Cortisone Health Dictionary

Cortisone: From 4 Different Sources


One of the corticosteroid hormones produced by the outer layer (cortex) of the adrenal glands. Corticosteroid drugs are synthetic derivatives that have similar properties as those produced in the body. They are used in pharmacy for allergies, Addison’s disease, rheumatism and inflammatory conditions. Prolonged over-use is known to weaken response of the body’s immune system to invasion of bacteria and infection.

Alternatives of limited efficacy: see entry – CORTICOSTEROIDS. These are known to produce increased output of adrenal hormones by their cortisone-like effect. 

Health Source: Bartrams Encyclopedia of Herbal Medicine
Author: Health Encyclopedia
A synthetic corticosteroid drug used to reduce inflammation in severe allergic, rheumatic, and connective tissue diseases and as a replacement hormone in Addison’s disease.

Side effects include peptic ulcer and bleeding in the stomach.

Health Source: BMA Medical Dictionary
Author: The British Medical Association
An early corticosteroid drug (see CORTICOSTEROIDS), now obsolete and replaced by PREDNISOLONE and HYDROCORTISONE.
Health Source: Medical Dictionary
Author: Health Dictionary
n. a naturally occurring *corticosteroid that is used mainly to treat deficiency of corticosteroid hormones in *Addison’s disease and following surgical removal of the adrenal glands. It is administered by mouth or injection and may cause serious side-effects such as stomach ulcers and bleeding, nervous and hormone disturbances, muscle and bone damage, and eye changes.
Health Source: Oxford | Concise Colour Medical Dictionary
Author: Jonathan Law, Elizabeth Martin

Corticosteroids

Natural steroid hormones or synthetic analogues, usually taken for suppressing inflammation (and immunity) and therefore having cortisone-like functions, or taken as analogues to adrenocortical androgen...or even testosterone, in order to impress the other gym members, make varsity by your junior year or to join the WWF and get newbie-mangled for two years by The Hangman or even the Hulkster Himself. Then, if your gonads don’t fall off and your back holds up you get promoted to Good Guy, have your chance to Take A Name and finally wear your chosen costume...a spandex violet nurse’s uniform.... corticosteroids

Prednisolone

A derivative of CORTISONE, which is ?ve or six times as active as cortisone and has less of the salt- and water-retaining properties of cortisone. It is given by mouth.... prednisolone

Cissus Quadrangula

Linn.

Synonym: Vitis quadrangula Wall.

Family: Vitaceae.

Habitat: Throughout the warmer parts of India, also cultivated in gardens.

English: Square Stalked Vine, Adamant Creeper.

Ayurvedic: Asthisamhaara, Asthisamhrita. Asthi-samyojaka, Vajravalli, Chaturdhaaraa.

Unani: Hadjod.

Siddha/Tamil: Perandai.

Action: The anabolic and steroidal principles of the aerial part showed a marked influence in the rate of fracture-healing. The drug exerts influence both on the organic and mineral phase of fracture-healing. Stem—alterative in scurvy (the plant is rich in vitamin C) and irregular menstruation.

The plant contains phytogenic steroid, ketosteroids, sitosterol, alpha- amyrin, alpha-ampyrone and tetra- cyclic triterpenoids. Phytogenic ste- riods showed bone healing properties. Coloside-A possesses smooth muscle relaxant effect. The total alcoholic extract of the plant neutralizes the anti- anabolic effect of the cortisone in healing of fractures. The aqueous extract of... cissus quadrangula

Corticotropin

Corticotropin is the British Pharmacopoeia name for the adrenocorticotrophic hormone of the PITUITARY GLAND, also known as ACTH. It is so-called because it stimulates the functions of the cortex of the suprarenal glands. This results, among other things, in an increased output of cortisone.... corticotropin

Dexamethasone

A CORTICOSTEROIDS derivative. As an antiin?ammatory agent it is approximately 30 times as e?ective as cortisone and eight times as e?ective as prednisolone. On the other hand, it has practically none of the salt-retaining properties of cortisone.... dexamethasone

Endocrine Glands

Organs whose function it is to secrete into the blood or lymph, substances known as HORMONES. These play an important part in general changes to or the activities of other organs at a distance. Various diseases arise as the result of defects or excess in the internal secretions of the di?erent glands. The chief endocrine glands are:

Adrenal glands These two glands, also known as suprarenal glands, lie immediately above the kidneys. The central or medullary portion of the glands forms the secretions known as ADRENALINE (or epinephrine) and NORADRENALINE. Adrenaline acts upon structures innervated by sympathetic nerves. Brie?y, the blood vessels of the skin and of the abdominal viscera (except the intestines) are constricted, and at the same time the arteries of the muscles and the coronary arteries are dilated; systolic blood pressure rises; blood sugar increases; the metabolic rate rises; muscle fatigue is diminished. The super?cial or cortical part of the glands produces steroid-based substances such as aldosterone, cortisone, hydrocortisone, and deoxycortone acetate, for the maintenance of life. It is the absence of these substances, due to atrophy or destruction of the suprarenal cortex, that is responsible for the condition known as ADDISON’S DISEASE. (See CORTICOSTEROIDS.)

