Graft Health Dictionary

See BONE TRANSPLANT.... bone graft

Also known as keratoplasty. If the cornea (see EYE) becomes damaged or diseased and vision is impaired, it can be removed and replaced by a corneal graft. The graft is taken from the cornea of a human donor. Some of the indications for corneal grafting include keratoconus (conicalshaped cornea), corneal dystrophies, severe corneal scarring following HERPES SIMPLEX, and alkali burns or other injury. Because the graft is a foreign protein, there is a danger that the recipient’s immune system may set up a reaction causing rejection of the graft. Rejection results in OEDEMA of the graft with subsequent poor vision. Once a corneal graft has been taken from a donor, it should be used as quickly as possible. Corneas can be stored for days in tissue-culture medium at low temperature. A small number of grafts are autografts in which a patient’s cornea is repositioned.

The Department of Health has drawn up a list of suitable eye-banks to which people can apply to bequeath their eyes, and an o?cial form is now available for the bequest of eyes. (See also DONORS; TRANSPLANTATION.)... corneal graft

A complication of a bone marrow transplant in which immune system cells in the transplanted marrow attack the recipient’s tissues. Graft-versus-host (GVH) disease may occur soon after transplantation or appear some months later. The first sign is usually a skin rash. This may be followed by diarrhoea, abdominal pain, jaundice, inflammation of the eyes and mouth, and breathlessness.

GVH disease can usually be prevented by administration of immunosuppressant drugs. If the disease develops, it can be treated with corticosteroid drugs and immunosuppressant drugs such as ciclosporin In some cases, however, it can be difficult to control.... graft-versus-host disease

A technique used to repair areas of lost or damaged skin that are too large to heal naturally, that are slow

to heal, or that would leave tethering or unsightly scars. A skin graft is often used in the treatment of burns or sometimes for nonhealing ulcers. A piece of healthy skin is detached from one part of the body and transferred to the affected area. New skin cells grow from the graft and cover the damaged area. In a meshed graft, donor skin is removed and made into a mesh by cutting. The mesh is stretched to fit the recipient site; new skin cells grow to fill the spaces in the mesh. In a pinch graft, multiple small areas of skin are pinched up and removed from the donor site. Placed on the recipient site, they gradually expand to form a new sheet of healthy skin. (See also skin flap.)... skin graft

When coronary arteries, narrowed by disease, cannot supply the heart muscle with su?cient blood, the cardiac circulation may be improved by grafting a section of vein from the leg to bypass the obstruction. Around 10,000 people in the United Kingdom have this operation annually and the results are usually good. It is a major procedure that lasts several hours and requires the heart to be stopped temporarily, with blood circulation and oxygenation taken over by a HEART-LUNG MACHINE.... coronary artery vein bypass grafting (cavbg)

A condition that is a common complication of BONE MARROW transplant (see TRANSPLANTATION). It results from certain LYMPHOCYTES in the transplanted marrow attacking the transplant recipient’s tissues, which they identify as ‘foreign’. GVHD may appear soon after a transplant or develop several months later. The condition, which is fatal in about a third of victims, may be prevented by immunosuppressant drugs such as ciclosporin.... graft versus host disease (gvhd)

An operation in which large breaches of SKIN surface due to wounding, burns or ulceration are closed by TRANSPLANTATION of skin from other parts. There are three methods by which this is done. Most frequently the epidermis only is transplanted, using a method introduced by Reverdin and by Thiersch, and known by their names. For this purpose, a broad strip of epidermis is shaved o? the thigh or upper arm, after the part has been carefully sterilised, and is transferred bodily to the raw or ulcerated surface, or is cut into smaller strips and laid upon it. A second method is for small pieces of the skin in its whole thickness to be removed from the arm and thigh, or even from other people, and then implanted and bound upon the raw surface. (This method has the disadvantage that the true skin must contract at the spot from which the graft is taken, leaving an unsightly scar.) When very large areas require to be covered, a third method is commonly used. A large ?ap of skin, amply su?cient to cover the gap, is raised from a neighbouring or distant part of the body, in such a way that it remains attached along one margin, so that blood vessels can still enter and nourish it. It is then turned so as to cover the gap; or, if it be situated on a distant part, the two parts are brought together and ?xed in this position until the ?ap grows ?rmly to its new bed. The old connection of the ?ap is then severed, leaving it growing in its new place.

Researchers are having success in growing human skin in the laboratory for grafting on to people who have been badly burned and have insu?cient intact skin surface to provide an autologous graft (one provided by the recipient of the graft). Other techniques being researched are the use of specially treated shark skin and the production of arti?cial skin.... skin-grafting

The term given to a method of SKIN-GRAFTING (see also GRAFT) in which strips of skin are shaved from a normal area and placed on a burned, injured or scarred area to be grafted.... thiersch’s graft

The process of transplanting healthy tissue from one part of the body to another (autografting), from one person to another (allografting), or from an animal to a person (xenografting).

Grafting is used to repair or replace diseased, damaged, or defective tissues or organs. The most common operations of this type are skin graft, bone graft, bone marrow transplant, corneal graft, kidney transplant, heart transplant, liver transplant, heart–lung transplant, heartvalve surgery, and microsurgery on blood vessels and nerves.

With autografting, the grafted tissue is usually assimilated well into the surrounding tissue at the new site.

The general risks of tissue rejection following other forms of grafting are discussed in transplant surgery.... grafting

(CABG) *coronary revascularization in which a segment of a coronary artery narrowed by atheroma is bypassed by an *autologous section of healthy saphenous vein or internal mammary artery at *thoracotomy. The improved blood flow resulting from one or more such grafts relieves *angina pectoris and reduces the risk of *myocardial infarction. Recently developed techniques of *minimally invasive surgery have enabled the operation to be performed without the need for thoracotomy.... coronary artery bypass graft

(SSG, Thiersch’s graft) a type of skin graft in which thin partial thicknesses of skin are used to cover and heal a wound. They are removed from one site on the body, cut into narrow strips or sheets, and placed onto the wound area to be healed.... split-skin graft

see split-skin graft. [K. Thiersch (1822–95), German surgeon]... thiersch’s graft