n. a drug used in the treatment of diarrhoea. It consists of a mixture of diphenoxylate hydrochloride (an opioid that reduces *peristalsis) and atropine (which relaxes the smooth muscle of the gut) in a ratio of 100 to 1.
Initial treatment of acute DIARRHOEA is to prevent or correct the loss of ?uid and ELECTROLYTES from the body. This is a priority especially in infants and elderly people. Rehydration can be achieved orally or, in severe cases, by urgent admission to hospital for the replacement of ?uid and electrolytes.
For adults with acute diarrhoea, short-term symptomatic treatment can be achieved with antimotility drugs such as codeine phosphate, co-phenotrope or loperamide hydrochloride. Adsorbent drugs, for example, KAOLIN, should not be used in acute diarrhoea, but bulk-forming drugs – ispaghula or methylcellulose
– can help to control the consistency of faeces in patients with ileostomies and colostomies (see ILEOSTOMY; COLOSTOMY), or those with diarrhoea caused by DIVERTICULAR DISEASE.
Irritable bowel syndrome, malabsorption syndrom, ulcerative colitis, Crohn’s disease and diverticular disease are often accompanied by diarrhoea; for more information on these conditions, see under separate entries.
ANTIBIOTICS may sometimes cause diarrhoea and this side-e?ect should be borne in mind when the cause of the condition is being investigated.... antidiarrhoeal treatments
Sickness induced by any form of transport, whether by sea, air, motor-car or train. (See also MOTION (TRAVEL) SICKNESS.)
Traveller’s diarrhoea is an all-toocommon a?iction of the traveller, which basks in a multiplicity of names: for example, Aden gut, Aztec two-step, Basra belly, Delhi belly, Gippy tummy, Hong Kong dog, Montezuma’s revenge, Tokyo trots, turista. It is caused by a variety of micro-organisms, usually E. coli. Some people seem to be more prone to it than others, although for no good cause. Obvious preventive measures include the avoidance of salads, unpeeled fruit and ice cream, and never drinking unboiled or unbottled water. If diarrhoea occurs, co-phenotrope and loperamide are often used to reduce the frequency of bowel movements in adults. Prophylactic antibacterial drugs are not advisable.... travel sickness
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