n. the formation of *dentine by *odontoblasts. Although dentinogenesis continues throughout life, very little dentine is formed later than a few years after tooth eruption unless it is stimulated by caries, abrasion, or trauma. Dentinogenesis imperfecta is a hereditary condition in which dentine formation is disturbed; this may result in loss of overlying enamel and excessive wear of the dentine.
(OI, fragilitas ossium, brittle bone disease) a congenital disorder of connective tissue formation that affects bone, teeth, and soft tissues. It has an estimated incidence of 1 in 20,000 and there are at least eight types, of varying severity, the worst being lethal at birth. Most types are inherited as autosomal *dominant characteristics. In all types the bones are brittle and fracture easily; the *sclerae may be blue and teeth are often deformed. See also dentinogenesis (imperfecta).... osteogenesis imperfecta
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