Human leucocyte antigen system Health Dictionary

A substance, usually a protein, that induces the formation of defending antibodies. Example: bacterial toxins, Juniper pollen (in allergies). Auto-immune disorders can occur when antibodies are formed against normal proteins created within the body.... antigen

A collective term for the brain, spinal cord, their nerves, and the sensory end organs. More broadly, this can even include the neurotransmitting hormones instigated by the CNS that control the chemical nervous system, the endocrine glands.... central nervous system

See IMMUNITY.

Age Disease and mode of administration

3 days BCG (Bacille Calmette-Guerin) by injection if tuberculosis in family in past 6 months.

2 months Poliomyelitis (oral); adsorbed diphtheria, whooping-cough (pertussis)1 and tetanus2 (triple vaccine given by injection); HiB injection.3

3 months Poliomyelitis (oral); diphtheria, whooping-cough (pertussis)1 and tetanus2 (triple vaccine given by injection); HiB injection.3

4 months Poliomyelitis (oral); diphtheria, whooping-cough (pertussis)1 and tetanus2 (triple vaccine given by injection); HiB injection.3

12–18 months Measles, mumps, and rubella (German measles)4 (given together live by injection).

(SCHOOL ENTRY)

4–5 years Poliomyelitis (oral); adsorbed diphtheria and tetanus (given together by injection); give MMR vaccine if not already given at 12–18 months.

10–14 females Rubella (by injection) if they have missed MMR.

10–14 BCG (Bacille Calmette-Guerin) by injection to tuberculin-negative children to prevent tuberculosis.

15–18 Poliomyelitis single booster dose (oral); tetanus (by injection).

1 Pertussis may be excluded in certain susceptible individuals.

2 Known as DPT or triple vaccine.

3 Haemophilus in?uenzae immunisation (type B) is being introduced to be given at same time, but di?erent limb.

4 Known as MMR vaccine. (Some parents are asking to have their infants immunised with single-constituent vaccines because of controversy over possible side-effects – yet to be con?rmed scienti?cally – of the combined MMR vaccine.)

Recommended immunisation schedules in the United Kingdom... immune system

A functional, not physical, system in the brain, generally considered to mediate emotions with metabolism.... limbic system

All the organs and tissues associated with the act of RESPIRATION or breathing. The term includes the nasal cavity (see NOSE) and PHARYNX, along with the LARYNX, TRACHEA, bronchi (see BRONCHUS), BRONCHIOLES and LUNGS. The DIAPHRAGM and other muscles, such as those between the RIBS, are also part of the respiratory system which is responsible for oxygenating the blood and removing carbon dioxide from it.... respiratory system

This extensive, complex and ?nely tuned network of billions of specialised cells called neurones (see NEURON(E)) is responsible for maintaining the body’s contacts with and responses to the outside world. The network also provides internal communication links – in concert with HORMONES, the body’s chemical messengers – between the body’s diverse organs and tissues, and, importantly, the BRAIN stores relevant information as memory. Each neurone has a ?lamentous process of varying length called an AXON along which passes messages in the form of electrochemically generated impulses. Axons are bundled together to form nerves (see NERVE).

The nervous system can be likened to a computer. The central processing unit – which receives, processes and stores information and initiates instructions for bodily activities – is called the central nervous system: this is made up of the brain and SPINAL CORD. The peripheral nervous system – synonymous with the cables that transmit information to and from a computer’s processing unit – has two parts: sensory and motor. The former collects information from the body’s many sense organs. These respond to touch, temperature, pain, position, smells, sounds and visual images and the information is signalled to the brain via the sensory nerves. When information has been processed centrally, the brain and spinal cord send instructions for action via motor nerves to the ‘voluntary’ muscles controlling movements and speech, to the ‘involuntary’ muscles that operate the internal organs such as the heart and intestines, and to the various glands, including the sweat glands in the skin. (Details of the 12 pairs of cranial nerves and the 31 pairs of nerves emanating from the spinal cord are given in respective texts on brain and spinal cord.)

Functional divisions of nervous system As well as the nervous system’s anatomical divisions, the system is divided functionally, into autonomic and somatic parts. The autonomic nervous system, which is split into sympathetic and parasympathetic divisions, deals with the automatic or unconscious control of internal bodily activities such as heartbeat, muscular status of blood vessels, digestion and glandular functions. The somatic system is responsible for the skeletal (voluntary) muscles (see MUSCLE) which carry out intended movements initiated by the brain – for example, the activation of limbs, tongue, vocal cords (speech), anal muscles (defaecation), urethral sphincters (urination) or vaginal muscles (childbirth). In addition, many survival responses – the most powerfully instinctive animal drives, which range from avoiding danger and pain to shivering when cold or sweating when hot – are initiated unconsciously and automatically by the nervous system using the appropriate neural pathways to achieve the particular survival reaction required.

The complex functions of the nervous system include the ability to experience emotions, such as excitement and pleasure, anxiety and frustration, and to undertake intellectual activities. For these experiences an individual can utilise many built-in neurological programmes and he or she can enhance performance through learning – a vital human function that depends on MEMORY, a three stage-process in the brain of registration, storage and recall. The various anatomical and functional divisions of the nervous system that have been unravelled as science has strived to explain how it works may seem confusing. In practical terms, the nervous system works mainly by using automatic or relex reactions (see REFLEX ACTION) to various stimuli (described above), supplemented by voluntary actions triggered by the activity of the conscious (higher) areas of the brain. Some higher functions crucial to human activity – for example, visual perception, thought, memory and speech – are complex and subtle, and the mechanisms are not yet fully understood. But all these complex activities rest on the foundation of relatively simple electrochemical transmissions of impulses through the massive network of billions of specialised cells, the neurones.... nervous system

Involving the whole body or organism, and not just individual parts.... systemic

Part of the nervous system which regulates the bodily functions that are not under conscious control: these include the heartbeat, intestinal movements, salivation, sweating, etc. The autonomic nervous system consists of two main divisions – the SYMPATHETIC NERVOUS SYSTEM and the PARASYMPATHETIC NERVOUS SYSTEM. The smooth muscles, heart and most glands are connected to nerve ?bres from both systems and their proper functioning depends on the balance between these two. (See also NERVES; NERVOUS SYSTEM.)... autonomic nervous system

This is a complex part of the nervous system, extending from the cortex to the medulla in the BRAIN, from which emerge descending spinal pathways which in?uence voluntary motor activity throughout the body. Although the normal functions of the system are poorly understood, there are characteristic signs of an extrapyramidal LESION. These include disturbance of voluntary movements, notably slowness and ‘poverty’ of movement; disturbance of muscular tone, which may be increased or decreased; and involuntary movements, such as a tremor, irregular jerking movements, or slow writhing movements.

