Giant Cell: From 1 Different Sources
any large cell, such as a *megakaryocyte. Giant cells may have one or many nuclei.
A generally slow growing malignant epithelial tumour, which has potential to invade and metastasise, especially if untreated.... basal cell carcinoma
In?ammation taking place in cellular tissue, and usually referring to infection in the subcutaneous tissue. A related word, cellulite, which has no medical meaning, is used in the slimming business to refer to excess fatty tissue in the arms, buttocks and thighs. (See ABSCESS; ERYSIPELAS.)... cellulitis
The smallest unit of living material that can function independently.... cell
Those embryonic cells with the potential to develop into ova (see OVUM) or spermatozoa (see SPERMATOZOON).... germ cell
See HYPERNEPHROMA.... renal cell carcinoma
Malignant tumour of squamous epithelium of skin, which generally spreads and metastasises.... squamous cell carcinoma
See: ARTERITIS. ... giant cell arteritis
A carbohydrate substance forming the skeleton of most plant structures. It is colourless, transparent, insoluble in water and is practically unaffected by digestion. In vegetable foods it therefore adds to the bulk, but it is of no value as a food-stu?. It is found in practically a pure state in cotton-wool.... cellulose
This is the basic cell from which all types of blood cells originate. Its appearance is believed to be similar to that of a LYMPHOCYTE.... haemopoietic stem cell
Also called Leydig cells, these cells are scattered between the SEMINIFEROUS TUBULES of the testis (see TESTICLE). LUTEINISING HORMONE from the anterior PITUITARY GLAND stimulates the interstitial cells to produce androgens, or male hormones.... interstitial cells
Star-shaped cells present in the blood-sinuses of the LIVER. They form part of the RETICULOENDOTHELIAL SYSTEM and are to a large extent responsible for the breakdown of HAEMOGLOBIN into the BILE pigments.... kupffer cells
These are a group of cells that line the capillaries of tissues that come in contact with the outside, like skin, sinuses, and lung mucosa. They, like their first cousin basophils, are produced in the red bone marrow and migrate to the appropriate tissues, where they stay. They bind IgE, supply the histamine and heparin response that gives you a healing inflammation, and cause allergies.... mast cells
See NEURON(E).... nerve cell
A type of cell found in one highly malignant form of lung cancer. The cell is small and either oval or round. The nucleus stains darkly and the cytoplasm is sparse and di?cult to identify. Oat-cell, or small-cell, carcinoma of the bronchus is usually caused by smoking, and comprises around 30 per cent of all bronchial cancers. It responds to radiotherapy and chemotherapy but, because the growth has usually spread widely by the time it is diagnosed, the prognosis is poor. Results of surgery are unsatisfactory.... oat cell
That fraction of the blood’s total volume made up of red cells. The packed cell volume is found by centrifuging blood in a tube and measuring the depth of the column of red cells as a fraction of the whole column of blood. (See also HAEMATOCRIT.)... packed cell volume
These are cells that produce ANTIBODIES and occur in bone-forming tissue as well as the lining of the gastrointestinal tract and the lungs. The cells develop in LYMPH NODES, SPLEEN and BONE MARROW when T-lymphocytes (see IMMUNITY) are stimulated by antigens (see ANTIGEN) to produce the precursor cells from which plasma cells originate.... plasma cells
Large specialised nerve cells occurring in great numbers in the cortex (super?cial layer of grey matter) of the cerebellum of the BRAIN. They have a ?ask-shaped body, an AXON and branching tree-like extensions called dendrites, which extend towards the surface of the brain (see NEURON(E)).... purkinje cells
See ERYTHROCYTES; BLOOD.... red blood cell
See OAT CELL.... small-cell carcinoma
A specialised white cell (lymphocyte) responsible for cell-mediated immunity. See also T-lymphocyte.... t-cell
See LEUCOCYTES.... white blood cell
See lymphocyte.... b-cell
A growth comprised of immature sperm cells in the male testis or of immature ova in the female ovary. A seminoma is one type of germ cell tumour (see testis, cancer of).... germ cell tumour
Not a medical term. Puffy skin from deposition of fat. “Orange peel skin”. Occurs chiefly in women as lumpy flesh on buttocks, thighs, stomach, knees and upper arm. Though not due to increased fluid in the tissues, it is sufficient to arrest the circulation. Constriction of capillaries causes toxic wastes to build up, forming nodules that lock away fat in the tissues. Hormone imbalance also suspected. Varicose veins may appear with cellulite from poorly supportive connective tissue. Usual cause: poor posture and unhealthy lifestyle.