Ovaries and testicles The ovary (see OVARIES) secretes at least two hormones – known, respectively, as oestradiol (follicular hormone) and progesterone (corpus luteum hormone). Oestradiol develops (under the stimulus of the anterior pituitary lobe – see PITUITARY GLAND below, and under separate entry) each time an ovum in the ovary becomes mature, and causes extensive proliferation of the ENDOMETRIUM lining the UTERUS, a stage ending with shedding of the ovum about 14 days before the onset of MENSTRUATION. The corpus luteum, which then forms, secretes both progesterone and oestradiol. Progesterone brings about great activity of the glands in the endometrium. The uterus is now ready to receive the ovum if it is fertilised. If fertilisation does not occur, the corpus luteum degenerates, the hormones cease acting, and menstruation takes place.

The hormone secreted by the testicles (see TESTICLE) is known as TESTOSTERONE. It is responsible for the growth of the male secondary sex characteristics.

Pancreas This gland is situated in the upper part of the abdomen and, in addition to the digestive enzymes, it produces INSULIN within specialised cells (islets of Langerhans). This controls carbohydrate metabolism; faulty or absent insulin production causes DIABETES MELLITUS.

Parathyroid glands These are four minute glands lying at the side of, or behind, the thyroid (see below). They have a certain e?ect in controlling the absorption of calcium salts by the bones and other tissues. When their secretion is defective, TETANY occurs.

Pituitary gland This gland is attached to the base of the brain and rests in a hollow on the base of the skull. It is the most important of all endocrine glands and consists of two embryologically and functionally distinct lobes.

The function of the anterior lobe depends on the secretion by the HYPOTHALAMUS of certain ‘neuro-hormones’ which control the secretion of the pituitary trophic hormones. The hypothalamic centres involved in the control of speci?c pituitary hormones appear to be anatomically separate. Through the pituitary trophic hormones the activity of the thyroid, adrenal cortex and the sex glands is controlled. The anterior pituitary and the target glands are linked through a feedback control cycle. The liberation of trophic hormones is inhibited by a rising concentration of the circulating hormone of the target gland, and stimulated by a fall in its concentration. Six trophic (polypeptide) hormones are formed by the anterior pituitary. Growth hormone (GH) and prolactin are simple proteins formed in the acidophil cells. Follicle-stimulating hormone (FSH), luteinising hormone (LH) and thyroid-stimulating hormone (TSH) are glycoproteins formed in the basophil cells. Adrenocorticotrophic hormone (ACTH), although a polypeptide, is derived from basophil cells.

The posterior pituitary lobe, or neurohypophysis, is closely connected with the hypothalamus by the hypothalamic-hypophyseal tracts. It is concerned with the production or storage of OXYTOCIN and vasopressin (the antidiuretic hormone).

PITUITARY HORMONES Growth hormone, gonadotrophic hormone, adrenocorticotrophic hormone and thyrotrophic hormones can be assayed in blood or urine by radio-immunoassay techniques. Growth hormone extracted from human pituitary glands obtained at autopsy was available for clinical use until 1985, when it was withdrawn as it is believed to carry the virus responsible for CREUTZFELDT-JAKOB DISEASE (COD). However, growth hormone produced by DNA recombinant techniques is now available as somatropin. Synthetic growth hormone is used to treat de?ciency of the natural hormone in children and adults, TURNER’S SYNDROME and chronic renal insu?ciency in children.

Human pituitary gonadotrophins are readily obtained from post-menopausal urine. Commercial extracts from this source are available and are e?ective for treatment of infertility due to gonadotrophin insu?ciency.

The adrenocorticotrophic hormone is extracted from animal pituitary glands and has been available therapeutically for many years. It is used as a test of adrenal function, and, under certain circumstances, in conditions for which corticosteroid therapy is indicated (see CORTICOSTEROIDS). The pharmacologically active polypeptide of ACTH has been synthesised and is called tetracosactrin. Thyrotrophic hormone is also available but it has no therapeutic application.

HYPOTHALAMIC RELEASING HORMONES which affect the release of each of the six anterior pituitary hormones have been identi?ed. Their blood levels are only one-thousandth of those of the pituitary trophic hormones. The release of thyrotrophin, adrenocorticotrophin, growth hormone, follicle-stimulating hormone and luteinising hormone is stimulated, while release of prolactin is inhibited. The structure of the releasing hormones for TSH, FSH-LH, GH and, most recently, ACTH is known and they have all been synthesised. Thyrotrophin-releasing hormone (TRH) is used as a diagnostic test of thyroid function but it has no therapeutic application. FSH-LH-releasing hormone provides a useful diagnostic test of gonadotrophin reserve in patients with pituitary disease, and is now used in the treatment of infertility and AMENORRHOEA in patients with functional hypothalamic disturbance. As this is the most common variety of secondary amenorrhoea, the potential use is great. Most cases of congenital de?ciency of GH, FSH, LH and ACTH are due to defects in the hypothalamic production of releasing hormone and are not a primary pituitary defect, so that the therapeutic implication of this synthesised group of releasing hormones is considerable.

