adj. damaging or destroying liver cells. Certain drugs, such as *paracetamol, can cause liver damage at high doses or with prolonged use.
Habitat: Assam and Arunachal Pradesh.
English: Storax, Oriental Sweet Gum.Ayurvedic: Shilaarasa, Turushka, Silhaka (substitute for Liquidamber orientalis, Hamamelidaceae).Siddha/Tamil: Neriyurishippal.Action: Resin—carminative, stomachic, antiscorbutic expectorant, antipyretic, anti-inflammatory, antistress, hepatoprotective. Externally used in scabies and leucoderma.
The ethyl acetate extract of the root of A. excelsa was studied for antistress effect in a variety of biological models of stress; also in stress-induced ulcers and CCl4-induced hepatotoxicity. Antistress was the most significant pharmacological property of the Storax.... altingia excelsaHabitat: Coastal areas of Bengal, Bihar and Western and Eastern Peninsula.
English: Palmyra Palm, Brab tree.Ayurvedic: Taala, Taada, Trinraj, Mahonnata, Lekhyapatra. Siddha/Tamil: Panai, Panaimaram.Action: Fresh sap—diuretic, cooling, antiphlegmatic, laxative, anti- inflammatory. Slightly fermented juice is given in diabetes. Palm- jaggery—used as an energy food for convalscents. Ash of dry spadix—antacid, antibilious (used in heartburn). Young root, terminal buds, leaf-stalks—used in gastritis and hiccups.
The sap is given as a tonic to asthmatic and anaemic patients. Jaggery is given for anaemia, for diseases characterized by a marked loss of potassium. Palm candy is used in coughs and pulmonary affections and as a laxative for children.The Ayurvedic Pharmacopoeia ofIn- dia recommends dried male inflorescence in dysuria.Jaggery solution may be used in hypertension and oedema due to heart and liver diseases, also as a food for typhoid patients.The sap is an excellent source of biologically available riboflavin.Aqueous MeOH extract of young shoots contains heat-stable toxin; edible part of young shoot, neurotoxic to rats, but not hepatotoxic.Dosage: Dried male inflorescence— 1-3 g (API Vol. III.)... borassus flabelliferMexican prickly poppy (Argemone mexicana).
Plant Part Used: Leaf, flower, root and stem.Dominican Medicinal Uses: Leaf/whole herb: prepared as a tea for blood-cleansing, cancer, stomach ulcers, delayed menstruation, vaginal infection, menopause symptoms; prepared as a douche for vaginal infection and inflammation; as a multi-herb mixture for ovarian cysts, uterine fibroids and tumors; root: boiled tea for stomach pain.Safety: Entire plant shown to be hepatotoxic due to sanguinarine and alkaloid content, especially concentrated in the seeds; internal use strongly cautioned against.Contraindications: Pregnancy, lactation, children.Laboratory & Preclinical Data: In vitro: antifungal, anti-HIV, anti-tumor, morphine-withdrawal alleviation, uterine stimulant (organic plant extracts).* See entry for Cardo santo in “Part 3: Dominican Medicinal Plant Profiles” of this book for more information, including references.
... cardo santoHabitat: Throughout the plains of India, especially in South India.
English: Sun Hemp.Ayurvedic: Shana, Shanapushpi, Malyapushpa.Unani: Sunn.Siddha/Tamil: Sanal, Manji, Sannappu.Folk: Jhanjhaniaa.Action: Leaf—demulcent, purgative, emetic, emmenagogue, abortifa- cient, ant-implantation. Given in diarrhoea, dysentery and bleeding disorders. Seeds—used in psoriasis and impetigo.
Seeds—hepatotoxic. Seed oil gave fatty acids—linoleic, linolenic and oleic.Pyrrolizidine alkaloids—junceine, tricodesmine, riddelline, seneciphyl- line and senecionine were also obtained.Dosage: Seed—1-3 g powder. (API Vol. III.)... crotalaria junceaHabitat: The temperate Himalayas from Kashmir to Kumaon at altitudes of 2,400-3,600 m.
English: Larkspur. Ayurvedic: Nirvishaa, Nirvishi. (Kyllinga triceps Rottb. is used as a substitute for Nirvishaa.)Unani: Jadwaar Khataai, Maatiryaaq.Folk: Root—astringent, vulnerary, deobstruent, alterative. Used for painful piles, muscular atrophy, gout and as a nervine tonic. Also used as an adulterant for aconite.Oral administration of the aqueous extract of the plant to rats with CCl4- induced hepatotoxicity revealed hepa- toprotective property of the plant.The roots contain campesterol, stig- masterol, sitosterol, cholesterol, delta- avenasterol and alkaloids including de- nudatine, denudatidine, condelphine, talatizidine and iso-talatizidine.... delphinium denudatumHabitat: Throughout India, up to 2,000 m on the hills.
English: Trailing Eclipta Plant.Ayurvedic: Bhringaraaja, Bhringa, Bhringaja, Bhrngaaraka, Bhrngaara, Maarkava, Kesharaaja, Keshranjana.Siddha/Tamil: Karisalaankanni.Folk: Bhangaraa.Action: Deobstruent, antihepato- toxic, anticatarrhal, febrifuge. Used in hepatitis, spleen enlargements, chronic skin diseases. Leaf—promotes hair growth. Its extract in oil is applied to scalp before bed time in insomnia. The herb is also used as an ingredient in shampoos.
Key application: As hepatoprotec- tive. (Indian Herbal Pharmacopoeia; The Ayurvedic Pharmacopoeia of India.)The herb should be dried at room temperature under shade. Its active principles are lost due to aerial oxidation during sun drying or drying under reduced pressure below 40°C. The herb contains wedelolactone and demethyl- wedelolactone, which showed a dose- dependenteffectagainstCCl4, d-galac- tosamine- or phalloidin-induced cyto- toxicity in primary cultured rat hep- atocytes, and exhibited potent anti- hepatotoxic property. The whole plant shows effect on liver cell regeneration. Immunoactive property has been observed against surface antigen of hepatitis B-virus. The plant is also reported to be effective in the treatment of peptic ulcer, inflammatory diseases, including rheumatoid arthritis, diseases of the gallbladder and skin infections.Aqueous extract of leaves exhibits myocardial depressant and hypoten- sive activity (unrelated to cholinergic and histaminergic effects).The roots are very rich in thio- phene acetylenes. Thiophene derivatives show activity against nematodes.Dosage: Whole plant—3-6 ml fresh juice; 13-36 g for decoction. (API Vol. II.)... eclipta albaHabitat: Native to tropical Southeast Asia; distributed throughout India; also planted in public parks.