Diseases There are several diseases that result from lesions to the extrapyramidal system, of which the most common is PARKINSONISM. Others include WILSON’S DISEASE, KERNICTERUS, CHOREA and ATHETOSIS.... extrapyramidal system

A glycoprotein hormone secreted by the PLACENTA in early pregnancy, and stimulating the CORPUS LUTEUM within the ovary (see OVARIES) to secrete OESTROGENS, PROGESTERONE, and relaxin. The hormone is essential for the maintenance of pregnancy up to about 6–8 weeks of gestation. A RADIOIMMUNOASSAY can be used to detect its presence, and pregnancy can be diagnosed as early as six days after conception by testing for it in the urine. Some tumours also secrete human chorionic gonadotrophin, particularly HYDATIDIFORM MOLE, which produces large amounts.... human chorionic gonadotrophin

A white blood cell.... leucocyte

See NERVOUS SYSTEM.... peripheral nervous system

A network of interdependent components that work together to attain the goals of the complex whole.... system

Part of the AUTONOMIC NERVOUS SYSTEM. It consists of scattered collections of grey matter known as ganglia, united by an irregular network of nerve-?bres; those portions where the ganglia are placed most closely and where the network of ?bres is especially dense being known as plexuses. The chief part of the sympathetic system consists of two ganglionated cords that run through the neck, chest, and abdomen, lying close in front of the spine. In conjunction with the other part of the autonomic nervous system – the parasympathetic – this part controls many of the body’s involuntary activities involving glands, organs and other tissues. (For further details, see NERVOUS SYSTEM.)... sympathetic nervous system

Lymph is the same fluid which oozes from a cut when bleeding stops. It surrounds every living cell. Lymph conveys to the blood the final products of digestion of food. It also receives from the blood waste products of metabolism. This is a two-way traffic.

Lymph fluid, loaded with waste, excess protein, etc, is sucked into the lymph tubes to be filtered by the spleen and the lymph nodes. The tubes are filled with countless one-way valves referred to collectively as the lymphatic pump, which propels the flow of lymph forwards. Lymph ultimately is collected in the main thoracic duct rising upwards in front of the spine to enter the bloodstream at the base of the neck.

A number of disorders may arise when the fluid becomes over-burdened by toxaemia, poor drainage and enlarged nodes (glands). Such un-eliminated wastes form cellulite – unwanted tissue formation and swelling. Thus, the soil may be prepared for various chronic illnesses from glandular disorders to arthritis. If the lymph is circulating freely it is almost impossible to become sick.

This system is capable of ingesting foreign particles and building up an immunity against future infection. Some herbal Lymphatics are also antimicrobials, natural alternatives to conventional antibiotics.

Treatment. Clivers is particularly relative to glandular swellings of neck and axillae.

For active inflammation: Echinacea, Goldenseal, Ginseng (Panax).

Alternatives. Teas: Clivers, Red Clover, Agnus Castus herb, Bladderwrack, Violet leaves, Marigold petals.

Decoctions: Blue Flag, Echinacea, Fenugreek seeds, Saw Palmetto.

Tablets/capsules. Agnus Castus, Echinacea, Bladderwrack, Red Clover, Thuja, Poke root, Fenugreek. Formula No 1. Echinacea 2; Clivers 1; Burdock 1; Poke root half. Dose: Liquid Extracts: one 5ml teaspoon. Tinctures: two 5ml teaspoons. Powders: 500mg (two 00 capsules or one-third teaspoon). Thrice daily.

Formula No 2. Equal parts: Blue Flag root, Poke root, Senna. Dose: as above.

Topical. Poultices: Slippery Elm, Fenugreek seeds, Marshmallow. Horsechestnut (Aesculus) ointment. ... lymphatic system

This refers to the whole circulatory system: the heart, the systemic circulation (the arteries and veins of the body) and the pulmonary circulation (the arteries and veins of the lungs). Blood circulates throughout the cardiovascular system bringing oxygen and nutrients to the tissues and removing carbon dioxide and other waste products.... cardiovascular system

The major histocompatibility complex, or human leucocyte antigen (HLA) region, consists of genetically determined antigens, situated on chromosome 6. Found in most tissues, though to a di?ering extent, the four gene loci are known as A, B, C, D, while the individual alleles at each locus are numbered 1, 2, 3, etc. The number of possible combinations is thus enormous, and the chance of two unrelated people being identical for HLA is very low.

HLA incompatibility causes the immune response, or rejection reaction, that occurs with unmatched tissue grafts. Strong associations between HLA and susceptibility to certain diseases – notably the AUTOIMMUNE DISORDERS such as rheumatoid arthritis, insulin-dependent diabetes, and thyrotoxicosis – have been described. Certain HLA antigens occur together more frequently than would be expected by chance (linkage disequilibrium), and may have a protective e?ect, conferring resistance to a disease. (See IMMUNITY.)... hla system

In simple terms, this is the genetic recipe for making a human being. GENOME is a combination of the words gene and chromosome, and a genome is de?ned as all the genetic material – known as deoxyribonucleic acid, or DNA – in a cell. Most genes encode sequences of AMINO ACIDS, the constituents of proteins, thus initiating and controlling the replication of an organism. The identi?cation and characterisation of the human genetic puzzle have been a key bioscience research target. The Human Genome Project was launched in 1990 (and completed in 2003) to produce a full sequence of the three million base pairs that make up the human genome.

Carried out as two separate exercises – one by a privately funded American team; another by an international joint venture between tax-funded American laboratories, a charitably funded British one and several other smaller research teams from around the world – the ?rst results were announced on 26 June 2000. In February 2001 the privately funded American group, known as Celera Genomics, announced that it had identi?ed 26,558 genes. At the same time the Human Genome Project consortium reported that it had identi?ed 31,000. Allowing for margins of error, this gives a ?gure much lower than the 100,000 or more human genes previously forecast by scientists. Interestingly, genes were found to make up only 3 per cent of the human genome. The remaining 97 per cent of the genome comprises non-coding DNA which, though not involved in producing the protein-initiating genetic activity, does have signi?cant roles in the structure, function and evolution of the genome.

One surprise from the Project so far is that the genetic di?erences between humans and other species seem much smaller than previously expected. For example, the Celera team found that people have only 300 genes that mice do not have; yet, the common ancestor of mice and men probably lived 100 million years or more in the past. Mice and humans, however, have around twice as many genes as the humble fruit ?y.

Cells die out when they become redundant during embryonic development: genes also die out during evolution, according to evidence from the Genome Project – a ?nding that supports the constant evolutionary changes apparent in living things; the Darwinian concept of survival of the ?ttest.