GALACTORRHOEA is frequently due to a microadenoma (see ADENOMA) of the pituitary. DOPAMINE is the prolactin-release inhibiting hormone. Its duration of action is short so its therapeutic value is limited. However, BROMOCRIPTINE is a dopamine agonist with a more prolonged action and is e?ective treatment for galactorrhoea.

Thyroid gland The functions of the thyroid gland are controlled by the pituitary gland (see above) and the hypothalamus, situated in the brain. The thyroid, situated in the front of the neck below the LARYNX, helps to regulate the body’s METABOLISM. It comprises two lobes each side of the TRACHEA joined by an isthmus. Two types of secretory cells in the gland – follicular cells (the majority) and parafollicular cells – secrete, respectively, the iodine-containing hormones THYROXINE (T4) and TRI-IODOTHYRONINE (T3), and the hormone CALCITONIN. T3 and T4 help control metabolism and calcitonin, in conjunction with parathyroid hormone (see above), regulates the body’s calcium balance. De?ciencies in thyroid function produce HYPOTHYROIDISM and, in children, retarded development. Excess thyroid activity causes thyrotoxicosis. (See THYROID GLAND, DISEASES OF.)... endocrine glands

Glucocorticoids

One of the two main groups of CORTICOSTEROIDS. CORTISOL, CORTISONE and corticosterone are part of this group and are essential for the body to utilise CARBOHYDRATE, FAT and PROTEIN – in particular, when the body is reacting to stress. Glucocorticoids occur naturally but can be synthesised, and they have strong anti-in?ammatory properties, being used to treat conditions in which in?ammation is a part.... glucocorticoids

Hydrocortisone

Hydrocortisone has the chemical formula, 17hydroxycorticosterone. It is closely allied to CORTISONE both in its structure (cortisone is an oxidation product of hydrocortisone) and in its action. Available in tablet, topical or injection form, hydrocortisone is used in adrenocortical insu?ciency, for the suppression of local and systemic in?ammatory and allergic disorders, and in the treatment of shock. Its mineralocorticoid effects – control of salt and water balance – mean that the drug should not be used long term except as replacement therapy in the treatment of ADDISON’S DISEASE or following adrenalectomy when hydrocortisone should be given with the mineral corticoid

?udrocortisone (see ADRENAL GLANDS; CORTICOSTEROIDS).... hydrocortisone

Immunosuppressant

An agent that acts to suppress the body’s natural immune response. This is totally understandable in tissue and organ transplants, and in some dangerous inflammatory conditions, but nearly all anti-inflammatory medications are immunosuppressant, including cortisone, antihistamines, and even aspirin. Some medical radicals are convinced that the chronic viral and fungal disorders of our age are partially facilitated by such medications.... immunosuppressant

Medicinal Yams

Dioscorea spp.

Dioscoreaceae

The growing need for steroidal drugs and the high cost of obtaining them from animal sources led to a widespread search for plant sources of steroidal sapogenins, which ultimately led to the most promising one. It is the largest genus of the family constituted by 600 species of predominantly twining herbs. Among the twining species, some species twine clockwise while others anti-clockwise (Miege, 1958). All the species are dioceous and rhizomatous. According to Coursey (1967), this genus is named in honour of the Greek physician Pedenios Dioscorides, the author of the classical Materia Medica Libri Quinque. Some of the species like D. alata and D. esculenta have been under cultivation for a long time for their edible tubers. There are about 15 species of this genus containing diosgenin. Some of them are the following (Chopra et al, 1980).

D. floribunda Mart. & Gal.

D. composita Hemsl; syn. D. macrostachya Benth.

D. deltoidea Wall. ex Griseb; syn. D. nepalensis Sweet ex Bernardi.

D. aculeata Linn. syn. D. esculenta

D. alata Linn. syn. D. atropurpurea Roxb.

D. Globosa Roxb; D. purpurea Roxb; D. rubella Roxb.

D. bulbifera Linn. syn. D. crispata Roxb.

D. pulchella Roxb.; D. sativa Thunb. Non Linn.

D. versicolor Buch. Ham. Ex Wall.

D. daemona Roxb. syn. D. hispida Dennst.

D. oppositifolia Linn.

D. pentaphylla Linn. syn. D. jacquemontii Hook. f.

D. triphylla Linn.

D. prazeri Prain & Burkil syn. D. clarkei Prain & Burkill

D. deltoidea Wall. var. sikkimensis Prain

D. sikkimensis Prain & Burkill

Among the above said species, D. floribunda, D. composita and D. deltoidea are widely grown for diosgenin production.

1. D. floribunda Mart. & Gal D. floribunda Mart. & Gal. is an introduction from central America and had wide adaptation as it is successfully grown in Karnataka, Assam, Meghalaya, Andaman and Goa. The vines are glabrous and left twining. The alternate leaves are borne on slender stems and have broadly ovate or triangular ovate, shallowly cordate, coriaceous lamina with 9 nerves. The petioles are 5-7cm long, thick and firm. Variegation in leaves occurs in varying degrees. The male flowers are solitary and rarely in pairs. Female flowers have divericate stigma which is bifid at apex. The capsule is obovate and seed is winged all round. The tubers are thick with yellow coloured flesh, branched and growing upto a depth of 30cm (Chadha et al, 1995).