English: Emblic, Indian gooseberry.Ayurvedic: Aaamalaki, Aaamalaka, Dhaatri, Kaayasthaa, Amoghaa, Amritaphala, Amla, Aaamalaa, Dhaatriphala, Vayasyaa, Vrshya, Shiva, Hattha.Unani: Aamalaa, Amlaj.Siddha/Tamil: Nellikkaai, Nelli.Action: Fruit—antianaemic, anabolic, antiemetic, bechic, astringent, antihaemorrhagic, antidiarrhoeal, diuretic, antidiabetic, carminative, antioxidant. Used in jaundice, dyspepsia, bacillary dysentery, eye trouble and as a gastrointestinal tonic. Juice with turmeric powder and honey is prescribed in diabetes insipidus. Seed—antibilious, antiasthmatic. Used in bronchitis. Bark—astringent. Leaf—juice is given in vomiting.
A decoction of powdered pericarp is prescribed for paptic ulcer.Key application: As an antacid. (Indian Herbal Pharmacopoeia.).The fruit is an important source of vitamin C, minerals and amino acids. The edible fruit tissue contains protein concentration threefold and vitamin C (ascorbic acid) concentration 160-fold than those of apple. The fruit also contains considerably higher concentration of most minerals and amino acids than apple.The fruit gave cytokinine-like substances identified as zeatin, zeatin ribo- side and zeatin nucleotide; suspension culture gave phyllembin. Phyllem- bin exhibits CNS depressant and spasmolytic activity, potentiates action of adrenaline and hypnotic action of Nembutal.The leaves contain gallic acid (10.8 mg/g dry basis), besides ascorbic and music acid. The methanol extract of the leaves is found to be effective in rat paw inflammation.The bark contains tannin identified as mixed type of proanthocyanidin.The fruit contains superoxide dis- mutase 482.14 units/g fresh weight and exhibits antisenescent (anti-aging) activity. Fruit, juice, its sediment and residue are antioxidant due to gallic acid. EtOH (50%) extract—antiviral.Aqueous extract of the fruit increases cardiac glycogen level and decreases serum GOT, GPT and LDH in rats having induced myocardial necrosis.Preliminary evidence suggests that the fruit and its juice may lower serum cholesterol, LDL, triglycerides and phospholipids without affecting HDL levels and may have positive effect on atherosclerosis. (Eur J clin Nutr, 42, 1988, 939-944; PhytotherRes, 14, 2000, 592-595.)An aqueous extract of the fruit has been reported to provide protection against radiation-induced chromosomal damage in both pre-and postirradiation treatment. The fruit is reported to enhance natural killer cell activity and antibody dependent cellular cytotoxicity in mice bearing Dalton's lymphoma ascites tumour. The extract of the fruit and ascorbic acid prevented hepatotoxic and nephrotoxic effects induced by lead and aluminium. The toxicity could be counteracted to a great extent by the fruit extract than by an amount of ascorbic acid alone equivalent to that contained in fruits. (The fruit can be used as a dietary supplement to counteract prolonged exposure to metals in population in industrial areas.)The fruits are reported to activate trypsin (proteolytic enzyme) activity.The fruits can be used as coagulant in the treatment of water and can purify low turbidity water.The fruits can be consumed safely all round the year.Dosage: Fresh fruit—10-20 g; pulp juice—5-10 ml. (API Vol. I.)... emblica officinalisHabitat: The temperate Himalayas up to 3,600 m and in Khasi Hills between 1,000 and 2,000 m.
English: Hemp Agrimony, Water Hemp, Hemp Eupatorium.Folk: Bundaar (Maharashtra), Tongollati (Assam).Action: Diuretic, cathartic, anti-tumoral. Used under strict medical supervision for blood impurities and tumours. Internal administration is not advised unless the hepatotoxic alkaloids are shown to be absent from the sample.
The herb contains volatile oil (about 0.5%); sesqiterpene lactones, the major one being eupatoriopicrin; flavonoids, pyrrolizidine alkaloids; immunoactive polysaccharides.Eupatoriopicrin has shown to be cy- tostatic as well as cytotoxic; it delayed transplanted tumour growth in mice in a dose-dependent manner.An aqueous extract of the plant exhibited anti-necrotic activity against carbon tetrachloride-induced hepato- toxicity in rats. The effect is attributed to the presence of flavonoids, rutoside, hyperoside and quercetin; phenolic acids, caffeic and chlorogenic; and not due to the presence of eupatoriopicrin.Acrylic acid and the lactic, malic and citric acids, present in the plant, also exhibited protective effect against acute toxicity induced by ethanol in mice.The polysaccharides have immuno- stimulatory activity and enhance phagocytosis in a number of immunolog- ical tests. The leaf oil is reported to exhibit fungicidal effect.A related species, Eupatorium odorum Linn., is known as Gondri in Ori- ssa.... eupatorium cannabinumHabitat: Native to the Mediterranean region; now cultivated mainly in Punjab, Assam, Maharashtra and Vadodara (Gujarat).
English: Fennel. (Poison hemlock has been misidentified as fennel.)Ayurvedic: Mishreyaa, Mishi, Mad- hurikaa, Madhuraa, Shatapushpaa, Shataahvaa. (Shatpushpaa is equated with Saunf and Shataahvaa with Soyaa. Some authors treat these as vice-versa.)Unani: Baadiyaan, Saunf.Siddha/Tamil: Sombu.Action: Carminative, stomachic, antispasmodic, emmenagogue, galactagogue, anti-inflammatory, diuretic. Relieves bloating, nausea, settles stomach and stimulates appetite. Also used in amenorrhoea and enuresis.
