n. an enzyme (a *hexokinase), found in the liver, that catalyses the conversion of glucose to glucose-6-phosphate. This is the first stage of *glycolysis.
(MODY, monogenic diabetes) a range of rare but important forms of type 2 *diabetes mellitus caused by a single autosomal *dominant genetic defect. The two commonest forms are mutations of the HNF-1? gene (MODY 3), which often responds to treatment with *sulphonylurea drugs, and mutations of the glucokinase gene (MODY 2), causing a mild elevation of blood glucose levels usually responsive to dietary management.... maturity-onset diabetes of the young
Health Encyclopedia