Apart from expanding our scienti?c knowledge, the new information – and promise of much more as the Genome Project continues – should enhance and expand the use of genetic engineering in the prevention and cure of disease. Studies are in progress on the gene for a receptor protein in the brain which will shed light on how the important neurotransmitter SEROTONIN in the brain works, and this, for example, should help the development of better drugs for the treatment of DEPRESSION. Another gene has been found that is relevant to the development of ASTHMA and yet another that is involved in the production of amyloid, a complex protein which is deposited in excessive amounts in both DOWN’S (DOWN) SYNDROME and ALZHEIMER’S DISEASE.... human genome

That part of the AUTONOMIC NERVOUS SYSTEM which is connected with the BRAIN and SPINAL CORD through certain nerve centres in the midbrain, medulla, and lower end of the cord. The nerves from these centres are carried in the third, seventh, ninth and tenth cranial nerves and the second, third and fourth sacral nerves. The action of the parasympathetic system is usually antagonistic to that of the sympathetic system. Thus it inhibits the action of the HEART and augments the action of the INTESTINE; whereas the sympathetic augments the action of the heart and inhibits that of the intestine. (See diagram of sympathetic and parasympathetic nervous systems under NERVOUS SYSTEM.)... parasympathetic nervous system

A vein or collection of veins which ?nish at both ends in a bed of capillary blood vessels. An important example is the hepatic portal system, comprising the portal vein and its tributaries. Blood from the stomach, pancreas, spleen and intestines drains into the veins that join up to comprise the portal vein into the liver, where it branches into sinusoids.... portal system

A collective term for all the organs involved in sexual reproduction. In the female these are the OVARIES, FALLOPIAN TUBES, UTERUS, VAGINA and VULVA. In the male these are the testes (see TESTICLE), VAS DEFERENS, SEMINAL VESICLES, URETHRA and PENIS.... reproductive system

See separate dictionary entry.... systemic lupus erythematosus (sle)

The heart and blood vessels, which together maintain a continuous flow of blood throughout the body. The system provides tissues with oxygen and nutrients, and carries away waste products. The circulatory system consists of 2 main parts: the systemic circulation, which supplies blood to the whole body apart from the lungs; and the pulmonary circulation to the lungs. Within the systemic circulation, there is a bypass (the portal circulation), which carries nutrient-rich blood from the stomach, intestine, and other digestive organs to the liver for processing, storage, or re-entry into general circulation.

In the systemic circulation, oxygen-rich blood from the pulmonary circulation is pumped under high pressure from the left ventricle of the heart into the aorta, from where it travels through arteries and smaller arterioles to all parts of the body. Within body tissues, the arterioles branch into networks of fine blood vessels called capillaries. Oxygen and other nutrients pass from the blood through the capillaries’ thin walls into body tissues; carbon dioxide and other wastes pass in the opposite direction. Deoxygenated blood is returned to the heart via venules, veins, and the venae cavae.

Venous blood returns to the right atrium of the heart to enter the pulmonary circulation. It is pumped from the right ventricle through the pulmonary artery

to the lungs, where carbon dioxide is exchanged for oxygen. The reoxygenated blood then returns through the pulmonary veins to the heart and re-enters the systemic circulation.... circulatory system

A type of virus that is responsible for warts and genital warts.

There are over 50 strains of human papillomavirus.

Infection with some of these strains is thought to be a causative factor in cervical cancer and anal cancer.... human papillomavirus

Also known as scleroderma, a rare autoimmune disorder that can affect many organs and tissues, particularly the skin, arteries, kidneys, lungs, heart, gastrointestinal tract, and

joints. The condition is 3 times as common in women and is most likely to appear between the age of 30 and 50.

The number and severity of symptoms varies. The most common symptom is Raynaud’s phenomenon. Also common are changes in the skin, especially of the face and fingers, which becomes shiny, tight, and thickened, leading to difficulty with movements. Other parts of the body may also be affected, leading to difficulty in swallowing, shortness of breath, palpitations, high blood pressure, joint pain, or muscle weakness. Progression of scleroderma is often rapid in the first few years and then slows down or even stops. In a minority of people, degeneration is rapid, and leads to death from heart failure, respiratory failure, or kidney failure.

There is no cure for scleroderma, but many of the symptoms can be relieved.... systemic sclerosis

A system in which prices for health services and payment methods are the same, regardless of who is paying. For instance, in an all payer system, federal or state government, a private insurer, a self-insured employer plan, an individual, or any other payer could pay the same rates. The uniform fee bars health care providers from shifting costs from one payer to another. See “cost shifting”.... all payer system

A complete system of theory and practices that has evolved independently of, and often prior to, the conventional biological approach. Many are traditional systems of medicine that are practised by individual cultures throughout the world. Traditional Oriental medicine and Ayurveda, India’s traditional system of medicine, are two examples.... alternative medical system

A system for planning of appointments between resources such as clinicians and facilities and patients. It is used in order to minimize waiting times, prioritize appointments and optimize the utilization of resources.... appointment scheduling system

A structured process developed to ensure that assessment is relevant, consistent, fair and valid. The system requires rules of operation, a regular review process and competent assessors.... assessment system

The several blood factors that enable the acid waste products of metabolism to be carried in the alkaline blood without disrupting its chemistry. These include carbolic acid, carbonates, phosphates, electrolytes, blood proteins, and erythrocyte membranes.... buffering system

The course of the circulation is as follows: the veins pour their blood, coming from the head, trunk, limbs and abdominal organs, into the right atrium of the HEART. This contracts and drives the blood into the right ventricle, which then forces the blood into the LUNGS by way of the pulmonary artery. Here it is contained in thin-walled capillaries, over which the air plays freely, and through which gases pass readily out and in. The blood gives o? carbon dioxide (CO2) and takes up oxygen (see RESPIRATION), and passes on by the pulmonary veins to the left atrium of the heart. The left atrium expels it into the left ventricle, which forces it on into the aorta, by which it is distributed all over the body. Passing through capillaries in the various tissues, it enters venules, then veins, which ultimately unite into two great veins, the superior and the inferior vena cava, these emptying into the right atrium. This complete circle is accomplished by any particular drop of blood in about half a minute.

In one part of the body there is a further complication. The veins coming from the bowels, charged with food material and other products, split up, and their blood undergoes a second capillary circulation through the liver. Here it is relieved of some food material and puri?ed, and then passes into the inferior vena cava, and so to the right atrium. This is known as the portal circulation.

The circle is maintained always in one direction by four valves, situated one at the outlet from each cavity of the heart.

The blood in the arteries going to the body generally is bright red, that in the veins dull red in colour, owing to the former being charged with oxygen and the latter with carbon dioxide (see RESPIRATION). For the same reason the blood in the pulmonary artery is dark, that in the pulmonary veins is bright. There is no direct communication between the right and left sides of the heart, the blood passing from the right ventricle to the left atrium through the lungs.

In the embryo, before birth, the course of circulation is somewhat di?erent, owing to the fact that no nourishment comes from the bowels nor air into the lungs. Accordingly, two large arteries pass out of the navel, and convey blood to be changed by contact with maternal blood (see PLACENTA), while a large vein brings this blood back again. There are also communications between the right and left atria, and between pulmonary artery and aorta. The latter is known as the ductus arteriosus. At birth all these extra vessels and connections close and rapidly shrivel up.... circulatory system of the blood

An information system that collects, stores and transmits information that is used to support clinical applications (e.g. transmission of laboratory test results, radiology results, prescription drug orders). Electronic medical records are one method by which clinical information systems can be created.... clinical information system

This is part of the body’s defence mechanism that comprises a series of 20 serum peptides (see PEPTIDE). These are sequentially activated to produce three signi?cant effects: ?rstly, the release of small peptides which provoke in?ammation and attract phagocytes (see PHAGOCYTE); secondly, the deposition of a substance (component C3b) on the membranes of invading bacteria or viruses, attracting phagocytes to destroy the microbes; thirdly, the activation of substances that damage cell membranes – called lytic components – which hasten the destruction of ‘foreign’ cells. (See IMMUNOLOGY.)... complement system

