Gamma Linolenic Acid (gla): From 1 Different Sources
A polyunsaturated fatty acid; an essential ingredient in the body’s production of prostaglandins. Present naturally in mother’s milk. The body produces GLA from linoleic acid present in food as an essential fatty acid (EFA). Vital to growth, cell structure and cardiac health. Sources: Evening Primrose oil; Sunflower seed oil, Borage and Blackcurrant. Preparations from the fermentation of rotten carrots. Helps lower blood pressure and prevent cholesterol build-up in the blood.
Increased intraocular pressure and its consequences... glaucoma
See MONONUCLEOSIS.... glandular fever
A colourless, pungent, fuming liquid. Secreted by the parietal cells in the lining of the stomach, it aids in the digestion of the food.... hydrochloric acid
The final end product of certain native or dietary proteins, especially the nucleoproteins found in the nucleus of cells. Unlike the much smaller nitrogenous waste product urea, which is mostly recycled to form many amino acids, uric acid is an unrecyclable metabolite. It is a bent nail that won’t restraighten, and it must be excreted: nucleoprotein to purine to uric acid to the outside in the urine or the sweat. (See GOUT, PURINES.)... uric acid
Ascorbic acid, or vitamin C (see APPENDIX 5: VITAMINS), is a simple sugar found in living tissues – its highest concentrations being in the adrenal cortex (see ADRENAL GLANDS) and the eye. Stress and CORTICOTROPIN lead to a loss of ascorbic acid from the adrenal cortex. Fresh fruit and vegetables, particularly blackcurrants, citrus fruits, berries and green vegetables, are the richest dietary sources; it may also be synthetically prepared. Ascorbic acid is easily eliminated from the diet by traditional methods of cooking, being very soluble in water and easily destroyed by heat, alkalis, traces of copper or by an oxidase released by damage to plant tissues. De?ciency may lead to SCURVY, traditionally associated with sailors, among elderly people living alone or in poor communities living at subsistence level. It has been claimed that large doses (1–2 g daily) will prevent the common cold, but few large controlled trials have been carried out and it is inadvisable for people to dose themselves with large quantities of ascorbic acid, which may result in the formation of oxalate stones in the urinary tract. (See also VITAMIN.)... ascorbic acid
See DNA.... deoxyribonucleic acid
A gland that secretes its products through a duct to the surface of the body or of an organ. The sweat glands in the skin and the salivary glands in the mouth are examples. The secretion is set o? by a hormone (see HORMONES) or a NEUROTRANSMITTER.... exocrine gland
A valuable antistaphylococcal antibiotic used both orally and topically. It is particularly useful in osteomyelitis (see BONE, DISORDERS OF).... fusidic acid
The term applied to the ends of the PENIS and the CLITORIS. In the penis the glans is the distal, helmet-shaped part that is formed by the bulbous corpus spongiosum (erectile tissue). In an uncircumcised man the glans is covered by the foreskin or PREPUCE when the penis is ?accid.... glans
See BREASTS.... mammary gland
One of the NON-STEROIDAL ANTIINFLAMMATORY DRUGS (NSAIDS) that is an analgesic (see ANALGESICS) for mild to moderate pain in RHEUMATOID ARTHRITIS, OSTEOARTHRITIS and other musculoskeletal disorders. Also used for DYSMENNORRHOEA and MENORRHAGIA. It must be used with care as it has several side-effects, in particular diarrhoea and occasional haemolytic ANAEMIA. It must not be used in patients with INFLAMMATORY BOWEL DISEASE (IBD).... mefenamic acid
An antibiotic drug, active against gram-negative (see GRAM’S STAIN) micro-organisms, used to treat and prevent infections of the URINARY TRACT.... nalidixic acid
Nicotinic acid is a member of the vitamin B complex. It is essential for human nutrition, the normal daily requirement for an adult being about 15–20 mg. A de?ciency of nicotinic acid is one of the factors in the etiology of PELLAGRA, and either nicotine acid or NICOTINAMIDE is used in the treatment of this condition. Nicotinic acid also reduces the concentration of blood lipids (see HYPERLIPIDAEMIA).... nicotinic acid
Group of chemicals found in cells and which carry biochemical codes for heredity and day-to-dayfunctioning of cells.... nucleic acid
This is an irritant poison that is used domestically for cleaning purposes. It is also found in many plants including rhubarb and sorrel. Oxalic acid, when swallowed, produces burning of the mouth and throat, vomiting of blood, breathlessness and circulatory collapse. Calcium salts, lime water or milk should be given by mouth. An injection of calcium gluconate is an antidote.... oxalic acid
This is an accessory sex gland in males which is wrapped round the URETHRA as this tube leaves the URINARY BLADDER. Opening into the urethra, the gland secretes an alkaline ?uid during ejaculation and is a constituent of SEMEN. The gland grows during adolescence and is sensitive to the concentrations of sex hormones.... prostate gland
A crystalline substance sparingly soluble in water that is used externally in ointments and pastes. It has antifungal properties and helps to loosen and remove scales. In high concentrations it is useful in treatment of verrucae (WARTS) and corns (see CORNS AND BUNIONS).... salicylic acid
The glands that produce the saliva injected when a mosquito or other ectoparasite bites, which prevent blood from clotting while the mosquito feeds.... salivary glands
See ADRENAL GLANDS.... suprarenal glands
A drug used in the control of bleeding. It inhibits the activation of PLASMINOGEN and FIBRINOLYSIS, and may be useful when bleeding cannot be stopped – for instance, dental extraction in HAEMOPHILIA. The drug is also useful in MENORRHAGIA.... tranexamic acid
A preparation used in the treatment of cholesterol gall-stones when laparoscopic CHOLECYSTECTOMY and endoscopic biliary procedures cannot be used (see GALL-BLADDER, DISEASES OF).... ursodeoxycholic acid
An organic acid produced by the LIVER when it is rapidly oxidising fatty acids – a metabolic process which occurs, for example, during starvation. The acid produced is then converted to ACETONE, which is excreted.... acetoacetic acid
In our context, a substance having a pH below that of neutral water (7.0) when in solution. Most metabolic waste products are acidic. Sour. See pH... acid
