Hydrochlorothiazide Health Dictionary

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Hydrochlorothiazide: From 3 Different Sources

A thiazide diuretic drug used to reduce oedema in people with heart failure, nephrotic syndrome, and cirrhosis. It is also given for hypertension. Adverse effects include leg cramps, dizziness, rash, and impotence. The drug may rarely cause gout and may aggravate diabetes mellitus.
Health Source: BMA Medical Dictionary
Author: The British Medical Association
n. a thiazide *diuretic used in combination with other drugs (e.g. *amiloride) to treat fluid retention (oedema) and high blood pressure.
Health Source: Oxford | Concise Colour Medical Dictionary
Author: Jonathan Law, Elizabeth Martin

Thiazides

Thiazides are a group of moderately potent DIURETICS which are e?ective when taken by mouth. They act by inhibiting the reabsorption of sodium and chloride in the renal tubules. They also have a blood-pressure-lowering e?ect. Chlorothiazide was the ?rst member of this group to be introduced. Their main use is to relieve OEDEMA in heart failure.

All thiazides are active by mouth with an onset of action within 1–2 hours, and a duration of 12–24 hours. Chlorthalidone is a thiazide-related compound that has a longer duration of action and only requires to be given on alternate days. The other thiazide drugs available include bendro?uazide, cyclopenthiazide, hydrochlorothiazide, hydro?umethiazide, indapamide, mefruside, methychlothiazide, metolazone, polythiazide and xipamide.... thiazides

Amiloride

n. a potassium-sparing *diuretic that causes the increased excretion of sodium and chloride; it is often combined with a thiazide or loop diuretic (e.g. hydrochlorothiazide as co-amilozide) to reduce the potassium loss that occurs with these drugs. Amiloride may produce dizziness and weakness and its continued use may lead to an excessive concentration of potassium in the blood.... amiloride

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