Food and drug administration Health Dictionary

Food And Drug Administration: From 1 Different Sources


(FDA) in the USA, the federal agency within the *Department of Health and Human Services responsible for ensuring that foods are safely edible; that medications (for humans and animals), biological products, and medical devices are safe and effective; and that cosmetics and electronic products that emit radiation are safe. The FDA is also responsible for ensuring the accuracy of the advertisements and labelling related to these products.
Health Source: Oxford | Concise Colour Medical Dictionary
Author: Jonathan Law, Elizabeth Martin

Food Poisoning

This illness is characterised by vomiting, diarrhoea and abdominal pain, and results from eating food contaminated with metallic or chemical poisons, certain micro-organisms or microbial products. Alternatively, the foods – such as undercooked red kidney beans or ?sh of the scombroid family (mackerel and tuna) – may contain natural posions. Food poisoning caused by chemical or metallic substances usually occurs rapidly, within minutes or a few hours of eating. Among micro-organisms, bacteria are the leading cause of food poisoning, particularly Staphylococcus aureus, Clostridium perfringens (formerly Cl. welchii), Salmonella spp., Campylobacter jejuni, and Escherichia coli O157.

Staphylococcal food poisoning occurs after food such as meat products, cold meats, milk, custard and egg products becomes contaminated before or after cooking, usually through incorrect handling by humans who carry S. aureus. The bacteria produce an ENTEROTOXIN which causes the symptoms of food poisoning 1–8 hours after ingestion. The toxin can withstand heat; thus, subsequent cooking of contaminated food will not prevent illness.

Heat-resistant strains of Cl. perfringens cause food poisoning associated with meat dishes, soups or gravy when dishes cooked in bulk are left unrefrigerated for long periods before consumption. The bacteria are anaerobes (see ANAEROBE) and form spores; the anaerobic conditions in these cooked foods allow the germinated spores to multiply rapidly during cooling, resulting in heavy contamination. Once ingested the bacteria produce enterotoxin in the intestine, causing symptoms within 8–24 hours.

Many di?erent types of Salmonella (about 2,000) cause food poisoning or ENTERITIS, from eight hours to three days after ingestion of food in which they have multiplied. S. brendeny, S. enteritidis, S. heidelberg, S. newport and S. thompson are among those commonly causing enteritis. Salmonella infections are common in domesticated animals such as cows, pigs and poultry whose meat and milk may be infected, although the animals may show no symptoms. Duck eggs may harbour Salmonella (usually S. typhimurium), arising from surface contamination with the bird’s faeces, and foods containing uncooked or lightly cooked hen’s eggs, such as mayonnaise, have been associated with enteritis. The incidence of human S. enteritidis infection has been increasing, by more than 15-fold in England and Wales annually, from around 1,100 a year in the early 1980s to more than 32,000 at the end of the 1990s, but has since fallen to about 10,000. A serious source of infection seems to be poultry meat and hen’s eggs.

Although Salmonella are mostly killed by heating at 60 °C for 15 minutes, contaminated food requires considerably longer cooking and, if frozen, must be completely thawed beforehand, to allow even cooking at a su?cient temperature.

Enteritis caused by Campylobacter jejuni is usually self-limiting, lasting 1–3 days. Since reporting of the disease began in 1977, in England and Wales its incidence has increased from around 1,400 cases initially to nearly 13,000 in 1982 and to over 42,000 in 2004. Outbreaks have been associated with unpasteurised milk: the main source seems to be infected poultry.

ESCHERICHIA COLI O157 was ?rst identi?ed as a cause of food poisoning in the early 1980s, but its incidence has increased sharply since, with more than 1,000 cases annually in the United Kingdom in the late 1990s. The illness can be severe, with bloody diarrhoea and life-threatening renal complications. The reservoir for this pathogen is thought to be cattle, and transmission results from consumption of raw or undercooked meat products and raw dairy products. Cross-infection of cooked meat by raw meat is a common cause of outbreaks of Escherichia coli O157 food poisoning. Water and other foods can be contaminated by manure from cattle, and person-to-person spread can occur, especially in children.

Food poisoning associated with fried or boiled rice is caused by Bacillus cereus, whose heat-resistant spores survive cooking. An enterotoxin is responsible for the symptoms, which occur 2–8 hours after ingestion and resolve after 8–24 hours.

Viruses are emerging as an increasing cause of some outbreaks of food poisoning from shell?sh (cockles, mussels and oysters).