Carbolic acid, or phenol, was the precursor of all ANTISEPTICS. It paralyses and then destroys most forms of life, particularly organisms such as bacteria. It has been superseded by less penetrative and harmful antiseptics.... carbolic acid
One of the bile acids (see BILE), used in the treatment of cholesterol gall-stones for patients with mild symptoms when other modern techniques are unsuitable. (See GALL-BLADDER, DISEASES OF.)... chenodeoxycholic acid
This is responsible for the sharp taste associated with citrus fruits, such as lemons and limes, and other fruits such as currants and raspberries. Although chemically di?erent from, it is similar in action and appearance to tartaric acid, obtained from grapes and other fruits, and similar to malic acid, found in apples and pears.... citric acid
Any one of certain glands in the body the secretion of which goes directly into the bloodstream and so is carried to di?erent parts of the body. These glands – the pituitary, thyroid, parathyroid, adrenal and reproductive – are also known as the ENDOCRINE GLANDS. Some glands may be both duct glands and ductless glands. For example, the PANCREAS manufactures a digestive juice which passes by a duct into the small intestine. It also manufactures, by means of special cells, a substance called INSULIN which passes straight into the blood.... ductless gland
Organs whose function it is to secrete into the blood or lymph, substances known as HORMONES. These play an important part in general changes to or the activities of other organs at a distance. Various diseases arise as the result of defects or excess in the internal secretions of the di?erent glands. The chief endocrine glands are:
Adrenal glands These two glands, also known as suprarenal glands, lie immediately above the kidneys. The central or medullary portion of the glands forms the secretions known as ADRENALINE (or epinephrine) and NORADRENALINE. Adrenaline acts upon structures innervated by sympathetic nerves. Brie?y, the blood vessels of the skin and of the abdominal viscera (except the intestines) are constricted, and at the same time the arteries of the muscles and the coronary arteries are dilated; systolic blood pressure rises; blood sugar increases; the metabolic rate rises; muscle fatigue is diminished. The super?cial or cortical part of the glands produces steroid-based substances such as aldosterone, cortisone, hydrocortisone, and deoxycortone acetate, for the maintenance of life. It is the absence of these substances, due to atrophy or destruction of the suprarenal cortex, that is responsible for the condition known as ADDISON’S DISEASE. (See CORTICOSTEROIDS.)
Ovaries and testicles The ovary (see OVARIES) secretes at least two hormones – known, respectively, as oestradiol (follicular hormone) and progesterone (corpus luteum hormone). Oestradiol develops (under the stimulus of the anterior pituitary lobe – see PITUITARY GLAND below, and under separate entry) each time an ovum in the ovary becomes mature, and causes extensive proliferation of the ENDOMETRIUM lining the UTERUS, a stage ending with shedding of the ovum about 14 days before the onset of MENSTRUATION. The corpus luteum, which then forms, secretes both progesterone and oestradiol. Progesterone brings about great activity of the glands in the endometrium. The uterus is now ready to receive the ovum if it is fertilised. If fertilisation does not occur, the corpus luteum degenerates, the hormones cease acting, and menstruation takes place.
The hormone secreted by the testicles (see TESTICLE) is known as TESTOSTERONE. It is responsible for the growth of the male secondary sex characteristics.
Pancreas This gland is situated in the upper part of the abdomen and, in addition to the digestive enzymes, it produces INSULIN within specialised cells (islets of Langerhans). This controls carbohydrate metabolism; faulty or absent insulin production causes DIABETES MELLITUS.
Parathyroid glands These are four minute glands lying at the side of, or behind, the thyroid (see below). They have a certain e?ect in controlling the absorption of calcium salts by the bones and other tissues. When their secretion is defective, TETANY occurs.
Pituitary gland This gland is attached to the base of the brain and rests in a hollow on the base of the skull. It is the most important of all endocrine glands and consists of two embryologically and functionally distinct lobes.
The function of the anterior lobe depends on the secretion by the HYPOTHALAMUS of certain ‘neuro-hormones’ which control the secretion of the pituitary trophic hormones. The hypothalamic centres involved in the control of speci?c pituitary hormones appear to be anatomically separate. Through the pituitary trophic hormones the activity of the thyroid, adrenal cortex and the sex glands is controlled. The anterior pituitary and the target glands are linked through a feedback control cycle. The liberation of trophic hormones is inhibited by a rising concentration of the circulating hormone of the target gland, and stimulated by a fall in its concentration. Six trophic (polypeptide) hormones are formed by the anterior pituitary. Growth hormone (GH) and prolactin are simple proteins formed in the acidophil cells. Follicle-stimulating hormone (FSH), luteinising hormone (LH) and thyroid-stimulating hormone (TSH) are glycoproteins formed in the basophil cells. Adrenocorticotrophic hormone (ACTH), although a polypeptide, is derived from basophil cells.
The posterior pituitary lobe, or neurohypophysis, is closely connected with the hypothalamus by the hypothalamic-hypophyseal tracts. It is concerned with the production or storage of OXYTOCIN and vasopressin (the antidiuretic hormone).
PITUITARY HORMONES Growth hormone, gonadotrophic hormone, adrenocorticotrophic hormone and thyrotrophic hormones can be assayed in blood or urine by radio-immunoassay techniques. Growth hormone extracted from human pituitary glands obtained at autopsy was available for clinical use until 1985, when it was withdrawn as it is believed to carry the virus responsible for CREUTZFELDT-JAKOB DISEASE (COD). However, growth hormone produced by DNA recombinant techniques is now available as somatropin. Synthetic growth hormone is used to treat de?ciency of the natural hormone in children and adults, TURNER’S SYNDROME and chronic renal insu?ciency in children.