2. D. composita Hemsl.

D. composita Hemsl. according to Knuth (1965) has the valid botanical name as D. macrostachya Benth. However, D. composita is widely used in published literature. It is a Central American introduction into Goa, Jammu, Bangalore, Anaimalai Hills of Tami Nadu and Darjeeling in W. Bengal. The vines are right twinning and nearly glabrous. The alternate leaves have long petioles, membraneous or coriaceous lamina measuring upto 20x18cm, abruptly acute or cuspidate-acuminate, shallowly or deeply cordate, 7-9 nerved. The fasciculate-glomerate inflorescence is single or branched with 2 or 3 sessile male flowers having fertile stamens. Male fascicle is 15-30cm long. The female flowers have bifid stigma. Tubers are large, white and deep-rooted (upto 45cm) (Chadha et al, 1995).

3. D. deltoidea Wall. ex. Griseb.

D. deltoidea Wall. ex. Griseb. is distributed throughout the Himalayas at altitudes of 1000-3000m extending over the states of Jammu-Kashmir, H. P, U. P, Sikkim and further into parts of W. Bengal. The glabrous and left twining stem bears alternate petiolate leaves. The petioles are 5-12 cm long. The lamina is 5-15cm long and 4-12cm wide widely cordate. The flowers are borne on axillary spikes, male spikes 8-40cm long and stamens 6. Female spikes are 15cm long, 3. 5cm broad and 4-6 seeded. Seeds are winged all round. Rhizomes are lodged in soil, superficial, horizontal, tuberous, digitate and chestnut brown in colour (Chadha et al, 1995). D. deltoidea tuber grows parallel to ground covered by small scale leaves and is described as rhizome. The tubers are morphologically cauline in structure with a ring of vascular bundles in young tubers which appear scattered in mature tubers (Purnima and Srivastava, 1988). Visible buds are present unlike in D. floribunda and D. composita where the buds are confined to the crown position (Selvaraj et al, 1972).

Importance of Diosgenin: Diosgenin is the most important sapogenin used as a starting material for synthesis of a number of steroidal drugs. For commercial purposes, its -isomer, yamogenin is also taken as diosgenin while analysing the sample for processing. Various steroidal drugs derived from diosgenin by artificial synthesis include corticosteroids, sex hormones, anabolic steroids and oral contraceptives. Corticosteroids are the most important group of steroidal drugs synthesized from diosgenin. First group of corticosteroids regulates carbohydrate and protein metabolism. The second group consists of aldosterone, which controls balance of potassium, sodium and water in the human body. The glucocorticoids in the form of cortisone and hydrocortisone are used orally, intramuscularly or topically for treatment of rheumatoid arthritis, rheumatic fever, other collegen diseases, ulcerative colitis, certain cases of asthma and a number of allergic diseases affecting skin, eye and the ear. These are also used for treatment of gout and a variety of inflammations of skin, eye and ear and as replacement therapy in Addison’s diseases. The minerato corticoides, desoxycorticosterone or desoxycortone are used in restoring kidney functions in cases of cortical deficiency and Addison’s disease.

Both male and female sex hormones are also synthesized from disosgenin. The main male sex hormone (androgen) which is produced from disogenin is testosterone. The main female sex hormones produced are oestrogen and progesterone. Recently oestrogen has also been used in cosmetic lotions and creams to improve the tone and colour of skin. One of the main uses of progesterone during recent years has been as antifertility agent for oral contraceptives. These artificial steroids have increased oral activity and fewer side effects, as they can be used in reduced doses. Oral contraceptives are also used for animals like pigs, cows and sheep to control fertility and to give birth at a prescribed period in a group of animals at the same time. These compounds are also used to reduce the interval between the lactation periods to have more milk and meat production. Anti-fertility compounds are also used as a pest-control measure for decreasing the multiplication of pests like rodents, pigeons and sea gulls (Husain et al, 1979).

Although yam tubers contain a variety of chemical substances including carbohydrates, proteins, alkaloids and tannins, the most important constituents of these yams are a group of saponins which yield sapogenins on hydrolysis. The most imp ortant sapogenin found in Dioscorea are diosgenin, yamogenin and pannogenin. Diosgenin is a steroid drug precursor. The diogenin content varies from 2-7% depending on the age of the tubers. Saponins including 5 spirastanol glucoside and 2 furostanol glucoside, 4 new steroid saponins, floribunda saponins C, D, E and F. Strain of A and B are obtained from D. floribunda (Husain et al, 1979). Rhizomes of D. deltoidea are a rich source of diosgenin and its glycoside. Epismilagenin and smilagenone have been isolated from D. deltoidea and D. prazeri (Chakravarti et al, 1960; 1962). An alkaloid dioscorine has been known to occur in D. hispida (Bhide et al,1978). Saponin of D. prazeri produced a fall of blood pressure when given intravenously and saponin of D. deltoidea has no effect on blood pressure (Chakravarti et al,1963). Deltonin, a steroidal glycoside, isolated from rhizomes of D. deltoidea showed contraceptive activity (Biokova et al, 1990).

