing community control over the determinants of health and thereby improving health.... community action for health

Core Activities

Activities which are essential for daily living, such as self care, mobility and communication.... core activities

Instrumental Activities Of Daily Living (iadl)

Activities with aspects of cognitive and social functioning, including shopping, cooking, doing housework, managing money and using the telephone. See also “activities of daily living (ADLs)”.... instrumental activities of daily living (iadl)

Intersectoral Action / Multisectoral Action

A recognized relationship between part or parts of different sectors of society which has been formed to take action on an issue to achieve health outcomes or intermediate health outcomes in a way which is more effective, efficient or sustainable than might be achieved by the health sector acting alone. For practical purposes, intersectoral action and multisectoral action are synonymous terms, the former perhaps emphasizing the element of coordination, the latter the contribution of a number of sectors.... intersectoral action / multisectoral action

Mental Health Problems In Children

Emotional and behavioural problems are common in children and adolescents, affecting up to one-?fth at any one time. But these problems are often not clear-cut, and they may come and go as the child develops and meets new challenges in life. If a child or teenager has an emotional problem that persists for weeks rather than days and is associated with disturbed behaviour, he or she may have a recognisable mental health disorder.

Anxiety, phobias and depression are fairly common. For instance, surveys show that up to

2.5 per cent of children and 8 per cent of adolescents are depressed at any one time, and by the age of 18 a quarter will have been depressed at least once. Problems such as OBSESSIVE COMPULSIVE DISORDER, ATTENTION DEFICIT DISORDER (HYPERACTIVITY SYNDROME), AUTISM, ASPERGER’S SYNDROME and SCHIZOPHRENIA are rare.

Mental-health problems may not be obvious at ?rst, because children often express distress through irritability, poor concentration, dif?cult behaviour, or physical symptoms. Physical symptoms of distress, such as unexplained headache and stomach ache, may persuade parents to keep children at home on school days. This may be appropriate occasionally, but regularly avoiding school can lead to a persistent phobia called school refusal.

If a parent, teacher or other person is worried that a child or teenager may have a mental-health problem, the ?rst thing to do is to ask the child gently if he or she is worried about anything. Listening, reassuring and helping the child to solve any speci?c problems may well be enough to help the child feel settled again. Serious problems such as bullying and child abuse need urgent professional involvement.

Children with emotional problems will usually feel most comfortable talking to their parents, while adolescents may prefer to talk to friends, counsellors, or other mentors. If this doesn’t work, and if the symptoms persist for weeks rather than days, it may be necessary to seek additional help through school or the family’s general practitioner. This may lead to the child and family being assessed and helped by a psychologist, or, less commonly, by a child psychiatrist. Again, listening and counselling will be the main forms of help o?ered. For outright depression, COGNITIVE BEHAVIOUR THERAPY and, rarely, antidepressant drugs may be used.... mental health problems in children

Multisectoral Action

See “intersectoral action”.... multisectoral action

National Plan Of Action

A broad intersectoral master plan for attaining national health goals through implementation of a strategy. It indicates what has to be done, who has to do it, during what time-frame, and with what resources. It is a framework leading to more detailed programming, budgeting, implementation and evaluation. It specifies, in operational terms, the steps to be taken in accordance with the strategy, keeping in mind the various objectives and targets to be attained and the programmes for attaining them.... national plan of action

Physical Activity

Any form of exercise or movement.... physical activity

Potassium-channel Activators

Drugs that have the ability to dilate ARTERIES and VEINS and are used to relieve pain in ANGINA of the HEART. Nicorandil is the main example.... potassium-channel activators

Reflex Action

One of the simplest forms of activity of the nervous system. (For the mechanism upon which it depends, see NERVOUS SYSTEM; NEURON(E).) Re?ex acts are divided usually into three classes.

Super?cial re?exes comprise the sudden movements which result when the skin is brushed or pricked, such as the movement of the toes that results from stroking the sole of the foot.

Deep re?exes depend upon the state of mild contraction in which muscles are constantly maintained when at rest, and are obtained, as in the case of the knee-jerk (see below), by sharply tapping the tendon of the muscle in question.

Visceral re?exes are those connected with various organs, such as the narrowing of the pupil when a bright light is directed upon the EYE, and the contraction of the URINARY BLADDER when distended by urine.

