Constriction Health Dictionary

Bloodlessness of a part of the body, due to contraction, spasm, constriction or blocking (by EMBOLUS or by THROMBUS) of the arteries: for example, of the heart.... ischaemia

Condition of constriction (reduction in size) of the pupil (see EYE). It may be the result of disease affecting the AUTONOMIC NERVOUS SYSTEM. Bright light causes miosis and some drugs

– for example, PILOCARPINE or OPIUM – have the same e?ect.... miosis

The constriction of the PENIS behind the glans by an abnormally tight foreskin that has been retracted. The condition causes swelling and severe pain. Sometimes the foreskin can be returned by manual manipulation after an ice pack has been applied to the glans or a topical local anaesthetic applied. Sometimes an operation to cut the foreskin is required.... paraphimosis

A feeling of constriction or su?ocation often accompanied by pain (see ANGINA PECTORIS).... angina

The word migraine derives from HEMICRANIA, the Greek for half a skull, and is a common condition characterised by recurring intense headaches. It is much more usual in women than in men and affects around 10 per cent of the population. It has been de?ned as ‘episodic headache accompanied by visual or gastrointestinal disturbances, or both, attacks lasting hours with total freedom between episodes’.

It usually begins at puberty – although young children can be affected – and tends to stop in middle age: in women, for example, attacks often cease after MENOPAUSE. It frequently disappears during pregnancy. The disorder tends to run in families. In susceptible individuals, attacks may be provoked by a wide variety of causes including: anxiety, emotion, depression, shock, and excitement; physical and mental fatigue; prolonged focusing on computer, television or cinema screens; noise, especially loud and high-pitched sounds; certain foods – such as chocolate, cheese, citrus fruits, pastry; alcohol; prolonged lack of food; irregular meals; menstruation and the pre-menstrual period.

Anything that can provoke a headache in the ordinary individual can probably precipitate an attack in a migrainous subject. It seems as if there is an inherited predispostion that triggers a mechanism whereby in the migrainous subject, the headache and the associated sickness persist for hours, a whole day or even longer.

The precise cause is not known, but the generally accepted view is that in susceptible individuals, one or other of these causes produces spasm or constriction of the blood vessels of the brain. This in turn is followed by dilatation of these blood vessels which also become more permeable and so allow ?uid to pass out into the surrounding tissues. This combination of dilatation and outpouring of ?uid is held to be responsible for the headache.

Two types of migraine have been recognised: classical and common. The former is relatively rare and the headache is preceded by a slowly extending area of blindness in one or both eyes, usually accompanied by intermittent ‘lights’. The phenomenon lasts for up to 30 minutes and is followed by a bad, often unilateral headache with nausea, sometimes vomiting and sensitivity to light. Occasionally, passing neurological symptoms such as weakness in a limb may accompany the attack. The common variety has similar but less severe symptoms. It consists of an intense headache, usually situated over one or other eye. The headache is usually preceded by a feeling of sickness and disturbance of sight. In 15–20 per cent of cases this disturbance of sight takes the form of bright lights: the so-called AURA of migraine. The majority of attacks are accompanied by vomiting. The duration of the headache varies, but in the more severe cases the victim is usually con?ned to bed for 24 hours.

Treatment consists, in the ?rst place, of trying to avoid any precipitating factor. Patients must ?nd out which drug, or drugs, give them most relief, and they must always carry these about with them wherever they go. This is because it is a not uncommon experience to be aware of an attack coming on and to ?nd that there is a critical quarter of an hour or so during which the tablets are e?ective. If not taken within this period, they may be ine?ective and the unfortunate victim ?nds him or herself prostrate with headache and vomiting. In addition, sufferers should immediately lie down; at this stage a few hours’ rest may prevent the development of a full attack.

When an attack is fully developed, rest in bed in a quiet, darkened room is essential; any loud noise or bright light intensi?es the headache or sickness. The less food that is taken during an attack the better, provided that the individual drinks as much ?uid as he or she wants. Group therapy, in which groups of around ten migrainous subjects learn how to relax, is often of help in more severe cases, whilst in others the injection of a local anaesthetic into tender spots in the scalp reduces the number of attacks. Drug treatment can be e?ective and those a?icted by migraine may ?nd a particular drug or combination of drugs more suitable than others. ANALGESICS such as PARACETAMOL, aspirin and CODEINE phosphate sometimes help. A combination of buclizine hydrochloride and analgesics, taken when the visual aura occurs, prevents or diminishes the severity of an attack in some people. A commonly used remedy for the condition is ergotamine tartrate, which causes the dilated blood vessels to contract, but this must only be taken under medical supervision. In many cases METOCLOPRAMIDE (an antiemetic), followed ten minutes later by three tablets of either aspirin or paracetamol, is e?ective if taken early in an attack. In milder attacks, aspirin, with or without codeine and paracetamol, may be of value. SUMATRIPTAN (5-hydroxytryptamine [5HT1] AGONIST – also known as a SEROTONIN agonist) is of value for acute attacks. It is used orally or by subcutaneous injection, but should not be used for patients with ischaemic heart disease. Naratriptan is another 5HT1 agonist that is an e?ective treatment for acute attacks; others are almotriptan, rizariptan and zolmitriptan. Some patients ?nd beta blockers such as propranolol a valuable prophylactic.

People with migraine and their relatives can obtain help and guidance from the Migraine Action Association.... migraine

The constriction of a passage or tube in the body that blocks the blood ?ow and disturbs the working of the affected organ. It is usually caused by compression or twisting. Strangulation customarily occurs when part of the INTESTINE herniates either inside the abdomen or outside as in an inguinal HERNIA. If a section of the intestine twists, this may strangulate and is known as a VOLVULUS.

Strangulation of a person’s neck, either with a ligature or with the hands, obstructs the jugular veins in the neck, preventing the normal out?ow of blood from the brain and head. The TRACHEA is also compressed, cutting o? the supply of air to the lungs. The combination of these effects leads to HYPOXIA and damage to the brain. If not quickly relieved, unconsciousness and death follow. Strangulation may be deliberate or accidental – the latter being a particular hazard for children, for example, when playing with a rope. Removal of the constriction, arti?cial respiration, and medical attention are urgently necessary.... strangulation

An indication that an individual is still alive. Chest movements (resulting from respiration), the existence of a pulse (showing that the heart is still beating) and constriction of the pupil of the eye in response to bright light are all vital signs. Other tests such as assessment of brain activity may also be needed in some circumstances: for example, when a patient is on a life-support machine. (See also GLASGOW COMA SCALE.)... vital sign

The process by which the refractive power of the lens of the EYE is increased by constriction of the ciliary muscle, producing an increased thickness and curvature of the lens. Rays of light from an object further than 6 metres away are parallel on reaching the eye. These rays are brought to a focus on the retina, mainly by the cornea. If the eye is now directed at an object

closer than 6 metres away, the rays of light from this near object will be diverging by the time they reach the eye. In order to focus these diverging beams of light, the refracting power of the lens must increase. In other words the lens must accommodate.