Agrotechnology: Dioscorea species prefer a tropical climate without extremity in temperature. It is adapted to moderate to heavy rainfall area. Dioscorea plants can be grown in a variety of soils, but light soil is good, as harvesting of tubers is easier in such soils. The ideal soil pH is 5.5-6.5 but tolerates fairly wide variation in soil pH. Dioscorea can be propagated by tuber pieces, single node stem cuttings or seed. Commercial planting is normally established by tuber pieces only. Propagation through seed progeny is variable and it may take longer time to obtain tuber yields. IIHR, Bangalore has released two improved varieties, FB(c) -1, a vigorously growing strain relatively free from diseases and Arka Upkar, a high yielding clone. Three types of tuber pieces can be distinguished for propagation purpose, viz. (1) crown (2) median and (3) tip, of which crowns produce new shoots within 30 days and are therefore preferred. Dipping of tuber pieces for 5 minutes in 0.3% solution of Benlate followed by dusting the cut ends with 0.3% Benlate in talcum powder in mo ist sand beds effectively checks the tuber rot. The treatment is very essential for obtaining uniform stand of the crop. The best time of planting is the end of April so that new sprouts will grow vigorously during the rainy season commencing in June in India. Land is to be prepared thoroughly until a fine tilth is obtained. Deep furrows are made at 60cm distance with the help of a plough. The stored tuber pieces which are ready for planting is to be planted in furrows with 30cm between the plants for one year crop and 45cm between the plants for 2 year crop at about 0.5 cm below soil level. The new sprouts are to be staked immediately. After sprouting is complete, the plants are to be earthed up. Soil from the ridges may be used for earthing up so that the original furrows will become ridges and vice versa. Dioscorea requires high organic matter for good tuber formation. Besides a basal doze of 18-20t of FYM/ha, a complete fertilizer dose of 300kg N, 150kg P2O5 and K2O each are to be applied per hectare. P and K are to be applied in two equal doses one after the establishment of the crop during May-June and the other during vigorous growth period of the crop (August- September). Irrigation may be given at weekly intervals in the initial stage and afterwards at about 10 days interval. Dioscorea vines need support for their optimum growth and hence the vines are to be trailed over pandal system or trellis. Periodic hand weeding is essential for the first few months. Intercropping with legumes has been found to smother weeds and provide extra income. The major pests of Dioscorea are the aphids and red spider mites. Aphids occur more commonly on young seedlings and vines. Young leaves and vine tips eventually die if aphids are not controlled. Red spider mites attack the underside of the leaves at the base near the petiole. Severe infestations result in necrotic areas, which are often attacked by fungi. Both aphids and spider mites can be very easily controlled by Kelthane. No serious disease is reported to infect this crop. The tubers grow to about 25-30 cm depth and hence harvesting is to be done by manual labour. The best season for harvesting is Feb-March, coinciding with the dry period. On an average 50-60t/ha of fresh tubers can be obtained in 2 years duration. Diosgenin content tends to increase with age, 2.5% in first year and 3-3.5% in the second year. Hence, 2 year crop is economical (Kumar et al, 1997).... medicinal yams

Betamethasone

n. a synthetic corticosteroid used to treat inflammatory and allergic conditions and congenital adrenal hyperplasia. The side-effects are those of *cortisone.... betamethasone

Corticosteroid

(corticoid) n. any steroid hormone synthesized by the adrenal cortex. There are two main groups of corticosteroids. The glucocorticoids (e.g. *cortisol, *cortisone, and corticosterone) are essential for the utilization of carbohydrate, fat, and protein by the body and for a normal response to stress. Naturally occurring and synthetic glucocorticoids have very powerful anti-inflammatory effects and are used to treat conditions that involve inflammation. The mineralocorticoids (e.g. *aldosterone) are necessary for the regulation of salt and water balance.... corticosteroid

Lecithin

n. one of a group of *phospholipids that are important constituents of cell membranes and are involved in the metabolism of fat by the liver. An example is phosphatidylcholine. Lecithins are present in the *surfactant that occurs in fetal lung tissue. The lecithin-sphingomyelin ratio (LS ratio) is used as a measure of fetal lung maturity; an LS ratio below 2 indicates a higher risk of *respiratory distress syndrome (RDS). In such cases cortisone may be given to stimulate fetal lung maturity and hence reduce the risk of RDS in the newborn.... lecithin

Curcuma Longa

Linn.

Synonym: C. domestica Valeton.

Family: Zingiberaceae.

Habitat: Cultivated all over India, particularly in West Bengal, Tamil Nadu and Maharashtra.

English: Turmeric.

Ayurvedic: Haridraa, Priyaka, Haridruma, Kshanda, Gauri, Kaanchani, Krimighna, Varavarni- ni, Yoshitapriyaa, Hattavilaasini, Naktaahvaa, Sharvari.

Unani: Zard Chob.

Action: Anti-inflammatory, cholagogue, hepatoprotective, blood-purifier, antioxidant, detoxi- fier and regenerator of liver tissue, antiasthmatic, anti-tumour, anticu- taneous, antiprotozoal, stomachic, carminative. Reduces high plasma cholesterol. Antiplatelet activity offers protection to heart and vessels. Also protects against DNA damage in lymphocytes.