The incidence of food poisoning in the UK rose from under 60,000 cases in 1991 to nearly 79,000 in 2004. Public health measures to control this rise include agricultural aspects of food production, implementing standards of hygiene in abattoirs, and regulating the environment and process of industrial food production, handling, transportation and storage.... food poisoning

Drug

An agent that is used therapeutically to treat diseases. It may also be defined as any chemical agent and/or biological product or natural product that affects living processes... drug

Food Intolerance

This is divided into food aversion, where a person simply avoids a food they dislike; food intolerance, where taking the food causes symptoms; and food allergy, where the symptoms are due to an immunological reaction. Some cases of food intolerance are due to idiosyncrasy – that is, a genetic defect in the patient, such as alactasia, where the intestine lacks the enzyme that digests milk sugar, with the result that individuals so affected develop diarrhoea when they drink milk. Intolerance to speci?c foods, as distinct from allergy, is probably quite common and may be an important factor in the aetiology of the IRRITABLE BOWEL SYNDROME (IBS).

For the diagnosis of true food allergy, it is necessary to demonstrate that there is a reproducible intolerance to a speci?c food; also, that there is evidence of an abnormal immunological reaction to it. Occasionally the allergic response may not be to the food itself but to food contaminants such as penicillin, or to food additives such as tartrazine. There may also be reactions to foods which have pharmacological effects, such as ca?eine in strong co?ee or histamine in fermented cheese, or such reactions may be due to the irritant e?ect on the intestinal mucosa (especially if it is already diseased) by, say, highly spiced curries.

Testing blood and skin for food allergy is beloved of some alternative practitioners but, in practice, the results of tests do not necessarily agree with what happens when the food is taken. Therefore, a careful history is as useful as any test in making a diagnosis.... food intolerance

Drug Dependence

One third of those taking tranquillisers become addicted. One of the problems of psychological dependence is the discomfort of withdrawal symptoms.

Symptoms. Tremors, restlessness, nausea and sleep disturbance. The greater potency of the drug, the higher the rebound anxiety. Many drugs create stress, weaken resistance to disease, tax the heart and raise blood sugar levels.

Drugs like Cortisone cause bone loss by imperfect absorption of calcium. Taken in the form of milk and dairy products, calcium is not always absorbed. Herbs to make good calcium loss are: Horsetail, Chickweed, Slippery Elm, Spinach, Alfalfa.

Agents to calm nerves and promote withdrawal may augment a doctor’s prescription for reduction of drug dosage, until the latter may be discontinued. Skullcap and Valerian offer a good base for a prescription adjusted to meet individual requirements.

Alternatives. Teas: German Chamomile, Gotu Kola, Hops, Lime flowers, Hyssop, Alfalfa, Passion flower, Valerian, Mistletoe, Oats, Lavender, Vervain, Motherwort. 1 heaped teaspoon to each cup boiling water; infuse 5-15 minutes; half-1 cup thrice daily.

Decoctions: Valerian, Devil’s Claw, Siberian Ginseng, Lady’s Slipper. Jamaica Dogwood, Black Cohosh.

Tablets/capsules. Motherwort, Dogwood, Valerian, Skullcap, Passion flower, Mistletoe, Liquorice. Powders. Formulae. Alternatives. (1) Combine equal parts Valerian, Skullcap, Mistletoe. Or, (2) Combine Valerian 1; Skullcap 2; Asafoetida quarter. Dose: 500mg (two 00 capsules or one-third teaspoon) thrice daily. Formula No 2 is very effective but offensive to taste and smell.

Practitioner. Tincture Nucis vom. once or twice daily, as advised.

Aloe Vera gel (or juice). Russians tested this plant on rabbits given heavy drug doses and expected to die. Their survival revealed the protective property of this plant: dose, 1 tablespoon morning and evening. Aromatherapy. Sniff Ylang Ylang oil. Lavender oil massage for its relaxing and stress-reducing properties.

Diet. Avoid high blood sugar levels by rejecting alcohol, white flour products, chocolate, sugar, sweets and high cholesterol foods.

Supplements. Daily. Multivitamins, Vitamin B-complex, B6, Vitamin C 2g, Minerals: Magnesium, Manganese, Iron, Zinc. Change of lifestyle. Stop smoking. Yoga.

