Danazol: From 3 Different Sources
A drug used for treating endometriosis, noncancerous breast disease, and menorrhagia. Danazol suppresses the release of gonadotrophin hormones, which in turn reduces the production of the hormone oestrogen. This action usually prevents ovulation and causes irregularity or absence of menstrual periods. Possible side effects include nausea, rash, and weight gain. Pregnancy should be avoided while taking danazol.
This drug inhibits pituitary gonadotrophin secretion (see PITUITARY GLAND; GONADOTROPHINS) and is used in the treatment of ENDOMETRIOSIS, MENORRHAGIA and GYNAECOMASTIA. The dose is usually of the order of 100 mg twice daily and side-effects may include nausea, dizziness, ?ushing and skeletal muscle pain. It is mildly androgenic (see ANDROGEN).
n. a synthetic *progestogen that inhibits the secretion by the pituitary gland of gonadotrophins. It is used to treat endometriosis, severe pain associated with cystic breast tumours, and severe urticaria. Possible side-effects include nausea, rashes, swelling of the feet and ankles, weight gain, oiliness of the skin, and, in women, menstrual disturbances, excessive growth of facial and body hair, and irreversible voice changes. Because of the severity of these effects, danazol is now rarely used in gynaecology.
The condition in which the endometrium (the cells lining the interior of the UTERUS) is found in other parts of the body. The most common site of such misplaced endometrium is the muscle of the uterus. The next most common site is the ovary (see OVARIES), followed by the PERITONEUM lining the PELVIS, but it also occurs anywhere in the bowel. The cause is not known. Endometriosis never occurs before puberty and seldom after the menopause. The main symptoms it produces are MENORRHAGIA, DYSPAREUNIA, painful MENSTRUATION and pelvic pain. Treatment is usually by removal of the affected area, but in some cases satisfactory results are obtained from the administration of a PROGESTOGEN such as NORETHISTERONE, norethynodrel and DANAZOL.... endometriosis
This has been de?ned as ‘any combination of emotional or physical features which occur cyclically in a woman before MENSTRUATION, and which regress or disappear during menstruation’. It is characterised by mood-changes, discomfort, swelling and tenderness in the breasts, swelling of the legs, a bloated feeling in the abdomen, headache, fatigue and constipation. The mood-changes range from irritability and mild depression to outbursts of violence. It may last for 3–14 days. How common it is is not known, as only the more severe cases are seen by doctors, but it has been estimated that one in ten of all menstruating women suffer from it severely enough to require treatment. The cause is not known, but it is probably due to some upset of the hormonal balance of the body. In view of the multiplicity of causes that have been put forward, it is not surprising that there is an equal multiplicity of treatments. Among these, one of the most widely used is PROGESTERONE. Others include pyridoxine, danazol, and gamma linolenic acid available in the form of oil of evening primrose. Whatever drug may be prescribed, counselling is equally essential and, in many cases, is all that is required.... premenstrual syndrome
(nettle rash, hives) n. an itchy rash resulting partly from the release of *histamine by *mast cells. This causes either short-lived itchy *weals, deeper swellings (angio-oedema), or both. Individual weals typically appear rapidly and resolve spontaneously within hours. Acute urticaria is common and represents an immediate response to such allergens as seafood or nuts; it has been linked with upper respiratory tract infections, although many cases remain unexplained. Chronic urticaria is not an allergic condition and may persist for years. Angio-oedema occurs when the weals involve the deeper levels of the skin, resulting in swelling of the lips, eyes, or tongue, which may constitute a medical emergency. Urticaria can be treated by taking antihistamines regularly, but sometimes immunosuppressant treatment is needed, especially in autoimmune subtypes. Cholinergic urticaria is a condition in which very small weals are brought on by heat, exercise, or emotion; treatment is with antihistamines, but other drugs, including danazol, may be used for severe cases.... urticaria
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