Glutathione Health Dictionary

Glutathione: From 1 Different Sources


n. a peptide containing the amino acids glutamic acid, cysteine, and glycine. It functions as a *coenzyme in several oxidation-reduction reactions. Glutathione serves as an *antioxidant: it reacts with potentially harmful oxidizing agents and is itself oxidized (see also selenium). This is important in ensuring the proper functioning of proteins, haemoglobin, membrane lipids, etc. High levels of glutathione in the blood are associated with longevity.
Health Source: Oxford | Concise Colour Medical Dictionary
Author: Jonathan Law, Elizabeth Martin

Albahaca

Basil (Ocimum basilicum).

Plant Part Used: Aerial parts: leaf, stem, flower.

Dominican Medicinal Uses: The aerial parts or leaves are traditionally prepared as a tea and taken orally for stomach ache, indigestion, gastro-intestinal pain, internal cleansing and women’s health conditions.

Safety: This herb is generally regarded as safe for human consumption in moderate amounts and widely used as a culinary seasoning.

Contraindications: The essential oil should not be used during pregnancy, lactation or in small children.

Drug Interactions: Synergistic effects may occur with drugs that share similar pharmacological activities as those described for this plant in the “Laboratory and Preclinical Data” section; metabolism of one of basil’s active constituents, estragole, may be hindered by concomitant use of medications metabolized by UGT2B7 or UGT1A9 phase II enzymes.

Clinical Data: No human clinical trials of this plant have been identified in the available literature.

Laboratory & Preclinical Data: The following biological activities of this plant have been investigated in laboratory and preclinical studies (in vitro or animal models): analgesic, antifungal, antimicrobial, antispasmodic, anti-ulcerogenic, gastric anti-ulcerogenic, glutathione S-transferase and smooth muscle relaxant.

* See entry for Albahaca in “Part 3: Dominican Medicinal Plant Profiles” of this book for more information, including references.... albahaca

Papaver Somniferum

Linn.

Family: Papaveraceae.

Habitat: Kashmir and throughout the plains of North India; cultivated in gardens.

English: Corn Poppy, Red Poppy.

Ayurvedic: Rakta Posta.

Siddha/Tamil: Sivappu, Kasakasa.

Folk: Laal Posta, Laal Kaskas.

Action: Latex from capsules— narcotic. Petal—expectorant, antitussive, sudorific. Used for diseases of the respiratory tract, for disturbed sleep and as a sedative for the relief of pain. (Included among unapproved herbs by German Commission E.)

The petals contain cyanidine derivatives. An alkaloid rhoeadine is present in leaves and flowers (0.031%), unripe capsules (0.035%) and in roots

Family: Papaveraceae.

Habitat: Native to Asia; now grown in Uttar Pradesh, Punjab, Rajasthan and Madhya Pradesh.

English: Opium Poppy.

Ayurvedic: Ahiphena, Aaphuuka. Post-daanaa (seed).

Unani: Afyum. Tukhm-e- khashkhaash (seed).

Siddha/Tamil: Kasakasa (seeds).

Action: Opium is obsolete as a drug. Narcotic, sedative, hypnotic, analgesic, sudorific, anodyne, antispasmodic. Crushed poppyheads were in use as a topical poultice for crippling pain in terminal diseases. Poppy seed—nutritive, demulcent, emollient, spasmolytic, devoid of narcotic properties. Specific against obstinate constipation, also used in catarrh of the bladder. Poppy seed oil is also free from narcotic properties. Used against diarrhoea, dysentery and scalds.

Opium contains isoquinoline alkaloids; the major one is morphine with narcotine, codeine, papaverine and thebaine. Poppy seeds, used in Indian medicine, do not contain alkaloids. The seeds contain thiamine 420, riboflavin 49, folic acid 30, pantothenic acid 2667 and niacin 1877 mcg/100 g. The seed oil (from Turkey) contains gamma-tocopherol 220, alpha-toco- pherol 40 and beta-tocopherol 20 mcg/ 100 g. Some low-molecular proteins (15% of total protein) have been isolated, along with cysteine, glutamic acid and arginine. The seeds yield a fatty oil (45%) containing palmitic, stearic, oleic, linoleic and linolenic acids.