Treatment. To activate capillary function and assist toxic elimination: Bladderwrack, Gotu Kola, Kola, Parsley tea. A diuretic may assist by eliminating excess fluid.
Gotu Kola tea: Quarter to half a teaspoon leaves to each cup boiling water; infuse 5-10 minutes. 1 cup morning and evening.
Formula. Tea. Equal parts: Alfalfa, Clivers, Fennel, Senna leaves. 1 heaped teaspoon to each cup boiling water: infuse 5-10 minutes. Half-1 cup morning and evening.
Seline. Tablets. Ingredients: Each tablet contains Lecithin 100mg; Pulverised Dandelion 100mg; Pulverised Horsetail 100mg; Pulverised extract Fucus 5:1 30mg; Vitamin C 40mg; Vitamin B6 1mg. 1 tablet thrice daily.
Aescin. Compound isolated from Horse-chestnuts to decrease capillary permeability and swelling. Topical. Decoction of Horse-chestnuts as a lotion. Or: infusion of Bladderwrack.
Aromatherapy and Herb essences. Combination for external use. Ingredients: Almond oil 47ml; Fennel oil 1ml; Juniper oil 1ml; Cypress essence 0.5ml; Lemon essence 0.5ml. Apply to affected areas morning and evening; small area 5 drops, large area 10 drops (Gerard). Gentle massage with a string glove, loofah or massage glove.
Diet. Reduce calorie intake. Raw fresh fruits and vegetable salads to account for 50 per cent of the diet. No sweet or dried fruits. Conservatively-cooked vegetables. Seafood. Iodine-rich foods. Wholegrain cereals. Protein: beans, chicken, poached eggs, fish, little lean meat: no pork, bacon or ham. Low-fat yoghurt. Cold-pressed unsaturated oils for salad dressings with lemon juice. Dandelion coffee to stimulate liver. Avoid sugar, alcohol, bananas and white flour products. Spring water.
Supportives. Stop smoking. Adopt an alternative to the contraceptive pill. To avoid fluid retention, 2-3 glasses of water daily. ... cellulite
A type of white blood cell that circulates through the body and is able to detect the presence of the foreign agents. Once exposed to an antigen on the agent, these cells differentiate into plasma cells to produce antibody.... b-lymphocyte (or b-cell)
See TRANSFUSION.... cell salvage transfusion
A defence mechanism involving the coordinated activity of two subpopulations of TLymphocytes, helper T-Cells and killer T-Cells. Helper T-Cells produce a variety of substances that stimulate and regulate other participants in the immune response. Killer T-Lymphocytes destroy cells in the body that bear foreign antigens (e.g. cells that are infected with viruses or other microorganisms).... cell-mediated immunity
The basic structural unit of body tissues. There are around 10 billion cells in the human body and they are structurally and functionally linked to carry out the body’s many complex activities.
Every cell consists essentially of a cell-body of soft albuminous material called cytoplasm, in which lies a kernel or nucleus which seems to direct all the activities of the cell. Within the nucleus may be seen a minute body, the nucleolus; and there may or may not be a cell-envelope around all. (See also MITOCHONDRIA.) Each cell nucleus carries a set of identical CHROMOSOMES, the body’s genetic instructions.
Cells vary much in size, ranging in the human body from 0·0025 mm to about 0·025 mm.