Human pituitary gonadotrophins are readily obtained from post-menopausal urine. Commercial extracts from this source are available and are e?ective for treatment of infertility due to gonadotrophin insu?ciency.
The adrenocorticotrophic hormone is extracted from animal pituitary glands and has been available therapeutically for many years. It is used as a test of adrenal function, and, under certain circumstances, in conditions for which corticosteroid therapy is indicated (see CORTICOSTEROIDS). The pharmacologically active polypeptide of ACTH has been synthesised and is called tetracosactrin. Thyrotrophic hormone is also available but it has no therapeutic application.
HYPOTHALAMIC RELEASING HORMONES which affect the release of each of the six anterior pituitary hormones have been identi?ed. Their blood levels are only one-thousandth of those of the pituitary trophic hormones. The release of thyrotrophin, adrenocorticotrophin, growth hormone, follicle-stimulating hormone and luteinising hormone is stimulated, while release of prolactin is inhibited. The structure of the releasing hormones for TSH, FSH-LH, GH and, most recently, ACTH is known and they have all been synthesised. Thyrotrophin-releasing hormone (TRH) is used as a diagnostic test of thyroid function but it has no therapeutic application. FSH-LH-releasing hormone provides a useful diagnostic test of gonadotrophin reserve in patients with pituitary disease, and is now used in the treatment of infertility and AMENORRHOEA in patients with functional hypothalamic disturbance. As this is the most common variety of secondary amenorrhoea, the potential use is great. Most cases of congenital de?ciency of GH, FSH, LH and ACTH are due to defects in the hypothalamic production of releasing hormone and are not a primary pituitary defect, so that the therapeutic implication of this synthesised group of releasing hormones is considerable.
GALACTORRHOEA is frequently due to a microadenoma (see ADENOMA) of the pituitary. DOPAMINE is the prolactin-release inhibiting hormone. Its duration of action is short so its therapeutic value is limited. However, BROMOCRIPTINE is a dopamine agonist with a more prolonged action and is e?ective treatment for galactorrhoea.
Thyroid gland The functions of the thyroid gland are controlled by the pituitary gland (see above) and the hypothalamus, situated in the brain. The thyroid, situated in the front of the neck below the LARYNX, helps to regulate the body’s METABOLISM. It comprises two lobes each side of the TRACHEA joined by an isthmus. Two types of secretory cells in the gland – follicular cells (the majority) and parafollicular cells – secrete, respectively, the iodine-containing hormones THYROXINE (T4) and TRI-IODOTHYRONINE (T3), and the hormone CALCITONIN. T3 and T4 help control metabolism and calcitonin, in conjunction with parathyroid hormone (see above), regulates the body’s calcium balance. De?ciencies in thyroid function produce HYPOTHYROIDISM and, in children, retarded development. Excess thyroid activity causes thyrotoxicosis. (See THYROID GLAND, DISEASES OF.)... endocrine glands
See GABA.... gamma aminobutyric acid
Short-wavelength penetrating electromagnetic rays produced by some radioactive compounds. More powerful than X-rays, they are used in certain RADIOTHERAPY treatments and to sterilise some materials.... gamma rays
Gamma-globulin describes a group of proteins present in the blood PLASMA. They are characterised by their rate of movement in an electrical ?eld, and can be separated by the process of ELECTROPHORESIS. Most gamma-globulins are IMMUNOGLOBULINS. Gamma-globulin injection provides passive or active immunity against HEPATITIS A. (See also GLOBULIN; IMMUNITY; IMMUNOLOGY.)... gamma-globulin
A bisphosphonate drug used in the treatment of osteoporosis and Paget’s disease of bone. The most common side effect is inflammation of the oesophagus, which causes heartburn or difficulty in swallowing. Other side effects can include headache and abdominal pain.... alendronic acid
One of the fatty acids in the body that are essential for growth.... arachidonic acid
A topical drug used to treat mild to moderate acne.... azelaic acid
A pair of oval, peasized glands whose ducts open into the vulva (the folds of flesh that surround the opening of the vagina). During sexual arousal, these glands secrete a fluid to lubricate the vulval region. Infection of the glands causes bartholinitis.... bartholin’s glands
A gland that secretes hormones directly into the bloodstream rather than through a duct. Examples include the thyroid gland, pituitary gland, ovaries, testes, and adrenal glands. (See also exocrine gland.)... endocrine gland
An infection of horses caused by the bacterium PSEUDOMONAS MALLEI. In rare cases, it is transmitted to humans, causing symptoms including fever and general aches and pains. Ulcers may develop where bacteria entered the skin; if bacteria enters the lungs, pneumonia may occur. In severe cases, septicaemia may follow. Treatment is with antibiotics.... glanders
A collection of CELLS or an ORGAN with a specialised ability to make and secrete chemical substances such as enzymes and hormones essential for the normal functioning of the body. Glands are classi?ed into two groups: ENDOCRINE and EXOCRINE. The former secrete their products, hormones, straight into the bloodstream; the latter’s secretions are discharged through ducts. (These functional differences are the reason why glands have been de?ned as ductless and ducted.) Examples of endocrine glands are the adrenals, PITUITARY GLAND and THYROID GLAND. Exocrine glands include SEBACEOUS GLANDS (in the skin) and the SALIVARY GLANDS in the mouth whose enzymes start the digestion of food. The BREASTS or mammary glands are exocrine glands that secrete milk. Though strictly speaking not a gland, LYMPH nodes (part of the lymphatic system) are sometimes called that. While they do not produce secretions, lymph glands do release white blood cells, an essential part of the body’s defence system.... gland
A method developed by two doctors in Glasgow that is used to assess the depth of COMA or unconsciousness suffered by an individual. The scale is split into three groups – eye opening, motor response, and verbal response – with the level of activity within each group given a score. A person’s total score is the sum of the numbers scored in each group, and this provides a reasonably objective assessment of the patient’s coma state – particularly useful when monitoring people who have suffered a head injury. (See also PERSISTENT VEGETATIVE STATE (PVS).)... glasgow coma scale