The lens loses its elasticity with age, and thus becomes less spherical when tension in the zonule relaxes. This results in an increased longsightedness (presbyopia) requiring reading glasses for correction. (See AGEING.)... accommodation

The sites in the body on which ADRENALINE and comparable stimulants of the SYMPATHETIC NERVOUS SYSTEM act. Drugs which have an adrenaline-like action are described as being adrenergic. There are ?ve di?erent types of adrenergic receptors, known as alpha1, alpha2, beta1, beta2 and beta3 respectively. Stimulation of alpha receptors leads to constriction of the bronchi, constriction of the blood vessels with consequent rise in blood pressure, and dilatation of the pupils of the eyes. Stimulation of beta1 receptors quickens the rate and output of the heart, while stimulation of beta2 receptors dilates the bronchi. Beta3 receptors are now known to mediate so-called non-shivering thermogenesis, a way of producing heat from specialised fat cells that is particularly relevant to the human infant.

For long it had been realised that in certain cases of ASTHMA, adrenaline had not the usual bene?cial e?ect of dilating the bronchi during an attack; rather it made the asthma worse. This was due to its acting on both the alpha and beta adrenergic receptors. A derivative, isoprenaline, was therefore produced which acted only on the beta receptors. This had an excellent e?ect in dilating the bronchi, but unfortunately also affected the heart, speeding it up and increasing its output – an undesirable e?ect which meant that isoprenaline had to be used with great care. In due course drugs were produced, such as salbutamol, which act predominantly on the beta2 adrenergic receptors in the bronchi and have relatively little e?ect on the heart.

The converse of this story was the search for what became known as BETA-ADRENOCEPTORBLOCKING DRUGS, or beta-adrenergic-blocking drugs. The theoretical argument was that if such drugs could be synthesised, they could be of value in taking the strain o? the heart – for example: stress ? stimulation of the output of adrenaline ? stimulation of the heart ? increased work for the heart. A drug that could prevent this train of events would be of value, for example in the treatment of ANGINA PECTORIS. Now there is a series of beta-adrenoceptor-blocking drugs of use not only in angina pectoris, but also in various other heart conditions such as disorders of rhythm, as well as high blood pressure. They are also proving valuable in the treatment of anxiety states by preventing disturbing features such as palpitations. Some are useful in the treatment of migraine.... adrenergic receptors

A method of treating blockage or narrowing of a blood vessel by recanalising the vessel – that is, inserting a balloon into the constriction to reopen it. The technique is used to treat a narrowed artery in the heart or a limb. About 65 per cent of patients treated bene?t, but when symptoms persist or recur the procedure may be repeated. There is a small risk of damage to the vessel or valve. New procedures under development include the use of lasers, cutting drills and suction to remove the deposits of ATHEROMA blocking the arteries.... angioplasty

An agent that causes the constriction of tissues, usually applied topically to stop bleeding, secretions, and surface inflammation and distension. Some, such as gallotannins, may actually bind with and “tan” the surface layer of skin or mucosa. (Examples: a styptic pencil, Oak Bark.)... astringent

Benth.

Synonym: C. forskohlii Briq. Plectranthus barbatus Andr.

Family: Lamiaceae.

Habitat: The sub-tropical Himalayas of Kumaon and Nepal; cultivated in Andhra Pradesh.

Ayurvedic: Gandira (Achyranthes aquatica Br. is also equated with Gandira). (Doubtful synonym.)

Folk: Garmar (Gujarat), Gurmal.

Action: Root and leaf—spasmolytic, antithrombotic, anti-inflammatory, lipolytic.

In experimental amoebiasis of rats, the root powder and ethanolic extract showed amoebicidal activity against Entamoeba histolytica.

An alcoholic extract of the roots and essential oil from it, were found to inhibit passive cutaneous anaphylaxis in the mouse and rat.

The plant produces the labdane diterpenoid, forskolin in its tuberous roots.

Forskolin was discovered during a screening of medicinal plants by Central Drug Research Institute, Luc- know, India, in 1974. (Planta Medica, 1985, 51, 473-477.) The screening revealed the presence of a hypoten- sive and spasmolytic principle, named coleonol (later the name was changed to forskolin). The basic mechanism of forskolin is the activation of an enzyme, adenylate cyclase, which increases the amount of cyclic adeno- sine monophosphate (cAMP) in cells. Raised intracellular cAMP level exhibits following physiological effects : inhibition of platelet activation and degranulation; inhibition of mast cell degranualation and histamine release; relaxation of the arteries and other smooth muscles; increased insulin secretion; increased thyroid function; increased lipolysis.

Forskolin, in clinical studies, reduced intraocular pressure when it was applied to the eyes for treating glaucoma. It has been shown to be a direct cerebral vasodilator. It has also been studied as a possible bron- chodilator (in the treatment of asthma) and has been shown to effectively reverse methacholine-induced broncho constriction in extrinsic asthmatics.

Standardized Coleus extracts containing forskolin (18% in 50 mg) find application in weight-loss programmes. (Michael T. Murray.)

Studies on forskolin and some 50 derivatives of the compound indicate that the natural product is more active than the analogs prepared from it.

The wild var. is known as Kaffir Potato.... coleus barbatus

Ergot poisoning, or ergotism, occasionally results from eating bread made from rye infected with the fungus, Claviceps purpurea. Several terrible epidemics (St Anthony’s Fire), characterised by intense pain and hallucinations, occurred in France and Germany during the Middle Ages (see ERYSIPELAS). Its symptoms are the occurrence of spasmodic muscular contractions, and the gradual production of gangrene in parts like the ?ngers, toes and tips of the ears because of constriction of blood vessels and therefore the blood supply.... ergot poisoning

The process by which bleeding stops. It involves constriction of blood vessels, the formation of a platelet plug, and blood clotting. The term is also used for surgical interventions to stop bleeding – for example, the use of diathermy. (See COAGULATION; HAEMORRHAGE.)... haemostasis

Pupillary constriction in the EYE in response to light. The direct light re?ex involves pupillary constriction in the eye into which a light is shone; the consensual light re?ex is the pupillary constriction that occurs in the other eye. The a?erent or inward pathway of the re?ex is via the optic nerve, and the e?erent or outward pathway is via the occulomotor nerve.... light reflex

A short-lived, fast acting hormone, made by the hypothalamus of the brain, along with its close relative vasopressin (anti-diuretic hormone), stored in the posterior pituitary, and released into the blood as needed. It stimulates certain smooth muscle coats, constricts certain blood vessels and facilitates the sensitivity of some tissues to other hormones and nerves. The main tissues affected are the uterus, including endo­and myometriums, vagina, breasts (both sexes), erectile tissue (both sexes), seminal vesicles, and with special-case effects on uterine muscle contractions in both birth and orgasm, the vascular constriction that lessens placental separation bleeding, and the let­down reflex that nursing mothers have when babies cry (or kittens mew...or husbands whine)... oxytocin