All animals and plants consist at ?rst of a single cell (the egg-cell, or ovum), which begins to develop when fertilised by the sperm-cell derived from the opposite sex. Development begins by a division into two new cells, then into four, and so on till a large mass is formed. These cells – among them stem cells (see STEM CELL) which have the potential to develop into a variety of specialised cells – then arrange themselves into layers, and form various tubes, rods, and masses which represent in the embryo the organs of the fully developed animal. (See FETUS.)
When the individual organs have been laid down on a sca?olding of cells, these gradually change in shape and in chemical composition. The cells in the nervous system send out long processes to form the nerves; those in the muscles become long and striped in appearance; and those which form fat become ?lled with fat droplets which distend the cells. Further, they begin to produce, between one another, the substances which give the various tissues their special character. Thus, in the future bones, some cells deposit lime salts and others form cartilage, while in tendons they produce long white ?bres of a gelatinous substance. In some organs the cells change little: thus the liver consists of columns of large cells packed together, while many cells, like the white blood corpuscles, retain their primitive characters almost entire.
Thus cells are the active agents in forming the body, and they have a similar function in repairing its wear and tear. Tumours, and especially malignant tumours, have a highly cellular structure, the cells being of an embryonic type, or, at best, forming poor imitations of the tissues in which they grow (see TUMOUR).... cells
Literally, those derived from embryonic mesoderm; practically, those in a tissue that give it structure and form. The opposite of parenchymal.... mesenchymal cells
A method of autologous blood TRANSFUSION – using a patient’s own blood, salvaged during a surgical operation – instead of conventional blood-bank transfusion.... perioperative cell salvage
These have almost completely replaced BONE MARROW TRANSPLANT, used to treat malignancies such as LEUKAEMIA and LYMPHOMA for the past 20 years. The high doses of CHEMOTHERAPY or RADIOTHERAPY used to treat these diseases destroy the bone marrow which contains stem cells from which all the blood cells derive. In 1989 stem cells were found in the blood during recovery from chemotherapy. By giving growth factors (cytokines), the number of stem cells in the blood increased for about three to four days. In a peripheral-blood stem-cell transplant, these cells can be separated from the peripheral blood, without a general anaesthetic. The cells taken by either method are then frozen and returned intravenously after the chemotherapy or radiotherapy is completed. Once transplanted, the stem cells usually take less than three weeks to repopulate the blood, compared to a month or more for a bone marrow transplant. This means that there is less risk of infection or bleeding during the recovery from the transplant. The whole procedure has a mortality risk of less than 5 per cent – half the risk of a bone marrow transplant.... peripheral-blood stem-cell transplants
The cells that produce the MYELIN sheath of the AXON of a medullated NERVE. They are wrapped around a segment of the axon, forming concentric layers.... schwann cell
See LYMPHOMA.... t-cell lymphoma
A type of lymphocyte which assists the B-Lymphocytes in producing antibodies.... t-helper cells
White blood cells that have matured in the thymus gland. There are at least two kinds of T-lymphocytes - helpers and suppressors. In AIDS, the number of helper cells is decreased.... t-lymphocytes (or t-cells)
A type of T-lymphocyte that stops antibody production when the invading antigen has been inactivated.... t-suppressor cells
Cellulite is a painless affection which consists of the fat layer growth.
This is not very unusual and many women around the world suffer from it. Generally, cellulite is your body’s way of protecting your organism when you’re pregnant.
On the other hand, you can develop cellulite from having a very unbalanced diet: unhealthy foods and drinks (sodas and fast food).
Also, the lack of workout and exercise will slow your calories from burning, making them stick mostly to your hips and thighs.
How Tea for Cellulite Works
A Tea for Cellulite’s main purpose is to make your blood veins work properly and eliminate the lipids surplus. Also, their action implies veins dilatation and increased blood pressure so that your entire body will work to get rid of the unwanted fats.