Notes. “Do not withdraw: insulin, anticoagulants, epileptic drugs, steroids, thyroxin and hormone replacement therapy (the endocrine glands may no longer be active). Long-term tranquillisers e.g., Largactil or any medicament which has been used for a long period. Patients on these drugs are on a finely-tuned medication the balance of which may be easily disturbed.” (Simon Mills, FNIMH)

Counselling and relaxation therapy.

The Committee on Safety of Medicines specifically warns against the abrupt cessation of the Benzodiazepines and similar tranquillisers because of the considerable risk of convulsions. ... drug dependence

Drug Addiction

See DEPENDENCE.... drug addiction

Generic Drug

A medicinal drug that is sold under its o?cial (generic) name instead of its proprietary (patented brand) name. NHS doctors are advised to prescribe generic drugs where possible as this enables any suitable drug to be dispensed, saving delay to the patient and sometimes expense to the NHS. (See APPROVED NAMES FOR MEDICINES.)... generic drug

Uricosuric Drug

A drug that increases the amount of URIC ACID excreted in the URINE. Among the drugs used are PROBENECID or a sulfa derivative. Uricosurics are used to treat GOUT and other disorders which cause raised blood-uric-acid concentrations.... uricosuric drug

Controlled Drug

One of a number of drugs subject to restricted use because of their potential for abuse. They include

opiates such as cocaine and morphine, amfetamine drugs, and barbiturate drugs. controlled trial A method of testing the effectiveness of new treatments or comparing different treatments. In a typical controlled drug trial, 2 comparable groups of patients suffering from the same illness are given courses of apparently identical treatment. However, only one group receives the new treatment; the second control group is given a placebo. Alternatively, the control group may be given an established drug that is already known to be effective. After a predetermined period, the 2 groups are assessed medically. Controlled trials must be conducted “blind’’ (the patients do not know which treatment they are receiving). In a “double-blind’’ trial, neither the patients nor the doctors who assess them know who is receiving which treatment. contusion Bruising to the skin and underlying tissues from an injury. convalescence The recovery period following an illness or surgery during which the patient regains strength before returning to normal activities.... controlled drug

Otc Drug

See over-the-counter drug.... otc drug

Brahmi Tea Or Food For The Brain

Brahmi Tea isbest known in Indian Ayurvedic medicine for its role against motor and nerve disorders. It possesses a pungent and bitter flavor, being a tonic, a mild sedative and a diuretic. Brahmi Tea description Brahmi is a perennial creeping herb, commonly found in India, Nepal, Sri Lanka, China, Vietnam and in the southern parts of the United States. It grows on wetlands and muddy shores. Brahmi is medicinally and culinary used. It is known as “food for the brain”, brahmi being used since the 6th century in Ayurvedic medicine as a cognitive enhancer. In India, the herb is still used by students and schoolchildren to help their brain functions. Brahmi tea is the resulting beverage from brewing the abovementioned plant. Brahmi Tea brewing Brahmi tea can be made by immersing ½ teaspoon of dried brahmi herbs into one cup of boiling water. Let it soak and steep it for about 5 minutes. Drink it slowly. Brahmi Tea benefits Brahmi tea has proven its efficiency in:
  • improving the memory and enhancing mental functions, agility and alertness (It is helpful in retention of new information)
  • calming the mind and promoting relaxation
  • improving motor learning ability
  • promoting greater concentration and focus
  • treating asthma
  • treating epilepsy
  • treating indigestion
Brahmi Tea side effects High doses of Brahmi tea may causeheadaches, nausea, dizziness and extreme drowsiness. Pregnant and nursing women should not intake this beverage. Brahmi tea is a medicinal beverage successfully used to enhance the memory processes and to promote relaxation. It is also efficient in dealing with indigestion, but not only.... brahmi tea or food for the brain

Crude Drug

A dried, unprocessed plant, and referring to one that was or is an official drug plant or the source of a refined drug substance. A—... crude drug

Drug Absorption

Drugs are usually administered distant to their site of action in the body; they must then pass across cell membranes to reach their site of action. For example, drugs given by mouth must pass across the gut membrane to enter the bloodstream and then pass through the endothelium of vessel walls to reach the site of action in the tissues. This process is called absorption and may depend on lipid di?usion, aqueous di?usion, active transport, or pinocytosis – a process in which a cell takes in small droplets of ?uid by cytoplasmic engulfment.... drug absorption