Key application: In dyspepsias such as mild, spastic, gastrointestinal afflictions, fullness, flatulence. Fennel syrup or honey can be used for the catarrh of the upper respiratory tract in children. Fennel oil preparations not recommended during pregnancy. (German Commission E, ESCOP, WHO.)German Commission E reported that fennel seed promotes gastrointestinal motility and in higher concentrations acts as antispasmodic. In experiments anethole and fenchone have been shown to have a secre- tolytic action in respiratory tract. The British Herbal Pharmacopoeia and Indian Herbal Pharmacopoeia report its carminative and spasmolytic property.Fennel seed contain about 8% volatile oil (about 50-60% anethole, among others 10-15% fenchone and methyl- chavicol), flavonoids, coumarins (including bergapten) and sterols.The extract of seeds inhibits the growth of micro-organism, especially Streptococcus mutans, that are responsible for dental caries and periodontal diseases.The essential oil from the seed is reported to be antibacterial, antifungal, antioxidant, emmenagogue, oxytocic and abortifacient.The fatty acid, petroselenic acid, obtained from the oil, exhibited antimicrobial activity.Anethole, a major constituent of fennel seed/oil has been found to be an active estrogenic agent with minimal hepatotoxicity and no teratogenic effect.The oil also exhibits anticarcino- genic activity and can be used as a che- moprotective agent.It possesses antioxidant activity close to BHT.Anethole and limonene are used in pharmaceutical compositions for decreasing the side effects of chemotherapy and increasing the immune function.Limonene showed the capacity to inhibit mammary tumours in rats.The boiling water extract of leaves shows hypotensive effect in rats.The methanolic extract of seed showed antispasmodic activity, while aqueous extract accelerated the spontaneous movement of rabbit stomach.Dosage: Dried fruit—3-6 g powder. (API Vol. I.)... foeniculum vulgareA localised (focal) form of liver disease in all tropical/subtropical countries results from invasive Entamoeba histolytica infection (amoebic liver ‘abscess’); serology and imaging techniques assist in diagnosis. Hydatidosis also causes localised liver disease; one or more cysts usually involve the right lobe of the liver. Serological tests and imaging techniques are of value in diagnosis. Whilst surgery formerly constituted the sole method of management, prolonged courses of albendazole and/or praziquantel have now been shown to be e?ective; however, surgical intervention is still required in some cases.
Hepato-biliary disease is also a problem in many tropical/subtropical countries. In southeast Asia, Clonorchis sinensis and Opisthorchis viverini infections cause chronic biliary-tract infection, complicated by adenocarcinoma of the biliary system. Praziquantel is e?ective chemotherapy before advanced disease ensues. Fasciola hepatica (the liver ?uke) is a further hepato-biliary helminthic infection; treatment is with bithionol or triclabendazole, praziquantel being relatively ine?ective.... liver disease in the tropics
Habitat: Throughout India, ascending up to 1,800 m in the hills.
Ayurvedic: Ahilekhana, Trikoshaki.Siddha/Tamil: Musumsukkai.Folk: Agmaki.Action: Tender shoots—gentle aperient, diuretic, stomachic; decoction used in biliousness and flatulence.
The root contains columbin; seed oil gave linoleic, oleic and palmitic acids. Fresh aerial parts exhibit potent anti- hepatotoxic activity.In carbon tetrachloride-induced liver dysfunction in albino rats, the recovery of liver, treated with the extract from aerial parts, was significant and there was marked decrease in serum levels of the enzymes, alanine, aminotransferase, aspartate amino- transferase and alkaline phosphatase.Kuruvikizhangu of Siddha medicine, used for acute diarrhoea and fever, is equated with Malothria per- pusilla (Blume) Cogn. Zehneria hook- eriana Arn., found in upper Gangetic plain from Nepal to Assam and in Peninsular India.... melothria maderaspatanaHabitat: Cultivated all over India for its fruits.
English: Bitter Gourd, Blsam Pear, Carilla.Ayurvedic: Kaaravellaka, Kaaravella, Kaathilla, Sushaavi.Unani: Karelaa.Siddha/Tamil: Paakal, Paharkai.Action: Seed/fruit—improves diabetic condition. Fruit—stomachic, laxative, antibilious, emetic, anthelmintic. Used in cough, respiratory diseases, intestinal worms, skin diseases, also for gout and rheumatism. Powdered fruit—applied to wounds and ulcers. Leaf— emetic, antibilious, purgative. Fruit, leaf and root—abortifacient. Leaf and seed—anthelmintic. Root— astringent; appled to haemorrhoids.
Immature fruits gave several nonbitter and bitter momordicosides. Fruits, seeds and tissue culture gave a polypeptide containing amino acids. Fruits also gave 5-hydroxytryptamine, charantin (a steroidal glucoside), dios- genin, cholesterol, lanosterol and beta- sitosterol. Bitter principles are cucur- bitacin glycosides.Hypoglycaemic effects of the fruit have been demonstrated by blood tests in both humans and animal studies.Researchers have warned that the fruit extract leads to a false negative test for sugar in the urine (due to its ability to maintain the indicator dye in the glucose oxidase strips and the alkaline copper salts in a reduced state).Chronic administration of the fruit extract (1.75 g/day for 60 days) to dogs led to testicular lesions with mass atrophy of the spermatogenic elements. The extract reduced the testicular content of RNA, protein and sialic acid as also the acid-phosphatase activity. (Medicinal Plants of India, Vol. 2,1987, Indian Council of Medical Research, New Delhi.)The fruits and seeds yielded a poly- peptide, p-insulin, which was considered similar to bovine insulin. (Fitoter- apia, 60,1989; Chem Abstr 112,1990.)The seed and fruit contain an inhibitor of HIV, MAP-30 (Momordi- ca anti-HIV-protein) which exhibited antiviral and antitumour activity in vitro. (Chem Abstr, 113, 1990; ibid, 117, 1992.) Another protein, MRK-29, found in the seed and fruit of a smaller var. of Bitter Gourd found in Thailand, was found to inhibit HIV reverse transcriptase and to increase tumour necrosis factor (TNF). (Planta Med, 67, 2001; Natural Medicines Comprehensive Database, 2007.)The seeds yield alpha-and beta- momorcharins (glycoproteins). When these glycoproteins were co-cultured with isolated hepatocytes, morphological changes in hepatocytes were observed, indicating hepatotoxicity. Another principle with antilipolytic and lipogenic activities, found along with the alpha-and beta-momorcharin in the seed extract, did not show toxic effect.Vicine is the hypoglycaemic constituent in the seed. Pure vicine has been found to possess 32.6% hypogly- caemic activity as against 22.2% shown by fresh juice, when tested on albino rats. The vicine is non-haemolytic.Dosage: Fresh fruit—10-15 ml juice (API, Vol. II); 10-20 ml juice (CCRAS.)... momordica charantiaHabitat: Throughout the hotter parts of India, particularly on cultivated land, up to 1,000 m.