Cleavers tea has been used for centuries, even in ancient Greece. It is considered probably the best tonic for the lymphatic system available. Discover all of its benefits and learn how to make the most of this type of tea. Description of Cleavers tea Cleavers is an annual green plant that grows mostly in Britain, North America and Eurasia regions. The green to white flowers look like small balls and they are very sticky, similar to the leaves. Scientifically named gallium aparine, cleavers is also called bedstraw, barweed, catchweed, grip grass. The entire cleavers plant is used in herbal medicine and is harvested just before it blooms in early summer. The active constituents of cleavers tea are chlorophyll, citric acide, rubichloric acid, galiosin and tannins. To benefit the most from these constituents, you can consume cleavers, usually found in the form of tea, extracts, capsule, or fresh for many cooking recipes. The roasted seeds are used as a coffee substitute and the young leaves can be eaten like spinach. Cleavers tea has a slightly bitter taste and no odor. Cleavers tea brew For a tasty Cleavers tea, take 2 to 3 teaspoons of the dried above-ground parts of the plant and infuse them in a 250 mg cup of hot water for 10 or 15 minutes. You may add sugar or honey to improve its taste and drink up to three times per day. Cleavers tea  Benefits Cleavers tea is a strong detoxifying for the lymphatic system. It is diuretic, thus treating most of urinary tract infections. It cleans the blood, the liver and kidneys. The tea can be used together with Uva Ursi or Echinacea for best results. Applied topically, Cleavers tea helps in the treatment of many skin conditions like acne, eczema, psoriasis, dandruff, itchy scalp, sunburns or even wounds. Cleavers tea can be used as a facial tonner because it helps clear the complexion. Cleavers tea Side effects Cleavers tea has no known side effects. Though it is widely safe, children, pregnant or nursing women should drink it with precaution. Cleavers tea can surely be included in a healthy lifestyle. As long as you don’t exaggerate with it, you can enjoy the benefits of this tea and even use the plant to prepare many tasty recipes and salads.... cleavers tea - best tonic for the lymphatic system available in nature

A health system that includes all the elements required to meet all the health needs of the population.... comprehensive health system

Also known as ‘expert systems’, these are computer software systems intended to help doctors make clinical decisions. Primary care medicine is especially noted for its uncertainty by virtue of being most patients’ ?rst point of contact with health care, confronting the clinician with many ‘undi?erentiated’ health problems. So far, these systems have not been as e?ective as expected because of a failure to ana-lyse the needs of primary care. Simple procedures to prompt the delivery of treatment to patients with chronic conditions have improved care quality, but work needs to be done on their cost-e?ectiveness. The aim of more complex computerised support systems will be to forecast likely future events and the possible e?ectiveness of proposed interventions, based on available information about the patient and an understanding of the risks and e?cacy of interventions by doctors and other experts.

One example, called ISABEL, can be accessed by paediatricians to check on their diagnosis and management of many childhood disorders.... computerised decision-support systems

See “decision analysis”.... decision support system

See “health system”.... health care delivery system

The generation and the use of appropriate health information to support decision-making, health care delivery and management of health services at national and subnational level.... health information system

Services, facilities, institutions, personnel or establishments, organizations and those operating them for the delivery of a variety of health programmes.... health system infrastructure

Research dealing with the entire health system or only part of it, the object being to ensure that the system is optimally planned and organized and that programmes are carried out by the health system infrastructure efficiently and effectively and with appropriate technology.... health systems research

The name of the causative agent of AIDS.... hiv (human immunodeficiency virus)

Human skills and capabilities generated by investments in education and health.... human capital

The people, institutions and resources, arranged together in accordance with established policies, to improve the health of the population they serve, while responding to people’s legitimate expectations and protecting them against the cost of ill-health through a variety of activities, the primary intent of which is to improve health. Health systems fulfil three main functions: health care delivery, fair treatment of all, and meeting non-health expectations of the population. These functions are performed in the pursuit of three goals: health, responsiveness and fair financing. A health system is usually organized at various levels, starting at the community level or the primary level of health care and proceeding through the intermediate (district, regional or provincial) to the central level.... health system

A composite index that measures the overall achievements in a country in three basic dimensions of human development— longevity, knowledge and a decent standard of living. It is measured by life expectancy, educational attainment and adjusted income per capita in purchasing power parity (PPP) US dollars. The HDI is a summary, not a comprehensive measure of human development.... human development index (hdi)

See ASSISTED CONCEPTION.... human fertilisation & embryology act 1990

See ASSISTED CONCEPTION.... human fertilisation & embryology authority (hfea)

See AIDS/HIV.... human immunodeficiency virus

See HLA SYSTEM.... human leucocyte antigen (hla)

UK legislation that lays down the framework and rules governing organ transplantation. The UK Transplant Support Service Authority (UKTSSA), a special health authority set up in 1991, is responsible for administering the NHS Organ Donor Registry and the Act (see APPENDIX 7: STATUTORY ORGANISATIONS).... human organs transplants act

The study of the interrelationships between humans, the tools they use, and the environment in which they live and work.... human-factor research

A network of organizations, usually including hospitals and medical practitioner groups, that provides or arranges to provide a coordinated continuum of services to a defined population and is held both clinically and financially accountable for the outcomes in the populations served.... integrated delivery system / integrated services network (isn)

A system of databases designed to process and exchange information to support decision-making as well as implementation, monitoring and evaluation of programmes, activities and projects. See also “health information system”.... management information system

The following conditions are discussed under their individual headings: APHASIA; BRAIN, DISEASES OF; CATALEPSY; CHOREA; CRAMP; EPILEPSY; HYSTERIA; LEARNING DISABILITY; MEMORY; MENTAL ILLNESS; MULTIPLE SCLEROSIS (MS); NERVES, INJURIES TO; NEURALGIA; NEURITIS; PARALYSIS; PSYCHOSOMATIC DISEASES; SPINE AND SPINAL CORD, DISEASES AND INJURIES OF; STROKE; TABES.... nervous system, disorders of

See “integrated delivery system”.... organized delivery system

The use of digital imaging systems to replace conventional X-ray pictures and other imaging techniques. Though expensive to operate, digital imaging and storage systems o?er promising possibilities for transmission of clinical images within and between hospitals and community health-care units, providing fast access and remote working that will bene?t patients and health-care sta? alike. When security and con?dentiality are assured, images could be transferred via the Internet and teleradiology. In future, hospitals might be able to eliminate the costly physical transfer and storage of X-ray ?lms. The integration of PACS with hospital information systems in the NHS will (hopefully) facilitate the introduction of electronic radiology.... picture archiving and communications system (pacs)

A system that is based on incorporating divergent provider modalities (e.g. public, private, non-profit, etc.).... pluralistic system

A system whereby reimbursement rates are set for a given period of time prior to the circumstances giving rise to actual reimbursement claims.... prospective payment system

This consists of highly specialised cells scattered throughout the body, but found mainly in the SPLEEN, BONE MARROW, LIVER, and LYMPH nodes or glands. Their main function is the ingestion of red blood cells and the conversion of HAEMOGLOBIN to BILIRUBIN. They are also able to ingest bacteria and foreign colloidal particles.... reticulo-endothelial system