Drug Assisted Rape

Also known as ‘date rape’, this is an unwelcome phenomenon in which an intending rapist undermines a potential victim’s resistance by giving her a hypnotic drug such as benzodiazepine. The British National Formulary warns that ?unitrazepam (Rohypnol®) tablets may be particularly subject to abuse – perhaps given to the unsuspecting victim in an alcoholic drink so the sedative e?ect is greatly enhanced.... drug assisted rape

Drug Binding

The process of attachment of a drug to a receptor or plasma protein, fat, mucopolysaccharide or other tissue component. This process may be reversible or irreversible.... drug binding

Drug Clearance

The volume of blood from which a drug is completely removed in one minute is known as clearance. Renal clearance of a drug is the amount of blood completely cleared of the drug by the kidney in one minute.... drug clearance

Drug Interactions

Many patients are on several prescribed drugs, and numerous medicines are available over the counter, so the potential for drug interaction is large. A drug may interact with another by inhibiting its action, potentiating its action, or by simple summation of effects.

The interaction may take place:

(1) Prior to absorption or administration – for example, antacids bind tetracycline in the gut and prevent absorption.

(2) By interfering with protein binding – one drug may displace another from binding sites on plasma proteins. The action of the displaced drug will be increased because more drug is now available; for example, anticoagulants are displaced by analgesics.

(3) During metabolism or excretion of the drug – some drugs increase or decrease the activity of liver enzymes which metabolise drugs, thus affecting their rate of destruction; for example, barbiturates, nicotine, and alcohol all activate hepatic enzymes. Altering the pH of urine will affect the excretion of drugs via the kidney.

(4) At the drug receptor – one drug may displace another at the receptor, affecting its e?cacy or duration of action.... drug interactions

Drug Metabolism

A process by which the body destroys and excretes drugs, so limiting their duration of action. Phase 1 metabolism consists of transformation by oxidation, reduction, or hydrolysis. In phase 2 this transformed product is conjugated (joined up) with another molecule to produce a water-soluble product which is easier to excrete.... drug metabolism

Drug Product

A finished dosage form, for eg., a tablet, capsule or solution that contains a drug substance... drug product

Drug Substance

An active ingredient that is intended to furnish pharmacological activity or other direct effect in diagnosis, cure, mitigation, treatment or prevention of diseases or to effect the structure or any function of the human body... drug substance

Drug Therapy

The use of drugs to treat a medical problem, to improve a person’s condition or to otherwise produce a therapeutic effect.... drug therapy

Drug Utilization Review (dur)

A formal programme for assessing drug prescription and use patterns. DURs typically examine patterns of drug misuse, monitor current therapies, and intervene when prescription or utilization patterns fall outside pre-established standards. DUR is usually retrospective, but can also be performed before drugs are dispensed.... drug utilization review (dur)

Food

Mixture of substances containing CARBOHYDRATE, FAT, PROTEIN, VITAMINS, TRACE ELEMENTS and water consumed by animals, including humans, to provide the necessary nutrients to maintain the body’s METABOLISM.... food

Food Standards Agency

An independent agency recently set up by the UK government. The aim is for the agency to protect consumers’ interests in every aspect of food safety and nutrition. The agency advises ministers and the food industry, conducts research and surveillance, and monitors enforcement of food safety and hygiene laws.... food standards agency

Generic Drug Substitution

Generic drugs have been licensed as equivalent to brand name drugs. Generics are usually less expensive and they may be substituted by the dispenser.... generic drug substitution