The extract of seeds showed highly significant antisecretory (antidiarr- hoeal activity) against E. coli entero- toxin-induced secretory responses in experimental animals.

The triglycerides isolated from seeds showed anti-tumour activity against Ehrlichs ascites in mice.

The aqueous extract of seeds showed marked hypoglycaemic activity when administered to glucose-loaded and al- loxan diabetic rats.

The seeds were found to increase the activity of carcinogen detoxifying enzyme, glutathione-S-transferase by more than 78% in the stomach, liver and oesophagus in mice.

Following Papaver sp. are found in India:

P. argemone Linn. (indigenous to the Mediterranean region; commonly grown in gardens in India) contains 0.15% of alkaloids including rhoeadine, protopine, and anthocyanins. Petals are sudorific.

P dubium Linn. (North-western Himalaya form Kashmir to Garhwal; as a winter weed in North Indian plains) contains rhoeagenine as the principal alkaloid, besides rhoeadine, protopine. Petals contain cyanidin B and pelargonidin C. Petals are sudorific.

P. hybridum Linn. (gardens of Punjab and Uttar Pradesh) is diaphoretic (petals). Plant latex contains alkaloids including berberine, coptisine, pahybrine, papaverrubines A, B, D and E and sanguinarine. Plant also gave glaucine and glucamine.

P. nudicaule Linn. (Gulmarg, Kashmir, at altitudes of 3,300-3,600 m), known as Iceland Poppy, gave alkaloids including papaverrubines B and D; leave gave cyanogenic glycosides including dhurrin and triglochinin. The flower and fruit are mild diaphoretic.

P. orientale Linn. (indigenous to Mediterranean region; grown in Indian gardens), known as Oriental Poppy, contains 0.16% of alkaloids including thebaine, isothebane, protopine, glaucidine and oripavine. Latex from poppy capsule is narcotic.... papaver somniferum

Aids

Acquired Immune Deficiency Syndrome. Infection by HIV virus may lead to AIDS, but is believed to be not the sole cause of the disease. It strikes by ravaging the body’s defence system, destroying natural immunity by invading the white blood cells and producing an excess of ‘suppressant’ cells. It savages the very cells that under normal circumstances would defend the body against the virus. Notifiable disease. Hospitalisation. AIDS does not kill. By lacking an effective body defence system a person usually dies from another infection such as a rare kind of pneumonia. There are long-term patients, more than ten years after infection with HIV who have not developed AIDS. There are some people on whom the virus appears to be ineffective. The HIV virus is transmitted by infected body fluids, e.g. semen, blood or by transfusion.

A number of co-factors are necessary for AIDS to develop: diet, environment, immoral lifestyle, drugs, etc also dispose to the disease which, when eliminated, suggest that AIDS needs not be fatal. However, there is no known cure. Smoking hastens onset. Causes include needle-sharing and sexual contacts. Also known as the ‘Gay Plague’ it can be transmitted from one member of the family to another non-sexual contact.

The virus kills off cells in the brain by inflammation, thus disposing to dementia.

Symptoms. Onset: brief fever with swollen glands. “Feeling mildly unwell”. This may pass off without incident until recurrence with persistent diarrhoea, night sweats, tender swollen lymph nodes, cough and shortness of breath. There follows weight loss, oral candida. Diagnosis is confirmed by appearance of ugly skin lesions known as Kaposi’s sarcoma – a malignant disease. First indication is the appearance of dark purple spots on the body followed by fungoid growths on mouth and throat.

While some cases of STDs have been effectively treated with phytotherapy, there is evidence to suggest it may be beneficial for a number of reasons. Whatever the treatment, frequent blood counts to monitor T-4 cells (an important part of the immune system) are necessary. While a phytotherapeutic regime may not cure, it is possible for patients to report feeling better emotionally and physically and to avoid some accompanying infections (candida etc).

Treatment. Without a blood test many HIV positives may remain ignorant of their condition for many years. STD clinics offer free testing and confidential counselling.