Key application: In dyspeptic conditions. (German Commission E, ESCOP, WHO.) As antiinflammatory, stomachic. (Indian Herbal Pharmacopoeia.)

The rhizomes gave curcuminoids, the mixture known as curcumin, consisting of atleast four phenolic diaryl- heptanoids, including curcumin and monodesmethoxycurcumin; volatile oil (3-5%), containing about 60% of turmerones which are sesquiterpene ketones, and bitter principles, sugars, starch, resin.

Curcumin related phenolics possess antioxidant, anti-inflammatory, gastroprotective and hepatoprotective activities. The antioxidant activity of curcumin is comparable to standard antioxidants—vitamin C and E, BHA and BHT.

The volatile oil, also curcumin, exhibited anti-inflammatory activity in a variety of experimental models (the effects were comparable to those of cortisone and phenylbutazone). Used orally, curcumin prevents the release of inflammatory mediators. It depletes nerve endings of substance P, the neu- rotransmitter of pain receptors.

Curcumin's cholesterol-lowering actions include interfering with intestinal cholesterol uptake, increasing the conversion of cholesterol into bile acids and increasing the excretion of bile acids via its choleretic effects.

Curcuminoids prevent the increases in liver enzymes, SGOT and SGPT; this validates the use of turmeric as a he- patoprotective drug in liver disorders. Curlone, obtained from the dried rhizome, is used against hepatitis.

Turmeric and curcumin increase the mucin content of the stomach and exert gastroprotective effects against stress, alcohol, drug-induced ulcer formation. (Curcumin at doses of 100 mg/kg weight exhibited ulcerogenic activity in rats.)

The ethanolic extract of the rhizome exhibited blood sugar lowering activity in alloxan-induced diabetic rats.

Piperine (a constituent of black and long pepper) enhances absorption and bioavailability of curcumin.

Dosage: Cured rhizome—1-3 g powder. (API Vol. I.)... curcuma longa

Polygonum Aviculare

Linn.

Family: Polygonaceae.

Habitat: From Kashmir to Kumaon.

English: Knotgrass, Knotweed, Mexican Sanguinaria.

Folk: Machoti, Kesri.

Action: Astringent and haemostatic. Used for excessive menstruation, bleeding piles; bleeding from bowel, stomach, lungs, nose, throat; mucous colitis, children's summer diarrhoea.

Key application: In mild catarrhs of the respiratory tract, inflammatory changes to the oral and pharyngeal mucosa. (German Commission E.)

The plant gave flavonoids including quercetin, avicularin, quercitrin, and derivatives of kaempferol, esculetin and scopoletin. The plant also gave gallic, caffeic, oxalic., silicic, chloro- genic and p-coumaric acids; tannins including catechin.

The methanolic extract of the plant showed high protection against CCl4- induced hepatotoxicity in mice. This activity is attributed to the presence of flavonoid glucosides.

The flavonoids exhibit astringent properties and are found to decrease capillary fragility and have a cortisonelike-effect on gingival tissue. (J Ethno- pharmacol, 74(1), 2001.)... polygonum aviculare

Strophanthus Kombe

Oliver.

Family: Apocynaceae.

Habitat: Native to tropical East Africa; runs wild at some places in West Bengal.

English: Strophanthus.

Action: Dry ripe seeds—cardiac glycosides (the mixture is known as Strophanthin-K) act like digitalis but are poorly absorbed from the digestive tract, are given by injection.

Strophanthus wightianus Wall. ex Wight, known as Nerivalli (Tamil) and Kambetti (Malyalam), is found along with western coast of Kerala.

The plant yields 2.1% of glycosides. The glycosides are known as caulo- side and divaricoside, the corresponding genins are caudogenin and sarmen- togenin; the latter a precursor of cortisone. Studies have indicated that the tinctures prepared from the seeds compare favourably with those from the seeds of S. kombe.... strophanthus kombe

Tendovaginitis

(tenovaginitis) n. inflammatory thickening of the fibrous sheath containing one or more tendons, usually caused by repeated minor injury. It usually occurs at the back of the thumb (de Quervain’s tendovaginitis) and results in pain on using the wrists. Treatment is by rest, injection of cortisone into the tendon sheath, and, if these fail, surgical incision of the sheath.... tendovaginitis