An unsaturated fatty acid occurring widely in the glycerides of plants. It is an essential nutrient for mammals, including humans.... linoleic acid
Numerous glands within the tarsal plates of the eyelids. Their secretions form part of the tears. (See EYE.)... meibomian glands
The most common of naturally occurring fatty acids, being present in most fats and oils in the form of triglyceride. It is used in the preparation of OINTMENTS, but not eye ointments.... oleic acid
One of the SALIVARY GLANDS. It is situated just in front of the ear, and its duct runs forwards across the cheek to open into the interior of the mouth on a little projection opposite the second last tooth of the upper row. The parotid gland is generally the ?rst of the salivary glands to become enlarged in MUMPS.... parotid gland
A yellow crystalline solid substance which is used as a ?xative for tissues being prepared for examination under a microscope; it is also used as a dye.... picric acid
A small reddish structure, 10 mm in length and shaped somewhat like a pine cone (hence its name), situated on the upper part of the midbrain (see BRAIN). Many theories have been expounded as to its function, but there is increasing evidence that, in some animals at least, it is affected by light and plays a part in hibernation and in controlling sexual activity and the colour of the skin. This it seems to do by means of a substance it produces known as MELATONIN. There is also growing evidence that it may play a part in controlling the circadian rhythms of the body – the natural variations in physiological activities throughout the 24-hour day.... pineal gland
See RNA.... ribonucleic acid
Oil secreting glands, mostly clustered around hair follicles. The oil, sebum, is released into the oil glands from the disintegrated cytoplasm of shedding holocrine cells that line the alveolar surfaces. The nature of the secretion is a direct reflection of the state of the body’s lipid metabolism.... sebaceous gland
The minute glands situated alongside hairs and opening into the follicles of the latter a short distance below the point at which the hairs emerge on the surface. These glands secrete an oily material, and are especially large upon the nose, where their openings form pits that are easily visible. In the mouth the glands open directly on the mucosal surface. (See also SKIN.)... sebaceous glands
See SKIN.... sweat glands
See ASPIRIN.... acetylsalicyclic acid
... adenitis means inflammation of a gland.
A drug used to treat hereditary angio-oedema (see under URTICARIA) – a serious anaphylactic (see ANAPHYLAXIS) reaction of the skin and respiratory tract resulting from a de?ciency in the body’s immunological defence mechanisms (see IMMUNITY).... aminocaproic acid
Two small glands opening either side of the external vaginal ori?ce. Their secretions help to lubricate the vulva, when a woman is sexually aroused. The glands may become infected and very painful; sometimes an abscess develops and local surgery is required. Otherwise antibiotics, analgesics and warm baths are usually e?ective.... bartholin’s glands
Chromic acid is used in several industries, particularly in chromium plating. Unless precautions are taken it may lead to dermatitis of the hands, arms, chest and face. It may also cause deep ulcers, especially of the nasal septum and knuckles.... chromic acid
Also known as the bulbourethral glands, these are a pair of glands whose ducts open into the urethra at the base of the PENIS. They secrete a ?uid that is one of the constituents of the SEMEN which carries the spermatozoa and is ejaculated into the VAGINA during coitus (sexual intercourse).... cowper’s glands
Pers.Cassine glauca (Rottb.)... elaeodendron glaucum
A potent diuretic, with a rapid onset, and a short duration (4–6 hours), of action. (See THIAZIDES; DIURETICS.)... ethacrynic acid
(Greek) The third letter of the Greek alphabet Gammah... gamma
A drug that is used in the treatment of PEDICULOSIS and SCABIES.... gamma benzene hexachloride
Regurgitation of acidic fluid from the stomach into the oesophagus due to inefficiency of the muscular valve at the lower end of the oesophagus. Also known as gastro-oesophageal reflux disease (GORD), acid reflux may inflame the oesophagus, resulting in heartburn due to oesophagitis. It may occur in pregnancy and often affects overweight people.... acid reflux
A gland that discharges cellular material in addition to the fluid it secretes. The term is usually applied to the type of sweat glands that appear in hairy body areas after puberty. (See also eccrine gland.)... apocrine gland
A type of sweat gland.... eccrine gland
Optical devices that use lenses to correct focusing errors in the eyes to achieve clear vision. Lenses are made of glass or plastic, and the shape and thickness are chosen during a vision test. Convex lenses are needed for hypermetropia (longsightedness), and concave lenses for myopia (shortsightedness). Tinted lenses protect the eyes from sunlight. (See also bifocal; contact lenses)... glasses
See eye, artificial.... glass eye
(Welsh) As precious as jewel Glaine, Glaina, Glayne, Glayna, Glaen, Glayn, Glaene, Glaena... glain
(Welsh) From the seashore Glann... glan
(Greek) In mythology, a woman murdered by Medea... glauce
The term given to the X-ray appearance of a stomach which is constricted in its middle part due either to spasm of the stomach muscle or to contraction of scar tissue from a gastric ulcer.... hour-glass stomach
Lysergic acid diethylamide belongs to the ergot group of ALKALOIDS. It has various effects on the brain, notably analgesic and hallucinogenic, thought to be due to its antagonism of 5hydroxytryptamine (5-HT). In small doses it induces psychic states, in which the individual may become aware of repressed memories. For this reason it may help in the treatment of certain anxiety states, if used under skilled supervision. LSD rapidly induces TOLERANCE, however, and psychological DEPENDENCE may occur, although not physical dependence. Serious side-effects include psychotic reactions, with an increased risk of suicide.... lysergic acid diethylamide (lsd)
Linn.