Green Tea Or The Wonder Drug

Green tea is considered a “wonder drug” because of its healthy contribution in human diets. Its antioxidant properties fight successfully against cancer, but not only. Green tea description Green tea is made from Camellia sinensis, an Asian plant, originating from China, Japan and South Korea. Oolong tea and black tea are prepared from the same plant as the green tea. A special feature of this type of tea is the ability to block the natural process of fermentation: after being picked, its leaves are steamed, dried and then rolled, thus blocking fermentation. Due to its constituents, it acts as an antioxidant, diuretic, cerebral and fattening burning stimulator, and also as a cancer protector. Green tea has been the subject of many scientific and medical studies so as to determine its health benefits. It seems that regular green tea drinkers may have a lower risk of developing heart diseases and certain types of cancer. There are several types of green tea available on the market: Bancha Tea, Chun Hao Tea , Dao Ren Tea , Dragonwell Tea , Genmaicha Tea , Gunpowder , Gyokuro Tea , Hojicha Tea , Kai Hua Long Ding Tea, Kukicha Tea , Matcha Tea , Sencha Tea , White Monkey Tea. Green Tea brewing To prepare green tea, use: two grams of tea per 100ml of water, or one teaspoon of green tea per five ounce cup. Green tea steeping time varies from thirty seconds to two, three minutes. The temperature differs as well, from 140°F to 190°F. Consumers recommend that lower-quality green teas to be steeped hotter and longer and higher-quality teas to be steeped cooler and shorter. In case of steeping the green tea too hot or too long, the resulting beverage is bitter and astringent. Green Tea benefits Green Tea lowers the risk of cancer. Studies have shown the green tea’s contribution against tumors growth, due to its high content of antioxidants, able to fight free radicals which are responsible for cancer spreading. Green Tea lowers the risk of stroke and heart diseases. The formation of blood clots (or thrombosis) is the main cause of the heart attacks and strokes. Green Tea has been acknowledged to exhibit abnormal blood clot formation. Green Tea lowers blood pressure. Green Tea is proven to block the effects of an enzyme secreted by the kidneys, considered to be one of the main causes of hypertension. Green Tea prevents tooth decay. Dental plaque and bacterial colonies that occur on the tooth surfaces and cause tooth decay can be inhibited by one of the compounds of the green tea. Also, this beverage has been shown to be effective against fighting gum diseases. Green Tea inhibits viruses Studies revealed that green tea can kill certain bacteria and staphs. It blocks the development of several viruses such as viral hepatitis. Green tea has also been successful in:
  • Slowing early aging;
  • Diets;
  • The treatment of physical or intellectual fatigue;
  • Treating fast cold and flu recovery;
  • Preventing allergenic reactions;
  • Balancing body fluids;
  • Improving the immune function of the epidermis;
  • Preventing and mending arthritis;
  • Improving bone structure
Green Tea side effects Green tea is not recommended to patients suffering from high blood pressure, gastric acid secretion, gastritis and ulcer. Due to the amount of caffeine contained, scientists advise a reduced consumption of green tea for pregnant and nursing women. Also, this tea should not be drunk after 5 p.m., because the consumption may lead to insomnia, palpitations and agitation. Green tea is a well known beverage, especially due to its medicinal contribution to a large array of diseases such as arthritis, heart diseases and several types of cancer.... green tea or the wonder drug

Drug Eruptions

Reactions on the skin due to drug allergy. Symptoms may manifest as urticaria or exanthemata. Aspirin may produce urticaria. Mercury, arsenic, gold, mepacrine and others manifest in their own distinctive rash or vesicles.

Treatment: same as for NETTLE RASH. ... drug eruptions

Institute Of Health Food Retailing

Professional body to ensure status of those whose career is in the health food industry. Encourages training, research and education in health food retailing, health and nutrition, and furthers these objects with meetings and seminars. Holders of the NAHS Diploma of Health Food Retailing may apply for membership. On acceptance they are awarded a certificate with authority to use the designatory letters M Inst HFR.

Address: Byron House, College Street, Nottingham NG1 5AQ. ... institute of health food retailing

Oral Administration

Giving a remedy by mouth. Such a route leads to its passage through the mucous membrane lining the intestines and from there into the bloodstream. ... oral administration

Combination Drug

A preparation containing more than one active substance.... combination drug

Drug Abuse

Use of a drug for a purpose other than that for which it is normally prescribed or recommended. Commonly abused drugs include stimulant drugs, such as cocaine and amfetamine drugs; central nervous system depressants, such as alcohol and barbiturate drugs; hallucinogenic drugs, such as LSD; and narcotics (see opioid drugs), such as heroin. Some drugs are abused in order to improve performance in sports (see sports, drugs and; steroids, anabolic).

Problems resulting from drug abuse may arise from the adverse effects of the drug, accidents that occur during intoxication, or from the habit-forming potential of many drugs, which may lead to drug dependence.... drug abuse

Drug Interaction

The effect of a drug when it is taken in combination with other drugs or with substances such as alcohol.... drug interaction

Drug Overdose

The taking of an excessive amount of a drug, which may cause toxic effects (see drug poisoning).... drug overdose

Food Fad

A like or dislike of a particular food or foods that is taken to extremes. A food fad may lead to undue reliance on, or avoidance of, a particular foodstuff. Fads are common in toddlers, adolescents, and in people who are under stress. When a food fad becomes obsessive or persistent, it may indicate a serious eating disorder. (See also anorexia nervosa; bulimia.)... food fad

Hallucinogenic Drug

A drug that causes hallucination.

