Granisetron Health Dictionary

Vomiting means the expulsion of the STOMACH contents through the mouth. When the e?ort of vomiting is made, but nothing is brought up, the process is known as retching. When vomiting occurs, the chief e?ort is made by the muscles of the abdominal wall and by the diaphragm contracting together and squeezing the stomach. The contraction of the stomach wall is no doubt also a factor, and an important step in the act consists in the opening at the right moment of the cardiac or upper ori?ce of the stomach. This concerted action of various muscles is brought about by a vomiting centre situated on the ?oor of the fourth ventricle in the BRAIN.

Causes Vomiting is brought about by stimulation of this nervous centre, and in most cases this is e?ected through sensations derived from the stomach itself. Thus, of the drugs which cause vomiting, some act only after being absorbed into the blood and carried to the brain, although most are irritants to the mucous membrane of the stomach (see EMETICS); various diseases of the stomach, such as cancer, ulcer and food poisoning act in a similar way. Stimulation – not only of the nerves of the stomach, but also of those supplying other abdominal organs – produces vomiting; thus in obstruction of the bowels, peritonitis, gall-stone colic, renal colic, and even in some women during pregnancy, vomiting is a prominent symptom.

Severe emotional shock may cause vomiting, as may acute anxiety and unpleasant experiences such as seeing an accident, suffering severe pain or travel sickness.

Direct disturbance of the brain itself is a cause: for example, a blow on the head, a cerebral tumour, a cerebral abscess, meningitis. Nausea and vomiting are common symptoms that may arise from local disease of the gastrointestinal tract, but they are also associated with systemic illness – for example, DIABETES MELLITUS or kidney failure (see KIDNEYS, DISEASES OF) – and also with disturbances of labyrinthine function, such as motion sickness and acute labyrinthitis.

Treatment The cause of the vomiting must be sought and treatment directed towards this. Symptomatic treatment for vomiting can be dangerous since accurate diagnosis of the cause may be hindered. If antinauseant drug treatment is indicated, the choice of drug depends on the cause of the vomiting.

Granisetron and ondansetron are 5hydroxytryptamine (5HT3) antagonists valuable in the treatment of nausea and vomiting induced by cytotoxic CHEMOTHERAPY or RADIOTHERAPY and prevention and treatment of post-operative nausea and vomiting. Prochlorperazine is valuable in the treatment of severe nausea, vomiting, VERTIGO and disorders of the LABYRINTH of the EAR, although extrapyramidal symptoms may occur, particularly in children, elderly and debilitated patients.

Vomiting may occur after surgical operations and this is due to the combined effects of analgesics, anaesthetic agents and the psychological stress of operation. Various drugs can be used to prevent or stop post-operative vomiting.

Nausea and vomiting are common symptoms in pregnancy. Drugs are best avoided in this situation as they may damage the developing FETUS. Simple measures, such as the taking of food before getting up in the morning and reassurance, are often all that is necessary.... vomiting

A group of drugs used to treat the nausea and vomiting caused by radiotherapy and anticancer drugs. They are also used to control nausea and vomiting following surgery. Common serotonin antagonists include granisetron and ondansetron.... serotonin antagonists

n. a drug used to control severe nausea and vomiting, especially when it results from chemotherapy and radiotherapy. Ondansetron works by opposing the action of the neurotransmitter *serotonin (5-hydroxytryptamine) at 5HT3 receptors. Side-effects include constipation, headache, and flushing. Related drugs with similar actions and effects include granisetron and palonosetron.... ondansetron