One of the steroidal AROMATASE INHIBITORS recently introduced for the treatment of patients with advanced postmenopausal breast cancer. It is better tolerated than non-steroidal aromatase inhibitors and acts by blocking the conversion of androgens (see ANDROGEN) to OESTROGEN in peripheral tissue.
A group of drugs that stop the action of the ENZYME, aromatase. This enzyme converts androgens (see ANDROGEN) to OESTROGENS. If this conversion is inhibited, the concentrations of oestrogens in the body are reduced – so these drugs operate against tumours, such as breast cancer, that depend on oestrogen for their growth. Aromatase inhibitors include anastrazole and formestane, and they are usually prescribed as second-line treatment after TAMOXIFEN, the prime drug treatment for breast cancer.... aromatase inhibitors
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