Hallucinogens include certain drugs of abuse, such as LSD, marijuana, mescaline, and psilocybin.

Some prescription drugs, including anticholinergic drugs and levodopa, occasionally cause hallucinations.... hallucinogenic drug

Health Food

A term applied to any food products thought to promote health.... health food

Irradiation Of Food

The treatment of food with ionizing radiation to kill bacteria, moulds, insects, and other parasites. It improves the keeping qualities of food and is a means of controlling some types of food poisoning. It does not destroy bacterial toxins, however, and may destroy vitamins. Irradiation does not render food radioactive.... irradiation of food

Antiepileptic Drug

see anticonvulsant.... antiepileptic drug

Antiplatelet Drug

any one of a class of drugs that reduce platelet aggregation (see platelet activation) and therefore the formation of clot (see thrombosis). Examples are *abciximab, *aspirin, *clopidogrel, prasugrel, and ticagrelor.... antiplatelet drug

Antiretroviral Drug

(ARV) any of a group of drugs that inhibit or slow the growth of *retroviruses, specifically HIV, and are used in the treatment of HIV infection and *AIDS. They include the *reverse transcriptase inhibitors and the *protease inhibitors (see also maraviroc; raltegravir). Treatment with a combination of antiretrovirals is known as highly active antiretroviral therapy (HAART).... antiretroviral drug

Drug Poisoning

The harmful effects on the body as a result of an excessive dose of a drug. Accidental poisoning is most common in young children. In adults, it usually occurs in elderly or confused people who are unsure about their treatment and dosage requirements. Accidental poisoning may also occur during drug abuse. Deliberate self-poisoning is usually a cry for help (see suicide; suicide, attempted). The drugs that are most commonly taken in overdose include benzodiazepine drugs and antidepressant drugs. Anyone who has taken a drug overdose and any child who has swallowed tablets that belong to someone else should seek immediate medical advice. It is important to identify the drugs that have been taken. Treatment in hospital may involve washing out the stomach (see lavage, gastric). Charcoal may be given by mouth to reduce the absorption of the drug from the intestine into the bloodstream. To eliminate the drug, urine production may be increased by an intravenous infusion. Antidotes are available only for specific drugs. Such antidotes include naloxone (for morphine) and methionine (for paracetamol).

Drug poisoning may cause drowsiness and breathing difficulty, irregular heartbeat, and, rarely, cardiac arrest, fits, and kidney and liver damage.

Antiarrhythmic drugs are given to treat heartbeat irregularity.

Fits are treated with anticonvulsants.

Blood tests to monitor liver function and careful monitoring of urine output are carried out if the drug is known to damage the liver or kidneys.... drug poisoning

Food Additives

Any substance added to food for the purposes of preservation or to improve its acceptability in terms of taste, colour, or consistency.

Preservatives, such as sodium nitrate, are added to food to control the growth of bacteria, moulds, and yeasts. Other additives, such as antioxidants, improve the keeping quality of food by preventing undesirable changes (they stop rancidity in foods containing fat, for example). Additives that improve texture include emulsifiers, stabilizers, thickeners, and gelling agents. Appearance and taste are improved by the use of colourings, flavourings, sweeteners, and flavour enhancers. Artificial sweeteners, such as saccharin, may be used instead of sugar, especially in products for diabetics or slimmers.

Certain additives may produce an allergic reaction in some people, and some are thought to be a factor in behavioural problems in children.... food additives

Food Allergy

An inappropriate or exaggerated reaction of the immune system to a food. Sensitivity to cow’s milk protein is a fairly common food allergy in young children. Other foods most commonly implicated in food allergy are nuts, wheat, fish, shellfish, and eggs. Food allergy is more common in people who suffer from other forms of allergy or hypersensitivity, such as asthma, allergic rhinitis, and eczema.Immediate reactions, occurring within an hour or sometimes minutes of eating the trigger food, include lip swelling, tingling in the mouth or throat, vomiting, abdominal distension, abnormally loud bowel sounds, and diarrhoea. Some serious allergies can cause anaphylactic shock, requiring immediate self-injection with adrenaline (epinephrine). The only effective treatment for food allergy is avoidance of the offending food. (See also food intolerance.)... food allergy

Food-borne Infection

Any infectious illness caused by eating food contaminated with viruses, bacteria, worms, or other organisms. There are 2 mechanisms by which food can become infected. First, many animals that are kept or caught for food may harbour disease organisms in their tissues or organs; and, if meat or milk from such an animal is eaten without being thoroughly cooked or pasteurized, the organisms may cause illness in their human host. In the , the only common infection of this type is food poisoning. Second, food may be contaminated with organisms spread from an infected person or animal, usually by flies moving from faeces to food.