A drug that stimulates the PARASYMPATHETIC NERVOUS SYSTEM. The actions of such drugs resemble those of ACETYLCHOLINE. Those cholinergic actions include stimulation of musculoskeletal muscle, reduction in the heart rate, greater tension in involuntary (or smooth) muscle, increasing glandular secretions such as saliva, and constriction of the pupil of the EYE. MYASTHENIA GRAVIS, GLAUCOMA, certain disorders of the cardiovascular system, and intestinal or bladder malfunction are among the conditions for which cholinergic drugs are prescribed.... parasympathomimetic

A substance produced in the blood PLATELETS which induces aggregation of platelets and thereby THROMBOSIS. It is also a vasoconstrictor (a substance that causes the constriction of blood vessels).... thromboxane

Not a medical term. Puffy skin from deposition of fat. “Orange peel skin”. Occurs chiefly in women as lumpy flesh on buttocks, thighs, stomach, knees and upper arm. Though not due to increased fluid in the tissues, it is sufficient to arrest the circulation. Constriction of capillaries causes toxic wastes to build up, forming nodules that lock away fat in the tissues. Hormone imbalance also suspected. Varicose veins may appear with cellulite from poorly supportive connective tissue. Usual cause: poor posture and unhealthy lifestyle.

Treatment. To activate capillary function and assist toxic elimination: Bladderwrack, Gotu Kola, Kola, Parsley tea. A diuretic may assist by eliminating excess fluid.

Gotu Kola tea: Quarter to half a teaspoon leaves to each cup boiling water; infuse 5-10 minutes. 1 cup morning and evening.

Formula. Tea. Equal parts: Alfalfa, Clivers, Fennel, Senna leaves. 1 heaped teaspoon to each cup boiling water: infuse 5-10 minutes. Half-1 cup morning and evening.

Seline. Tablets. Ingredients: Each tablet contains Lecithin 100mg; Pulverised Dandelion 100mg; Pulverised Horsetail 100mg; Pulverised extract Fucus 5:1 30mg; Vitamin C 40mg; Vitamin B6 1mg. 1 tablet thrice daily.

Aescin. Compound isolated from Horse-chestnuts to decrease capillary permeability and swelling. Topical. Decoction of Horse-chestnuts as a lotion. Or: infusion of Bladderwrack.

Aromatherapy and Herb essences. Combination for external use. Ingredients: Almond oil 47ml; Fennel oil 1ml; Juniper oil 1ml; Cypress essence 0.5ml; Lemon essence 0.5ml. Apply to affected areas morning and evening; small area 5 drops, large area 10 drops (Gerard). Gentle massage with a string glove, loofah or massage glove.

Diet. Reduce calorie intake. Raw fresh fruits and vegetable salads to account for 50 per cent of the diet. No sweet or dried fruits. Conservatively-cooked vegetables. Seafood. Iodine-rich foods. Wholegrain cereals. Protein: beans, chicken, poached eggs, fish, little lean meat: no pork, bacon or ham. Low-fat yoghurt. Cold-pressed unsaturated oils for salad dressings with lemon juice. Dandelion coffee to stimulate liver. Avoid sugar, alcohol, bananas and white flour products. Spring water.

Supportives. Stop smoking. Adopt an alternative to the contraceptive pill. To avoid fluid retention, 2-3 glasses of water daily. ... cellulite

A rare, life-threatening allergic reaction that occurs in people with an extreme sensitivity to a particular substance (allergen), often insect venom, a food item, or a drug (see allergy). When the allergen enters the bloodstream, massive amounts of histamine and other chemicals are released, causing sudden, severe lowering of blood pressure and constriction of the airways. Other symptoms may include abdominal pain, diarrhoea, swelling of the tongue and throat, and itchy rash.

Anaphylactic shock requires emergency medical treatment. An injection of

adrenaline may be life-saving. Antihistamine drugs and corticosteroid drugs may also be given.... anaphylactic shock

See: WEAKNESS.

ASTHMA. Spasmodic contraction of the bronchi following exercise, emotional tension, infection, allergens, pollens, house dust, colds.

Symptoms. Obstruction of airways with wheezing, rales or whistling sounds with a sense of constriction. Often related to eczema – ‘eczema of the epithelium’. Infantile eczema treated with suppressive ointments may drive the condition ‘inwards’ and worsen asthma. “My son’s eczema has got better, but he now has asthma” is a common observation.

Causes: hypersensitivity to domestic animals, horses and pet birds. Common salt. Red or white wine allergy. An older generation of practitioners recognised a renal-bronchial asthma encouraged by faulty kidney function. With addition of a relaxing diuretic (Dandelion, Buchu or Parsley root) to a prescription, respiratory symptoms often abate.

Broncho-dilators such as Ephedra and Wild Thyme are widely used by the practitioner. To relieve spasm: Lobelia, Pleurisy root. White Horehound, Ammoniacum, Cramp bark, Garlic, Grindelia, Hyssop.

Anti-cough agents serve to remove sticky sputum: Coltsfoot, Garden Thyme, Slippery Elm bark, Maidenhair Fern, Linseed, Bayberry bark.

For the chronic asthmatic, bacterial invasion spells distress, when Echinacea or Balm of Gilead should be added. Where an irregular pulse reveals heart involvement, add: Hawthorn or Lily of the Valley.

Lobelia is of special value for the anxious patient with spasm of the bronchi. Should be tried before resorting to powerful spray mists which frequently produce gastro-intestinal disturbance.

Alternatives. Teas. Coltsfoot, Comfrey, Horehound (White), Mullein, Skullcap, Marshmallow, Thyme, Valerian, Wild Cherry bark, Elecampane, Plantain. Formula: equal parts herbs Coltsfoot, Mullein, Valerian. 1-2 teaspoons to each cup boiling water; infuse 10-15 minutes; dose, 1 cup twice daily and when necessary.

Antispasmodic Drops. See entry.

Practitioner. Ephedra, Lobelia, Gelsemium, Grindelia, Euphorbia (pill-bearing spurge), Skunk Cabbage, Senega, Pulsatilla, Lily of the Valley (cardiac asthma), Thyme. Formula. Equal parts, Tincture Lobelia simp; Tincture Belladonna; Tincture Ephedra. 5-10 drops thrice daily (maintenance), 10-20 drops for spasm.

Cockayne, Ernest, FNIMH. Hyssop tea for children throughout childhood to avoid respiratory disorders. Dr Finlay Ellingwood. Gelsemium 3.5ml; Lobelia 3.5ml. Distilled water to 120ml. One 5ml teaspoon in water every 3 hours.

Dr Alfred Vogel. Ephedra 20 per cent; Ipecac 15 per cent; Hawthorn berry 10 per cent; Blessed Thistle 5 per cent; Burnet Saxifrage 5 per cent; Garden Thyme 5 per cent; Grindelia 1 per cent. 10-15 drops in water thrice daily.

Dr Wm Thomson. 1 teaspoon Ephedra herb to cup boiling water; infuse 10-15 minutes. Half-1 cup 2-3 times daily.

