An alternative name for vitamin B.
The name given by the British Pharmacopoeia Commission to vitamin B12, found to be an e?ective substitute for liver in the treatment of pernicious ANAEMIA. It has now been replaced by HYDROXOCOBALAMIN as the standard treatment for this condition (see also COBALAMINS).
Hydroxocobalamin, or vitamin B12, has now replaced CYANOCOBALAMIN in the treatment of pernicious ANAEMIA. It has the practical advantage that fewer injections are required than in the case of cyanocobalamin. Like cyanocobalamin, it belongs to the group of substances known as cobalamins which have an ENZYME action in practically every metabolic system in the body and are essential for normal growth and nutrition. (See APPENDIX 5: VITAMINS.)... hydroxocobalamin
One of two proteins secreted from the lining of the stomach whose sole purpose is (it seems) to cradle B12 in a pre-fitted styrofoam mold and (A) carry it through the Seven Levels of Digestive Hell until it reaches those few absorption sites in the last foot of small intestine that understand its “Special Needs” (sounds either sexually kinky or the airplane dinner label on kosher food for flying Hassidim jewelers) and finally (B) slip it from one protein to the other, and thence into the cell membranes where its is turn handed over to (C) the specialized blood protein that can carry it safely to the final target tissues (3 times out of 4, the bone marrow). Cyanocobalamin (B12) has parts that fall off, radicals that twirl around in five directions on three charge potentials, and is as durable as a 49¢ water pistol. And, if we have an ulcer, chronic enteritis or long-standing steatorrhea, we either get B12 shots (and hope the liver still makes that blood carrier) or walk around with pernicious anemia and a hematocrit of 16.... intrinsic factor
A disease occurring most commonly in patients in or from the tropics, and characterised by diarrhoea with large, fatty stools; ANAEMIA; sore tongue; and weight loss. Its manifestations resemble those of non-tropical sprue, or gluten enteropathy, and COELIAC DISEASE.
Causes Tropical sprue is thought to be due to an inborn error of metabolism, characterised primarily by an inability to absorb fats from the intestines. Its epidemiological pattern suggests that an infection such as DYSENTERY may be the precipitating factor. Subsequently there is interference with the absorption of carbohydrates, vitamins, and minerals, leading to anaemia and HYPOCALCAEMIA.
Symptoms Of gradual or rapid onset, there is initial weakness, soreness of the tongue, dif?culty swallowing, indigestion, diarrhoea and poor appetite. Anaemia is typically macrocytic, and mild HYPOGLYCAEMIA may occur. Untreated, the patient steadily loses weight and, unless appropriate treatment is started early, death may be expected because of exhaustion and some intercurrent infection.
Treatment This consists of bed rest, a high-protein diet (initially skimmed milk), and treatment of the anaemia and any other de?ciencies present. Minimum fat should be given to sufferers, who should also take folic acid and cyanocobalamin for the anaemia; large vitamin-B-complex supplements (such as Marmite®) are helpful. Vitamins A and D, together with calcium supplements, help to raise the concentration of calcium in the blood. A long convalescence is often required, which may lead to marked depression, and patients should be sent home to a temperate climate.
Non-tropical sprue is the result of GLUTEN hypersensitivty and is treated with a gluten-free diet.... sprue
B12 (cyanocobalamin) a vitamin of the B complex. The form of vitamin B12 with coenzyme activity is 5-deoxyadenosyl cobalamin, which is necessary for the synthesis of nucleic acids, the maintenance of *myelin in the nervous system, and the proper functioning of *folate, another B vitamin. The vitamin can be absorbed only in the presence of intrinsic factor, a protein secreted in the stomach. A deficiency of vitamin B12 affects nearly all the body tissues, particularly those containing rapidly dividing cells. The most serious effects of a deficiency are *pernicious anaemia and degeneration of the nervous system. Vitamin B12 is manufactured only by certain microorganisms and is contained only in foods of animal origin. Good sources are liver, fish, and eggs. The adult RNI (see Dietary Reference Values) is 1.5 ?g/day. Vegans can be at risk of deficiency.... vitamin
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