Immunization is available against certain food- and water-borne infections such as typhoid fever.... food-borne infection

Antisecretory Drug

any drug that reduces the normal rate of secretion of a body fluid, usually one that reduces acid secretion into the stomach. Such drugs include *antimuscarinic drugs, H2-receptor antagonists (see antihistamine), and *proton-pump inhibitors.... antisecretory drug

Antiviral Drug

a drug effective against viruses that cause disease. Antiviral drugs include *DNA polymerase inhibitors (e.g. *aciclovir, *foscarnet, *ganciclovir), *ribavirin, and *oseltamivir; they are used for treating herpes, cytomegalovirus and respiratory syncytial virus infections, and influenza. Antiviral drugs are also used for treating HIV infection and AIDS (see antiretroviral drug).... antiviral drug

Designer Drug

a psychoactive drug produced by minor chemical modification of existing illegal substances so as to circumvent prohibitive legislation. These drugs are manufactured in secret laboratories for profit, without regard to any probable medical and social dangers to the consumers.... designer drug

Disease-modifying Antirheumatic Drug

(DMARD) any of various drugs used in the treatment of rheumatic disease: they affect the progression of the disease by suppressing the disease process. DMARDs include drugs affecting the immune response (immunomodulators), such as *immunosuppressants (e.g. methotrexate) and *cytokine inhibitors; *gold salts; *penicillamine; *sulfasalazine; and *hydroxychloroquine.... disease-modifying antirheumatic drug

Drug-eluting Stent

see stent.... drug-eluting stent

Drug Intolerance

lowered threshold or heightened sensitivity to the normal pharmacological action and dosage of a drug. It is unpredictable but there is some evidence of familial history.... drug intolerance

Nonsteroidal Anti-inflammatory Drug

see NSAID.... nonsteroidal anti-inflammatory drug

Cytotoxic Drug

any drug that damages or destroys cells: usually refers to those drugs used to treat various types of cancer. There are various classes of cytotoxic drugs, including *alkylating agents (e.g. *chlorambucil, *cyclophosphamide, *melphalan), *antimetabolites (e.g. *fluorouracil, *methotrexate, *mercaptopurine), *anthracycline antibiotics (e.g. *doxorubicin, *daunorubicin, *dactinomycin), *vinca alkaloids, and platinum compounds (e.g. *carboplatin, *cisplatin). Other cytotoxic drugs include *taxanes and *topoisomerase inhibitors, and some *monoclonal antibodies (e.g. *bevacizumab, *trastuzumab) have cytotoxic activity. All these drugs offer successful treatment in some conditions and help reduce symptoms and prolong life in others. Cytotoxic drugs destroy cancer cells by interfering with cell division, but they also affect normal cells, particularly in bone marrow (causing *myelosuppression), hair follicles (causing hair loss), the stomach lining (resulting in severe nausea and vomiting), mouth (causing soreness), and fetal tissue (they should not be taken during the later stages of pregnancy). Dosage must therefore be carefully controlled. See also chemotherapy.... cytotoxic drug

Oral Hypoglycaemic Drug

(oral antihyperglycaemic drug) one of the group of drugs that reduce the level of glucose in the blood and are taken by mouth for the treatment of type 2 *diabetes mellitus. They include the *sulphonylurea group (e.g. glibenclamide, gliclazide), metformin (a *biguanide), *alpha-glucosidase inhibitors, *meglitinides, *thiazolidinediones, *DPP-IV inhibitors, and *SGLT-2 inhibitors.... oral hypoglycaemic drug

Over-the-counter Drug

(OTC drug) a drug that may be purchased directly from a pharmacist without a doctor’s prescription. Current government policy is to extend the range of OTC drugs: a number have already been derestricted (e.g. ibuprofen, ranitidine) and this trend is increasing, which will place an additional advisory responsibility on pharmacists.... over-the-counter drug

Sulpha Drug

see sulphonamide.... sulpha drug



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