An ENZYME produced by glandular tissue in the PROSTATE GLAND. When the gland enlarges (see PROSTATE, DISEASES OF), greater amounts of PSA are secreted, raising the concentration of the enzyme in the blood. This is especially so in cancer of the prostate, and testing the level of PSA is an indicator that the disease may be present. There is much controversy about the use of PSA as a screening test. Its proponents claim that its use reduces deaths from prostate cancer; its opponents suggest that it does this only by bringing to light many cases that needed no treatment and would not have caused death in any case. Further, if the level of PSA is very high, the disease is already advanced; where the result is equivocal it is uncertain whether the bene?ts of treatment outweigh the risks.... prostate specific antigen (psa)

Major government schemes to ensure adequate health services to substantial sectors of the community through direct provision of services.... state medicine (health care systems)

A review of studies in which evidence has been systematically searched for, studied, assessed and summarized according to predetermined criteria.... systematic review

A school of thought evolving from earlier systems analysis theory and propounding that virtually all outcomes are the result of systems rather than individuals. In practice, the systems approach is characterized by attempts to improve the quality and/or efficiency of a process through improvements to the system.... systems approach

An error that is not the result of an individual’s actions, but the predictable outcome of a series of actions and factors that comprise a diagnostic or treatment process.... systems error

Creutzfeldt-Jakob disease. See: BOVINE SPONGIFORM ENCEPHALOPATHY. ... mad-cow disease, human

Wounds caused by one person biting another. Human bites rarely cause serious tissue damage or blood loss, but infection is likely, particularly if the bite is deep. There is a risk of tetanus infection. Transmission of hepatitis B, herpes simplex, and AIDS by a bite is a theoretical hazard.... bites, human

Your immune system consists of a series of antibodies and other microorganisms whose main purpose is to defend your system against external attacks. When we have a cold or flu, the main thing that keeps us alive is this line of defense that keeps all bacteria, infections and microbes away from us. Unfortunately, our immune system is not strong enough to fight all causes, so we need to enhance its power by taking a treatment. How a Tea for Immune System Works A Tea for Immune System must contain enough active constituents to fight a wide range of diseases. First of all, it must contain minerals, manganese, magnesium, iron, volatile oils, acids, tannins, nutrients and enzymes. These teas can be taken as cures for a short amount of time (1 or 2 weeks) to enhance your body strength, so you mustn’t exaggerate when taking it. Efficient Tea for Immune System A Tea for Immune System must contain a lot of active constituents and it must be very effective. If you don’t know which teas to choose from, here’s a list to guide you on: - Garlic Tea – can be found almost anywhere on the globe and it has a wide range of uses, from cuisine to pharmaceutical purposes. Also a great cure for diarrhea, this Tea for Immune System has a rather unpleasant taste and smell. Feel free to add honey, lemon, ginger or mint in order to make it more adequate. - Green Tea – probably the most important tea in the world, Green Tea contains all the ingredients necessary to promote a healthy life, full of great benefits. However, don’t take it in case you suffer from menstrual and menopausal pains in order to avoid stomach and uterus irritations. - Yerba Mate Tea – the South American tea has a series of health advantages and it’s been named by the scientific society “the new green tea”. Drink it from a traditional bombilla or straight from a normal glass, but make sure you know which the risks are and that you’re taking this treatment under supervision. - Ginseng Tea – this wonderful Chinese Tea is used as a main ingredient in the Asian cuisine, but also as a great adjuvant in cases of nausea, vomiting and auto-immune deficiencies. However, make sure that you’re using the right amount of herbs when preparing this decoction in order to avoid developing a acid foods and drinks intolerance! Tea for Immune System Side Effects When taken properly, these teas are generally safe. However, drinking more tea than it’s recommended may lead to constipation, upset stomach or even death. Talk to your doctor before starting any kind of herbal treatment and find out which are the risks. Don’t take a treatment based on a Tea for Immune System if you’re pregnant, breastfeeding, on anti coagulants, blood thinners or preparing for a surgery. Also, children must be kept away from these teas since there’s no study to prove how safe it is for them. When in doubt, always ask your doctor. If he says there’s nothing that could interfere with your treatment, choose a tea that fits you best and enjoy its health benefits!... tea for immune system

The collection of glands around the body that produce hormones.

These glands include the thyroid gland, pancreas, testes, ovaries, and adrenal glands.

Their hormones are responsible for numerous bodily processes, including growth, metabolism, sexual development and function, and response to stress.

Any increase or decrease in the production of a specific hormone interferes with the process it controls.

To prevent under- or overproduction, hormone secretion from many endocrine glands is regulated by the pituitary gland, which is in turn influenced by the hypothalamus in the brain according to a feedback mechanism.... endocrine system

The complete set of human genetic material. The human genome consists of 23 chromosomes, which, together, contain about 30,000 genes. All body cells contain 2 sets of the 23 chromosomes, one set inherited from the father and the other from the mother. An international research programme, the Human Genome Project, was launched in 1990 with the aim of identifying all the human genes. The first rough draft of the project was published in 2000.... genome, human

The nervous system is responsible for almost any reaction that comes from your body. From eyes to muscles and even hair, your body is a very complex electric system directed by your brain. Most of the problems that a person has in a lifetime are related to a nervous system failure. In order to treat this kind of problems or prevent them from happening, you may want to try a tea instead of all those traditional pills. How a Tea for Nervous System Works A Tea for Nervous System is indeed helpful if it contains an important amount of nutrients, enzymes, tannins, volatile oils and minerals (sodium, iron, magnesium and manganese). You may want to avoid a tea that has an elevated acids level since it may cause you even more damages. A Tea for Nervous System will make your body send all the active constituents to the affected areas and heal the damaged tissue. Efficient Tea for Nervous System In order to work properly, a Tea for Nervous System must show results in a short time period and be one hundred percent safe (you don’t want any more complications than you already have). However, before starting any kind of herbal treatment, remember to take the indicated dose and never surpass it in order to avoid other health problems. If you don’t know which teas could be helpful for you, here’s a list for guidance: - Oolong Tea – contains half the amount of caffeine that other teas have so it’s best for your health to give it a try every once in a while. This Tea for Nervous System will also strengthen your entire organism and rejuvenate the aspect of your skin. However, don’t drink more than 2 cups per day. - Green Tea – as the scientists have proved, this decoction contains all the ingredients necessary to sustain life, so it’s good for a number of other health complaints, such as infertility, headaches, nausea, loss of appetite, anemia and asthenia. Just make sure you avoid it at all costs in case you’re experiencing some menstrual or menopausal symptoms (it may cause uterine contractions and internal bleedings). - Black Tea – some say that it does more damages than good for your nervous system and some others think that this tea is worth a try. Having an elevated level of caffeine, this tea is highly addictive. In right amount, it can treat infertility, erectile dysfunctions, sore throats and colds. However, ask an herbalist before starting a treatment based on this Tea for Nervous System in order to find out which are the risks. Tea for Nervous System Side Effects When taken according to specifications, these teas are generally safe. However, exceeding the number of cups recommended per day may lead to other health complaints, such as nausea, diarrhea, uterine contractions, internal bleedings and headaches. If you’ve tried one of these teas and something doesn’t feel quite right, talk to your doctor as soon as possible! Don’t take a Tea for Nervous System if you’re pregnant, breastfeeding, on blood thinners or anticoagulants. The same advice if you’re preparing for a surgery (some of the active compounds in these teas may interfere with your anesthetic and cause death). But if you have the green light from your doctor, choose a tea that fits best your requirements and enjoy its wonderful health benefits!... tea for nervous system

The organs and ducts by which bile is formed, concentrated, and carried from the liver to the duodenum (the first part of the small intestine). Bile is secreted by the liver cells and collected by a network of bile ducts that carry the bile out of the liver by way of the hepatic duct. A channel called the cystic duct branches off the hepatic duct and leads to the gallbladder where bile is concentrated and stored. Beyond this junction, the hepatic duct becomes the common bile duct and opens into the duodenum at a controlled orifice called the ampulla of Vater. The presence of fat in the duodenum after a meal causes secretion of a hormone, which opens the ampulla of Vater and makes the gallbladder contract, squeezing stored bile into the duodenum.