Traditional. 2 teaspoons shredded Elecampane root in cup cold water; stand overnight. Next day, heat to boiling point when required. Strain. Sips, hot, with honey: 1 cup 2-3 times daily.

Potter’s Asthma & Bronchitis Compound 32. 40g medicinal teabags. Ingredients: Clove BPC 4.84 per cent; Elecampane root 17.24 per cent; Horehound 26.20 per cent; Hyssop 17.24 per cent; Irish Moss 17.24 per cent; Liquorice 17.24 per cent. Dose: 1-2 teaspoons when necessary.

Chinese Medicine. Decoction or extract from the Gingko tree widely used, as also is Ephedra, Garlic, Liquorice and Bailcalensis.

Tablets/capsules. Lobelia. Iceland Moss, (Gerard). Euphorbia (Blackmore).

Powders. Formula. Lobelia 2; Hyssop 1; Elderflowers 1; Grindelia quarter; Liquorice quarter: pinch Cayenne. Dose: 750mg (three 00 capsules or half a teaspoon) 2-3 times daily.

Aromatherapy. 6 drops Rosemary oil in 2 teaspoons Almond oil for massage upper chest to relieve congestion.

Inhalation. See: INHALATIONS, FRIAR’S BALSAM.

Nebulizer. A germicidal solution is made from 5 drops oil Eucalyptus in one cup boiling water. Use in nebulizer for droplet therapy.

Ioniser – use of.

Cider Vinegar. Sips of the vinegar in water for whoop.

Supportives. Yoga. Singing. Cures have been reported of patients on taking up singing. “During singing, up to 90 per cent of the vital capacity may be used without a conscious effort to increase tidal volume.” (Dr M. Judson, New England Journal of Medicine)

Diet. Low salt, low fat, high fibre, cod liver oil, carrots, watercress, Soya beans or flour, lecithin, sunflower seed oil, green vegetables, raw fruit, fresh fish. These foods are valuable sources of antioxidant vitamins and minerals essential for the body’s defence mechanism. A diet deficient in these reduces ability of the airways to withstand the ravages of cigarette smoke and other air pollutants.

Foods that are craved are ones often causing sensitivity. Among problem foods are: milk, corn, wheat, eggs, nuts, chocolate, all dairy products, fat of meats. Check labels for tartrazine artificial colouring.

Salt intake. Linked with chest diseases. “Those who eat a lot of salt had more sensitive airways than those with low salt intake . . . excess salt tended to cause most pronounced symptoms.” (Institute of Respiratory Diseases, Oavia, Italy)

Asthma mortality could be significantly reduced by sufferers lowering their salt consumption, an epidemiologist predicted.

Supplements. Daily. Vitamin B6 50-100mg. Vitamin C 500mg. Vitamin E 400iu. Magnesium, Zinc. Cod liver oil: 2 teaspoons.

Anti-allergic bedding. Provides a protective barrier against the house dust mite on mattresses and bedding. Droppings from the tiny pests are worse in the bedroom. ... asthenia

A substance that causes constriction (narrowing) of the airways in the lungs. Bronchoconstrictors, such as histamine, are released during an allergic reaction. They may

provoke an asthma attack. The effect can be reversed by a bronchodilator drug.... bronchoconstrictor

An itchy, purple-red swelling, usually on a toe or finger, caused by excessive constriction of small blood vessels below the surface of the skin in cold weather. Chilblains are most common in the young and the elderly, and women are more susceptible to them.... chilblain

An operation to relieve pressure on muscles by making an incision in the fascia (fibrous connective tissue) that surrounds them. The operation is usually performed to treat compartment syndrome, a painful condition in which constriction of a group of muscles causes obstruction of blood flow. Fasciotomy is also sometimes performed as a surgical emergency after an injury has resulted in muscle swelling or bleeding within a muscle compartment.... fasciotomy

Abnormal paleness of the skin and mucous membranes, particularly noticeable in the face. Pallor is not always a symptom of disease. It may be due to a deficiency of the skin pigment melanin that may affect people who spend very little time in daylight. It is also a feature of albinism. In addition, pallor may be caused by constriction of small blood vessels in the skin, which may occur in response to shock, severe pain, injury, heavy blood loss, or fainting.Disorders that cause pallor include anaemia, pyelonephritis, kidney failure, and hypothyroidism. Lead poisoning is a rare cause.... pallor

Expressionless eye with pinpoint pupil (pupil constriction). The iris is compressed against the cornea thus arresting fluid circulation and raising intra-ocular pressure. Medical emergency. Two kinds: acute (closed angle) and chronic.

Acute. Eye is brick red and brick hard. Agonisingly painful, vision much reduced, pupil dilated and oval, the cornea steamy and the iris greenish, sees rainbow rings around lights, misty vision, pain in head and eyes, colours appear dull, can read for only short periods, unable to walk confidently downstairs, damage to retina and optic nerve from build-up of fluid.

Etiology: Damage from past inflammations, high blood pressure, steroids, stress, diet deficiencies, injury. Develops more in far-sighted people.

Ocular emergency requiring immediate hospital specialist treatment. If admission to hospital is delayed Pilocarpine may save the day: 1 drop of 1 per cent solution to each eye to constrict the pupil and open the drainage angle. This lasts 4-5 hours. Apply 1 drop 4 times every 24 hours. In the absence of Pilocarpine, a practitioner may prescribe Tincture Gelsemium BPC 1963, 5 drops in water not more than thrice daily.

A history of eyelids that are stuck down in the mornings reveals blockage from inflammatory exudate, tension rises and may precipitate glaucoma.

Chronic (gradual and long-continued). Usually in the elderly. Sometimes genetic. Chronic rise in painless intra-ocular pressure arrests blood supply to the optic discs thus disrupting bundles of retinal nerve fibres. ‘Deeply cupped discs’. Condition usually unsuspected. A sight destroyer.

Symptoms: bumping into objects and people. As above.

Treatment. Surgical drainage incision through the iris relieves tension. The object is to contract the pupil and focussing (ciliary) muscle which promotes the escape of watery fluid from the eye. Agents which contract the pupil are Pilocarpine, Adrenalin. Promotion of the body’s own supply of Adrenalin is mildly assisted by Ginseng. All cases should receive Echinacea to enhance resistance. Herbal medicine often stabilises the condition, with remedies such as Pulsatilla.

Alternatives:– Maintenance anti-inflammatory. Tea: fresh or dried herbs. Equal parts: Nettles, Marigold petals, Horsetail. Mix. 2 teaspoons to each cup boiling water; infuse 15 minutes. Dose: half-1 cup thrice daily.

Traditional. It was common practice in the South of France to douche the eye with dilute lemon juice, doubtless because Vitamin C has an osmotic effect, drawing away fluid.

Rutin (Buckwheat). 20mg thrice daily. Tablets, powder, etc.

Canasol. A non-hallucinogenic alkaloid of the marijuana plant (cannabis) has been used with success. Blood Tonics. See entry. Healthy blood contributes to healthy eyes and common blood tonics have been responsible for some cures in the early stages.

