Dichroa febrifuga Health Dictionary

Dichroa Febrifuga: From 1 Different Sources


Lour.

Family: Saxifragaceae.

Habitat: The temperate Himalayas from Nepal to Bhutan and Khasi Hills.

Folk: Basak

Action: Febrifuge, antipyretic, antiparasitic (used for malarial fever). Dried roots, known as Chang Shan, dried leafy tops, known as Shu Chi, in Chinese medicine, are used for malarial fever. Dried roots (Chang Shan) contain the alkaloid dichroine A and B, dichrin A and B.

The active principle febrifugine compared to quinine was estimated to be 16 to 64 times more efficacious against Plasmodium gallinaceum in chicks, about 100 times against Plasmodium lophurae in ducks also against Plasmodium relictum in canaries. The aqueous extract of the plant inhibited the infecting rate of the parasite Plasmodium berghei up to 10 days and increased the mean survival time to twice that of untreated control at 2.5 g/kg dose.

Clinical trials with febrifugine indicated that the drug given in four oral doses totalling 2-5 mg/day reduces the parasite count.
Health Source: Indian Medicinal Plants
Author: Health Dictionary

Soymida Febrifuga

A. Juss.

Family: Meliaceae.

Habitat: Peninsular India, Rajasthan and Bihar.

English: Indian Red-Wood, Bastard Cedar.

Ayurvedic: Maansrohini, Rohini, Rohinaa, Prahaarvalli.

Siddha/Tamil: Somi-maram, Wond.

Action: Bark—antipyretic (particularly prescribed in malaria), bitter tonic in general debility, astringent (used for diarrhoea and dysentery); used as a gargle in stomatitis, applied to rheumatic swellings. The bark is much inferior to cinchona bark, but a good substitute for oak bark.

The plant contains mainly tetra- nor-triterpenoids and flavonoids. The heartwood gave febrifugine A and B, febrinins A and B; flavonoids— naringenin, quercetin, myricetin and dehydromyricetin. The Root heart- wood yielded sitosterol, obtusifoliol, syringetin and dihydrosyringetin. The bark contains tetranor-triterpenoids with modified furan ring.

Petroleum ether extract of the bark yielded a steroid, methyl angolensate, ether extract yielded a steroid glyco- side.

Dosage: Bark—3-5 g powder. (CCRAS.)... soymida febrifuga



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