What you need to know about cellulite is that this is not regular fat and, at times, even thin women have it. Keeping a diet will not make it go away so don’t starve yourself to death!
Efficient Tea for Cellulite
When choosing a Tea for Cellulite, you must keep in mind a couple of facts: it must be very efficient and safe. Since having a cellulite will not hurt more than your feelings, alternative medicine practitioners advice against all pills that promise to work miracles on your body and recommend, instead, an herbal treatment. If you don’t know which teas to choose from, here’s a list to guide you on:
- Horse Chestnut Tea – it has anti inflammatory properties. Its main active constituent, Aescin, improves your blood flow by decreasing the pore size of your capillary walls. This will make your skin look a lot smoother and reduce the cellulite level.
- Ginkgo Biloba Tea – is a great vasodilator whose main goal is to improve circulation. This Tea for Cellulite will also stop cholesterol level from enhancing and it can be used to treat memory loss, stress, anxiety, headaches and anemia. However, don’t drink more than 3 cups per day or you’ll get diarrhea.
- Green Tea – has blood thinning properties, so you must avoid it at all costs in case you’re already on regular blood thinners. A cup of Green Tea per day will also improve your general health and bring relief in case you’re suffering from infertility, anemia, headaches or stress.
However, don’t take it if you’re on menopause or menstruation in order to avoid stomach irritations and uterine contractions.
- Dandelion Tea – will enhance your liver’s ability to process lipids faster and energize your entire body. However, this Tea for Cellulite is also a strong diuretic and purgative so you may want to avoid it if you suffer from diarrhea or upset stomach. Also, too much dandelion tea might cause urinary tract infections.
Tea for Cellulite Side Effects
When taken properly, these teas are generally safe. However, exceeding the number of cups recommended per day may weaken your digestive and nervous systems and lead to vomiting, nausea, headaches and even hallucinations.
Before starting a treatment based on a Tea for Cellulite, talk to your doctor in order to find out which are the risks. Don’t take any of these teas if you’re pregnant, breastfeeding, on blood thinners, anticoagulants or preparing for a surgery. Children shouldn’t be allowed to take an herbal treatment since there is no study to prove how safe it is for them.
But if you have the green light from your doctor and nothing could interfere with your Tea for Cellulite cure, choose a tea that fits best your needs and enjoy its health benefits!... tea for cellulite
A growth composed of cells that produce various hormones. These cells, amine precursor uptake and decarboxylation (APUD) cells, occur in different parts of the body. Some tumours of the thyroid gland, pancreas, and lungs are cell tumours, as are a carcinoid tumour (see carcinoid syndrome) and phaeochromocytoma (a type of adrenal tumour).... apud cell tumour
Also called cytopathology, the branch of cytology concerned with the effects of disease on cells.... pathology, cellular
A form of anaemia growing into an acute social problem, affecting people of African, Asian, and Mediterranean origin. Thalassaemias are caused by defects of a gene that produces the globin part of haemoglobin. Such defects in the DNA can now be detected in the womb before birth. The name derives from sickle-shaped cells instead of circular red blood cells. Few sufferers survive beyond their 40th year.
Symptoms. Unhealthy pallor, listlessness, sore tongue, dizziness, vague aches and pains, rapid pulse and breathing, tinnitus, palpitation. The skull may be disproportionately large, resistance to infection feeble, chances of survival poor. This form of anaemia is linked with defective colour vision. Impaired liver function. Stunted growth, great pain. Sufferers have a higher risk of infection.
Malaria. Sufferers are less likely to die of malaria because their red cells do not support the growth of malaria parasites very well.
Carriers: Carriers of the sickle-cell gene can now be identified by a simple blood test.
Treatment. No specifics exist but supportive herbal treatment has been known to increase output of red cells and raise haemoglobin levels:– Red Clover flowers, Yellow Dock, Echinacea, Burdock, Wild Indigo, Gentian, Nettles, Birch leaves, Sage, Walnut leaves, Centaury, Gota Kola (Indian Pennywort). Alternatives:– Tea. Mix equal parts: Iceland Moss, Nettles, Red Clover flowers. 2 teaspoons to each cup boiling water; infuse 15 minutes; 1 cup morning and evening.