Ayurvedic: Bhuumyaamalaki, Bahu- patri, Bhuudhaatri, Bahuphalaa, Taamalaki.Unani: Bhui Aaamalaa.Siddha/Tamil: Keelkaay Nelli.Action: Plant—diuretic, deobstru- ent, astringent, anti-inflammatory, styptic. Used as a single drug in the treatment of jaundice. Used in prescriptions for dyspepsia, indigestion, chronic dysentery, urinary tract diseases, diabetes, skin eruptions.
The leaves yielded lignans—phyl- lanthin (bitter), hypophyllanthin (nonbitter); niranthin, nirtetralin and phyl- tetralin. The whole plant gave a number of flavonoids, including quercetin, quercitrin, astragalin, rutin, kaempfer- ol. Isolation of a hydrolysable tannins, amarulone, is reported from the plant.The plant is reported to show antiviral activity against hepatitis B virus and related hepadna virus. It was also found to effectively repair CCl4-induced liver damage in rats.The herb exhibited hypotensive and hypoglycaemic activity. (Indian J Exp Biol 1995, 33 (11) 861-864.)Phyllanthus fraternus Webster: The ethanolic extract of the plant exhibited hepatotoxic-protective activity in albino rats pretreated with CCl-4, The petroleum extract is reported to possess analgesic and anti-inflammatory properties. The flavonoids, isolated from the ethanolic extract of the plant, exhibit hypoglycaemic activity in alloxan-treated albino rats. The ethanolic and aqueous extracts of the plant exhibit antibacterial and antifun- gal activity.Dosage: Root, stem, leaf—3-6. powder. (API, Vol. I and III.)... phyllanthus amarusHabitat: Warmer parts of India, from Central Himalayas to Assam, lower hills of West Bengal; Uttar Pradesh, Andhra Pradesh, Western
Ghats from Konkan southwards to Trivandrum. Often cultivated.English: Indian Long Pepper, Joborandi.Ayurvedic: Pippali, Maagadhi, Maagadha, Maagadhaa, Maagad- hikaa, Magadhodbhavaa, Vaidehi, Upkulyaa, Pippalikam, Chapalaa, Kanaa, Krishnaa. Uushnaa, Shaun- di, Kolaa, Tikshna-tandulaa.Unani: Filfil Daraaz, Daarfilfil.Siddha/Tamil: Thippili, Arisi thippili. Thippiliver (root).Action: Fruits—used for diseases of the respiratory tract (cough, bronchitis, asthma); as sedative (in insomnia and epilepsy); as chola- gogue (in obstruction of bile duct and bladder), as emmenagogue, as digestive, appetizer and carminative (in indigestion); as general tonic and haematinic (in anaemia, chronic fevers and for improving intellect). Applied locally on muscular pains and inflammations.
Several aristolactams and dioxoa- porphines have been isolated from Indian long pepper. It also contains the long chain isobutyl amide, longamide, besides guineensine and the lignans, pluviatilol, methyl pluviatilol (farge- sin), sesamin and asarinine.Piperine is the major alkaloid of peppers.Piperine is antipyretic, hypotensive, analeptic, CNS stimulant. It has been reported to exert significant protection against CCl4-induced hepatotoxicity in mice. It improves drug availability in experimental animals, and is used for enhancing the efficacy of co- administered medicaments.Piperine enhanced bioavailability of hexobarbital, phenytoin, propranolol and theophylline. (Sharon M. Herr.) (Piperine is also a component of Piper nigrum.)N - isobutyl - deca - trans - 2 - trans - 4 - dienamide, isolated from the fruit, exhibited antitubercular property.Milk extract of the fruit effectively reduced passive cutaneous anaphylaxis in rats. It protected guinea-pigs against antigen-induced bronchospasm.In China, Piper longum oil constituents were reported to inhibit the increase in serum total cholesterol induced by triton in mice.The root powder exhibited antifer- tility activity.A related species, P. peepuloides Roxb., is known as Saamvali Peepal. It is used specifically against obstinate skin diseases and as a sialagogue.Dosage: Fruit—1-3 mg (API, Vol. IV); root—1-3 g powder. (CCRAS.)... piper longumForsk
Synonym: P. Ispaghula Roxb.Family: Plantaginaceae.Habitat: Cultivated In Parts Of Rajasthan And Maharashtra.
English: Ispaghula, Spogel Seeds, Blond Psyllium.Ayurvedic: Ashvagola. Ashwakarna (Also Equated With Shorea Robusta).Unani: Aspaghol.Siddha/Tamil: Isapppa.Folk: Isabgol.Action: Seed And Husk—Laxative, Diuretic, Demulcent, Bechic, Cholinergic. Used In Inflammatory Conditions Of The Mucous Membrane Of Gastrointestinal And Genitourinary Tract, Chronic Amoebic And Bacillary Dysentery; Also In Hypercholesterolemia.
