Estimate of the degree of malignancy of a neoplasm.
n. 1. the severity of a malignant tumour according to its degree of *differentiation. Low-grade tumours (grade 1) closely resemble normal tissues, are well differentiated, and have a good prognosis. High-grade tumours (grade 3) show a poor resemblance to normal tissues, are poorly differentiated, and have a poor prognosis. Benign tumours are not graded. 2. the severity of a non-neoplastic disease.
the grade (from one to five) given to an area of prostate cancer, reflecting the level of differentiation of the tumour. The tumour pattern is assessed by examining the gland at low magnification. Higher grades indicate poorer differentiation. [D. F. Gleason (1920–2008), US pathologist]... gleason grade