Decoction. Mix equal parts; Echinacea, Walnut leaves, Balm of Gilead buds; 1 teaspoon to each cup water gently simmered for 20 minutes. Half-1 cup, cold, 3 times daily, before meals.
Tablets/capsules. Sarsaparilla. Ginseng. Iceland Moss. Red Clover. Echinacea. Gentian.
Powders. Formula: Echinacea 1; Fringe Tree half; Ginseng half; White Poplar bark 1. Dose: 500mg (two 00 capsules or one-third teaspoon) thrice daily before meals.
Liquid extracts. Formula. Echinacea 2; Dandelion 1; Oat Husk (avena sativa) 1. Mix. Dose, 1-2 teaspoons before meals, in water or one of the above teas or decoctions.
Tinctures. Same combination. Dose: 2-3 teaspoons.
Dong quai. See entry.
Pollen. Claimed to be of value.
Diet. Dandelion coffee. Molasses. Desiccated liver. Calf liver, fresh. Green leafy vegetables contain chlorophyll, iron and folic acid. Cider vinegar. Dried beans, apricots and shellfish. Dandelion leaves in salads. Milk, eggs, meats, Soya. Carrot juice to increase red cells.
Supplements. Daily. Vitamin B12. Vitamin C, 1g; Folic acid 400mcg, Floradix. Of particular value: Vitamin E 400iu. Zinc.
Note: Those at risk should submit themselves for screening. The disease cannot be cured but can be controlled largely by orthodox measures and sometimes by natural medicine. ... anaemia: sickle cell
(APC) a cell, such as a *dendritic cell or a *macrophage, that processes antigen for presentation to a T lymphocytes (see helper T cell).... antigen-presenting cell
cells that share the metabolic property of amine-precursor uptake and decarboxylation. They have a wide distribution, especially in the mucosa of the gastrointestinal tract and pancreas, and their function is to synthesize and release polypeptides that serve as regulator peptides and neurotransmitters. They are often known as the diffuse neuroendocrine system.... apud cells
cells that stain readily with silver salts. Such cells occur, for example, in the crypts of Lieberkühn in the intestine.... argentaffin cells
Cells, also called blood corpuscles, present in blood for most or part of their lifespan. They include red blood cells, which make up about 45 per cent by volume of normal blood, white blood cells, and platelets. Blood cells are made in the bone marrow by a series of divisions from stem cells.
Red blood cells (also known as RBCs, red blood corpuscles, or erythrocytes) transport oxygen from the lungs to the tissues (see respiration). Each is packed with haemoglobin, enzymes, minerals, and sugars. Abnormalities can occur in the rate at which RBCs are either produced or destroyed, in their numbers, and in their shape, size, and haemoglobin content, causing forms of
anaemia and polycythaemia (see blood, disorders of).
White blood cells (also called WBCs, white blood corpuscles, or leukocytes) protect the body against infection and fight infection when it occurs. The 3 main types of are granulocytes (also called polymorphonuclear leukocytes), monocytes, and lymphocytes. Granulocytes are further classified as neutrophils, eosinophils, or basophils, and each type of granulocyte has a role in either fighting infection or in inflammatory or allergic reactions. Monocytes and lymphocytes also play an important part in the immune system. Lymphocytes are usually formed in the lymph nodes. One type, a T-lymphocyte, is responsible for the delayed hypersensitivity reactions
White (see allergy) and Red blood blood cell is also involved in cell (neutrophil) protection against cancer. T-lymphocytes manufacture chemicals, known as lymphokines, which affect the function of other cells. In addition, the T-cells moderate the activity of B-lymphocytes, which form the antibodies that can prevent a second attack of certain infectious diseases. Platelets (also known as thrombocytes), are the smallest blood cells and are important in blood clotting.