Key Application ? In Chronic Constipation And Irritable Bowel. (German Commission E.) Also In Constipation Due To Duodenal Ulcer Or Diverticulitis (Who.) German Commission E Also Noted That Blond Psyllium Seed Lowers Serum Cholesterol Levels. It Has Also Been Shown To Slow Sugar Absorption Thereby Reducing Blood Glucose. (Escop.) Use Of Blond Psyllium Husk Up To Six Months Did Not Clinically Alter Vitamin Or Mineral Status In A Review Of Eight Human Trials. It Did Not Reduce Absorption Of Calcium. (J Am Geriatr Soc, 43, 1995; Am J Clin Nutr, 71, 2000; Natural Medicines Comprehensive Database, 2007.)The Seed Contains Amino Acids Including Valine, Alanine, Glutamic Acid, Glycine, Cystine, Lysine, Leucine And Tyrosine; And A Mucilage Consisting Of A Mixture Of Polysaccharides Composed Mainly Of Xylose, Arabinose And Galacturonic Acid; Rhamnose And Galactose Are Also Present. The Seeds Also Gave Aucubin, The Antibacterial Principle. The Seed Coat Contains Fatty Acids Mainly Linoleic, Oleic And Palmitic Acids In Decreasing Concentrations.The Seeds Show A Liver Protective Effect On Induced Hepatotoxicity In Mice. In China, The Plant Is Used Clinically To Treat Certain Types Of Hepatitis (Activity Due To Aucubin Content).Dosage: Husk—5-10 G. (Ccras.)... plantago ovataHabitat: From Kashmir to Kumaon.
English: Knotgrass, Knotweed, Mexican Sanguinaria.Folk: Machoti, Kesri.Action: Astringent and haemostatic. Used for excessive menstruation, bleeding piles; bleeding from bowel, stomach, lungs, nose, throat; mucous colitis, children's summer diarrhoea.
Key application: In mild catarrhs of the respiratory tract, inflammatory changes to the oral and pharyngeal mucosa. (German Commission E.)The plant gave flavonoids including quercetin, avicularin, quercitrin, and derivatives of kaempferol, esculetin and scopoletin. The plant also gave gallic, caffeic, oxalic., silicic, chloro- genic and p-coumaric acids; tannins including catechin.The methanolic extract of the plant showed high protection against CCl4- induced hepatotoxicity in mice. This activity is attributed to the presence of flavonoid glucosides.The flavonoids exhibit astringent properties and are found to decrease capillary fragility and have a cortisonelike-effect on gingival tissue. (J Ethno- pharmacol, 74(1), 2001.)... polygonum aviculareHabitat: Native to the Mediterranean region, cultivated in Nilgiri Hills.
English: Rosemary.Folk: Rusmari.Action: Essential oil from flowers and leaves—anti-inflammatory, astringent, antiseptic, stomachic, carminative; used externally in circulatory disorders. Flowering tops and leaves—carminative, diuretic, emmenagogue; vapor baths afford relief in incipient catarrh, rheumatism and muscular affections.
Key application: Leaf—internally in dyspeptic complaints; externally in supportive therapy for rheumatic diseases and circulatory problems. (German Commission E.) Shows improvement of hepatic and biliary function.(ESCOP.) Carminative, spasmolytic of hepatic and biliary function. (ESCOP.) Carminative, spasmolytic. (The British Herbal Pharmacopoeia.)In research using rats, the essential oil and ethanolic extract of rosemary decreased drug-induced hepatotoxici- ty and the suppression of bone marrow cells. Phenolic compounds in the herb exhibit antioxidant activity. (Sharon M. Herr.)The herb contains volatile oil (1.02.5%), composed mainly of 1, 8-cineole (20-25%), alpha-pinene (15-25%), camphor (10-25%), others include bor- neol, isobutyl acetate, camphene, li- monene, linalool, 3-octanone, terpine- ol, verbenol; flavonoids including api- genin, diosmetin, diosmin; rosmarinic acid and other phenolic acids; diter- penes; rosmaricine; ursolic acid, olea- nolic acid and their derivatives.The anti-inflammatory effect of Rosemary has been attributed to ros- marinic acid, ursolic acid and apigenin. Among flavonoids, diosmin is reported to be more effective in decreasing capillary fragility than rutin. A ros- maricine derivative exhibits stimulant and mild analgesic activity.The phenolic fraction, isolated from the leaves, also from the oil, exhibits antioxidant activity.Pressed juice of leaves possesses a strong antibacterial action on Staphylococcus aureus, E. coli and Bacillis sub- tilis.An infusion of the plant with borax is used as a hair wash for preventing hair loss.Rosemary oil, in combination with the essential oil from thyme, lavender and cedarwood, showed improvement in hair growth by 44% after 7 months of treatment for alopecia areata. (Natural Medicines Comprehensive Database, 2007.)... rosmarinus officinalisHabitat: Native to Mediterranean region; cultivated all over India.
English: Garden Rue.Unani: Sudaab, Suddaab.Siddha/Tamil: Aruvada.Action: Herb—stimulating, antispasmodic, stomachic; irritant, abortifacient. Used as an emme- nagogue, in hysterical conditions, cough and croupy affections, colic and flatulence. Leaf—used in atonic amenorrhoea, menorrhoea and colic. Externally, used for sciatica, headache, muscular chest pain, bronchitis and arthritic conditions. (Fresh juice of leaves, internally, can lead to painful irritations of the stomach and intestines). Oil— antispasmodic, antiepileptic, em- menagogue, rubefacient. (Toxic in large doses.)
