A term applied to any condition that cannot be alleviated or cured by surgery, particularly cancers.
Cancers are classi?ed according to the type of cell from which they are derived as well as the organ of origin. Hence cancers arising within the bronchi, often collectively referred to as ‘lung cancer’, include both adenocarcinomas, derived from epithelium (surface tissue), and carcinomas from glandular tissue. Sarcomas are cancers of connective tissue, including bone and cartilage. The behaviour of cancers and their response to therapy vary widely depending on this classi?cation as well as on numerous other factors such as how large the cancer is, how fast the cells grow and how well de?ned they are. It is entirely wrong to see cancer as a single disease entity with a universally poor prognosis. For example, fewer than one-half of women in whom breast cancer (see BREASTS, DISEASES OF) is discovered will die from the disease, and 75 per cent of children with lymphoblastic LEUKAEMIA can be cured.
Incidence In most western countries, cancer is the second most important cause of death after heart disease and accounts for 20–25 per cent of all deaths. In the United Kingdom in 2003, more than 154,000 people died of malignant disease. There is wide international variation in the most frequently encountered types of cancer, re?ecting the importance of environmental factors in the development of cancer. In the UK as well as the US, carcinoma of the BRONCHUS is the most common. Since it is usually inoperable at the time of diagnosis, it is even more strikingly the leading cause of cancer deaths. In women, breast cancer was for a long time the most common malignant disease, accounting for a quarter of all cancers, but ?gures for the late 1990s show that lung cancer now heads the incidence list – presumably the consequence of a rising incidence of smoking among young women. Other common sites are as follows: males – colon and rectum, prostate and bladder; females – colon and rectum, uterus, ovary and pancreas.
In 2003, of the more than 154,000 people in the UK who died of cancer, over 33,000 had the disease in their respiratory system, nearly 13,000 in the breast, over 5,800 in the stomach and more than 2,000 in the uterus or cervix, while over 4,000 people had leukaemia. The incidence of cancer varies with age; the older a person is, the more likely it is that he or she will develop the disease. The over-85s have an incidence about nine times greater than those in the 25–44 age group. There are also di?erences in incidence between sexes: for example, more men than women develop lung cancer, though the incidence in women is rising as the effects of smoking work through. The death rate from cancer is falling in people under 75 in the UK, a trend largely determined by the cancers which cause the most deaths: lung, breast, colorectal, stomach and prostate.
Causes In most cases the causes of cancer remain unknown, though a family history of cancer may be relevant. Rapid advances have, however, been made in the past two decades in understanding the di?erences between cancer cells and normal cells at the genetic level. It is now widely accepted that cancer results from acquired changes in the genetic make-up of a particular cell or group of cells which ultimately lead to a failure of the normal mechanisms regulating their growth. It appears that in most cases a cascade of changes is required for cells to behave in a truly malignant fashion; the critical changes affect speci?c key GENES, known as oncogenes, which are involved in growth regulation. (See APOPTOSIS.)
Since small genetic errors occur within cells at all times – most but not all of which are repaired – it follows that some cancers may develop as a result of an accumulation of random changes which cannot be attributed to environmental or other causes. The environmental factors known to cause cancer, such as radiation and chemicals (including tar from tobacco, asbestos, etc.), do so by increasing the overall rate of acquired genetic damage. Certain viral infections can induce speci?c cancers (e.g. HEPATITIS B VIRUS and HEPATOMA, EPSTEIN BARR VIRUS and LYMPHOMA) probably by inducing alterations in speci?c genes. HORMONES may also be a factor in the development of certain cancers such as those of the prostate and breast. Where there is a particular family tendency to certain types of cancer, it now appears that one or more of the critical genetic abnormalities required for development of that cancer may have been inherited. Where environmental factors such as tobacco smoking or asbestos are known to cause cancer, then health education and preventive measures can reduce the incidence of the relevant cancer. Cancer can also affect the white cells in the blood and is called LEUKAEMIA.
Treatment Many cancers can be cured by surgical removal if they are detected early, before there has been spread of signi?cant numbers of tumour cells to distant sites. Important within this group are breast, colon and skin cancer (melanoma). The probability of early detection of certain cancers can be increased by screening programmes in which (ideally) all people at particular risk of development of such cancers are examined at regular intervals. Routine screening for CERVICAL CANCER and breast cancer (see BREASTS, DISEASES OF) is currently practised in the UK. The e?ectiveness of screening people for cancer is, however, controversial. Apart from questions surrounding the reliability of screening tests, they undoubtedly create anxieties among the subjects being screened.