Modern phytotherapeutic treatment:–

1. Anti-virals. See entry.

2. Enhance immune function.

3. Nutrition: diet, food supplements.

4. Psychological counselling.

To strengthen body defences: Garlic, Echinacea, Lapacho, Sage, Chlorella, Reisha Mushroom, Shiitake Mushroom. Of primary importance is Liquorice: 2-4 grams daily.

Upper respiratory infection: Pleurisy root, Elecampane.

Liver breakdown: Blue Flag root, Milk Thistle, Goldenseal.

Diarrhoea: Bayberry, Mountain Grape, American Cranesbill, Slippery Elm, lactobacillus acidophilus.

Prostatitis: Saw Palmetto, Goldenrod, Echinacea.

Skin lesions: External:– Comfrey, Calendula or Aloe Vera cream.

To help prevent dementia: a common destructive symptom of the disease: agents rich in minerals – Alfalfa, Irish Moss, Ginkgo, St John’s Wort, Calcium supplements.

Nervous collapse: Gotu Kola, Siberian Ginseng, Oats, Damiana.

Ear Inflammation: Echinacea. External – Mullein ear drops.

With candida: Lapacho tea. Garlic inhibits candida.

Anal fissure: Comfrey cream or Aloe Vera gel (external).

Practitioner: Formula. Liquid extract Echinacea 30ml (viral infection) . . . Liquid extract Poke root 10ml (lymphatic system) . . . Liquid extract Blue Flag root 10ml (liver stimulant) . . . Tincture Goldenseal 2ml (inflamed mucous membranes) . . . Liquid extract Guaiacum 1ml (blood enricher) . . . Decoction of Sarsaparilla to 100ml. Sig: 5ml (3i) aq cal pc.

Gargle for sore throat: 5-10 drops Liquid extract or Tincture Echinacea to glass water, as freely as desired.

Abdominal Castor oil packs: claimed to enhance immune system.

Chinese medicine: Huang Qi (astragalus root).

Urethral and vaginal irrigation: 2 drops Tea Tree oil in strong decoction Marshmallow root: 2oz to 2 pints water. Inject warm.

Diet. Vitamin C-rich foods, Lecithin, Egg Yolk, Slippery Elm gruel, Red Beet root, Artichokes. Garlic is particularly indicated as an anti-infective.

Nutrition. Vitamin A is known to increase resistance by strengthening the cell membrane; preferably taken as beta carotene 300,000iu daily as massive doses of Vitamin A can be toxic. Amino acid – Glutathione: Garlic’s L-cysteine relates.

Vitamin C. “The virus is inactivated by this vitamin. Saturating cells infected with the HIV virus with the vitamin results in 99 per cent inactivation of the virus. The vitamin is an anti-viral and immune system modulator without unwanted side-effects. The ascorbate, when added to HIV cells, substantially reduced the virus’s activity without harming the cells at specific concentrations. Patients taking large doses report marked improvement in their condition. Minimum daily oral dose: 10 grams.” (Linus Pauling Institute, Science and Medicine, Palo Alto, California, USA)

Periwinkle. An anti-AIDS compound has been detected in the Madagascan Periwinkle (Catharanthus roseus), at the Chelsea Physic Garden.

Mulberry. The black Mulberry appears to inhibit the AIDS virus.

Hyssop. An AIDS patient improved to a point where ulcers were healed, blood infection eliminated, and Kaposi’s sarcoma started to clear when her mother gave her a traditional Jamaican tea made from Hyssop, Blessed Thistle and Senna. From test-tube research doctors found that Hyssopus officinalis could be effective in treatment of HIV/AIDS. (Medical Journal Antiviral Research, 1990, 14, 323-37) Circumcision. Studies have shown that uncircumcised African men were more than five to eight times more likely to contract AIDS than were circumcised men; life of the virus being short-lived in a dry environment. (Epidemiologist Thomas Quinn, in Science Magazine)

Study. A group of 13 HIV and AIDS patients received 200mg capsules daily of a combination of Chelidonium (Greater Celandine) 175mg; Sanguinaria (Blood root) 5mg; and Slippery Elm (Ulmus fulva) 20mg. More than half the patients enjoyed increased energy and improved immune function with reduction in both size and tenderness of lymph nodes. (D’Adamo P. ‘Chelidonium and Sanguinaria alkaloids as anti-HIV therapy. Journal of Naturopathic Medicine (USA) 3.31-34 1992)

Bastyr College of Naturopathy, Seattle, MA, USA. During 1991 the College carried out a study which claimed that a combination of natural therapies including nutrition, supplements, herbal medicine, hydrotherapy and counselling had successfully inhibited HIV and other viral activity in all patients in controlled trials lasting a year.