Family: Papilionaceae; Fabaceae.
Habitat: Native to the Mediterranean regions. Now grown in Punjab, Jammu and Kashmir and South India.
English: Licorice, Liquorice.
Ayurvedic: Yashtimadhu, Mad- huyashtyaahvaa, Madhuli, Mad- huyashtikaa, Atirasaa, Madhurasaa, Madhuka, Yastikaahva, Yashtyaah- va, Yashti, Yashtika, Yashtimadhuka. Klitaka (also equated with Indigofera tinctoria). (Klitaka and Klitanakam were considered as aquatic varieties of Yashtimadhu.)
Unani: Asl-us-soos, Mulethi. Rubb-us-soos (extract).
Siddha/Tamil: Athimathuram.
Action: Demulcent, expectorant, antiallergic, anti-inflammatory, spasmolytic, mild laxative, antistress, antidepressive, antiulcer, liver protective, estrogenic, em- menagogue, antidiabetic. Used in bronchitis, dry cough, respiratory infections, catarrh, tuberculosis; genitourinary diseases, urinary tract infections; abdominal pain, gastric and duodenal ulcers, inflamed stomach, mouth ulcer. Also used for adrenocorticoid insufficiency.
Key application: In catarrh of the upper respiratory tract and gastric, duodenal ulcers. (German Commission E, ESCOP, WHO.)The British Herbal Compendium indicates the use of liquorice for bronchitis, chronic gastritis, peptic ulcer, rheumatism and arthritis, adrenocor- ticoid insufficiency, and to prevent liver toxicity. Indian Herbal Pharmacopoeia recognizes its use as an anti- inflammatory and antiulcer agent.The main chemical constituent of liquorice is glycyrrhizin (about 29%), a triterpene saponin with low haemolytic index. Glycyrrhetinic (gly- cyrrhetic) acid (0.5-0.9%), the agly- cone of glycyrrhizin is also present in the root. Other active constituents of liquorice include isoflavonoids, chal- cones, coumarins, triterpenoids and sterols, lignans, amino acids, amines, gums and volatile oils.Hypokalemia is the greatest threat when liquorice preparations high in glycyrrhizin are prescribed for prolonged periods. Liquorice causes fluid retention. Patients should be placed on a high potassium and low sodium diet. Special precautions should be taken with elderly patients and patients with hypertension or cardiac, renal or hepatic disease.A special liquorice extract known as DGL (deglycyrrhizinated liquorice) is used in the treatment of peptic ulcer. Oral liquorice preparations, containing glycyrrheti- nic acid, are used for the treatment of viral infections—viral hepatitis, common cold. Topical preparations, containing glycyrrhetinic acid, are used for herpes, eczema, psoriasis.In Japan, a preparation of glycyrrhi- zin, cysteine and glycine is used by injection for the treatment of acute and chronic hepatitis.
Dosage: Root—2-4 g powder. (API Vol. I.)... glycyrrhiza glabra
Also known as mandelamine, a non-toxic keto-acid used in the treatment of infections of the urinary tract, especially those due to the Escherichia coli and the Streptococcus faecalis or Enterococcus. It is administered in doses of 3 grams several times daily. As it is only e?ective in an acid urine, ammonium chloride must be taken at the same time.... mandelic acid
A unicellular gland in cestodes, which encircles the ootype. Its function is not known.... mehlis’s glands
One of the early antituberculous (see TUBERCULOSIS) antibiotics. It tended to cause DYSPEPSIA and has been replaced by newer antituberculous drugs with fewer side-effects. The ?rst-line drugs for tuberculosis are now rifampicin, isoniazid, and ethambutol.... para-amino salicylic acid
See CYANIDE POISONING.... prussic acid poisoning
Disease of the PROSTATE GLAND can affect the ?ow of URINE so that patients present with urological symptoms.
Prostatitis This can be either acute or chronic. Acute prostatitis is caused by a bacterial infection, while chronic prostatitis may follow on from an acute attack, arise insidiously, or be non-bacterial in origin.
Symptoms Typically the patient has pain in the PERINEUM, groins, or supra pubic region, and pain on EJACULATION. He may also have urinary frequency, and urgency.
Treatment Acute and chronic prostatitis are treated with a prolonged course of antibiotics. Patients with chronic prostatitis may also require anti-in?ammatory drugs, and antidepressants.
Prostatic enlargement This is the result of benign prostatic hyperplasia (BPH), causing enlargement of the prostate. The exact cause of this enlargement is unknown, but it affects 50 per cent of men between 40 and 59 years and 95 per cent of men over 70 years.
Symptoms These are urinary hesitancy, poor urinary stream, terminal dribbling, frequency and urgency of urination and the need to pass urine at night (nocturia). The diagnosis is made from the patient’s history; a digital examination of the prostate gland via the rectum to assess enlargement; and analysis of the urinary ?ow rate.
Treatment This can be with tablets, which either shrink the prostate – an anti-androgen drug such as ?nasteride – or relax the urinary sphincter muscle during urination. For more severe symptoms the prostate can be removed surgically, by transurethral resection of prostate (TURP), using either electrocautery or laser energy. A new treatment is the use of microwaves to heat up and shrink the enlarged gland.
Cancer Cancer of the prostate is the fourth most common cause of death from cancer in northern European males: more than 10,000 cases are diagnosed every year in the UK and the incidence is rising by 3 per cent annually.
Little is known about the cause, but the majority of prostate cancers require the male hormones, androgens, to grow.
Symptoms These are similar to those resulting from benign prostatic hypertrophy (see above). Spread of the cancer to bones can cause pain. The use of a blood test measuring the amount of an ANTIGEN, PROSTATE SPECIFIC ANTIGEN (PSA), can be helpful in making the diagnosis – as can an ULTRASOUND scan of the prostate.