If complete surgical removal of the tumour is not possible because of its location or because spread from the primary site has occurred, an operation may nevertheless be helpful to relieve symptoms (e.g. pain) and to reduce the bulk of the tumour remaining to be dealt with by alternative means such as RADIOTHERAPY or CHEMOTHERAPY. In some cases radiotherapy is preferable to surgery and may be curative, for example, in the management of tumours of the larynx or of the uterine cervix. Certain tumours are highly sensitive to chemotherapy and may be cured by the use of chemotherapeutic drugs alone. These include testicular tumours, LEUKAEMIA, LYMPHOMA and a variety of tumours occurring in childhood. These tend to be rapidly growing tumours composed of primitive cells which are much more vulnerable to the toxic effects of the chemotherapeutic agents than the normal cells within the body.
Unfortunately neither radiotherapy nor currently available chemotherapy provides a curative option for the majority of common cancers if surgical excision is not feasible. New e?ective treatments in these conditions are urgently needed. Nevertheless the rapidly increasing knowledge of cancer biology will almost certainly lead to novel therapeutic approaches – including probably genetic techniques utilising the recent discoveries of oncogenes (genes that can cause cancer). Where cure is not possible, there often remains much that can be done for the cancer-sufferer in terms of control of unpleasant symptoms such as pain. Many of the most important recent advances in cancer care relate to such ‘palliative’ treatment, and include the establishment in the UK of palliative care hospices.
Families and patients can obtain valuable help and advice from Marie Curie Cancer Care, Cancer Relief Macmillan Fund, or the British Association of Cancer United Patients.
www.cancerbacup.org.uk
www.mariecurie.org.uk... cancer
Symptoms. Weight loss. Pain upper abdomen. Change of bowel habit. Phlebitis. Low blood sugar. Sugar in the urine. Jaundice when head of the pancreas is involved. As little benefit is said to be gained from chemotherapy or radiotherapy, and because a majority of these tumours are unresectable, there would appear to be good grounds for herbal medicine, either as primary or supportive treatment.
Of possible therapeutic value for relief of accompanying gastric and pressure symptoms only: Sarsaparilla, Liquorice, Dandelion, Peppermint, Fennel, German Chamomile.
Tea. Barberry bark. 1 teaspoon to each cup of cold water. Steep overnight. Dose: half-1 cup 3 or more times daily.
Formula. Equal parts: Barberry bark, Dandelion, Galangal. Dose: Powders: 500mg (two 00 capsules or one-third teaspoon). Liquid extracts: 1 teaspoon (5ml). Tinctures: 2 teaspoons. Thrice daily to commence: after fourteen days increase as tolerated.
Primrose oil. High doses GLA believed to improve immune system and prevent weight loss.
Macrobiotic diet. A retired English doctor had cancer of the pancreas, inoperable, the size of a cricket ball, for which conventional treatment could do nothing. Regression being almost impossible, he would die within a few months. In the meantime he was advised to try the Macrobiotic diet comprising wholefoods, compost grown vegetables, vegetable oils and natural drinks such as carrot juice and herbal teas. He and his wife, living in Italy, carefully followed the diet, drank water only from a local spring and ate vegetables organically grown on their own land. The tumour diminished in size and the doctor recovered.
Note: Cessation of cigarette smoking will result in a decreased incidence of the disease in the male adult population. (American Journal of Public Health 1989 79 1016)
A substance found in fish oil has been shown experimentally to prevent cancer of the pancreas. Mackerel, herring and sardines are among fish with the ingredient.
Treatment by oncologist or general practitioner. ... cancer – pancreas
Causes. Smoking, alcohol, jagged teeth, chemical irritants, septic toxins, sprayed fruit and vegetables, poisoning by lead, arsenic and other chemicals, additives, hot foods, spicy curries and peppers, chewing tobacco.
Over 80 per cent found to be present in old syphilitic cases. Charles Ryall, surgeon, Cancer Hospital, regarded the two as comparable with that between syphilis and tabes. Dr F. Foester, Surgeon, concluded that epithelioma of the tongue as far more frequently preceded by syphilis than any other form of cancer.
(Hastings Gilford FRCS, “Tumours and Cancers”)
The condition may arise from a gumma or patch of leucoplakia (white patches) – at one time known as smoker’s tongue.
Of possible value. Alternatives:– Many plants have been shown to produce neoplastic activity, as observed in discovery of anti-cancer alkaloids of the Vinca plant (Vinchristine) and Mistletoe. Dr Wm Boericke confirms clinical efficacy of Clivers, promoting healthy granulations in ulcers and tumour of the tongue. Dr W.H. Cook advises a mouthwash of Goldenseal. For scirrhous hardening, juice of fresh Houseleek has a traditional reputation.
Tinctures. Equal parts Condurango and Goldenseal. 30-60 drops before meals in water; drops increased according to tolerance.
Local paint. Thuja lotion.
Case record. Dr Brandini, Florence, had a patient, 71, with inoperable cancer of the tongue. In the midst of his pain he asked for a lemon which immediately assuaged the pain. The next day gave him even greater relief. The doctor tried it on a number of similar patients with the same results, soaking lint in lemon juice.
Diet. See: DIET – CANCER.