Patients chosen for the trial were HIV positive, not on anti-viral drugs and showing symptoms of a compromised immune system, but without frank AIDS (generally taken to be indicated by Karposi’s sarcoma and/or PCP-pneumocystitis carinii pneumonia).

Symptoms included: Lymphadenopathy in at least two sites, oral thrush, chronic diarrhoea, chronic sinusitis, leukoplakia, herpes, night sweats and fatigue.

Assessment was subjective and objective (including T-cell ratio tests). The patients did better than comparable groups in published trials using AZT.

Treatment was naturopathic and herbal. Patients receiving homoeopathy and acupuncture did not do as well as those receiving herbs.

Best results with herbs were: Liquorice (1g powder thrice daily); St John’s Wort (Yerba prima tablets, 3, on two days a week only). Patients reported a great increase in the sense of well-being on St John’s Wort. An equivalent dose of fresh plant tincture would be 10ml. The tincture should be of a good red colour. The College did not use Echinacea, which would stimulate the central immune system and which would therefore be contra-indicated.

Supplements given daily. Calcium ascorbate 3g+ (to bowel tolerance). Beta-carotene 300,000iu. Thymus gland extract tablets 6. Zinc 60mg (with some Copper). B-vitamins and EFAs.

To control specific symptoms: most useful herbs were: Tea Tree oil for fungal infections; Goldenseal and Gentian as bitters. Ephedra and Eyebright for sinusitis. Carob drinks for non-specific enteritis. Vitamin B12 and topical Liquorice for shingles.

Counselling and regular massage were used to maintain a positive spirit. Studies show all long term HIV positive survivors have a positive attitude and constantly work at empowering themselves.

Results showed significant improvements in symptoms suffered by HIV patients despite a slow deterioration in blood status. Methods used in the study had dramatically reduced mortality and morbidity. A conclusion was reached that AIDS may not be curable but it could be manageable. (Reported by Christopher Hedley MNIMH, London NW1 8JD, in Greenfiles Herbal Journal) ... aids

Selenium

n. a *trace element that is an essential component of the enzyme glutathione peroxidase, which catalyses the oxidation of *glutathione by hydrogen peroxide. It thus has important *antioxidant properties. The adult RNI (see Dietary Reference Values) is 60 ?g/day for women and 70 ?g/day for men. Dietary deficiency of selenium results in *cardiomyopathy; vegetarians and vegans can be at risk of deficiency. Symbol: Se.... selenium

Petroselinum Crispum

(Mill.) Airy-Shaw.

Synonym: Apium crispum Mill.

Family: Umbelliferae; Apiaceae.

Habitat: Native to Europe, now cultivated throughout India.

English: Parsley.

Unani: Fitraasaaliyum, Karafs-e- Kohi.

Action: Diuretic (used for bladder disorders, painful urination, retention of excess fluid in the tissues), antispasmodic, uterine tonic, emmenagogue, sedative (used for PMS and menopausal hot flushes, also in prostatitis), carminative, expectorant, aperient, antiseptic, anti-inflammatory.

Key application: For flushing out the efferent urinary tract in disorders of the same and in prevention and treatment of kidney gravel. (German Commission E.) Contraindicated in kidney inflammations.

The British Herbal Compendium approves the internal use of the herb for flatulent dyspepsia, dysuria and rheumatic conditions.

The leaves and roots contain furo- coumarins—psoralen, 5-and 8-meth- oxy psoralen, imperatorin, oxypeuce- danin, iso-pimpinelin. Myristicin has been isolated from the leaf oil. The plant gave flavonoids—apiin, luteolin, apigenin-7-glucoside, luteolin-7-glu- coside among others.

Myristicin showed high activity as an inducer of the detoxifying enzyme system, Glutathione S-transferase (GST) in the liver and small intestines of female mice (may be considered as a cancer chemoprotective agent).