Ruta graveolens has been included among unapproved herbs by German Commission E.The herb contains a volatile oil, with 2-undecanone (30.73) 2-nona- none (18.06), 2-nonyl acetate (11.03), psoralen (1.28) and bergapten and xan- thotoxin (7.24%); rutin (about 2%). The flavonoids include quercetin; cou- marins include bergapten, daphnore- tin, isoimperatorin, naphthoherniarin, psoralen, pangelin, rutamarin, rutarin, scopoletin and umbelliferone. Tissue culture of the plant gave furacridone alkaloids. Tissue culture of the root gave gravacridondiol and its glucoside.The spasmolytic activity of the herb is attributed to the presence of bergapten, xanthotoxin and the essential oil. Anti-inflammatory and antitumour activity is due to rutin. The furo- coumarins are responsible for the herb's phototoxicity.The herb is hepatotoxic, and is con- traindicated in kidney diseases and bleeding disorders. (Sharon M. Herr.) Maximum safe level is 0.001% for Rue and 0.0002% for the oil. (Natural Medicines Comprehensive Database, 2007.)... ruta graveolensHabitat: Canada to Florida. Dried roots of S. albidum are imported into India.
English: Ague tree.Unani: Sassafras.Action: Root—used earlier for rheumatism, gout, kidney complaints and skin diseases.
Safrole is the main constituent of the volatile oil (80-90%), in addition to condensed tannins, resin, cinnam- ic acid derivatives. Safrole and its metabolite, L-hydroxysafrole are both neuro- and hepatotoxic (carcinogenic in animals). Its internal use is no more advised. Safrole-free extracts are ineffective.... sassafras albidumHabitat: The Western Himalayas and Kashmir at elevation of 3,0003,900 m.
Folk: Poshkar, Hatermuula (Kashmir).Action: Root—nervine tonic. Used as an adulterant of Saussurea lappa.
Whole plant extract gave senecio- nine.Habitat: The Nilgiris and Uttar Pradesh. Introduced into Indian gardens
English: Groundsel.Action: Formerly used as a diuretic, diaphoretic and emmenagogue, in dysmenorrhoea and bilious pains. No more recommended for internal use due to high concentration of hepatotoxic alkaloids. Infusion is used as a lotion in chronic mastitis, gout and haemorrhoids. Extracts of the plant are haemostatic.
From the dried plant material alkaloids (0.053-00.095%) have been isolated, including, seneciphylline, sene- cionine and retrorsine. Senecionine and retrorsine have been demonstrated to induce hepatic necrosis in experimental animals. The plant contains 950 mcg/kg of iodine on fresh basis.A related species used in Western herbal, Senecio aureus Linn. (Golden Groundsel, Squaw Weed) is a uterine relaxant, stimulant to gravid uterus and a soothing drug for nervous and vascular irritability, menopausal symptoms, hot flushes. Alkaloids include senecifo- line, senescine, senecionine and otose- nine—pyrrolizidine alkaloids, in isolation, are highly toxic to liver. The plant is recommended only for external use as a douche for excessive vaginal discharge.... senecio jacquemontianusHabitat: Europe and from the Mediterranean to Caucasian region. Russian Comfrey or Blue Comfrey has been introduced in Simla; Prickly Camfrey is cultivated in Western India.
English: Comfrey, Knitbone.Folk: Sankuutan (Maharashtra).Action: Vulnerary (The British Herbal Pharmacopoeia), astringent, demulcent, haemostatic, tissue- restorative (repairs broken bones and lacerated flesh, promotes formation of a callus).
Key application: Externally for fractures and sprains, to promote bone growth and formation of callus. (German Commission E.)Allantoin, a cell proliferant, helps repair damaged tissues. Antiinflammatory action is due to rosmarinic acid and other phenolic acids. Used for stomach ulcers, irritable bowel syndrome, colitis, hiatus hernia; pleurisy, bronchitis (contraindicated in oede- matous conditions of the lung); and for the treatment of fractures, sickets, varicose ulcers. Experiments, during the 1960s, reveal that pyrrolizidine alkaloids are toxic to liver (dispute still unresolved); it is still not clear if these are hepatotoxic in the context of the whole plant. The aerial parts are considered safe.Russian Comfrey or Blue Comfrey has been equated with Symphytum peregrinum Ledeb. (introduced into India in Simla).The Plant is a good source of al- lantoin, a drug used in the treatment of gastric ulcers, disorders of liver and cancer. Tincture of the fresh herb is reported to be used for asthma, bronchitis and congestive conditions of the lungs.... symphytum officinaleHabitat: All over India; also grown as green manure and as cover crop.
English: Purple Tephrosia, Wild Indigo.Ayurvedic: Sharapunkhaa, Vishikha-punkhaa, Sarphokaa.Unani: Sarponkhaa, Sarphukaa.Siddha/Tamil: Kattu-kolingi, Kolingi, Paavali, Mollukkay, Kollukkayvelai.Action: The drug is considered specific for the treatment of inflammation of spleen and liver (is known as Plihaa-shatru, Plihaari in Indian medicine).
Dried herb—diuretic, deobstruent, laxative. Given for the treatment of cough, bronchitis, bilious febrile attacks, insufficiency of the liver, jaundice (not effective in infantile cirrhosis), kidney disorders and for the treatment of bleeding piles, boils, pimples. Also used as a gargle. Root—decoction used in dyspepsia, diarrhoea, cough, bronchitis, adenoids, asthma and rheumatism. Juice is applied to skin eruptions. A liniment prepared from the root is employed in elephantiasis. Oil from seeds—specific against eruptions of the skin, eczema, scabies, leprosy. Seed extract—hypoglycaemic.Powdered aerial parts prevented elevation of SGOP, SGPT and bilirubin levels.Hepatoprotective effect of aerial parts was evaluated against (+)-galac- tosamine-induced and carbon tetra- chloride-induced hepatotoxicity in rats.The leaves contain rutin and rote- noids (0.65-0.80% on dry basis). Rote- noid content is highest in the seed (1.60-1.80%).The leaves also contain a triterpe- noid, lupeol, and beta-sitosterol.Seeds contain a diketone-pongamol; a dimethylchromene flavanone iso- lonchocarpin; furanoflavones karan- jin and kanjone; a flavanone purpurin; and sitosterol. A flavonoid, lanceolarin B, is also present in seeds.The plant extract led to marked lowering of blood glucose level in normal and alloxan-induced diabetic rabbits. In diabetic rabbits the extract exerted 60-70% hypoglycaemic effect as compared to tolbutamide.Shveta Sharapunkhaa (stems: covered with white hair; flowers: pale pink or pale violet) is equated with T. villosa Pers.The roots gave a prenylated fla- vanone 7-methylglabranin; pods contain rotenoids—villosin, villon, vil- losol, villosinol, villinol and villosone.The fresh root is credited with hy- poglycaemic properties, but leaves did not show any such effect. The juice of the leaf is given in dropsy. Ayurve- dic classical texts describe it as a special drug for treating sterility in women.Boiled leaves of T. uniflora subspecies petrosa (Kant-punkhaa) are used for the treatment of syphilis. The medicinal properties of the plant are more or less similar to those of T. purpurea, but to a milder degree.T. spinosa Pers. (South India, ascending to 400 m in hills) is also known as Kant-punkhaa (Mulukolingi in Tamil Nadu).The root is applied to inflammations and swellings of joints; a decoction is given in rheumatism.Chalcones, spinochalones A and B and flemistrictin A have been isolated from the root. Spinochalone C and spinoflavonones A and B, and fulvin- ervin A have been isolated from the plant.Dosage: Plant, root, seed—3-5 g powder. (CCRAS.)... tephrosia purpureaHabitat: Native to Europe. Imported for use in Unani medicine.