Bilberries. Mr Eric Wright suffered from glaucoma for many years. At 74 he was nearly blind, walked with a white stick, and couldn’t read or write. Improvement was impressive after taking Bilberry extract. His specialist agreed that his sight was at its best in three years since surgery to reduce intra-ocular pressure.

Diet. Begin 3-day fast, followed by 3 days on fruit and vegetable juices. Wholefoods thereafter. Increase protein intake. Repeat fast every 3 months. Fresh Bilberries as desired. Dr Rolf Ulrich links coffee with glaucoma. (Clinical Physiology)

Supplements. Daily. Vitamin A 7500iu, Vitamin B1 15mg, Vitamin B2 10mg, Vitamin B6 10mg, Vitamin C 3g, Vitamin E 500mg, Zinc.

Notes. Stress automatically raises intra-ocular pressure for which relaxation techniques are indicated. Tobacco worsens by causing constriction of blood vessels supplying the optic nerve. Abstain alcohol. Glaucoma becomes more prevalent in an ageing population. Patients with a strong history and with high blood pressure and diabetes should be screened.

To be treated by a general medical practitioner or hospital specialist. ... glaucoma

Repeated involuntary contraction of the diaphragm.

Causes: eating too fast, carbonated drinks, stomach irritation (hot peppers, vinegars, alcohol). Where persistent, there may be constriction of the lower gullet by early neoplasm caused by drinking piping-hot tea when X-ray and specialist advice should be sought.

Alternatives. Teas. Celery seed. Spearmint. Mustard seed. Fennel seed, Dill seed, Coriander seed, Peppermint. Caraway seed.

Decoction. Blue Cohosh. Black Cohosh. Calamus. Valerian.

Tablets/capsules. Capsicum (Cayenne), Papaya, Peppermint, Cinnamon, Celery seed, Liquorice, Ginger. Old English traditional. 1-2 teaspoons Onion juice every few minutes.

Cinnamon, oil of. 3 drops on sugar. (John Wesley)

Blue Cohosh, or Black Cohosh. 10 drops Tincture in little water, hourly.

Cloves, oil of. 1-2 drops in teaspoon honey.

Wild Yam. Liquid Extract. 15-30 drops in water, every 10 minutes.

Capsicum (Cayenne). Tincture, 3-5 drops in water, hourly.

Cramp Bark. (Muscle relaxant).

Slippery Elm gruel.

Supportives: deep breathing; holding the breath as long as possible. Hot foot bath. Stick a finger in each ear for 20 seconds. ... hiccups

The degree of hotness of a body or substance. In the human body, the temperature must be maintained at around 37°C for optimum functioning. Body temperature is maintained by the hypothalamus, which monitors blood temperature and activates mechanisms to compensate for changes. When body temperature falls, shivering creates heat by muscle activity, and constriction of blood vessels in the skin minimizes heat loss. When the body temperature rises, sweating results in cooling, and dilation of blood vessels in the skin increases heat loss.... temperature

n. either of two peptides: angiotensin I or angiotensin II. Angiotensin I is derived, by the action of the enzyme *renin, from a protein (alpha globulin) secreted by the liver into the bloodstream. As blood passes through the lungs, another enzyme, angiotensin-converting enzyme (ACE), acts on angiotensin I to form angiotensin II. This peptide causes constriction of blood vessels and stimulates the release of the hormones *vasopressin and *aldosterone, which increase blood pressure. See also ACE inhibitor; angiotensin II antagonist.... angiotensin

n. a small branch of an *artery, leading into many smaller vessels – the *capillaries. By their constriction and dilation, under the regulation of the sympathetic nervous system, arterioles are the principal controllers of blood flow and pressure.... arteriole

n. a drug that causes constriction of blood vessels and widening of the bronchial passages (see sympathomimetic). It is used mainly as a nasal *decongestant but also to reverse hypotension following epidural or spinal anaesthesia. It may cause nausea, insomnia, headache, and dizziness.... ephedrine

High blood pressure. The World Health Organisation defines high blood pressure (arterial hypertension) as that with a persistent sphygomanometer reading of 160/90, and over. Average blood pressure is 120/80 for men but lower in women. The diastolic pressure (lower figure) represents pressure to which the arterial walls are subject and is the more important figure.

Main causes of a raised pressure include increase in blood thickness, kidney disorder or loss of elasticity in the arteries by hardening or calcification.

Well defined physical problems account for 10 per cent of high blood pressure cases. By the age of 60, a third of the peoples of the West are hypertensive. Other causes: genetic pre-disposition, endocrine disorders such as hyperactive thyroid and adrenal glands, lead and other chemical poisoning, brain tumour, heart disorder, anxiety, stress and emotional instability.

Other causes may be food allergies. By taking one’s pulse after eating a certain food one can see if the food raises the pulse. If so, that food should be avoided. Most cases of high blood pressure are related to lifestyle – how people think, act and care for themselves. When a person is under constant stress blood pressure goes up. It temporarily increases on drinking the stimulants: alcohol, strong tea, coffee, cola and caffeine drinks generally.

Symptoms. Morning headache (back of the head), possible palpitation, visual disturbances, dizziness, angina-like pains, inability to concentrate, nose-bleeds, ringing in the ears, fatigue, breathlessness (left ventricular failure).

Dr Wm Castelli, Director of the Framlingham Heart Study in Massachusetts, U.S.A., records: “The greatest risk is for coronary heart disease (CHD). Hypertensives have more than double the risk of people with normal blood pressure and seven times the risk of strokes.”

In countries where salt intake is restricted, a rise in blood pressure with age is not seen.

Simple hypotensive herbs may achieve effective control without the side-effects of sleep disturbance, adverse metabolic effects, lethargy and impaired peripheral circulation.

Essential hypertension is where high blood pressure is not associated with any disease elsewhere; it accounts for 90 per cent cases. Most of the remainder have kidney disease except for a few other abnormalities.

Alternatives. Balm, Black Haw, Black Cohosh (blood pressure of the menopause), Cactus, Cramp bark, Chamomile (German). Garlic, Buckwheat, Lily of the Valley, Balm, Mistletoe, Motherwort. Passion flower, Nettles, Lime flowers, Wood Betony, Yarrow, Rosemary, Hawthorn flowers, Olive leaves, Dandelion. Where there is nerve excitability: Valerian.

Tea No 1. Equal parts: Hawthorn leaves and flowers, Mistletoe, Lime flowers. Mix. 2 teaspoons to each cup boiling water; infuse 5-10 minutes. 1 cup 2-3 times daily. Alternative:–

Tea No 2. Equal parts: Nettles, Lime flowers, Yarrow, Passion flower. Mix. 2 teaspoons to each cup boiling water; infuse 5-10 minutes. 1 cup 2-3 times daily.

Nettles. Nettle tea is capable of removing cholesterol deposits (“fur”) from artery walls, increasing their elasticity. Like so many herbs they are rich in chlorophyll. The tea may be made as strong as desired. Mistletoe. 2-3 teaspoons cut herb (fresh or dried) to cup cold water. Allow to infuse overnight (at least 8 hours). 1 cup morning and evening.