The flavonoids, particularly api- genin, have been shown to be anti- inflammatory, to inhibit histamine release and to act as a free radical scavenger. Apiole, a constituent of the volatile oil, is reportedly antipyretic and phthalides of the root, seed and leaf are sedative in mice.

Both apiole and myristicin exhibit aquaretic and uterine stimulant activity, while sodium retention has been observed. (Natural Medicines Comprehensive Database, 2007.)

In homoeopathy, the herb is used for the treatment urinary disorders—sudden urge to urinate with severe pain, dribbling of urine after urination, gleet discharge and for amenorrhoea and neuralgic dysmenorrhoea.... petroselinum crispum

Saccharum Officinarum

Linn.

Family: Gramineae; Poaceae.

Habitat: Uttar Pradesh, Bihar and Punjab.

English: Sugarcane, Noble Cane.

Ayurvedic: Ikshu, Dirgha-chhada, Bhuurirasa, Morata, Asipatra, Madhutrna, Gudamuula, Trnarasa.

Unani: Gannaa, Naishakar.

Siddha/Tamil: Karumbu, Nanal.

Action: Cane Juice—restorative, cooling, laxative, demulcent, diuretic, antiseptic. Used in general debility, haemophilic conditions, jaundice and urinary diseases.

The Ayurvedic Pharmacopoeia ofIn- dia recommends the juice of the stem in haemorrhagic diseases and anuria; and the root in dysuria.

Sugarcane juice contains surcose (70-80% of soluble solids in the juice), glucose and fructose. Non-sugar constituents present in the cane juice are carbohydrates other than sugars. As- paragine and glutamine are prominent amino acids in the juice. Other amino acids include alanine, gamma- amino butyric acid, aspartic and glutamic acids, glycine, leucine, lysine, serine and tyrosine. The presence of phenylalanine, histidine, valine, proline, threonine and arginine, pipecolic acid, methionine and tryptophan has also been reported.

Aconitic acid constitutes about three-fourths of the total carboxylic acid present in the juice.

Vitamins present in the juice are: thiamine, riboflavin, niacin, pantothenic acid, biotin, and vitamin D; enzymes include diastase, invertase, lac- tase, peroxidase, tyrosinase.

Phenols in the cane juice are mainly polyphenols from tannin and antho- cyanin from the rind.

Cane juice contains glycolic acid which improves skin complexion as it has antiwrinkle effect, prevents scaly growth and increases natural collagen and elastin in the skin.

Enzymes present in the seeds include large quantities of diastase and invertase.

An ester, vanilloyl-l-O-beta-D-glu- coside, has been isolated from the bagasse.

The leaves contain alpha-amylase and glutathione-S-transferase.

Dosage: Stem—200-400 ml juice; rootstock—15-30 g for decoction. (API, Vol. IV.)... saccharum officinarum

Syzygium Aromaticum

(Linn.) Merr. & Perry.

Synonym: Eugenia aromatica Kuntze.

Eugenia caryophyllata Thunb. Caryophyllus aromaticus Linn.

Family: Myrtaceae.

Habitat: Cultivated in Tamil Nadu and Kerala.

English: Clove.

Ayurvedic: Lavanga, Devakusum, Devapushpa, Shrisangya, Shripra- suunaka.

Unani: Qaranful, Laung.

Siddha/Tamil: Kiraambu, Lavangam.

Action: Carminative, antiinflammatory, antibacterial. Flower buds—antiemetic, stimulant, carminative. Used in dyspepsia, gastric irritation. Oil—employed as a local analgesic for hypersensitive dent- lines and carious cavaties; internally as a carminative and antispasmodic.

Key application: In inflammatory changes of oral and pharyngeal mucosa; in dentistry; for topical anesthesia. (German Commission E.)

Eugenin, triterpene acids, crategolic acid and steroid glucosides afford anti- inflammatory and antiseptic proper ties to the buds. Eugenol, a major component of the oil, is antibacterial. Acetone extract of clove, eugenol and acetyleugenol possess cholagogue activity. The eugenol and acetyleugenol components of the clove oil inhibit arachidonate-, adrenalin- and collagen- induced platelet aggregation.