English: Germander, Wall Germander.Unani: Usqurdiyun, Kamaazariuus.Action: Gastric stimulant, diuretic, sudorific. Used in spleen disorders and rheumatism; topically in skin diseases.
The herb contains iridoid glyco- sides, including harpagide and acetyl harpagide; clerodane and neoclero- dane diterpenes; phenylpropanoids; volatile oil, containing about 60% ca- ryophyllene; tannins and polyphenols.One of the major furanoneoerodane diterpenes, teucrin A, is hepatotoxic.Ether extract of the flowering herb shows antibacterial activity.... teucrium chamaedrysHabitat: Western Himalayas from Kashmir to Nepal at 1,500-3,500 m.
English: Coughwort, Coltsfoot, Asses' Foot.Unani: Fanjiyun.Action: Leaves and flowers— anticatarrhal, antitussive, expectorant, antispasmodic, demulcent, anti-inflammatory. Used for dry, unproductive, irritative cough, smoker's cough, whooping cough, bronchial asthma (effect shortlived), laryngitis.
Key application: In acute catarrh of the respiratory tract with cough and hoarseness; acute, mild inflammation of the oral and pharyngeal mucosa. Contraindicated during pregnancy and nursing. (German Commission E.)The leaves and flowers contain flavo- noids including rutin, hyperoside and isoquercetin; pyrrolizidine alkaloids including senkirkine and tussilagine (about 0.015%); mucilage (about 8%) consisting of polysaccharides based on glucose, galactose, fructose, arabinose and xylose; inulin, tannins.Polysaccharides are antiinflammatory and immuno-stimulating, as well as demulcent. Flavonoids also have anti-inflammatory and antispasmod- ic action. Pyrrolizidine alkaloids have caused hepatotoxicity in rats fed daily on high doses, but not on daily low dose regimes. These are largely destroyed when the herb is boiled.The leaf contains an inhibitor of platelet activating factor (PAF). The PAF inhibitor can account for Coltsfoot's efficacy in asthma. The constituent, tussilagone has respiratory stimulant and cardiovascular (including pressor) activities. In animal studies, Coltsfoot is reported to have a pres- soreffect similartodopaminebut without tachyphylasis. (Natural Medicines Comprehensive Database, 2007.)... tussilago farfaraHabitat: A woody, shrubby vine, cultivated in Punjab, Rajasthan, Delhi, Uttar Pradesh Maharashtra, Karnataka, Andhra Pradesh and Tamil Nadu for edible fruits.
English: Wine Grape, European Grape. (Chinese: P'u-t'ao.)Ayurvedic: Draakshaa, Go-stani, Mrdvikaa. Dehydrated fruit— Daakh, Munnakaa, Kishmish.Unani: Angoor. Dehydrated fruit—Daakh, Maweez, Zabeeb, Munaqqaa, Kishmish.Siddha: Draksha.Action: Dried fruits, seedless— nourishing and invigorating. Used in prescriptions for cough, respiratory tract catarrh, subacute cases of enlarged liver and spleen; and in alcohol-based tonics (Aasavs).
The Ayurvedic Pharmacopoeia ofIn- dia recommends dried mature fruits (5-10 g) in anaemia, jaundice, dyspepsia, constipation, haemorrhagic diseases, gout, cough, dyspnoea, and alcoholism.Grape vine contains flavonoids, tannins, tartrates, inositol, carotenes, cho- line and sugars. The fruit contains tar- taric and malic acids, sugars, pectin, tannin, flavone glycosides, vitamins A, B1, B2, C and minerals; anthocyanins in red leaves and red grapes. Antho- cyanins reduce capillary permeability. Red leaves are astringent and anti- inflammatory; an infusion is used for diarrhoea, heavy menstrual bleeding and uterine haemorrhage; also in the treatment of varicose veins and haemorrhoids.Oligomeric proanthocyanidin extract of the seed is used in atherosclerosis due to its free radical scavenging ability, also in venous insufficiency, night vision, oedema due to injury and post surgery oedema.Proanthocyanidin extract decreased hepatotoxicity of acetaminophen in mice. Grape polyphenols, extracted from skin and seeds decreased hepatic injury from alcohol, but had no effect on ethanol-induced lipid changes in rats. (Sharon M. Herr.)Dosage: Dried mature fruits—5-10 g. (API, Vol. III.)... vitis viniferaHabitat: Throughout the drier and subtropical parts of India.