Faults in these re?exes give valuable evidence as to the presence and site of neurological disorders. Thus, absence of the knee-jerk, when the patellar tendon is tapped, means some interference with the sensory nerve, nerve-cells, or motor nerve upon which the act depends – as, for example, in POLIOMYELITIS, or peripheral NEURITIS; whilst an exaggerated jerk implies that the controlling in?uence exerted by the BRAIN upon this re?ex mechanism has been cut o? – as, for example, by a tumour high up in the SPINAL CORD, or in the disease known as MULTIPLE SCLEROSIS (MS).... reflex action

Tissue Plasminogen Activator (tpa, Tpa)

A natural PROTEIN that occurs in the body. It has the property of breaking down a THROMBUS in a blood vessel (see THROMBOLYSIS). It is e?ective only in the presence of FIBRIN and activates plasminogen, which occurs normally on the surface of the ?brin. TPA is an important thrombolytic treatment immediately after a myocardial infarction (see HEART, DISEASES OF).... tissue plasminogen activator (tpa, tpa)

Active Principle

There are active and passive (in-active) constituents in all plants. An active principle is the most active constituent.

The amount of active constituent of a plant is not constant. The percentage of active constituent varies greatly. For this reason official pharmacy standardises drugs. See: WHOLE PLANT. ... active principle

Teas For Children

Drinking tea is considered to be good for every adult, thanks to the many health benefits various types of tea have. However, this isn’t the case when it comes to children, babies included. Find out more about the types of tea for children, as well as the ones they shouldn’t drink. Be careful with teas for children Teas have plenty of health benefits when it comes to children, as well. You just have to be careful with the type of tea you give your child to drink. Some can help a lot, especially when it comes to colds or stomach problems, but other types of tea might lead to unpleasant side effects. The biggest problem revolves around the caffeine content found in teas; these include the teas made from the Camellia sinensis plant: green tea, black tea, white tea, and oolong tea. If your child drinks one of these teas that contain caffeine, it might give him an upset stomach, sleeping problems, or it might make him easily irritable. Teas for children Considering the fact that children like sweet things, fruit-flavored teas should tempt them. Not only is the aromatic taste pleasant, but drinking fruit-flavored teas should definitely be healthier for children than drinking soda. The fruit-flavored teas for children include apple, banana, raspberry, strawberry, cherry, passion fruit, or mango. The children are bound to enjoy it both hot during winter, and cold during summer (either prepared as iced tea, or simply left to cool at room temperature). Herbal teas are also recommended, especially thanks to the health benefits they have. Benefits of teas for children You can prepare tea for your child if he has small health problems, such as coughing, nausea, colic, or even anxiety. Generally, it is recommended to prepare only half a cup of tea for children, not a full cup. Also, steeping time shouldn’t be as long as usual, as the tea shouldn’t be too strong; steeping time can be half the usual time. Use honey, stevia or fruit juice to sweeten it. With this, the result will be a pleasant-tasting tea for children. For colic, you can prepare a cup of chamomile tea or peppermint tea for your child. To treat nausea, as well as motion sickness, prepare ginger tea. Also, if your child is constipated, prepare oatmeal with flaxseed tea instead of water. The tea you should use for coughs depends on the type of cough. If your child has a mild cough, you can give him peppermint tea. If the child’s coughing is caused by a sore throat, prepare marshmallow root tea or slippery elm tea . Meanwhile, for coughs with congestion, licorice or coltsfoot tea is better. If your child has a fever, you can give him half a cup of the following types of tea: lemon balm, chamomile, peppermint, licorice or elder flower. Also, if your child has anxiety problems, try chamomile or oat straw tea; you can also prepare passionflower tea for children aged over 4, or skullcap tea for children aged over 6. Herbal tea can be good for children. You just have to pick the right one, in order to make sure it won’t end up harming your children.... teas for children

Adrenal-activator

An agent which stimulates the adrenal glands thereby increasing secretion of cortisol and adrenal hormones. A herb with a mild cortico-steroid effect. Liquorice. Ginseng. Sarsaparilla. ... adrenal-activator

Acting Out

Impulsive actions that may reflect unconscious wishes. The term is most often used by psychotherapists to describe behaviour during analysis when the patient “acts out” rather than reports fantasies, wishes, or beliefs. Acting out can also occur as a reaction to frustrations encountered in everyday life, often taking the form of antisocial, aggressive behaviour.... acting out

Actinic

Pertaining to changes caused by the ultraviolet rays in sunlight, as in actinic dermatitis (inflammation of the skin) and actinic keratosis (roughness and thickening of the skin).... actinic

Displacement Activity

The transference of feelings from one object or person to another.