The main disorders affecting the biliary system are gallstones, congenital biliary atresia and bile duct obstruction.

(See also gallbladder, disorders of.)... biliary system

A hormone produced by the placenta in early pregnancy. Human chorionic gonadotrophin (HCG) stimulates the ovaries to produce oestrogen and progesterone, which are needed for a healthy pregnancy. HCG is excreted in the urine, and its presence in urine is the basis of pregnancy tests on urine samples. ... gonadotrophin, human chorionic

(HLA) A type of protein belonging to the group known as histocompatibility antigens, which play a role in the immune system.... human leukocyte antigen

The group of organs responsible for digestion. It consists of the digestive tract (also known as the alimentary tract or canal) and various associated organs. The digestive tract consists of the mouth, pharynx, oesophagus, stomach, intestines, and the anus. The intestines are the small intestine (comprising the duodenum, jejunum, and ileum) and the large intestine (comprising the caecum, colon, and rectum). The associated organs, such as the salivary glands, liver, and pancreas, secrete digestive juices that break down food as it goes through the tract.

Food and the products of digestion are moved from the throat to the rectum by peristalsis (waves of muscular contractions of the intestinal wall).

Food is broken down into simpler substances before being absorbed into the bloodstream.Physical breakdown is performed by the teeth, which cut and chew, and the stomach, which churns the food. The chemical breakdown of food is performed by the action of enzymes, acids, and salts.

Carbohydrates are broken down into simple sugars. Proteins are broken down into polypeptides, peptides, and amino acids. Fats are broken down into glycerol, glycerides, and fatty acids.

In the mouth, saliva lubricates food and contains enzymes that begin to break down carbohydrates. The tongue moulds food into balls (called boli) for easy swallowing. The food then passes into the pharynx. From here, it is pushed into the oesophagus and squeezed down into the stomach, where it is mixed with hydrochloric acid and pepsin. Produced by the stomach lining, these substances help break down proteins. When the food has been converted to a semi-liquid consistency, it passes into the duodenum where bile salts and acids (produced by the liver) help to break down fats. Digestive juices released by the pancreas into the duodenum contain enzymes that further break down food. Breakdown ends in the small intestine, carried out by enzymes produced by glands in the intestinal lining. Nutrients are absorbed in the small intestine. The residue enters the large intestine, where water is absorbed. Undigested matter is expelled via the rectum and anus as faeces.... digestive system

The muscles of the body that are attached to the skeleton. These muscles are responsible for voluntary movement, and also support and stabilize the skeleton. In most cases, a muscle attaches to a bone (usually by means of a tendon) and crosses over a joint to attach to another bone. Muscles can produce movement by contracting and shortening to pull on the bone to which they are attached. They can only pull, not push, and are therefore arranged so that the pull of one muscle or group of muscles is opposed to another, enabling a movement to be reversed. Although most actions of the skeletal muscles are under conscious control, reflex movements of certain muscles occur in response to stimuli.

There are more than 600 muscles in the body, classified according to the type of movement they produce.

An extensor opens out a joint, a flexor closes it; an adductor draws a part of the body inwards, an abductor moves it outwards; a levator raises it, a depressor lowers it; and constrictor or sphincter muscles surround and close orifices.... muscular system

The female organs involved in ovulation, sexual intercourse, nourishing a fertilized ovum until it has developed into a full-grown fetus, and childbirth. With the exception of the vulva, which protects the opening of the vagina, these organs lie within the pelvic cavity.

Ova (eggs) are released at monthly intervals from the 2 ovaries, which also secrete oestrogen hormone; and progesterone hormones that control the reproductive cycle. The ova travel through the fallopian tubes to the uterus. Fertilization takes place if a sperm released into the vagina during sexual intercourse travels through the cervix and uterus to penetrate an ovum while it is in the fallopian tube.... reproductive system, female

The male organs involved in the production of sperm and in sexual intercourse. Sperm and male sex hormones (androgen hormones) are produced in the testes, which are suspended in the scrotum. From each testis, sperm pass into an epididymis, where they mature and are stored. Shortly before ejaculation, sperm are propelled into a duct called the vas deferens, which carries the sperm to the seminal vesicles behind the bladder. These 2 sacs produce seminal fluid, which is added to the sperm to produce semen.

Semen travels along 2 ducts to the urethra.

The ducts pass through the prostate gland, which produces secretions that are added to the semen.

At orgasm, semen is ejaculated from the urethra through the erect penis, which is placed in the woman’s vagina during sexual intercourse.... reproductive system, male

See lupus erythematosus.... systemic lupus erythematosus

A substance secreted by a specific type of tumour that can be detected in the blood and may be used to help monitor a patient’s response to therapy.

Alpha-fetoprotein is an example of a tumour-specific antigen.... tumour-specific antigen

See urinary tract.... urinary system

see blood group.... abo system

(APC) a cell, such as a *dendritic cell or a *macrophage, that processes antigen for presentation to a T lymphocytes (see helper T cell).... antigen-presenting cell

acute physiological and chronic health evaluation: a tool used to assess the severity of illness in a critically ill patient and to estimate mortality. The assessment uses information from 12 physiological measurements, including temperature, blood pressure, arterial pH, and certain blood results.... apache scoring system

another name for the *hepatitis B antigen, which was first discovered in the blood of an Australian aborigine. This disease is caused by a virus of which the Australia antigen forms part.... australia antigen

(CEA) a protein produced in the fetus but not in normal adult life. It may be produced by carcinomas, particularly of the colon, and is a rather insensitive marker of malignancy. It is an example of an *oncofetal antigen that is used as a *tumour marker, particularly in the follow-up of colorectal cancer.... carcino-embryonic antigen

a process that enables patients to voice concerns about the standard of care they receive. In the UK, any complaints should be raised as soon as possible, in the first instance locally with the NHS provider involved. Various statutory and voluntary advice and advocacy services are available to assist in this. If a patient is not satisfied with the outcome of local resolution, the matter can be referred to the *Parliamentary and Health Service Ombudsman. Legal action cannot usually proceed at the same time and only a small proportion of complaints proceed to law. Disciplinary procedures are separate from the complaints procedure although complaints may prompt or inform disciplinary action.... complaints system