The numbers, shapes, and appearance of the various types of blood cell are of great value in the diagnosis of disease (see blood count; blood film).... blood cells
An inherited blood disease in which the red blood cells contain haemoglobin S, an abnormal type of haemoglobin. This crystallizes in the capillaries, making red cells sickle-shaped and fragile, and leading to haemolytic anaemia. The abnormal cells are unable to pass easily through tiny blood vessels. The blood supply to organs is blocked intermittently, causing sickle cell crises. The disease affects mainly black people.Symptoms usually appear after age 6 months, often beginning with painful swelling of the hands and feet. Chronic haemolytic anaemia causes fatigue, headaches, shortness of breath on exertion, pallor, and jaundice. Sickle cell crises start suddenly; they are sometimes brought on by an infection, cold weather, or dehydration, but may also occur for no apparent reason. The sufferer may experience pains (especially in the bones), blood in the urine (from kidney damage) or damage to the lungs or intestines. If the brain is affected, seizures, a stroke, or unconsciousness may result.
In some affected children, the spleen enlarges and traps red cells at a particularly high rate, causing a life-threatening form of anaemia. After adolescence, the spleen usually stops functioning, increasing the risk of infection in those affected.
Diagnosis is made from examination of a blood smear and electrophoresis.
Supportive treatment may include folic acid supplements, and penicillin and immunization to protect against infection.
Life-threatening crises are treated with intravenous infusions of fluids, antibiotics, oxygen therapy, and analgesic drugs.
If the crisis still does not respond, an exchange blood transfusion may be performed.
This may be done regularly for people who suffer frequent severe crises.... sickle cell anaemia
see Hürthle cell tumour.... askanazy cells
see islets of Langerhans.... beta cells
(blood corpuscle) any of the cells that are present in the blood in health or disease. The cells may be subclassified into three major categories, namely red cells (*erythrocytes); white cells (*leucocytes), which include granulocytes, lymphocytes, and monocytes; and *platelets (see illustration). The blood cells account for approximately 40% of the total volume of the blood in health; red cells comprise the vast majority.... blood cell
(echinocyte) a red blood cell (erythrocyte) with abnormal small thorny projections. See crenation.... burr cell
parafollicular cells of the thyroid gland, which are derived from neural crest tissue. They produce *calcitonin. *Medullary carcinoma of the thyroid has its origin in the C cells.... c cells
(perikaryon) the enlarged portion of a *neuron (nerve cell), containing the nucleus. It is concerned more with the nutrition of the cell than with propagation of nerve impulses.... cell body
see epiretinal membrane.... cellophane maculopathy
a machine that aspirates blood lost during surgery and immediately spins, washes, and filters it for retransfusion back into the patient’s body (see autotransfusion). The process, called intraoperative cell salvage, is used in surgery that has significant blood loss, such as orthopaedic and vascular surgery and Caesarean section, and avoids the costs and risks of *allogeneic transfusion.... cell saver
molecules on the surface of cell membranes that are responsible for most cellular functions directly related to their immediate environment. Many have very precise functions of adhesion (see adhesion molecules), metabolic exchange, hormone reception, respiration, and immune reactions. Cell-to-cell exchanges involve specialized surface structures (junctions), which form a communicating nexus.... cell-surface molecules
(clear-cell adenocarcinoma) a variant of *adenocarcinoma that tends to arise from the kidneys or the female genital tract. In the latter case it is linked to intrauterine exposure to *diethylstilbestrol during the 1950s and 1960s and takes the form of a vaginal cancer, which can be treated by radical surgery followed by radiotherapy.... clear-cell carcinoma
a group of lymphomas in which abnormal T *lymphocytes are concentrated in the skin. The most common form is *mycosis fungoides.... cutaneous t-cell lymphoma