Clove terpenes show significant activity as inducers of detoxifying enzyme, glutathione-S-transferase (GST) in mouse liver and intestine and bring about carcinogen detoxification.

Whole cloves might have chemopro- tective activity against liver and bone marrow toxicity. (The Review of Natural Products by Facts and Comparisons, 1999.)

Dosage: Dried flower-bud—0.5-2.0 g powder. (API, Vol. I.)... syzygium aromaticum

Cataract

Gradual loss of sight following chemical disturbance in the lens protein of the eye resulting in degeneration and loss of transparency. Greyish white pupil which in normality is jet black. Occurs chiefly in the elderly due to injury of the lens capsule, glaucoma, the use of microwave or diet-mineral deficiency (calcium). In the ageing process there is a lack of antioxidant protection of the lens usually due to low Vitamin C, the major antioxidant in lens physiology. May also be congenital.

High blood glucose levels, diabetes, drugs, steroids, Down’s syndrome, kidney failure, uraemia and chronic diarrhoea predispose. There is no pain. Vision is as if looking through a frosted glass.

Treatment. Restore lens metabolism.

“My father-in-law knew people who had been cured by steeping Wild Burdock burrs and taking a small drink 3-4 times a day” (John Tobe, in “Cataract, Glaucoma and other Eye Disorders”) Cider Vinegar. 2 teaspoons to glass water, sips once or twice daily.

Chinese medicine. Hachimi jiogan to increase glutathione content of the lens.

Topical. Greater Celandine. 5-10 drops fresh juice of plant to 4oz distilled extract Witch Hazel. 10-20 drops in an eyebath half filled with warm water; use as a douche.

Cineraria maritima (Dusty Miller). 2-3 drops fresh plant juice applied to the eye with a medicine dropper. Same refers to Yucca and Chaparral. For early non-diabetic cataract.

Diet. Lacto-vegetarian. Carrot juice. Brewer’s Yeast, yellow-green vegetables. Spinach as an item of diet appears to reduce risk of cataract.

Supplementation. Vitamin C slows down the ageing process of the lens, protecting it from damage by free radicals: 1500mg daily. Vitamin B2. Vitamin E, 400iu daily. Selenium, 200mcg daily. Amino acids: cysteine, methionine, glutathione.

General. Surgical treatment is invariably successful. Cold packs and manipulation of the neck improve circulation and drainage of the head. ... cataract

Gerson Cancer Therapy

GERSON CANCER THERAPY is described in A Cancer Therapy; Results of Fifty Cases, Gerson, Max; 3rd edition, 1977, Pub: The Gerson Institute Bonita, CA 92002, USA.

Basically, the therapy consists of a vegetarian diet with meals of vegetables, fruits and whole grains, fresh or freshly prepared. Drinking water is replaced by hourly, fresh, raw juices of vegetables and fruits. Refined, altered, denatured or enhanced foodstuffs are forbidden. The diet is sodium, chloride, fat and protein restricted. Supplemental potassium, iodine, thyroid and crude liver extract comprise the medical armamentarium. A repeatable choleretic, enemas of a solution of boiled coffee, is administered to lower serum toxin levels. Coffee is a potent enhancer of the carcinogen detoxifying enzyme system, glutathione S-translerase (Wattenburg). The Gerson cancer therapy reduces accumulated tissue sodium and chloride, promoting diuresis. Gerson Therapy Center: Hospital de Baja California, at La Gloria, Mexico

Diet. Lunch and dinner contain ample cooked food, mainly to act as a ‘blotter’ to the daily intake of 5.25 pints fresh raw fruit juices that are the backbone of the therapy. Ingredients of the juices include 41bs raw organic carrots a day, with no harm to the liver. (JAM, May 1991, p5. Beata Bishop on her recovery from metastasised malignant melanoma)

The Gerson therapy is based on the ‘holistic’ philosophy which states that cancer represents a clinical manifestation of an underlying toxic condition. Such condition should receive primary treatment that is lifestyle orientated. The theme is: detoxification through internal cleansing. The diet and supplements are re-inforced by ‘positive thinking’ and supported by meditation and emotional balance. ... gerson cancer therapy




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