(HHS) the major US government agency providing health care. The department was created in 1953 and assumed its current name in 1980. HHS administers more than 300 health and health-related programmes and services, including *Medicare and *Medicaid. Other activities include research, immunization services, and providing financial assistance for low-income families. Almost a quarter of federal spending occurs through HHS.... department of health and human services

(differential blood count) a determination of the proportions of the different kinds of white cells (leucocytes) present in a sample of blood. Usually 100 white cells are counted and classified under the microscope or by electronic apparatus, so that the results can readily be expressed as percentages of the total number of leucocytes and the absolute numbers per litre of blood. The information often aids diagnosis of disease.... differential leucocyte count

(EWS) a system to detect deteriorating patients on the ward. Certain physical parameters are accorded scores: the higher the scores for individual patients, the greater the deterioration in their condition. Parameters scored include blood pressure, respiratory rate, pulse rate, blood oxygen saturation, and level of consciousness. Adjustments can be made for increased age.... early warning system

a nondepartmental public body set up in 2007 to promote human rights and equality in regard to age, disability, gender, race, religion and belief, pregnancy and maternity, marriage and civil partnership, sexual orientation, and human rights. It replaced the Commission for Racial Equality, the Disability Rights Commission, and the Equal Opportunities Commission.... equality and human rights commission

a continuous compression bandage consisting of four layers that are applied and left in situ for up to seven days to treat venous leg ulcers, increasing the chance of healing by up to 30%. Thorough assessment of the patient’s status must be undertaken before the application.... four-layer system

one of the cylindrical units of which compact *bone is made. A Haversian canal forms a central tube, around which are alternate layers of bone matrix (lamellae) and lacunae containing bone cells. The lacunae are linked by minute channels (canaliculi).... haversian system

(House–Brackmann score, House–Brackmann scale, House–Brackmann facial weakness scale) a six-point grading system for patients with *Bell’s palsy or other forms of facial nerve palsy. Grade I is normal function; grade VI is a total palsy. [J. W. House and D. E. Brackmann (21st century), US otorhinolarygologists]... house–brackmann facial nerve grading system

see human placental lactogen.... human chorionic somatomammotrophin

see HIV.... human immunodeficiency virus

commercially available preparations of *follicle-stimulating hormone and *luteinizing hormone. They are used mainly to treat infertility in women with gonadotrophin deficiency due to hypopituitarism and to stimulate superovulation in women undergoing in vitro fertilization.... human menopausal gonadotrophins

Acts of the UK parliament in 1990 and 2008, establishing and amending principles for the legal supervision, by the Human Fertilisation and Embryology Authority, of the creation, use, and storage of human embryos outside the body and of their use in treatment and research. The 2008 amendments included a ban on sex selection for social reasons, recognition of same-sex couples as potential legal parents, and regulations related to developing areas of research using embryos. The 1990 Act had also reduced the legal time limit for most abortions from 28 weeks gestation (as in the 1967 Abortion Act) to 24 weeks. Interpretation and regulation of principles and practice in this rapidly developing area of research and practice continue and are often controversial.... human fertilisation and embryology acts

a massive international research project to isolate all the genes in human DNA and determine the sequence of genes on human chromosomes. The project began in 1988 and the full draft sequence was published in 2001; the high-quality sequence was completed in 2003. The human genome comprises some 3 × 109 nucleotide base pairs (see DNA) forming 22,000–25,000 genes, distributed among 23 pairs of chromosomes. Knowledge of the entire human genome has already resulted in the identification of the genes associated with many hereditary disorders and revealed the existence of a genetic basis or component for many other diseases not previously known to have one. Theoretically, this would enable the development of targeted drugs and the large-scale genetic screening of populations. See pharmacogenomics; targeted agent.... human genome project

(human chorionic somatomammotrophin) a protein hormone of 190 amino acids produced by the placenta during most but not all pregnancies. Despite its name it does not appear to have a role in lactation and its exact function remains obscure. It does, however, seem to contribute to the development of diabetes in some pregnancies.... human placental lactogen

a legal framework adopted by the United Nations following World War II that sought to define and promote fundamental entitlements, conditions, and freedoms to be afforded to all human beings. In the UK the Human Rights Act 1998 enacts the provisions of the 1950 European Convention on Human Rights, which sets out, via fourteen articles, an individual’s rights, entitlements, and freedoms.... human rights

the UK government agency, established by the Human Tissue Act 2004, that regulates the removal, use, and storage of human organs and tissue from both the living and the deceased for certain purposes as defined by the statute. These purposes include clinical research, clinical audit, and medical education. Anyone handling such material for those purposes should have a licence issued by the authority. Membership of the authority comprises clinical, scientific, academic, and lay representatives.... human tissue authority

(loop system) a device for helping people with some types of *hearing aid or *cochlear implant to hear more effectively in certain situations. Electrical signals from a television, sound system, or microphone are passed through an amplifier to a wire that is positioned in a loop encompassing the desired listening area. This creates an electromagnetic field that can be picked up by a coil within the hearing aid or cochlear implant. Induction loops are installed in such places as public buildings, lecture theatres, classrooms, and churches. See also assistive listening device.... induction loop system

(injury severity scale, ISS) a system used, particularly in *triage, for grading the severity of an injury. See also abbreviated injury scale.... injury scoring system

see IUS.... intrauterine system

see induction loop system.... loop system

(MSA) a condition that results from degeneration of cells in the *basal ganglia (resulting in *parkinsonism), the *cerebellum (resulting in *ataxia), the *pyramidal system, and the *autonomic nervous system (resulting in symptoms of autonomic failure, such as postural hypotension).... multiple system atrophy

the system of dual control of certain activities of the body by means of both nerves and circulating hormones. The functioning of the autonomic nervous system is particularly closely linked to that of the pituitary and adrenal glands. The system can give rise to neuroendocrine tumours (NETs), which have special structural features and often produce active hormones. See also neurohormone; neurosecretion.... neuroendocrine system

a protein normally produced only by fetal tissue but often produced by certain tumours. An example is *carcino-embryonic antigen (CEA), which has been used as a *tumour marker, especially in colorectal carcinomas.... oncofetal antigen

see PACS.... picture archiving and communication system

a collection of nerve fibres in the central nervous system that extend from the *motor cortex in the brain to the spinal cord and are responsible for initiating movement. In the medulla oblongata the fibres form a *pyramid (hence the name), within which they cross from one side of the brain to the opposite side of the spinal cord; this is called the decussation of the pyramids. Damage to the pyramidal system manifests in a specific pattern of weakness in the face, arms, and legs, abnormally brisk reflexes, and an extensor *plantar reflex (Babinski response).... pyramidal system

(NSF, nephrogenic fibrosing dermopathy) a rare condition, first reported in 1997, that occurs exclusively in patients with chronic kidney disease (CKD), who develop large areas of hardened skin with fibrotic nodules and plaques. Flexion contractures with an accompanying limitation of range of motion can also occur. Exposure to gadolinium, used as a contrast agent in magnetic resonance imaging, has been identified as a causative factor, but many patients with severe CKD have been exposed to gadolinium without consequence. Linear gadolinium preparations (Omniscan, OptiMARK) appear to carry the highest risk of NSF. There is no cure for the condition.... nephrogenic systemic fibrosis

