Factor Ix: From 2 Different Sources
A protein in blood that plays an important role in the clotting mechanism. A deficiency of factor causes a rare genetic bleeding disorder known as Christmas disease.
(Christmas factor) a *coagulation factor normally present in blood. Deficiency of the factor results in *haemophilia B.
One of two proteins secreted from the lining of the stomach whose sole purpose is (it seems) to cradle B12 in a pre-fitted styrofoam mold and (A) carry it through the Seven Levels of Digestive Hell until it reaches those few absorption sites in the last foot of small intestine that understand its “Special Needs” (sounds either sexually kinky or the airplane dinner label on kosher food for flying Hassidim jewelers) and finally (B) slip it from one protein to the other, and thence into the cell membranes where its is turn handed over to (C) the specialized blood protein that can carry it safely to the final target tissues (3 times out of 4, the bone marrow). Cyanocobalamin (B12) has parts that fall off, radicals that twirl around in five directions on three charge potentials, and is as durable as a 49¢ water pistol. And, if we have an ulcer, chronic enteritis or long-standing steatorrhea, we either get B12 shots (and hope the liver still makes that blood carrier) or walk around with pernicious anemia and a hematocrit of 16.... intrinsic factor
An aspect of personal behaviour or lifestyle, an environmental exposure, or an inborn or inherited characteristic, which, on the basis of scientific evidence, is known to be associated with health-related condition(s) considered important to prevent.... risk factor
A coagulative blood protein that is a constituent of the COAGULATION cascade – an essential component in the clotting of blood. Those people with the inherited disorder, HAEMOPHILIA, have abnormally low amounts of factor VIII and so bleed more when cut. They are treated with a concentrated version to reduce the tendency to bleed.... factor viii
See BLOOD GROUPS.... rh factor
See BLOOD GROUPS.... rhesus factor
A chemical, psychological, physiological, social, environmental or genetic factor or conditions that predisposes an individual to the development of a disease or injury.... health risk factor
The study of the interrelationships between humans, the tools they use, and the environment in which they live and work.... human-factor research
Hard tick (ie tick with a hard dorsal scutum) belonging to the family Ixodidae. Includes amongst others, the genera Amblyomma, Dermacentor, Ixodes Rhipicephalus and Hyalomma.... ixodid
An agent involved in the clotting mechanism of the blood. It helps in the activation of THROMBOPLASTIN in the blood PLASMA (see COAGULATION).... lipoid factor
(CSF) one of a group of substances (haemopoietic growth factors or hormones) that are produced in the bone marrow and stimulate the production of specific blood cells. Genetically engineered granulocyte colony-stimulating factor (G-CSF) stimulates neutrophil production and also limits bone marrow toxicity from chemotherapy.... colony-stimulating factor
(EGFR) a protein on the surface of cells (see receptor) that binds with epidermal *growth factor and is therefore involved in cell division. EGFR is expressed at increased levels in numerous tumours, particularly of the head and neck, and in colorectal cancer, in which it can be a target for antibody therapy with *cetuximab. *Tyrosine kinase inhibitors acting specifically on the EGFR include gefitinib and erlotinib in lung and pancreatic cancer.... epidermal growth factor receptor
n. (in biochemistry) a substance that is essential to a physiological process, often a substance the nature of which is unknown. See also coagulation factors; growth factor.... factor
an inherited mutation in the gene coding for coagulation Factor V, which results in an increased susceptibility to develop venous *thrombosis.... factor v leiden
a *coagulation factor normally present in blood. Deficiency of the factor is inherited, but rarely causes spontaneous bleeding. However, bleeding does occur after surgery or trauma to the blood vessels.... factor xi
n. a genus of widely distributed parasitic ticks. Several species are responsible for transmitting *Lyme disease, *tularaemia, Queensland tick typhus, and *Russian spring-summer encephalitis. The bite of a few species can give rise to a serious paralysis, caused by a toxin in the tick’s saliva.... ixodes
n. any disease caused by the presence of *ticks.... ixodiasis
n. a family of *ticks.... ixodidae
(NGF) a protein (see growth factor), consisting of two polypeptide chains, that is required for the development and longevity of some neurons, including those in the sympathetic nervous system and some central nervous system and sensory neurons. Nerve growth factor is necessary for axon growth and also for initiating new neuronal connections with other cells. The role of NGFs in preventing the degeneration of brain cells is being explored in research into Alzheimer’s disease.... nerve growth factor
(PDGF) see growth factor.... platelet-derived growth factor
(TGF) a protein – a *cytokine – that controls growth, proliferation, and other functions in most cells. It plays a role in asthma and other respiratory diseases and is also involved in diseases elsewhere in the body. There are two classes: TGF-? and TGF-?.... transforming growth factor
(TNF) either of two proteins, TNF-? or TNF-?, that function as *cytokines. Produced by macrophages, monocytes, T lymphocytes, and various other cells, they mediate many responses, including inflammation, and have a marked action against tumour cells. Anti-TNF drugs (see cytokine inhibitor) are used in the treatment of several disorders, especially rheumatoid arthritis and ankylosing spondylitis.... tumour necrosis factor
(VEGF) a *growth factor made by both normal cells and their abnormal or malignant counterparts to stimulate new blood vessel formation (see angiogenesis). It can be targeted by a family of drugs known as *angiogenesis inhibitors, which include *bevacizumab.... vascular endothelial growth factor
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