a type of T *lymphocyte that destroys cancerous cells, virus-infected cells, and *allografts. Cytotoxic T cells recognize peptide antigens attached to proteins that are encoded by the *HLA system.... cytotoxic t cell
see islets of Langerhans.... d cells
a type of haemopoietic cell with specialized antigen-presenting functions. The head and neck are common sites for dendritic cell pathology. See antigen-presenting cell.... dendritic cell
n. any of the gastrin-secreting cells of the stomach lining located predominantly in the gastric *antrum. Gastrin stimulates the production of gastric acid by parietal cells in the stomach. Increased G-cell activity is associated with the formation of duodenal ulcers and the *Zollinger-Ellison syndrome.... g-cell
types of *neurons (nerve cells) within the central nervous system. Golgi type I neurons have very long axons that connect different parts of the system; Golgi type II neurons, also known as microneurons, have only short axons or sometimes none.... golgi cells
an abnormal white blood cell that has the appearance of an immature lymphocyte with fine hairlike cytoplasmic projections around the perimeter of the cell. It is found in a rare form of leukaemia (hairy-cell leukaemia) most commonly occurring in young men.... hairy cell
a type of T *lymphocyte that plays a key role in cell-mediated immunity by recognizing foreign antigen on the surface of *antigen-presenting cells when this is associated with the individual’s *MHC antigens, having been processed by antigen-presenting cells. Helper T cells stimulate the production of *cytotoxic T cells, which destroy the target cells.... helper t cell
an androgen-producing tumour of the ovary found in older women and often resulting in *virilization. Such tumours are so called as they tend to occur around the area of the ovary where the blood vessels enter (the hilum). They are usually small and are treated by surgical removal, with resolution of most of the symptoms.... hilar cell tumour
a malignant tumour of the thyroid gland that arises from Hürthle (or Askanazy) cells, altered follicular cells of the gland that have large nuclei and stain deeply with eosin (these cells are also found in benign nodules and Hashimoto’s disease). Hürthle cell carcinoma is not as common as papillary, follicular, or anaplastic thyroid carcinomas (see thyroid cancer). [K. W. Hürthle (1860–1945), German histologist]... hürthle cell tumour
see luteinizing hormone.... interstitial-cell-stimulating hormone
a group of autoantibodies directed against components of the insulin-secreting beta cells of the pancreas. They are usually detectable in the blood of people presenting with type 1 diabetes. Antibodies against *glutamic acid decarboxylase (GAD) in the beta cells have become a more specific test for islet cell antibodies, to help confirm a diagnosis of type 1 diabetes.... islet cell antibodies
a new technique still under evaluation for curing type 1 *diabetes mellitus, which involves the injection of donated cells from the pancreatic *islets of Langerhans into the liver, where it is hoped they will seed and survive. The transplanted cells then take over insulin production from the recipient’s diseased pancreas.... islet cell transplantation
any tumour arising in a cell of the pancreatic *islets of Langerhans. These tumours, which include *insulinomas, *glucagonomas, and *somatostatinomas, form one of the two major subclasses of gastrointestinal neuroendocrine tumours, the other being the *carcinoid tumours.... islet cell tumour
overgrowth of cells of the *reticuloendothelial system. This includes disorders previously called histiocytosis X, including eosinophilic granuloma, Hand–Schüller–Christian disease, and Letterer–Siwe disease. [P. Langerhans (1847–88), German physician and anatomist]... langerhans cell histiocytosis
see interstitial cells. [F. von Leydig (1821–1908), German anatomist]... leydig cells
a long-lived lymphocyte that is formed following primary infection. It enables a faster and more robust immune response following a second exposure to the antigen.... memory cell
see juxtaglomerular apparatus.... mesangial cells
(NK cell) a type of *lymphocyte that is able to kill virus-infected cells and cancerous cells and mediates rejection of bone-marrow grafts. NK cells are a part of natural (or innate) *immunity. Their function is regulated by a balance between activating receptors, which recognize proteins on cancerous or virus-infected cells, and inhibitory receptors specific for certain molecules encoded by the *HLA system.... natural killer cell