This is usually performed consciously to obtain emotional relief in a manner that will not cause harm to oneself or to another person.

Some psychotherapists believe that displacement is an unconscious defence mechanism, which prevents disturbing feelings from entering consciousness.... displacement activity

Plasminogen Activator

See tissue plasminogen activator.... plasminogen activator

Tissue-plasminogen Activator

A substance produced by body tissues that prevents abnormal blood clotting. Also called , it is produced by the inner lining of blood vessels. can be prepared artificially for use as a thrombolytic drug, which is called alteplase. This is used in the treatment of myocardial infarction, severe angina pectoris, and arterial embolism, including pulmonary embolism. Possible side effects include bleeding or the formation of a haematoma at the injection site and an allergic reaction. (See also fibrinolysis.)... tissue-plasminogen activator

Children

Massive and long continued medication should be avoided, parents acquiring some ability to distinguish between the purely miserable and the critically ill. It is easy to become alarmed at the sight of a child in the throes of a convulsion or feverishness when there may be a tendency to over-prescribe. German Chamomile tea is a splendid children’s remedy. Liquid Extract and Tincture doses for children are 1 drop and 2 drops, respectively, for each year of age.

Anti-depressants should not be given for bed-wetting, drugs for sleep problems or strong laxatives for the chronically constipated. Mild herbal alternatives exist. Fresh carrot juice daily helps a child to avoid some complaints. Some herbs are not advised for children under 12, except under the care of a qualified practitioner.

Parental smoking habits are known to be responsible for crying and digestive symptoms in infants. Sleeplessness. German Chamomile or Balm tea: children 2-10 years quarter to half a cup; over 10 years: 1 cup. Babies: 3-6 teaspoons in feeding bottle – sweeten with honey if necessary.

Night seizures, with screaming: Passion Flower tea. 1 heaped teaspoon to cup boiling water; infuse 5-15 minutes. Strain. A few teaspoons at bedtime. When a brain storm starts place pinch of salt on the tongue. Calcium deficiency. Nettle tea. Carrot juice. Cod Liver oil with fresh orange juice.

Colic. Any tea: Dill, Catnep, Spearmint or Fennel. Few teaspoons frequently. Abdominal massage: 3 drops Chamomile oil in teaspoon olive oil.

Constipation. Prune or carrot juice. Dandelion coffee.

Cough. Oil of Thyme – few drops in water.

Crusta Lacta (milk rash). Weak teas: Plantain, Heartsease, Red Clover. Anoint with St John’s Wort oil. Buttermilk, Wheatgerm.

Diarrhoea. Teas: Yarrow, Tormentil. Breast feeding during the first 4-6 months of life reduces the risk of children’s diarrhoea.

Digestion, weak. Teas: Fennel, Caraway, Dill. 1 teaspoon crushed seeds to cup boiling water. Infuse 15 minutes in a covered vessel. Teaspoon doses for under 2s; half-1 cup thereafter. Also for flatulence. Feverishness. Alarm at a baby’s fever and fractiousness may attract complete medical treatment including nose drops, cough linctus, antipyretics and antibiotics, together with something to let the parents get some sleep. Avoid where possible. Mild fevers: teas – Yarrow, Marigold, Thyme, Elderflowers and Peppermint, Catmint, Carragheen Moss. Sweeten with honey. Topical: Flannels wrung out in these hot teas. Zinc can cut short the common cold. Echinacea tablets/capsules offer antiviral protection.

It is common for a child to convulse with fever. A feverish child, kept cool, is less likely to have convulsions. Remove most of child’s clothes so he can lose heat through the skin. Fruit juices (Vitamin C) in abundance. Do not feed solid foods. Wash in lukewarm (not cold) water.

Eyes. Deep hollows under the eyes reveal exhaustion, for which blood and nerve tonics and iron supplements are indicated.

Growth problems. Under-developed children respond well to herbal aids: Gentian, Ginseng, Horsetail, Marigold, Oats, German Chamomile, Wood Betony, Kelp, Alfalfa. Supplementation with brewer’s yeast, Calcium, Pollen and Zinc yield convincing results.