Garlic. Juice from one Garlic corm expressed through a juicer taken morning and evening. Garlic dilates blood vessels. Alternative: 2-3 Garlic capsules at night.

Blood pressure of pregnancy: See – PREGNANCY.

Tablets/capsules: Cramp bark, Mistletoe, Motherwort, Rutin, Garlic.

Powders. Formula. Buckwheat (rutin) 1; Motherwort 1; Mistletoe half; Valerian quarter. Dose: 500mg (two 00 capsules or one-third teaspoon) thrice daily.

Liquid extracts, tinctures. Formula. Equal parts: Cactus, Mistletoe, Valerian. Dose: liquid extracts, one 5ml teaspoon; tinctures, two 5ml teaspoons; thrice daily.

Practitioner Formula. Tinctures: equal parts: Lily of the Valley, Mistletoe, Valerian. Dose: 30-60 drops thrice daily.

Where high blood pressure is due to faulty kidney function diuretics such as Dandelion or Bearberry will be added according to individual requirements. Dandelion root is one of the most widely-used potassium-conserving agents for increasing flow of urine, as well as being a mild beta-blocker to reduce myocardial infarction. Broom (Sarothamnus scoparius) (diuretic) is not used in cases of high blood pressure. It is good practice to assess kidney function in all new cases of hypertension for renal artery stenosis.

Evidence from two major studies confirms that diuretics rather than beta-blockers should be the treatment of choice for most elderly hypertensives. The addition of a diuretic (Yarrow, etc) to prescriptions for the elderly is commended.

Prevention. Chances of developing high blood pressure are said to be reduced by a daily dose of Cod

Liver oil. Results from studies at the University of Munich, Germany, show that when an ounce of Cod Liver oil was added to the typical Western diet, better pressure readings and lower cholesterol levels followed. When the flavour renders it objectionable to the palate, taste may be masked by stirring briskly into fruit juice.

General. Stop smoking. Watch weight. Moderate exercise. Avoidance of stress by relaxation, yoga, music, etc. These relieve constriction of peripheral blood vessels. Curb temper

Diet. Avoid processed and fast foods high in fat and salt, and empty calories. Cheese and meat sparingly. Eat plenty of natural foods. Positively reject coffee, strong tea and alcohol. “There is a significant drop in plasma Cortisol with a fall in blood pressure after stopping alcohol.” (Dr J.F. Potter, University of Birmingham, England) It is well-documented that a vegetarian diet is associated with a lower blood pressure.

Salt. The association of salt with blood pressure is larger than generally appreciated and increases with age and initial blood pressure. Even a small reduction in salt (3g) may reduce a systolic and diastolic pressure by 5mmHg and 2.5mmHg respectively. All processed foods containing salt should be avoided. Supplementation. Inositol, zinc, Vitamin C, Vitamin B6. (Dr C. Pfeiffer) Vitamin E to improve circulation. Check with practitioner pressure level before starting 200iu increasing to 400iu daily. Magnesium: 300mg daily. Choline.

See: BLOOD PRESSURE. ... hypertension

n. a drug that causes constriction of blood vessels and is used to relieve migraine. It is administered in combination with cyclizine and caffeine. Common side-effects are nausea and vomiting, and ergotism may develop as a result of high doses; because of this it has largely been superseded by *5HT1 agonists.... ergotamine

5-hydroxytryptamine (see serotonin).

5HT1 agonist (triptan) any one of a class of drugs that stimulate *serotonin (5-hydroxytryptamine) receptors and are effective in the relief of *migraine headaches by causing constriction of cerebral blood vessels. The group includes almotriptan, naratriptan, *sumatriptan, and zolmitriptan.... 5ht

Inner ear disorder. Constriction of cerebral blood vessels (vasospasm) increases pressure of fluids in the balancing mechanism. Ages 40-60; more in men.

Etiology. Obscure; though cases may be traced to auto-toxaemia, Vitamin B deficiency, menstruation, malaria drugs (chloroquine).

Symptoms: dizziness, nausea, vomiting, tinnitus, sound distortions, heavy sweating, loss of hearing; usually in one ear only. Early diagnosis essential for effective treatment. This may mean reference to a department of otolaryngology or otoneurology.

Treatment. Antispasmodics. Nervines. Sometimes a timely diuretic reduces severity – Uva Ursi, Dandelion root, Wild Carrot.

Alternatives. Current European practice: Betony, German Chamomile, Passion flower, Hawthorn, Hops, Feverfew, White Willow.

Tea. Combine, equal parts: Valerian, Wild Carrot, Agrimony. 2 teaspoons to each cup boiling water; infuse 15 minutes. Half-1 cup every 2 hours during attack; thrice daily thereafter.

Decoction. Mistletoe: 2 teaspoons to each cup cold water steeped overnight. Bring to boil. Allow to cool. Half-1 cup, as above.

Tablets/capsules. Feverfew, Mistletoe, Prickly Ash.

Formula. Ginkgo 2; Dandelion 1; Black Cohosh 1. Dose: Liquid Extracts: 1 teaspoon. Tinctures: 2 teaspoons. Powders: 500mg (two 00 capsules or one-third teaspoon). Thrice daily.

Feverfew tincture. See: FEVERFEW.

Dr J. Christopher: inject into ears, at night, few drops oil of Garlic (or contents of Garlic capsule).

Cider vinegar. 2 teaspoons to glass water: as desired.

Aromatherapy. Inhalants: Eucalyptus or Rosemary oils.

Diet: gluten-free, low salt; good responses observed. High fibre. Avoid dairy products and chocolate. Vitamins: B-complex, B1; B2; B6; E; F. Brewer’s yeast, Niacin.

Minerals: Calcium. Magnesium. Phosphorus. Dolomite. ... meniere’s disease

Constriction of the gullet and throat. Sense of rising pressure from chest to jaw that can simulate early heart attack.

Causes: emotional tension, hiatus hernia, food allergy and the damaging potential of hot drinks. Alternatives. Acute case: Cramp bark. German Chamomile tea, freely. Phytomedicines for chronic condition or as preventatives: Passion flower, Skullcap, Wild Yam, Lobelia, Mistletoe, Valerian. Formula. Cramp bark 2; Chamomile 1; Peppermint 1. Dose – Liquid extracts: 1-2 teaspoons. Tinctures: 2-3 teaspoons. Powders: 750mg (three 00 capsules or half a teaspoon) 3 or more times daily.

Milk. Drink whole glass cold milk, with or without 1 drop oil Peppermint, immediately on onset of pain. May relieve spasms in seconds. ... oesophageal spasm

A greenish-brown alkaline liquid secreted by the liver. Bile carries away waste products formed in the liver and also helps to break down fats in the small intestine for digestion.