Yucca Tea Benefits

Yucca Tea has been known for a long time thanks to its ability to treat a wide range of aliments, such as skin sores, dandruff and hair loss. Native Americans used a decoction of Yucca Tea applied topically oh the scalp in order to make the hair grow faster and look shinier. Yucca is a perennial shrub with ever green, stiffed leaves and white flowers. The yuccas are widely known and cultivated as decorative plants, being used in many types of Native American wedding ceremonies. Yucca grows mainly in the North American regions and also in the West Indies, where it is used only for its medical purpose. Yucca Tea Properties Aside from decorating weddings in a delightful way, Yucca can be made into a decoction very useful in alternative medicine. Although it remains yet unknown to Asian and European public, Yucca Tea continues to be a great medical treatment in Indian and American regions thanks to its active ingredients. The main chemical ingredient of Yucca Tea are saponins (mostly is soluble in hot and cold water and can be found in almost any Indian drug store as a chemical ingredient), a precursor of cortisone, which is a natural substance known for its ability to prevent intestine toxins from being released. Yucca Tea Benefits Aside from its use as a natural cosmetic treatment that can prevent affections of the scalp, Yucca Tea is also very useful in other medical areas. You may find Yucca Tea Helpful in case you’re suffering from one of the following conditions: - Arthritis and osteoarthritis, by increasing bone cell and coronary walls action. - Inflammations, by stopping bacteria and microbes eruption. - Asthma, by clearing the respiratory ways and enhancing the system’s power to recover from asthma crisis. - Headaches and blood clots, by nourishing both the nervous and the circulatory systems. - Dandruff, when applied topically at room’s temperature. How to make Yucca Tea Infusion Preparing Yucca Tea Infusion couldn’t be any easier. Just use a teaspoon of dried leaves for every cup of tea you want to make, add boiling water and wait 15 minutes for the health benefits to be released. Strain and drink the tea hot or cold. However, you need to pay attention to your bowel movement. If you notice anything unusual, lower the amount of herbs you’re using. Yucca Tea Side Effects When taken properly, Yucca Tea is safe, just make sure you don’t take more than 3 cups per day. High dosages may lead to a number of complications, such as stomach upset, bitter taste, nausea and vomiting. If you’ve been taking this tea for a while and you’ve noticed some unusual changes in your general health, talk to a specialist as soon as possible. Yucca Tea Contraindications Don’t take Yucca Tea if you are pregnant or breastfeeding. Also, if you’re on blood thinners, anticoagulants or preparing for a major surgery, avoid taking a treatment based on Yucca Tea at all costs. If your general health is good, but you’re still unsure about this tea, talk to a herbalist in order to gather more information about the risks and benefits of Yucca Tea.... yucca tea benefits

Adrenal Glands

Two organs situated one upon the upper end of each kidney. Each gland encloses a central part known as the medulla, and an outer cortex which exercises some control over sexual development. Addison’s Disease or tumours may cause defective hormone secretion and profoundly interfere with the metabolism of salt. Stresses of modern life may exhaust the glands.

The medulla, or core of the gland, secretes adrenalin and noradrenalin, known as the ‘fight or flight’ hormones that move the body into top gear to meet an emergency. Mental or physical stress may cause it to swing into action; increasing the heart beat, elevating blood pressure and releasing glycogen from the liver.

The cortex secretes a hormone – aldosterone (the salt and water hormone) which regulates water retention in the body. Also, the cortex secretes cortisone which raises the level of sugar in the blood . . . insulin reduces it. Also secreted are the adrenal sex hormones that complement the gonads.

Re-vitalisers for exhausted or hypoactive adrenals: Borage, Cayenne, Ginger root, Ginseng, Gotu Kola, Hawthorn, Liquorice, Mullein, Parsley root, Sarsaparilla, Wild Yam. ... adrenal glands

Borage

Borago officinalis L. French: Bourrache. German: Boretsch. Spanish: Borraja. Italian: Borrana. Oil from seeds.

Constituents: pyrrolizidine alkaloids, choline.

Action: adrenal gland restorative, galactagogue, demulcent, emollient, diuretic, refrigerant, anti- depressive. Stimulates production of prostaglandin EI. Oil contains two important fatty acids: gamma- linolenic acid (GLA) and linoleic acid. Assists assimilation of iron.

Uses: To strengthen adrenal glands weakened by intake of steroids (cortisone, etc). Stress, mental exhaustion, depression. Helps to prevent inflammation of stomach and intestines in cases of toxicity, allergy and infection. Colitis, Gastritis, Gastric ulcer. “Borage cheers the heart and raises drooping spirits” (Dioscorides). Old Italian remedy to increase breast milk in nursing mothers. Chronic catarrh. Borage oil is combined with Evening Primrose oil to reduce cholesterol deposits. Leaky-gut syndrome (Borage seed oil). External use said to defer wrinkling and skin dryness of old age. Used internally under directions of a qualified practitioner.

Preparations: Thrice daily.

Tea: 1 teaspoon to each cup boiling water; infuse 15 minutes. Half-1 cup.

Home tincture: 1oz cut herb to 20oz 45 per cent alcohol (Vodka, etc) in wide-neck bottle. Macerate and shake daily for 4 days. Filter. Bottle. Dose: 1-2 teaspoons in water.

Liquid Extract: half-1 teaspoon.

Capsules: (oil) (Salus).

Fresh juice: 1 teaspoon.

Pharmacy only. ... borage

Devil’s Claw

Harpagophytum procumbens D.C. Rhizome. Native of the Kalahari Desert.

Keynote: rheumatism. A versatile remedy.

Constituents: flavonoids, iridoid glycosides.

Action: anti-inflammatory, antirheumatic, analgesic (mild), liver tonic, cholagogue, diuretic, sedative, detoxicant, stomachic, lymphatic, stimulant, cortisone-like action.

Use s. Inflammatory arthritic stiff joints. Gout. Lumbago, sciatica, polymyalgia, neuralgia, liver congestion. Gall bladder disorders. Itching skin conditions. Piles. Inflammatory conditions of the veins. Avoid in pregnancy. Not given in presence of gastric or duodenal ulcer.