Hyperactivity. Nerve restoratives for highly-strung children: Teas: Lime flowers, Chamomile, Lemon Balm, B-vitamins. Porridge. Tablets: Passion flower, Valerian, Skullcap. Vitamins B6 and C. Powders: formula. Passion flower 2; Valerian 1; Liquorice 1. Dose: 250mg (one 00 capsule or one-sixth teaspoon) thrice daily.

Irritability and impaired school performance may be due to Tartrazine and other additives, sugar, and anticonvulsant drugs. See previous paragraph.

Infection. Infection of the upper respiratory tract may manifest as inflammation of the middle ear, nasal discharge or tonsillitis. Echinacea tablets, powder or liquid extract indicated. For specific infection such as measles, see under MEASLES, or other appropriate entry.

Skin. Reject cow’s in favour of goat’s milk. See appropriate entry for each skin disease (ECZEMA, etc). Care of skin after bathing: St John’s Wort oil, Evening Primrose oil. ... children

Behavioural Problems In Children

Behavioural problems range from mild, short-lived periods of unacceptable behaviour, which are common in most children, to more severe problems such as conduct disorders and refusal to go to school. Behavioural problems may occasionally occur in any child; specialist management is called for when the problems become frequent and disrupt school and/or family life. Some behavioural problems can occur whatever the family or home situation. In some cases, however, stressful external events, such as moving home or divorce, may produce periods of problem behaviour.

Behavioural problems that are common in babies and young children include feeding difficulties (see feeding, infant) and sleeping problems, such as waking repeatedly in the night. In toddlers, breath-holding attacks, tantrums, separation anxiety, and head-banging are problems best dealt with by a consistent and appropriate approach. Problems with toilet-training are usually avoided if the training is delayed until the child is physically and emotionally ready.

Between the ages of 4 and 8, behavioural problems such as nail-biting and thumb-sucking, clinginess, nightmares, and bed-wetting (see enuresis) are so common as to be almost normal.

They are best dealt with by a positive approach that concentrates on rewarding good behaviour.

In most cases, the child grows out of the problem, but sometimes medical help may be needed.... behavioural problems in children

Actinobacillus

n. a genus of Gram-negative nonmotile aerobic bacteria that are characteristically spherical or rodlike in shape but occasionally grow into branching filaments. Actinobacilli cause disease in animals that can be transmitted to humans.... actinobacillus

Actinomyces

n. a genus of Gram-positive nonmotile fungus-like bacteria that cause disease in animals and humans. The species A. israelii is the causative organism of human *actinomycosis.... actinomyces

Actinotherapy

n. the treatment of disorders with *infrared or *ultraviolet radiation.... actinotherapy

Action Potential

the change in voltage that occurs across the membrane of a nerve or muscle cell when a *nerve impulse is triggered. It is due to the passage of charged particles across the membrane (see depolarization) and is an observable manifestation of the passage of an impulse.... action potential

Active/passive

adj. the ethical distinction between actively doing something to a patient and simply allowing it to happen or failing to act (the acts and omissions doctrine). For instance, doctors should act to save life if possible, but when death is inevitable it is permissible to let it happen, although the prohibition against killing would not allow active intervention. See also dying.... active/passive

Active Transport

(in biochemistry) an energy-dependent process in which certain substances (including ions, some drugs, and amino acids) are able to cross cell membranes against a concentration gradient. The process is inhibited by substances that interfere with cellular metabolism (e.g. high doses of digitalis).... active transport

Activin

n. a protein complex that enhances the biosynthesis and secretion of follicle-stimulating hormone and helps to regulate the menstrual cycle. Inhibin is closely related and exerts an opposite effect: it down-regulates FSH synthesis and inhibits FSH secretion.... activin

Activities Of Daily Living

(ADLs) the tasks of everyday life. Basic ADLs include self-care tasks, such as bathing, dressing, eating, grooming, toileting, and moving. Instrumental ADLs include housework, shopping, managing finances, taking medication, and cooking. Inability to perform ADLs is a practical measure of disability in many disorders; problems are much more prevalent in the elderly.... activities of daily living

Actomyosin

n. a protein complex formed in muscle between actin and myosin during the process of contraction. See striated muscle.... actomyosin

Children’s Auditory Performance Scale

(CHAPS) a questionnaire designed to assess children’s hearing abilities in certain situations. It is used in the diagnosis of *auditory processing disorder.... children’s auditory performance scale