The waste products in bile include the pigments bilirubin and biliverdin, which give bile its greenish-brown colour; bile salts, which aid in the breakdown and absorption of fats; and cholesterol. Bile passes out of the liver through the bile ducts and is then concentrated and stored in the gallbladder. After a meal, bile is expelled and enters the duodenum (the first section of the small intestine) via the common bile duct. Most of the bile salts are later reabsorbed into the bloodstream to be recycled by the liver into bile. Bile pigments are excreted in the faeces. (See also biliary system; colestyramine.)

bile duct Any of the ducts by which bile is carried from the liver, first to the gallbladder and then to the duodenum (the first section of the small intestine). The bile duct system forms a network of tubular canals. Canaliculi (small canals) surround the liver cells and collect the bile. The canaliculi join together to form ducts of increasing size. The ducts emerge from the liver as the 2 hepatic ducts, which join within or just outside the liver to form the common hepatic duct. The cystic duct branches off to the gallbladder; from this point the common hepatic duct becomes the common bile duct and leads into the duodenum.

(See also biliary system.)

bile duct cancer See cholangiocarcinoma. bile duct obstruction A blockage or constriction of a bile duct (see biliary system). Bile duct obstruction results in accumulation of bile in the liver (cholestasis) and jaundice due to a buildup of bilirubin in the blood. Prolonged obstruction of the bile duct can lead to secondary biliary cirrhosis. The most common cause of obstruction is gallstones. Other causes include a tumour affecting the pancreas (see pancreas, cancer of), where the bile duct passes through it, or cancer that has spread from elsewhere in the body. Cholangiocarcinoma (cancer of the bile ducts) is a very rare cause of blockage. Bile duc.

obstruction is a rare side effect of certain drugs. It may also be caused by cholangitis (inflammation of the bile ducts), trauma (such as injury during surgery), and rarely by flukes or worms.

Bile duct obstruction causes “obstructive” jaundice, which is characterized by pale-coloured faeces, dark urine, and a yellow skin colour.

There may also be itching.

Other symptoms may include abdominal pain (with gallstones) or weight loss (with cancer).

Treatment depends on the cause, but surgery may be necessary.

Gallstones may be removed with an endoscope (see ERCP).... bile

(norepinephrine) n. a hormone, closely related to *adrenaline and with similar actions, secreted by the medulla of the *adrenal gland and also released as a *neurotransmitter by sympathetic nerve endings. Among its many actions are constriction of small blood vessels leading to an increase in blood pressure, increased blood flow through the coronary arteries and a slowing of the heart rate, increase in the rate and depth of breathing, and relaxation of the smooth muscle in intestinal walls.... noradrenaline

n. constriction of the pylorus due to muscle spasm, leading to delayed gastric emptying. It is usually associated with duodenal or pyloric ulcers.... pylorospasm

n. an enzyme released into the blood by the kidney in response to stress. It reacts with a substrate from the liver to produce *angiotensin, which causes constriction of blood vessels and thus an increase in blood pressure. Excessive production of renin results in the syndrome of *renovascular hypertension.... renin

a ringlike constriction in the lower part of the gullet (oesophagus). The cause is unclear. Patients may be asymptomatic or experience episodic difficulty in swallowing. Diagnosis is made at gastroscopy or *barium swallow. Antisecretory agents and endoscopic balloon dilatation are reserved for symptomatic patients. [R. Schatzki (20th century), German-born US physician]... schatzki ring

A group of conditions characterized by bleeding in the absence of injury or by abnormally prolonged and excessive bleeding after injury. The disorders result from defects in mechanisms by which bleeding is normally stopped: blood coagulation, plugging of damaged blood vessels by platelets, and constriction of blood vessels (see blood clotting).

Coagulation disorders are usually due a deficiency of or abnormality in the enzymes (coagulation factors) involved in blood clotting. Defects may be congenital or acquired later in life. The

main congenital coagulation defects are von Willebrand’s disease, haemophilia, and Christmas disease.

Acquired defects of coagulation factors may develop at any age due to severe liver disease, digestive system disorders that prevent the absorption of vitamin K (needed to make certain coagulation factors), or the use of anticoagulant drugs. Disseminated intravascular coagulation (DIC) is an acquired disorder that is both complex and serious. It may be the result of underlying infection or cancer. In this condition, platelets accumulate and clots form within small blood vessels; coagulation factors are used up faster than they can be replaced, and severe bleeding may result.

Coagulation disorders are treated by replacement of the missing factor, factors extracted from fresh blood, or fresh frozen plasma. Genetically engineered factors may be used. Anticoagulants are sometimes used to suppress excess clotting activity in.

Thrombocytopenia, which results from insufficient platelets in the blood, produces surface bleeding into the skin and gums and multiple small bruises. Platelet defects may be inherited, associated with the use of certain drugs (including aspirin), or a complication of certain bone marrow disorders such as myeloid leukaemia. Treatment consists of platelet transfusions. Rarely, abnormal bleeding is caused by a bloodvessel defect or scurvy. Elderly people and patients on long-term courses of corticosteroid drugs may suffer mild abnormal bruising due to loss of skin support to the smallest blood vessels.

Treatment is rarely required.... bleeding disorders

(adrenoreceptor, adrenergic receptor) any cell *receptor that binds with the catecholamines adrenaline or noradrenaline, the neurotransmitters of the *sympathetic nervous system. There are two principal types of adrenoceptor, alpha (?) and beta (?), with various subtypes of each. Alpha adrenoceptors have a slightly higher affinity for adrenaline than for noradrenaline; they can be divided into subtypes ?1 and ?2. ?1-adrenoceptors mediate contraction of smooth muscle; in the walls of arteries, for example, their stimulation causes constriction of arteries and a rise in blood pressure. ?2-adrenoceptors occur in the presynaptic membranes of neurons in the sympathetic nervous system, where they restrict the release of catecholamines from these neurons. Beta adrenoceptors also have two subtypes. ?1-adrenoceptors have an equal affinity for adrenaline and noradrenaline and are found mainly in cardiac muscle; their stimulation causes an increase in heart rate. ?2-adrenoceptors have a slightly higher affinity for adrenaline. They mediate relaxation of smooth muscle in the blood vessels, bronchi, bladder, uterus, and other organs and thus cause widening of the airways and *vasodilatation.