Preparations: Thrice daily.

Tablets: dosage as on bottle.

Alternative: a tea is made by dissolving tablets in a cup of boiling water.

Decoction. Quarter to half a teaspoon in each cup water gently simmered 15 minutes. Dose: half a cup. Liquid Extract, BHC Vol 1. (1:1, 25 per cent ethanol). Dose: 1-2ml.

Powder. 250mg capsules; maintenance dose, 2 capsules thrice daily with meals. Or applied to open wounds for healing. ... devil’s claw

Drug Dependence

One third of those taking tranquillisers become addicted. One of the problems of psychological dependence is the discomfort of withdrawal symptoms.

Symptoms. Tremors, restlessness, nausea and sleep disturbance. The greater potency of the drug, the higher the rebound anxiety. Many drugs create stress, weaken resistance to disease, tax the heart and raise blood sugar levels.

Drugs like Cortisone cause bone loss by imperfect absorption of calcium. Taken in the form of milk and dairy products, calcium is not always absorbed. Herbs to make good calcium loss are: Horsetail, Chickweed, Slippery Elm, Spinach, Alfalfa.

Agents to calm nerves and promote withdrawal may augment a doctor’s prescription for reduction of drug dosage, until the latter may be discontinued. Skullcap and Valerian offer a good base for a prescription adjusted to meet individual requirements.

Alternatives. Teas: German Chamomile, Gotu Kola, Hops, Lime flowers, Hyssop, Alfalfa, Passion flower, Valerian, Mistletoe, Oats, Lavender, Vervain, Motherwort. 1 heaped teaspoon to each cup boiling water; infuse 5-15 minutes; half-1 cup thrice daily.

Decoctions: Valerian, Devil’s Claw, Siberian Ginseng, Lady’s Slipper. Jamaica Dogwood, Black Cohosh.

Tablets/capsules. Motherwort, Dogwood, Valerian, Skullcap, Passion flower, Mistletoe, Liquorice. Powders. Formulae. Alternatives. (1) Combine equal parts Valerian, Skullcap, Mistletoe. Or, (2) Combine Valerian 1; Skullcap 2; Asafoetida quarter. Dose: 500mg (two 00 capsules or one-third teaspoon) thrice daily. Formula No 2 is very effective but offensive to taste and smell.

Practitioner. Tincture Nucis vom. once or twice daily, as advised.

Aloe Vera gel (or juice). Russians tested this plant on rabbits given heavy drug doses and expected to die. Their survival revealed the protective property of this plant: dose, 1 tablespoon morning and evening. Aromatherapy. Sniff Ylang Ylang oil. Lavender oil massage for its relaxing and stress-reducing properties.

Diet. Avoid high blood sugar levels by rejecting alcohol, white flour products, chocolate, sugar, sweets and high cholesterol foods.

Supplements. Daily. Multivitamins, Vitamin B-complex, B6, Vitamin C 2g, Minerals: Magnesium, Manganese, Iron, Zinc. Change of lifestyle. Stop smoking. Yoga.

Notes. “Do not withdraw: insulin, anticoagulants, epileptic drugs, steroids, thyroxin and hormone replacement therapy (the endocrine glands may no longer be active). Long-term tranquillisers e.g., Largactil or any medicament which has been used for a long period. Patients on these drugs are on a finely-tuned medication the balance of which may be easily disturbed.” (Simon Mills, FNIMH)

Counselling and relaxation therapy.

The Committee on Safety of Medicines specifically warns against the abrupt cessation of the Benzodiazepines and similar tranquillisers because of the considerable risk of convulsions. ... drug dependence

Kaposi’s Sarcoma

Vascular tumour. Begins with small reddish-purple plaques and skin nodules on the legs and feet. May remain benign for many years. Usually associated with AIDS, but the classical form may also be seen in renal transplant and elderly male patients receiving cortisone preparations. The tumours may appear anywhere in the body, especially around eyes and nose, giving a bruised appearance.

Diagnosis is difficult to the inexperienced practitioner. Referral to a dermatologist for skin biopsy. Homosexuals are at risk from semen ejaculated into a foreign environment. The blood abnormality extends to the lymph system for which Lymphatics such as Echinacea, Saw Palmetto and Poke root are indicated. See: AIDS.

Treatment by a general medical practitioner or hospital specialist. ... kaposi’s sarcoma

Oedema

n. excessive accumulation of fluid in the body tissues: historically known as dropsy. The resultant swelling may be local, as with an injury or inflammation, or more general, as in heart or kidney failure. In generalized oedema there may be collections of fluid within the chest cavity (pleural effusions), abdomen (see ascites), or within the air spaces of the lung (pulmonary oedema). It may result from heart or kidney failure, cirrhosis of the liver, acute nephritis, the nephrotic syndrome, starvation, allergy, or drugs (e.g. cortisone steroids). In such cases the kidneys can usually be stimulated to get rid of the excess fluid by the administration of *diuretic drugs. Subcutaneous oedema commonly occurs in the legs and ankles due to the influence of gravity and (in women) before menstruation; the swelling subsides with rest and elevation of the legs. —oedematous adj.... oedema



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