A method of diagnosing genetic abnormalities in a fetus using a small sample of tissue taken from the chorionic villi at edge of the placenta. Because the cells have the same chromosome makeup as those in the fetus, they can be used to detect genetic abnormalities. Chorionic villus sampling (CVS) is usually performed in the first 3 months of pregnancy in women who are at a higher-than-normal risk of having a child with a chromosomal disorder, such as Down’s syndrome, or a genetic disease, such as thalassaemia. Chromosome analysis of the villi cells takes place in the laboratory. CVS slightly increases the risk of miscarriage. choroid A layer of tissue at the back of the eye, behind the retina. The choroid contains many blood vessels that supply nutrients and oxygen to the retinal cells and to surrounding tissues in the eye. choroiditis Inflammation of the choroid. It is often caused by infections such as toxocariasis or toxoplasmosis, more rarely by sarcoidosis, syphilis, and histoplasmosis. It sometimes has no obvious cause. Treatment includes corticosteroid drugs for the inflammation, and antibiotic drugs for any causative infection.
(CVS) an invasive procedure for *prenatal diagnosis in which a sample of placental tissue (containing chorionic *villi) is aspirated through the cervix or abdomen under ultrasound visualization. It is usually performed between the 10th and 13th weeks of gestation. The cells so obtained are subjected to chromosomal analysis to determine if any abnormalities are present in the fetus. This enables the diagnosis of chromosomal abnormalities, such as Down’s syndrome.
A glycoprotein hormone secreted by the PLACENTA in early pregnancy, and stimulating the CORPUS LUTEUM within the ovary (see OVARIES) to secrete OESTROGENS, PROGESTERONE, and relaxin. The hormone is essential for the maintenance of pregnancy up to about 6–8 weeks of gestation. A RADIOIMMUNOASSAY can be used to detect its presence, and pregnancy can be diagnosed as early as six days after conception by testing for it in the urine. Some tumours also secrete human chorionic gonadotrophin, particularly HYDATIDIFORM MOLE, which produces large amounts.... human chorionic gonadotrophin
One of the minute processes thickly distributed upon the inner surface of the small INTESTINE, giving it, to the naked eye, a velvety appearance, and greatly assisting absorption of digested food. (See also DIGESTION; ABSORPTION; ASSIMILATION.)... villus
A procedure performed during a mother’s labour in which a blood sample is taken from a vein in the scalp of the FETUS. This enables tests to be performed that indicate whether the fetus is, for example, suffering from a shortage of oxygen (HYPOXIA). If so, the obstetrician will usually accelerate the baby’s birth.... fetal blood sampling
A hormone produced by the placenta in early pregnancy. Human chorionic gonadotrophin (HCG) stimulates the ovaries to produce oestrogen and progesterone, which are needed for a healthy pregnancy. HCG is excreted in the urine, and its presence in urine is the basis of pregnancy tests on urine samples. ... gonadotrophin, human chorionic
one of the thin-walled projections outwards of the arachnoid membrane into the blood-filled sinuses of the dura, acting as a one-way valve for the flow of cerebrospinal fluid from the subarachnoid space into the bloodstream. Large villi, known as arachnoid granulations (or Pacchionian bodies), are found in the region of the superior sagittal sinus. They may be so distended as to cause pitting of the adjacent bone.... arachnoid villus
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