(NSCLC) any type of lung cancer other than *small-cell lung cancer. Such cancers include *adenocarcinoma of the lung, large-cell carcinomas, and squamous-cell carcinoma of the lung.... non-small-cell lung cancer
a posterior ethmoidal sinus air cell (see paranasal sinuses). They are surgically important because of their proximity to the optic nerve and internal carotid artery. [A. Onodi (1857–1919), Hungarian rhinolaryngologist]... onodi cell
see parietal cells.... oxyntic cells
(oxyntic cells) cells of the *gastric glands that secrete hydrochloric acid in the fundic region of the stomach.... parietal cells
rows of supporting cells between the sensory hair cells of the organ of Corti (see cochlea).... phalangeal cells
cells with cytoplasmic processes that form intercellular bridges. The germinative layer of the *epidermis is sometimes called the prickle cell layer.... prickle cells
a type of neuron found in the *cerebral cortex, with a pyramid-shaped cell body, a branched dendrite extending from the apex towards the brain surface, several dendrites extending horizontally from the base, and an axon running in the white matter of the hemisphere.... pyramidal cell
a large binucleate cell that is characteristic of *Hodgkin’s disease. [D. Reed Mendenhall (1874–1964), US pathologist; C. Sternberg (1872–1935), Austrian pathologist]... reed–sternberg cell
(Treg cell) a type of T *lymphocyte that suppresses immune responses.... regulatory t cell
a cell that is not undergoing division. See interphase.... resting cell
the cells that lay down the *myelin sheath around the axon of a medullated nerve fibre. Each cell is responsible for one length of axon, around which it twists as it grows, so that concentric layers of membrane envelop the axon. The gap between adjacent Schwann cells forms a *node of Ranvier. [T. Schwann (1810–82), German anatomist and physiologist]... schwann cells
cells found in the walls of the seminiferous tubules of the *testis. Compared with the germ cells they appear large and pale. They anchor and probably nourish the developing germ cells, especially the *spermatids, which become partly embedded within them. A Sertoli-cell tumour is a rare testicular tumour causing *feminization. [E. Sertoli (1842–1910), Italian histologist]... sertoli cells
progressive renal disease developing in 5–8% of patients with *sickle-cell disease. Infarcts in the cortex can occur with sickle-cell crises and present with pain and haematuria. Acute or more insidious damage to the medulla will lead to a urinary concentrating defect and later to papillary necrosis and/or fibrosis. Occlusion of vessels within the glomerular capillary tuft leads to a secondary form of *focal segmental glomerulosclerosis and can present with the *nephrotic syndrome.... sickle-cell nephropathy
(SCLC) a type of bronchial carcinoma characterized by small cells (or oat cells), small round or oval cells with darkly staining nuclei and scanty indistinct cytoplasm. Small-cell carcinoma is usually related to smoking and accounts for about one-quarter of bronchial carcinomas; it carries a poor prognosis due to early distant spread, typically to bones, liver, and brain. Treatment is primarily with chemotherapy and radiotherapy and paraneoplastic symptoms (see paraneoplastic syndrome) from *ectopic hormone production are common. Compare non-small-cell lung cancer.... small-cell lung cancer
see Reed–Sternberg cell.... sternberg–reed cell
a type of T *lymphocyte that prevents an immune response by B cells or other T cells to an antigen.... suppressor t cell
a form of cancer that affects the urothelium, which lines the urinary collecting system of the kidney, ureters, bladder, and the proximal part of the urethra. It is the most common type of bladder cancer.... transitional cell carcinoma
see regulatory T cell.... treg cell
haemopoietic *stem cells collected from umbilical cord blood donated at birth, which can be stored indefinitely and used if a sibling or any other blood-compatible baby develops an illness (such as leukaemia) that could only be treated by cord-blood stem-cell transplantation. This facility is now available in the UK and the USA.... umbilical cord blood banked stem cells
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