A group of rare, inherited conditions, varying widely in severity, in which blisters appear on the skin after minor injury or occur spontaneously. The conditions can be diagnosed by a skin biopsy. There is no specific treatment. The outlook varies from gradual improvement in mild cases to progressive serious disease in the most severe cases.
any one of a group of genetically determined disorders characterized by blistering of skin and mucous membranes that occurs secondarily to minor mechanical trauma. Many different types exist: milder cases are restricted to skin and mucosal fragility; other types may be complicated by the development of skin squamous cell carcinomas (dystrophic) or death in early childhood due to overwhelming sepsis or airway involvement.
A collection of fluid beneath the outer layer of the skin that forms a raised area. A blister contains fluid that has leaked from blood vessels in underlying skin layers after minor damage and protects the damaged tissue. Common causes are burns and friction. Blisters may also occur with pemphigus, pemphigoid, dermatitis herpetiformis, some types of porphyria, and some skin diseases. These include eczema, epidermolysis bullosa, impetigo, and erythema multiforme. Small blisters develop in the viral infections chickenpox, herpes zoster (shingles), and herpes simplex. Generally, blisters are best left intact, but large or unexplained blisters need medical attention.... blister
a hereditary disorder (inherited as an autosomal *recessive condition) associated with *trisomy of chromosome no. 20. Clinical features include *epidermolysis bullosa, dwarfism, learning disabilities, and pigmentary degeneration of the retina. [E. A. Cockayne (1880–1956), British physician]... cockayne’s syndrome
n. 1. a triangular overgrowth of the cornea, usually the nasal side, by thickened and degenerative conjunctiva. It is most commonly seen in people from dry hot climates, is caused by prolonged exposure to sunlight, and only rarely interferes with vision. 2. a triangular overgrowth of nail-fold skin extending onto the nail bed. It may occur as a result of such conditions as *lichen planus and *epidermolysis bullosa.... pterygium
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