Treatment This could be surgical, with removal of the prostate (either via an abdominal incision, total prostatectomy, or transurethrally), or could be by radiotherapy. In more advanced cancers, treatment with anti-androgen drugs, such as cyprotexone acetate or certain oestrogens, is used to inhibit the growth of the cancer.... prostate gland, diseases of
... thyroid gland, diseases of
The glands which provide substances for the development of the egg and the formation of the shell in trematodes and cestodes.... vitelline glands
Foods that produce acid when metabolised. Ash from these foods contains sulphur, phosphoric acid and chlorine, all essential for efficient metabolism. Breads, cereals, cheese, chicken, chocolate, cocoa, coffee, cranberries, eggs, fish, flour, fowl, grain products, lentils, meats (lean), nuts, oats, oatmeal, oysters, pasta, peanuts, peanut butter, pearl barley, plums, prunes, rhubarb, rabbit, rice (white), sugar, sweet corn, tea, veal, wholemeal bread, wheatgerm. ... acid foods
Adeno-carcinoma. A hormone-related tumour in elderly men. Enlargement of the gland may be benign or carcinomatous. Fibrosis (hardening) may arise from inflammation. Obstruction of the outlet of the bladder through swelling of the gland (prostatism) may cause uraemia.
Symptoms. Bladder irritability; increased frequency during the night. Feeble forked stream of urine. Sometimes blood. Three quarters of such tumours are located in the posterior lobe of the prostate gland – readily accessible to the examining finger through the front wall of the rectum. Rectal examination reveals a hard rugged prostate. Cystoscopy confirms. Bone pains in the low back or pelvis reflect a stage where the tumour has already spread. Anaemia, weight loss, urgency.
All symptoms are worse by alcohol and spicy foods.
Harvard University scientists report: heavy consumption of animal fat, especially the fat in red meat appears to increase the chance that a man will develop advanced prostate cancer.
Of therapeutic value. Comfrey, Echinacea, Horsetail, Poke root, Thuja, Cornsilk, Goldenseal.
Tea. Combination. Comfrey leaves, Horsetail, Cornsilk. Equal parts. 2-3 teaspoons to each cup boiling water. Drink freely.
Formula No. 1. Echinacea 2; Comfrey 1; Poke root half; Thuja half. Mix. Dose: Powders: 500mg (two 00 capsules or one-third teaspoon). Liquid extracts: 1 teaspoon. Tinctures: 2 teaspoons. Thrice daily in water or cup of Cornsilk tea.
Formula No. 2. (Alternative) Echinacea 2; Goldenseal 1; Gotu Kola 1; Poke root half. Mix. Dose: Powders: 500mg (two 00 capsules or one-third teaspoon). Liquid extracts: 1 teaspoon. Tinctures: 2 teaspoons in water or cup of Cornsilk tea.
Bee pollen. Of value.
Garlic. Of value.
Diet. See: DIET – CANCER.
There is a very low incidence of prostate cancer in countries where Soya products are widely consumed – Soya contains a female hormone which is a protector factor.
Supplements. Morning and evening.
Vitamin A 7500iu or more. Large doses may be required. Vitamin C 1-2g. Vitamin E 200iu. Calcium 500mg. Selenium 100mcg. Zinc.
Study. Men with prostate cancer may not need to undergo radical prostatectomy (removal of the prostate gland). A 10-year follow-up study of men with early prostate cancer left untreated showed that 10 years later only 8.5 per cent of the 223 patients had died from prostate cancer. The survival rate of 86.8 per cent in the untreated group was nearly identical to a subgroup who met all the conditions for radical prostatectomy. (Journal of American Medical Association, 22/29 April 1992)
Commonly treated with female sex hormone or by orchidectomy.
It would appear that surgical removal of the gland offers little benefit, and possibly a disadvantage to patients wishing to leave well alone, particularly the elderly. Treatment by a general medical practitioner or oncologist. ... cancer – prostate gland
Active Constituents: Aloes (Cape) BP 50.00mg. Pulverised Fennel (BHMA Master File 006/2) BHP (1983) 15.00mg. Pulverised Valerian BP 30.00mg. Pulverised Holy Thistle BHP (1983) (BHMA Master File 51/1) 60.00mg. A traditional herbal remedy for the relief of occasional or non-persistent constipation. Not for pregnancy or nursing mothers. (Gerard House) ... gladlax tablets
One pinch Glauber salts in an early morning cup of tea, every day, was once taken as a preventative for gout. ... glauber salts
Traps in the lymphatic system that collect byproducts of body infection and which support the immune system in its role as body protector. ... lymph glands
A test for meningitis that involves pressing a clear glass against a rash. If the rash remains visible, it may be a form of purpura, which sometimes occurs in meningitis.... glass test
The active ingredient of many sunscreen preparations. Its abbreviation is.... para-aminobenzoic acid
see aspirin.... acetylsalicylic acid
a technique for creating a mechanical bond between resin-based materials and the enamel of teeth; it is used to retain and seal the margins of composite fillings, to retain brackets of fixed orthodontic appliances, and to retain resin-based *fissure sealants and adhesive bridges. Phosphoric acid is used to create a porous surface into which a bonding agent can flow.... acid-etch technique
adj. 1. describing bacteria that have been stained and continue to hold the stain after treatment with an acidic solution. For example, tuberculosis bacteria are acid-fast when stained with a *carbol fuchsin preparation. 2. describing a stain that is not removed from a specimen by washing with an acidic solution.... acid-fast
an organic compound containing an amino group (–NH2) and a carboxyl group (–COOH). Amino acids are fundamental constituents of all *proteins. They are classified as *essential amino acids, i.e. those that cannot be synthesized by the body, and nonessential amino acids, which can be synthesized by the body. Certain amino acids present in the body are not found in proteins; these include *citrulline, *ornithine, *taurine, and *gamma-aminobutyric acid.... amino acid
(aspartate) see amino acid.... aspartic acid
an antiseptic, active against fungi and bacteria, used as a preservative in foods and pharmaceutical preparations and, combined with salicylic acid, in the form of an ointment (Whitfield’s ointment) for the treatment of ringworm.... benzoic acid
