A specific enzyme inhibitor drug that prevents testosterone from being converted into the more potent male hormone, dihydrotestosterone. The drug is used to treat noncancerous prostatic enlargement (see prostate, enlarged), improving the flow of urine. Side effects include impotence and decreased libido and ejaculate volume.
Finasteride is a drug which inhibits the ENZYME that metabolises TESTOSTERONE into the more potent ANDROGEN, dihydrotestosterone. This action results in a reduction of prostate tissue. The drug is used to treat an enlarged PROSTATE GLAND, thus improving urinary ?ow. Its side-effects include reduced LIBIDO, and IMPOTENCE. Finasteride o?ers an alternative to PROSTATECTOMY for some men but a signi?cant minority do not improve. Women of childbearing age should not handle broken or crushed tablets.
n. a drug that causes shrinkage of the prostate gland. It is administered by mouth both to relieve the symptoms of urinary retention caused by an enlarged gland obstructing the outflow of urine from the bladder and to reduce the risk of urinary retention. An *anti-androgen, the drug acts by reducing androgenic stimulation of the prostate, inhibiting the enzyme 5?-reductase, responsible for converting testosterone to its more active metabolite, *dihydrotestosterone, within the gland. Side-effects include impotence and breast pain and enlargement. A low-dose formulation of finasteride is used to treat baldness in men.
n. any one of a group of drugs that inhibit the action of testosterone on the prostate gland by blocking androgen receptors, competing for binding sites, or decreasing androgen production. They are therefore used in the treatment of prostate cancer, which is an androgen-dependent tumour. Anti-androgens include *abiraterone acetate, *bicalutamide, *cyproterone, *finasteride, and *flutamide.... anti-androgen
a male accessory sex gland that opens into the urethra just below the bladder and vas deferens (see illustration). The prostate is divided into different anatomical regions called McNeal’s zones (transition, central, peripheral, and anterior fibromuscular zones). During ejaculation it secretes an alkaline fluid that forms part of the *semen. The prostate may become enlarged in elderly men (benign prostatic hyperplasia; BPH). This may result in obstruction of the neck of the bladder, impairing urination. The bladder dilates and the increased pressure is transmitted through the ureters to the kidney nephrons, leading to damage and impaired function of the kidneys. Treatment is by transurethral *resection of the prostate (see also prostatectomy) or by means of drugs (e.g. *finasteride, alpha blockers).... prostate gland