The presence in the urine of haemoglobin. Haemoglobin is mainly contained in red blood cells, but a small amount is free in the blood plasma. Excessive breakdown of red blood cells, which may be due to heavy exercise, cold weather, falciparum malaria, or haemolytic anaemia, increases the concentration of free haemoglobin in the plasma. The excess haemoglobin is excreted in the urine.
The presence of blood pigment in the URINE caused by the destruction of blood corpuscles in the blood vessels or in the urinary passages. It turns urine a dark red or brown colour. In some people this condition, known as intermittent haemoglobinuria, occurs from time to time, especially on exposure to cold. It is also produced by various poisonous substances taken in the food. It occurs in malarious districts in the form of one of the most fatal forms of MALARIA: BLACKWATER FEVER. (See also MARCH HAEMOGLOBINURIA.)
n. the presence in the urine of free haemoglobin. The condition occurs if haemoglobin, released from disintegrating red blood cells, cannot be taken up rapidly enough by blood proteins. The condition sometimes follows strenuous exercise. It is also associated with certain infectious diseases (such as blackwater fever), ingestion of certain chemicals (such as arsenic), and injury.
A complication of walking and running over long distances. It is due to damage to red blood cells in the blood vessels of the soles of the feet. This results in HAEMOGLOBIN being released into the bloodstream, which is then voided in the URINE – the condition known as HAEMOGLOBINURIA. No treatment is required.... march haemoglobinuria
(PNH) a type of acquired haemolytic *anaemia that results from an abnormality of the red blood cell membrane. It is due to a defect in the formation of glycosylphosphatidylinositol (GPI), whose role is to anchor proteins to the lipid framework of the membrane. This leads to increased *complement-mediated destruction of red blood cells, which results in the release of haemoglobin in the circulation and then in the urine, giving the latter a reddish colour. Some patients may develop blood clots.... paroxysmal nocturnal haemoglobinuria
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