compound glands of the small intestine, found in the *duodenum and the upper part of the jejunum. They are embedded in the submucosa and secrete mucus. [J. C. Brunner (1856–1927), Swiss anatomist]... brunner’s glands
small glands in the mucous membrane lining the mouth. They secrete material that mixes with saliva.... buccal glands
see Cowper’s glands.... bulbourethral glands
(cholalic acid) see bile acids.... cholic acid
see Krebs cycle.... citric acid cycle
a drug that interferes with the *penicillinases that inactivate *beta-lactam antibiotics, such as *amoxicillin or *ticarcillin. Combined with the antibiotic, clavulanic acid can overcome drug resistance.... clavulanic acid
(bulbourethral glands) a pair of small glands that open into the urethra at the base of the penis. Their secretion contributes to the seminal fluid, but less than that of the prostate gland or seminal vesicles. [W. Cowper (1660–1709), English surgeon]... cowper’s glands
see bile acids.... deoxycholic acid
an *amino acid that is essential for normal growth and development but cannot be synthesized by the body. Essential amino acids are obtained from protein-rich foods in the diet, such as meat, fish, eggs, and dairy products. Adults require eight essential amino acids: leucine, isoleucine, valine, phenylalanine, threonine, methionine, tryptophan, and lysine. Children require an additional nine, as their body’s requirement is greater than can be synthesised by it: tyrosine, glycine, cysteine, arginine, proline, histidine, glutamine, serine, and asparagine.... essential amino acid
an organic acid with a long straight hydrocarbon chain and an even number of carbon atoms. Fatty acids are the fundamental constituents of many important lipids, including *triglycerides. Some fatty acids can be synthesized by the body; others, the *essential fatty acids, must be obtained from the diet. Examples of fatty acids are palmitic acid, oleic acid, and stearic acid. See also fat; saturated fatty acid; unsaturated fatty acid.... fatty acid
a derivative of folic acid involved in purine synthesis. It is used to reverse the biological effects of methotrexate and other *dihydrofolate reductase inhibitors and so to prevent excessive toxicity. This action is termed folinic acid rescue. Folinic acid has a potentiating effect with *fluorouracil, with which it is often used.... folinic acid
an apparatus that detects gamma rays emitted by radioactive isotopes that have been introduced into the body as *tracers. It contains an activated sodium iodide crystal (see scintillator) and a large array of photomultiplier tubes. Using lead *collimators, the position of the source of the radioactivity can be plotted and displayed on a TV monitor or photographic film (see scintigram).... gamma camera
a device that allows high doses of radiation in the form of gamma rays to be accurately focused on pathological tissue, with less risk of damaging adjacent normal tissue compared with conventional radiotherapy. Multiple cobalt-60 sources deliver the gamma irradiation. The device is used in the treatment of vestibular schwannomas, certain brain tumours, vascular lesions of the brain, trigeminal neuralgia, and some forms of epilepsy.... gamma knife
tubular glands that lie in the mucous membrane of the stomach wall. There are three varieties: the cardiac, parietal (oxyntic), and pyloric glands, and they secrete *gastric juice.... gastric glands
n. the smooth rounded surface of the *frontal bone in the middle of the forehead, between the two eyebrows.... glabella
n. the middle and largest segment of the *sternum.... gladiolus
n. a surgical procedure that involves excising the *glans, which preserves the penis and is an option for men with penile cancer.... glansectomy
n. the undesirable effects of scattered stray light on the retina, causing reduced contrast and visual performance as well as annoyance and discomfort. Glare is most commonly caused by cataract or corneal opacity... glare
a dental filling material that is based on a *cement of a silicate glass and an organic acid.... glass ionomer
n. a drug that modifies the body’s immune response and is used to reduce the frequency of relapses in people with relapsing/remitting multiple sclerosis. Side-effects include flushing and palpitations.... glatiramer
pl. n. small anterior subcapsular lens opacities seen in acute (angle-closure) glaucoma.... glaukomflecken
a sugar acid derived from glucose. Glucuronic acid is an important constituent of *chondroitin sulphate (found in cartilage) and *hyaluronic acid (found in synovial fluid).... glucuronic acid
(glutamate) see amino acid; neurotransmitter.... glutamic acid
(GAD) a common enzyme that, because of similarities to certain bacterial proteins, can provoke an autoimmune reaction against the beta cells of the pancreas (see islet cell antibodies) progressing to type 1 *diabetes mellitus.... glutamic acid decarboxylase
see bile acids.... glycocholic acid
a derivative of *histamine that was formerly used to test for acid secretion in the stomach in conditions involving abnormal gastric acid secretion, such as *Zollinger-Ellison syndrome.... histamine acid phosphate
a product formed during the metabolism of the amino acids phenylalanine and tyrosine. In normal individuals homogentisic acid is oxidized by the enzyme homogentisic acid oxidase. In rare cases this enzyme is lacking and a condition known as *alcaptonuria, in which large amounts of homogentisic acid are excreted in the urine, results.... homogentisic acid
an acid *mucopolysaccharide that acts as the binding and protective agent of the ground substance of connective tissue. It is also present in the synovial fluid around joints and in the vitreous and aqueous humours of the eye.... hyaluronic acid
(prussic acid) an intensely poisonous volatile acid that can cause death within a minute if inhaled. It has a smell of bitter almonds. See cyanide.... hydrocyanic acid
(5-HIAA) a metabolite of *serotonin, the most common secretion product of *carcinoid tumours. Measured over 24 hours in the urine, this is the most reliable screening test for such tumours.... 5-hydroxyindoleacetic acid