Drugs that stimulate these receptors (alpha agonists and beta agonists) are described as *sympathomimetic. Drugs that block their effects are the *alpha blockers and *beta blockers.... adrenoceptor

(beta-adrenergic receptor blocker) a drug that prevents stimulation of the beta *adrenoceptors at the nerve endings of the sympathetic nervous system. Blockade of ?1 receptors causes a decrease in heart rate and force; blockade of ?2 receptors causes constriction of the airways and the arteries. Beta blockers include *acebutolol, *atenolol, *bisoprolol, *oxprenolol, *propranolol, and *sotalol; they are used to control abnormal heart rhythms, to treat angina, and to reduce high blood pressure (although they are no longer regarded by some experts as the first choice of drug for treating hypertension in the absence of heart disease, being less effective than newer antihypertensive drugs). Beta blockers that block both ?1 and ?2 receptor sites cause constriction of air passages in the lungs, and these drugs should not be used in patients with asthma and bronchospasm. Other beta blockers are relatively selective for the heart (cardioselective) and are less likely to constrict the airways. Some beta blockers (e.g. *carteolol, *levobunolol, and *timolol) reduce the production of aqueous humour and therefore the pressure inside the eye; they are taken as eye drops in the treatment of *glaucoma.... beta blocker

the constriction of the shaft of the *humerus, below the head. It is frequently the point at which fracture of the humerus occurs.... surgical neck

(Adie’s pupil) a pupil that is dilated as a result of damage to the nerves supplying the ciliary muscle and iris. It reacts poorly to light but may constrict better for near vision, with slow redilation on refixation at a distance. The tonic pupil is sensitive to dilute 0.1% pilocarpine drops, which cause marked constriction but have little effect on a normal pupil. The tonic pupil may become miotic (see miosis) over time.... tonic pupil

any nerve, usually belonging to the autonomic nervous system, that controls the circulation of blood through blood vessels by its action on the muscle fibres within their walls or its action on the heartbeat. The *vagus nerve slows the heart and reduces its output, but sympathetic nerves increase the rate and output of the heart and increase blood pressure by causing the constriction of small blood vessels at the same time.... vasomotor nerve

(antidiuretic hormone, ADH) n. a hormone, released by the pituitary gland, that increases the reabsorption of water by the kidney, thus preventing excessive loss of water from the body. Vasopressin also causes constriction of blood vessels. Synthetic vasopressin is administered to treat *diabetes insipidus and to control bleeding from *oesophageal varices by restricting arterial blood flow to the liver.... vasopressin

n. a tumour of the *argentaffin cells in the glands of the intestine (see apudoma). Carcinoids typically occur in the tip of the appendix and are among the commonest tumours of the small intestine. They may also occur in the rectum and other parts of the digestive tract and in the bronchial tree (bronchial carcinoid adenoma). Carcinoids sometimes produce 5-hydroxytryptamine (serotonin), prostaglandins, and other physiologically active substances, which are inactivated in the liver. If a gastrointestinal tumour has spread to the liver, excess amounts of these substances are released into the systemic circulation and the carcinoid syndrome results – flushing, headache, diarrhoea, bronchial constriction causing asthma-like attacks, and in some cases damage to the right side of the heart associated with fibrosis of the tricuspid valve. Bronchial carcinoids can give rise to the syndrome without metastasizing.... carcinoid

a major genetic disorder caused by a constriction near the end of the long arm of an *X chromosome: it is inherited as an X-linked *dominant characteristic. The fragile-X syndrome is second only to *Down’s syndrome as a cause of learning disability. Affected males have unusually high foreheads, unbalanced faces, large jaws, long protruding ears, and large testicles. They have an IQ below 50 and are prone to violent outbursts. Folic acid helps to control their behaviour. About one-third of the females with this mutation on one of their two X chromosomes also show developmental delay. Screening for the characteristic chromosome can be done by *amniocentesis or *chorionic villus sampling.... fragile-x syndrome

Hyptis suaveolens

FAMILY: Lamiaceae

SYNONYMS: Mesosphaerum suaveolens, mint weed, bush mint, bush tea, pignut, chan, wild spikenard.

GENERAL DESCRIPTION: An erect, annual herb up to 3 metres high, belonging to the mint family, with a hollow stem, and bearing purple-blue lipped flowers and dark brown, shield-shaped fruits. The oval leaves, which are wrinkled along the edge and pointed, have a strong mint-like aroma when crushed; the taproot is white or brown. It is a very well known pseudo-cereal plant in the Latin America region.

DISTRIBUTION: A native of tropical America, growing in warm and semi-warm regions, commonly found in the rain forests of Ecuador, as well as in the Caribbean and Hawaii; it has also been naturalized in Australia since the mid-nineteenth century. This herb is commonly found alongside roadsides and watercourses and is considered a weed in many tropical areas around the world, especially because the plant can be invasive.

OTHER SPECIES: The mint family is generally known to produce the most variation in essential oil composition and therefore there are many chemotypes of H. suaveolens. Ocotea essential oil from the flowers of the Ocotea quixos tree, which is native to the deep Amazon, is another species found in South America, which yields a little-known essential oil sharing many of phytochemical properties and functions of H. suaveolens.

HERBAL/FOLK TRADITION: Dorado Azul has been used by many indigenous cultures in India, Nigeria and elsewhere for hundreds of years to treat bacterial infections, diarrhoea, tumours, skin diseases, gastro-intestinal disorders and as a natural mosquito repellent and pesticide. The herb has also traditionally been used for the treatment of asthma, hormonal balance (oestrogen), inflammation, muscular aches and pains and for wound healing.

Today the essential oil of Dorado Azul is recognized largely for its role in treating respiratory conditions and in supporting the sinuses and lungs, much like mint and eucalyptus. In addition to its respiratory benefits, Dorado Azul oil is also proving to be a very effective ingredient in essential oil blends that repel insects and pests. Indeed, recent studies have confirmed it is effective as a natural crop and grain insecticide. A study in 1999 revealed that the oil was effective against both gram positive (Bacillus cereus and Staphylococcus aureus) and negative (E. coli, Pseudomonas spp.) bacterial strains; as well as Candida albicans. A further study exhibited broad-spectrum antibacterial and antifungal activity against Aspergillus niger and Micrococcus luteus respectively.

ACTIONS: Analgesic, anti-inflammatory, antifungal, antimicrobial, antioxidant, anticancer, insecticidal, anti-infectious, expectorant, immune stimulant.

EXTRACTION: Essential oil distilled from the stems, leaves and flowers.

CHARACTERISTICS: The essential oil is a reddish liquid with a fresh-herbaceous odour. It blends well with peppermint, eucalyptus, ravintsara, tea tree, myrtle, balsam and spice oils.

PRINCIPAL CONSTITUENTS: Main constituents are sabinene (16.5 per cent), trans-?-bergamotene and ?-caryophyllene (19.8 per cent), terpinen-4-ol (9.6 per cent) and ?-pinene (8.6 per cent). Another study (using a different chemotype) reported sabinene (30 per cent), terpinen-4-ol (11.4 per cent), terpinolene (5.6 per cent), 1,8-cineole (5.2 per cent), ?-pinene (4.4 per cent) and ?-terpinene (4.2 per cent).

SAFETY DATA: No reported contra-indications: however since there are many variable chemotypes of this oil, the safety data will depend on the specific chemical make-up of the individual oil.

AROMATHERAPY/HOME: USE

Skin Care: Infected skin conditions.

Circulation Muscles And Joints: Arthritic and rheumatoid-type pain, circulatory stimulant, muscular aches and pains.

Digestive System: Indigestion, candida and other intestinal tract problems.

Respiratory System: Asthma, bronchitis, colds, coughs, ’flu, sinus congestion, allergic reactions that cause constriction and compromised breathing.

Immune System: Tonic.

Nervous System: Nervous debility.

OTHER USES: ‘Chan’ is commonly used locally as a refreshing, healthy drink, which is made by leaving the seeds to soak in water and refrigerating the mix.... dorado azul