Gonadorelin analogue Health Dictionary

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Gonadorelin Analogue: From 1 Different Sources

(GnRH analogue, LHRH analogue) any one of a group of analogues of *gonadotrophin-releasing hormone (gonadorelin), which stimulates release of the gonadotrophins luteinizing hormone (LH) and follicle-stimulating hormone (FSH) from the pituitary gland. They are more powerful than the naturally occurring hormone, initially increasing the secretion of gonadotrophins by the pituitary: this acts to block the hormone receptors and to inhibit the release of further gonadotrophins, which suppresses production of oestrogens and androgens. Gonadorelin analogues include *buserelin, *goserelin, leuprorelin, and triptorelin. They are used in the treatment of endometriosis, fibroids, and some types of infertility. GnRH analogues are also used in the treatment of advanced prostate cancer. After causing an initial rise in plasma testosterone for approximately ten days the level then falls to the same low level as that achieved by castration. Because the initial flare in testosterone may cause an acute enlargement of the cancer, *anti-androgens are given usually for the first two weeks following the first injection of the gonadorelin analogue.
Health Source: Oxford | Concise Colour Medical Dictionary
Author: Jonathan Law, Elizabeth Martin

Gonadorelin

A hormone that stimulates the PITUITARY GLAND to secrete three hormones: gonadotrophic, luteinising and follicle-stimulating. Gonadorelin can be made arti?cially and given by intravenous injection. It is used to stimulate the OVARIES when treating infertile women, and to investigate suspected disease of the HYPOTHALAMUS. Analogues of the hormone (buserelin and goserelin) are chemically similar and can be used to suppress release of gonadorelin, so cutting the production of pituitary hormones. The two analogues are given to treat

ENDOMETRIOSIS, breast cancer (see BREASTS, DISEASES OF) and prostate cancer (see PROSTATE GLAND, DISEASES OF).... gonadorelin

Lhrh Analogue

A synthetically produced agent with the same properties as LUTEINISING HORMONERELEASING HORMONE (LHRH).... lhrh analogue

Somatostatin Analogues

Synthetic versions of the hormone somatostatin that acts on the pituitary gland, controlling the release of growth hormone.

These drugs are used to treat acromegaly and symptoms associated with some other hormone-secreting tumours (particularly in carcinoid syndrome).

Octreotide is a common somatostatin analogue.... somatostatin analogues

Analogue

n. a drug that differs in minor ways in molecular structure from its parent compound. Examples are *calcipotriol (an analogue of vitamin D), *betahistine (an analogue of histamine), and the *gonadorelin analogues. Useful analogues of existing drugs are either more potent or cause fewer side-effects. *Carboplatin and *oxaliplatin, for example, are less toxic analogues of *cisplatin.... analogue

Analogue Image

a traditional X-ray image on film that is in shades that range smoothly from black to white with no appreciable steps from one shade of grey to the next (see grey scale). Analogue images can be converted to digital format (see digitization) for manipulation and storage by computers and other electronic devices.... analogue image

Gnrh Analogue

see gonadorelin analogue.... gnrh analogue

Insulin Analogues

a group of synthetic human insulins with specific alterations in their amino-acid sequences designed to modify their rate of absorption from the subcutaneous injection site. Some are absorbed more rapidly and have a shorter duration of action than conventional short-acting human insulin; others are absorbed more slowly at a more consistent rate than conventional medium-acting *isophane insulin to give a more sustained control of fasting and premeal blood glucose levels and therefore a reduced risk of *hypoglycaemia. These analogues include the short-acting insulin aspart, insulin glulisine, and insulin lispro; the long-acting insulin detemir and insulin glargine; and the ultra-long-acting insulin degludec.... insulin analogues

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