Children’s Centre

(Sure Start Children’s Centre) a building housing a range of services to support children up to five years of age and their families, including childcare, early education, parenting advice, and access to health advice. Over 3 000 ‘Sure Start’-branded Children’s Centres were established under Labour governments from 1997 to 2010. Many centres have subsequently closed, with the result that provision is no longer universal across the UK. See also health inequalities.... children’s centre

Cumulative Action

the toxic effects of a drug produced by repeated administration of small doses at intervals that are not long enough for it to be either broken down or excreted by the body.... cumulative action

Human Fertilisation And Embryology Acts

Acts of the UK parliament in 1990 and 2008, establishing and amending principles for the legal supervision, by the Human Fertilisation and Embryology Authority, of the creation, use, and storage of human embryos outside the body and of their use in treatment and research. The 2008 amendments included a ban on sex selection for social reasons, recognition of same-sex couples as potential legal parents, and regulations related to developing areas of research using embryos. The 1990 Act had also reduced the legal time limit for most abortions from 28 weeks gestation (as in the 1967 Abortion Act) to 24 weeks. Interpretation and regulation of principles and practice in this rapidly developing area of research and practice continue and are often controversial.... human fertilisation and embryology acts

Optical Activity

the property possessed by some substances of rotating the plane of polarization of polarized light. A compound that rotates the plane to the left is described as laevorotatory (or l-); one that rotates the plane to the right is described as dextrorotatory (or d-).... optical activity

Participatory Action Research

(PAR) a radical approach to public health issues that actively involves communities in collaboration, reflection, data collection, and activities that empower them to improve their own health. See empowerment.... participatory action research

Plasminogen Activators

enzymes that convert the inactive substance *plasminogen to the active enzyme *plasmin, which digests blood clots (see fibrinolysis). There are two types of plasminogen activators, *tissue-type plasminogen activator (tPA) and urokinase-like plasminogen activator (uPA). See blood coagulation.... plasminogen activators

Potassium-channel Activator

any one of a class of drugs that enhance the movement of potassium ions through the *ion channels in cell membranes. In the case of smooth muscle cells, such as those in the walls of arteries, their sensitivity to the normal stimuli to contract is reduced. The result is relaxation of the muscle fibres and widening of the arteries. Potassium-channel activators are used for improving the blood supply to the heart muscle in angina pectoris. Possible side-effects include headache, flushing, vomiting, dizziness, and weakness. A currently available member of the class is nicorandil.... potassium-channel activator

Pulseless Electrical Activity

(electromechanical dissociation) the appearance of normal-looking complexes on the electrocardiogram that are, however, associated with a state of *cardiac arrest. It is usually caused by large pulmonary emboli (see pulmonary embolism), *cardiac tamponade, tension *pneumothorax, severe disturbance of body salt levels, severe haemorrhage, or hypothermia causing severe lack of oxygen to the heart muscle.... pulseless electrical activity

Platelet Activation

the process whereby platelets adhere to collagen released from endothelial cells in damaged blood vessels and aggregate to form a plug. An important metabolic pathway in platelets converts membrane phospholipids to *thromboxane A2 (TXA2), which can activate platelets. ADP, released from platelet granules, and *thrombin are other activators. The adhesive and aggregation reactions of platelets are mediated through surface membrane glycoproteins (Glp), Glp Ib and Glp IIb/IIIa. Aspirin acts as an *antiplatelet drug by irreversibly inhibiting one of the enzymes of this pathway, cyclo-oxygenase. Clopidrogel inhibits the ADP receptor on platelet membranes, and *abciximab blocks platelet aggregation by inhibiting Glp IIb/IIIa (see illustration overleaf).... platelet activation

Reticular Activating System

the system of nerve pathways in the brain concerned with the level of consciousness – from the states of sleep, drowsiness, and relaxation to full alertness and attention. The system integrates information from all of the senses and from the cerebrum and cerebellum and determines the overall activity of the brain and the autonomic nervous system and patterns of behaviour during waking and sleeping.... reticular activating system

Sure Start Children’s Centre

see children’s centre.... sure start children’s centre

Tissue-type Plasminogen Activator

(tPA, TPA) a natural protein, found in the body and able to be manufactured by genetic engineering, that can break up a thrombus (see thrombolysis). It requires the presence of *fibrin as a cofactor and is able to activate *plasminogen on the fibrin surface, which distinguishes it from the other plasminogen activators, *streptokinase and *urokinase. tPAs include reteplase and tenecteplase, given to treat acute myocardial infarction, and *alteplase.... tissue-type plasminogen activator



Recent Searches