(crypts of Lieberkühn) simple tubular glands in the mucous membrane of the *intestine. In the small intestine they lie between the villi. They are lined with columnar *epithelium in which various types of secretory cells are found. In the large intestine Lieberkühn’s glands are longer and contain more mucus-secreting cells. [J. N. Lieberkühn (1711–56), German anatomist]... lieberkühn’s glands
see essential fatty acid.... linolenic acid
a sulphur-containing compound that can be readily interconverted to and from its reduced form, dihydrolipoic acid. Lipoic acid functions in carbohydrate metabolism as one of the *coenzymes in the oxidative decarboxylation of pyruvate and other ?-keto acids.... lipoic acid
(LSD) an illegal hallucinogenic drug that was formerly used to aid treatment of certain psychological disorders. Side-effects include digestive upsets, dizziness, tingling, anxiety, sweating, dilated pupils, muscle incoordination and tremor. Alterations in sight, hearing, and other senses occur, psychotic effects, depression, and confusion are common, and tolerance to the drug develops rapidly. Because of these toxic effects, LSD is no longer used clinically. See Appendix 12 for a list of street names for illicit drugs.... lysergic acid diethylamide
a strong corrosive mineral acid, HNO3, the concentrated form of which is capable of producing severe burns of the skin. Swallowing the acid leads to intense burning pain and ulceration of the mouth and throat. Treatment is by immediate administration of alkaline solutions, followed by milk or olive oil.... nitric acid
see osmium tetroxide.... osmic acid
see fatty acid.... palmitic acid
(PAS reaction) a test for the presence of glycoproteins, polysaccharides, certain mucopolysaccharides, glycolipids, and certain fatty acids in tissue sections. The tissue is treated with periodic acid, followed by *Schiff’s reagent. A positive reaction is the development of a red or magenta coloration.... periodic acid–schiff reaction
modified sebaceous glands on the inner surface of the *prepuce.... preputial glands
see hydrocyanic acid.... prussic acid
see folate.... pteroylglutamic acid
(pyruvate) a compound, derived from carbohydrates, that may be oxidized via a complex series of reactions in the *Krebs cycle to yield carbon dioxide and energy in the form of ATP.... pyruvic acid
a gland that produces *saliva. There are three pairs of salivary glands: the *parotid glands, *sublingual glands, and *submandibular glands (see illustration). They are stimulated by reflex action, which can be initiated by the taste, smell, sight, or thought of food.... salivary gland
a *fatty acid in which all the carbon atoms are linked by single bonds and the molecule is unable to accept additional atoms (i.e. it cannot undergo addition reactions with other molecules). These fats occur mainly in animal and dairy products, and a diet high in these foods may contribute to a high serum cholesterol level, which may increase the risk of *coronary artery disease. Compare unsaturated fatty acid.... saturated fatty acid
an amino sugar. Sialic acid is a component of some *glycoproteins, *gangliosides, and bacterial cell walls.... sialic acid
see fatty acid.... stearic acid
one of a pair of *salivary glands situated in the lower part of the mouth, one on either side of the tongue. The sublingual glands are the smallest salivary glands; each gland has about 20 ducts, most of which open into the mouth directly above the gland.... sublingual gland
(submaxillary gland) one of a pair of *salivary glands situated below the parotid glands. Their ducts (Wharton’s ducts) open in two papillae under the tongue, on either side of the frenulum.... submandibular gland
see submandibular gland.... submaxillary gland
a powerful corrosive acid, H2SO4, widely used in industry. Swallowing the acid causes severe burning of the mouth and throat and difficulty in breathing, speaking, and swallowing. The patient should drink large quantities of milk or water or white of egg; gastric lavage should not be delayed. Skin or eye contact should be treated by flooding the area with water.... sulphuric acid
a simple coiled tubular *exocrine gland that lies in the dermis of the *skin. A long duct carries its secretion (*sweat) to the surface of the skin. Sweat glands occur over most of the surface of the body; they are particularly abundant in the armpits, on the soles of the feet and palms of the hands, and on the forehead.... sweat gland
see meibomian glands.... tarsal glands
see bile acids.... taurocholic acid
an *astringent used for a variety of skin conditions. It is also applied topically to produce sloughing, especially for the removal of warts.... trichloracetic acid
an antifungal agent, applied to the skin for the treatment of athlete’s foot.... undecenoic acid
a *fatty acid in which one (monounsaturated) or many (polyunsaturated) of the carbon atoms are linked by double bonds that are easily split in chemical reactions so that other substances can connect to them. These fats occur in fish and plant-derived foods, and a diet high in unsaturated fats is associated with low serum cholesterol levels. Compare saturated fatty acid.... unsaturated fatty acid
see sodium valproate.... valproic acid
(VMA) a metabolite of *catecholamines excreted in abnormal amounts in the urine in conditions of excess catecholamine production, such as *phaeochromocytoma. The measurement of VMA levels in a 24-hour urine sample was formerly used as a screening test for this condition, but in the UK it has been largely superseded by the urinary metanephrine test (see metanephrine and normetanephrine).... vanillylmandelic acid
the two pairs of glands that open at the junction of the vagina and vulva. The more posterior of the two are the greater vestibular glands (Bartholin’s glands); the other pair are the lesser vestibular glands. Their function is to lubricate the entrance to the vagina during coitus.... vestibular glands
(zolendronate) a *bisphosphonate drug that is used to treat Paget’s disease and malignant *hypercalcaemia and is also establishing a role in treating bone metastases, both in terms of symptom relief and preventing bone fractures.... zoledronic acid
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