The toxin has two components, one having haemagglutinin activity and the other neurotoxic activity which produces most of the symptoms. It has a lethal dose of as little as 1 mg/kg and is highly selective for cholinergic nerves. Thus the symptoms are those of autonomic parasympathetic blockade (dry mouth, constipation, urinary retention, mydriasis, blurred vision) and progress to blockade of somatic cholinergic transmission (muscle weakness). Death results from respiratory muscle paralysis. Treatment consists of supportive measures and 4 aminopyridine and 3, 4 di-aminopyridine, which may antagonise the e?ect of the toxin.... botulism
Habitat: Native to Europe and North America. Distributed in Western Himalayas from Kumaon westwards at 1,700-4,200 m.
English: Common Juniper.Ayurvedic: Hapushaa, Havushaa, Haauber, Matsyagandha.Unani: Abahal, Haauber, Hubb-ul- arar, Aarar.Action: Berries—diuretic, urinary antiseptic, carminative, digestive, sudorific, anti-inflammatory, emmenagogue. Used for acute and chronic cystitis, renal suppression (scanty micturition), catarrh of the bladder, albuminuria, amenorrhoea, leucorrhoea. Aerial parts—abortifacient.
Key application: In dyspepsia. (German Commission E.) Juniper berry may increase glucose levels in diabetics. (ESCOP.) As a diuretic.(The British Herbal Pharmacopoeia.)The Ayurvedic Pharmacopoeia of India recommends the dried fruit in malabsorption syndrome.Animal studies have shown an increase in urine excretion as well as a direct effect on sooth muscle contraction. (German Commission E, ESCOP.)Con- traindicated in kidney disease. (Sharon M. Herr.)(In Kerala, Hapushaa and Mundi are considered to be synonyms; Syphaer- anthus indicus,Asteraceae, is used as Hapushaa.)The major constituents of the volatile oil are alpha-pinene, sabinene and alpha-terpinene. Methanolic extract of the plant gave several labdane diter- penoids and diterpenes. The leaves contain the biflavones, cupressufla- vone, amentoflavone, hinokiflavone, isocryptomerin and sciadopitysin. The berries also contain condensed tannins. Seeds gave haemagglutinin.Juniperus recurva Buch-Ham ex D. Don, syn. J. excelsa auct. non-Bieb. (temperate Himalaya from Kashmir to Bhutan) is known as Weeping Blue Juniper. J. macropoda Boiss. (the Himalaya from Nepal onwards) is known as Himalayan Indian Juniper. Both the species are used like J. communis var. saxatillis.The berries gave a diterpene ketone, sugrol, beta-sitosterol glucoside and 10-nonacosanol.Plant extract can be used in toothpastes and mouth-rinses to reduce dental plaque and bleeding.Dosage: Dried fruit—2-6 g powder. (API, Vol. III.)... juniperus communisAn influenzal infection provides later protection only against the specific strain of virus concerned; the same holds true for immunization. Strains are classified according to the presence of different subtypes of two glycoproteins (antigens) on the viral surface: *haemagglutinin (H) and *neuraminidase (N). Small changes in the structure of these antigens, which occur frequently in influenza A and B viruses, require the continual development of new vaccines to protect against annual outbreaks of the disease. Major changes in antigenic structure occur much more rarely, when there is genetic recombination between strains that can infect more than one species (most strains of the virus are highly species-specific). However, when it does occur, it could result in the development of hybrid strains causing new forms of influenza that are difficult to contain; the pandemic of 1918–19 is thought to have arisen in this way (see also avian influenza; swine influenza).... influenza
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