(PSA) a protease enzyme produced by the glandular epithelium of the prostate. Its effect is to liquefy the semen within the ejaculate. Overall PSA has a half-life of 2–3 days. Increased quantities are secreted when the gland becomes enlarged or inflamed, and levels of PSA in the blood are significantly elevated in cancer of the prostate. Although there is no clear ‘cut-off’ level for normality, over 4 ng/ml in the blood is associated with a 20% risk of prostate cancer, even in patients with normal-feeling prostates on rectal examination. Age-specific PSA reference ranges are often used. Newer PSA assays can measure free PSA and compare it to the total PSA in the blood. Low free:total PSA ratios indicate a greater risk of prostate cancer and improve the discrimination between cancer and benign disease in men with a PSA in the range 4–10 ng/ml. PSA levels tend to be much higher in advanced prostate cancer and the rate of fall on treatment (e.g. after radical prostatectomy or radiotherapy) is a good prognostic indicator of response.... prostate specific antigen

(RIS) a computer database used to keep details of all the patients attending a clinical radiology department. It records patient demographics, imaging procedures done, medications given and dosage, person performing the imaging, and time and place of examination. Radiologist reports interpreting the images will also feature here. The RIS is vital to the functioning of a picture archiving and communications system (see PACS) and the electronic medical record system.... radiology information system

the system of nerve pathways in the brain concerned with the level of consciousness – from the states of sleep, drowsiness, and relaxation to full alertness and attention. The system integrates information from all of the senses and from the cerebrum and cerebellum and determines the overall activity of the brain and the autonomic nervous system and patterns of behaviour during waking and sleeping.... reticular activating system

(RES) a community of cells – *phagocytes – spread throughout the body. It includes *macrophages and *monocytes. The RES is concerned with defence against microbial infection and with the removal of worn-out blood cells from the bloodstream. See also spleen.... reticuloendothelial system

any of various methods in which the application of an agreed numerical scale is used as a means of estimating the degree of a clinical situation, e.g. the severity of an injury, the degree of patient recovery, or the extent of malignancy. Examples include the *Glasgow Coma Scale (or scoring system) and the *injury scoring system.... scoring system

a type of health-care system in which there is only one purchaser of health-care services, usually the government. The NHS is a single-payer system.... single-payer system

the system of blood vessels that supplies all parts of the body except the lungs. It consists of the aorta and all its branches, carrying oxygenated blood to the tissues, and all the veins draining deoxygenated blood into the vena cava. Compare pulmonary circulation.... systemic circulation

see shock.... systemic inflammatory response

a protein produced by cancer cells. Its presence in the blood can be revealed by means of a simple blood test, aiding the diagnosis of malignant melanoma and other cancers at their earliest – and most treatable – stages of development.... tumour-associated antigen

see cardiovascular system.... vascular system

those parts of the body involved in balance. The peripheral vestibular system, or *vestibular apparatus, is in the inner ear. The central vestibular system comprises those parts of the brain that are involved in balance. The central vestibular system receives other inputs as well as from the ear, in particular inputs from the eyes and proprioceptors.... vestibular system

Amenorrhoea/lack of menstruation (M,B):

French basil, carrot seed, celery seed, cinnamon leaf, dill, sweet fennel, hops, hyssop, juniper, laurel, lovage, sweet marjoram, myrrh, parsley, rose (cabbage & damask), sage (clary & Spanish), tarragon, yarrow.

Dysmenorrhoea/cramp, painful or difficult menstruation (M,C,B):

Melissa, French basil, carrot seed, chamomile (German & Roman), cypress, frankincense, hops, jasmine, juniper, lavandin, lavender (spike & true), lovage, sweet marjoram, rose (cabbage & damask), rosemary, sage (clary & Spanish), tarragon, yarrow.

Cystitis (C,B,D):

Canadian balsam, copaiba balsam, bergamot, cedarwood (Atlas, Texas & Virginian), celery seed, chamomile (German & Roman), cubebs, eucalyptus blue gum, frankincense, juniper, lavandin, lavender (spike & true), lovage, mastic, niaouli, parsley, Scotch pine, sandalwood, tea tree, thyme, turpentine, yarrow.

Frigidity (M,S,B,V):

Cassie, cinnamon leaf, jasmine, neroli, nutmeg, parsley, patchouli, black pepper, cabbage rose, rosewood, clary sage, sandalwood, ylang ylang.

Lack of nursing milk (M):

Celery seed, dill, sweet fennel, hops.

Labour pain & childbirth aid (M,C,B):

Cinnamon leaf, jasmine, true lavender, nutmeg, parsley, rose (cabbage & damask), clary sage.

Leucorrhoea/white discharge from the vagina (B,D):

Bergamot, cedarwood (Atlas, Texas & Virginian), cinnamon leaf, cubebs, eucalyptus blue gum, frankincense, hyssop, lavandin, lavender (spike & true), sweet marjoram, mastic, myrrh, rosemary, clary sage, sandalwood, tea tree, turpentine.

Menopausal problems (M,B,V):

Cypress, sweet fennel, geranium, jasmine, rose (cabbage & damask).

Menorrhagia/excessive menstruation (M,B):

Chamomile (German & Roman), cypress, rose (cabbage & damask).

Premenstrual tension/PMT (M,B,V):

Carrot seed, chamomile (German & Roman), geranium, true lavender, sweet marjoram, neroli, tarragon.

Pruritis/itching (D):

Bergamot, Atlas cedarwood, juniper, lavender, myrrh, tea tree.

Sexual overactivity (M,B):

Hops, sweet marjoram.

Thrush/candida (B,D):

Bergamot, geranium, myrrh, tea tree.

Urethritis (B,D):

Bergamot, cubebs, mastic, tea tree, turpentine.

Immune System

Chickenpox (C,S,B):

Bergamot, chamomile (German & Roman), eucalyptus (blue gum & lemon), true lavender, tea tree.

Colds/’flu (M,B,V,I):

Angelica, star anise, aniseed, copaiba balsam, Peru balsam, French basil, West Indian bay, bergamot, borneol, cabreuva, cajeput, camphor (white), caraway, cinnamon leaf, citronella, clove bud, coriander, eucalyptus (blue gum, lemon & peppermint), silver fir, frankincense, ginger, grapefruit, immortelle, juniper, laurel, lemon, lime, sweet marjoram, mastic, mint (peppermint & spearmint), myrtle, niaouli, orange (bitter & sweet), pine (longleaf & Scotch), rosemary, rosewood, Spanish sage, hemlock spruce, tea tree, thyme, turpentine, yarrow.

Fever (C,B):

French basil, bergamot, borneol, camphor (white), eucalyptus (blue gum, lemon & peppermint), silver fir, ginger, immortelle, juniper, lemon, lemongrass, lime, mint (peppermint & spearmint), myrtle, niaouli, rosemary, rosewood, Spanish sage, hemlock spruce, tea tree, thyme, yarrow.

Measles (S,B,I,V):

Bergamot, eucalyptus blue gum, lavender (spike & true), tea tree.... genito-urinary and endocrine systems