English: Winter Cherry. (Physalis alkekengi is also known as Winter Cherry.)Ayurvedic: Ashwagandhaa, Haya- gandhaa, Ashwakanda, Gandharva- gandhaa, Turaga, Turagagandhaa, Turangagandhaa, Vaajigandhaa, Gokarnaa, Vrishaa, Varaahakarni, Varadaa, Balyaa, Vaajikari. (A substitute for Kaakoli and Kshira- kaakoli.) Cultivated var.: Asgandh Naagori. (Indian botanists consider the cultivated plants distinct from the wild ones.)Unani: Asgandh.Siddha: Amukkuramkizhangu.Action: Root—used as an antiinflammatory drug for swellings, tumours, scrofula and rheumatism; and as a sedative and hypnotic in anxiety neurosis. Leaf— anti-inflammatory, hepatopro- tective, antibacterial. Fruits and seeds—diuretic. Withanine— sedative, hypnotic. Withaferin A—major component of biologically active steroids; as effective as hydrocortisone dose for dose. Antibacterial, antitumour, an- tiarthritic, significantly protective against hepatotoxicity in rats.
The root contains several alkaloids, including withanine, withananine, withananinine, pseudo-withanine, somnine, somniferine, somniferinine. The leaves of Indian chemotype contain 12 withanolides, including withaferin A. Steroidal lactones ofwithano- lide series have been isolated.Withanine is sedative and hypnotic. Withaferin A is antitumour, an- tiarthritic and antibacterial. Anti-inflammatory activity has been attributed to biologically active steroids, of which withaferin A is a major component. The activity is comparable to that of hydrocortisone sodium succinate.Withaferin A also showed significantly protective effect against CCl4- induced hepatotoxicity in rats. It was as effective as hydrocortisone dose for dose.The root extract contains an ingredient which has GABA mimetic activityThe free amino acids present in the root include aspartic acid, glycine, tyrosine, alanine, proline, tryptophan, glutamic acid and cystine.The Ayurvedic Pharmacopoeia ofIn- dia recommends Ashwagandha in im- potency. This claim could not be sustained in a recent experiment and raises a doubt about the equation of classical Ashwagandha with Withania somnifera. A methanolic extract of With- ania somnifera root induced a marked impairment in libido, sexual performance, sexual vigour and penile dysfunction in male rats. (Llayperuma et al, Asian J Androl, 2002, 295-298.)The total alkaloids of the root exhibited prolonged hypotensive, brady- cardiac and depressant action of the higher cerebral centres in several experimental animals.A withanolide-free aqueous fraction isolated from the roots of Withania somnifera exhibited antistress activity in a dose-dependent manner in mice. (Phytother Res 2003, 531-6.)(See also Simon Mills; American Herbal Pharmacopoeia, 2000; Natural Medicines Comprehensive Database, 2007.)Dosage: Root—3-6 g powder. (API, Vol. I.)... withania ashwagandhaConstituents: iridoid glycosides, tannins, volatile oil.
Action: anti-diarrhoea, anti-inflammatory, anti-rheumatism, antimicrobial, antiseptic (mild), stomach bitter, diaphoretic, brain tonic, antispasmodic. Has been associated with cases of liver disease and is not now used internally.
Uses: Summer diarrhoea in children, irritable bowel, acute dyspepsia, lack of appetite, chronic bronchitis, skin disorders, pyorrhoea and inflammation of the gums (tea used as a mouth wash). To induce weight loss in slimming diets. Travel sickness, cellulitis, flatulence. Gout.
Preparations: Average dose: 2-4g. Thrice daily. Tea. 1 teaspoon to each cup boiling water; infuse 15 minutes. Dose half a cup.
Liquid extract. Half-1 teaspoon in water.
Powder, capsules: 250mg. Dose: 2 capsules between meals.
Note: Given to facilitate weight loss it has been known to be hepatotoxic. Of historic interest only. ... germander
Alternatives. All types of irritation, including itching of anus and vulva.
Teas. Chaparral, Chickweed, Figwort, Dandelion, Boneset, Marigold, Nettles, Red Clover.
Tea formula. Equal parts: Figwort, Meadowsweet, Juniper berries. 1 heaped teaspoon to each cup boiling water; infuse 15 minutes; 1 cup thrice daily.
Tea (cold). Barberry bark: one heaped teaspoon to each cup cold water steeped overnight. Dose: 1 cup thrice during the following day.
Tablets/capsules. Blue Flag, Dandelion, Echinacea, Devil’s Claw, Poke root, Seaweed and Sarsaparilla, Wild Yam.
Formula. Echinacea 2; Dandelion 2; Poke root half. Dose – Powders: 500mg (two 00 capsules or one- third teaspoon). Liquid Extracts: one 5ml teaspoon. Tinctures: two 5ml teaspoons).
Practitioner. Tinctures BHP (1983). Barberry (Berberis vulgaris) 2; Kava Kava 1; Figwort 1. Dose: 1-2 teaspoons in water thrice daily for severe anal or vulval attack.
Topical. Wipe affected area with: (a) Witch Hazel water. (b) Witch Hazel water plus 2-3 drops Tincture Goldenseal (severe, anus or vulva). (c) Cider vinegar. (d) Jojoba oil. (e) Aloe Vera (anus and vulva). (f) Well diluted essential oils of Aromatherapy: Lavender, Aniseed. (g) 2-3 drops Australian Tea Tree oil to 100ml water. (h) Zinc and Castor oil cream. (i) Bathe with strong infusion Tansy (anus).
Evening Primrose oil capsules. Contain gamolenic acid which has a significant effect on relieving itching by its antihistamine action.
Diet. Gluten-free.
Vitamins. A. B-complex. B3. B6. B12. D. F.
Minerals. Zinc.
Note: Constantine Hering MD, physician, sums up the law of cure: “The direction of disease is inwards and upwards. The direction of cure is downwards and outwards. Symptoms that move deeper into the body and from the surface towards the head are considered dangerous. Any skin eruption, or itching, or nervous symptoms moving from the head towards the feet would be regarded as favourable.
“Itch is an effort of the central nervous system to move a deeper disturbance towards the skin where the irritation may be distressing but where it is least damaging.”
Perhaps the most common cause of chronic itching in the 1990s is Candida. ... itching
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