Treatment by a general medical practitioner or hospital oncologist. ... cancer – tongue
Symptoms include: soreness of the mouth and throat, loss of appetite, etc.
For inoperable cancer chemotherapy is often deemed first choice of treatment. To some people this therapy is an endurance test. Many wear wigs because their hair has fallen out. Nausea and vomiting are common side-effects which may have an adverse effect upon moral and physical well-being. Often there is loss of quality of life.
Severity of the vomiting may be increased by defective function of kidneys, liver and pancreas; natural treatments are aimed at strengthening these organs with a possible improvement in a patient’s well-being and quality of life.
Teas. To rid the sickening taste, smell of sour brine and copper, and to dispel nausea: German Chamomile or Black Horehound. Anti-neoplasms – Vinca rosea herb or Violet leaves. 2 teaspoons to each cup boiling water; infuse 15 minutes. 1 cup freely.
Powders. Formula. Echinacea (to strengthen immune system) 2; Blue Flag root (anti-neoplasm) 1; Black Horehound (anti-emetic) 1; Ginkgo (anti-depressive) 2. Dose: 500mg (two 00 capsules or one-third teaspoon) every 3 hours with water or Violet leaf tea.
Liquid Extracts. Formula. Echinacea 2; Blue Flag root 1; Black Horehound 1; Ladyslipper 1. One 5ml teaspoon in water every 3 hours.
Vincristine. Dosage as on marked product.
External. For irritable skin rash: packs steeped in Castor oil, Aloe Vera gel or juice, or Houseleek juice. Note. Sips of Ginger ale have been known to relieve symptoms. ... chemotherapy
Heart transplant Replacement of a person’s unhealthy heart with a normal heart from a healthy donor. The donor’s heart needs to be removed immediately after death and kept chilled in saline before rapid transport to the recipient. Heart transplants are technically demanding operations used to treat patients with progressive untreatable heart disease but whose other body systems are in good shape. They usually have advanced coronary artery disease and damaged heart muscle (CARDIOMYOPATHY). Apart from the technical diffculties of the operation, preventing rejection of the transplanted heart by the recipient’s immune system requires complex drug treatment. But once the patient has passed the immediate postoperative phase, the chances of ?ve-year survival is as high as 80 per cent in some cardiac centres. A key di?culty in doing heart transplants is a serious shortage of donor organs.... heart surgery
Symptoms: bleeding, with alteration of bowel habit. Common in diverticular disease where large polyps may be undetected. Early detection by flexible sigmoidoscopy at hospital is essential to accurate diagnosis. Sudden episodes of unexplained diarrhoea and constipation.
The term refers to cancers of the ascending colon, caecum, transverse colon, hepatic flexure, descending colon, splenic flexure, sigmoid colon and rectum. The large bowel tumours are almost wholly adeno-carcinoma.
Common causes: ulcerative colitis, Crohn’s disease, necrotic changes in polyps. The colon is at risk from cancer on a diet high in protein, fat and alcohol and which is low in fibre. An exception is the average diet in Finland where a high fat intake is present with a low incidence of cancer. Strong evidence advanced, includes the heavy consumption of yoghurt (acidophylus lacto bacillus) by the population.
A study of 8006 Japanese men living in Hawaii revealed the close relationship between cancer of the rectum and alcohol consumption. A family history of pernicious anaemia predisposes.
A 19-year prospective study of middle-aged men employed by a Chicago electric company reveals a strong correlation between colorectal cancer and Vitamin D and calcium deficiency. Results “support the suggestion that Vitamin D and calcium may reduce the risk of colorectal cancer”. (Lancet, 1985, Feb 9, i, 307)
Patients with ulcerative colitis of more than 10 years standing carry the increased risk of developing colorectal cancer. There is evidence that malignancy in the bowel may be reduced by saponins. Alternatives of possible value. Inoperable lesions may respond to: Bayberry, Goldenseal, Echinacea, Wild Yam, Stone root, Black root, Mistletoe, Clivers, Marshmallow root, Violet leaves, Chickweed, Red Clover, Thuja.
Tea. Equal parts: Red Clover, Gotu Kola, Violet leaves. 2-3 teaspoons to each cup boiling water; infuse 15 minutes. Freely, as tolerated.
Tablets/capsules. Echinacea, Goldenseal, Wild Yam.
Formula. Echinacea 2; Bayberry 1; Wild Yam 1; Stone root 1; Goldenseal half; Liquorice quarter. Mix. Dose: Powders: 500mg (two 00 capsules or one-third teaspoon). Liquid extracts: 1 teaspoon. Tinctures: 2 teaspoons. Thrice daily and at bedtime.
Mistletoe: Injections of fresh plant (Iscador). (Dr Rudolph Steiner Institute, Switzerland)
Violet leaves: Daily irrigations of strong infusion.
Chickweed: Bathe rectum with strong infusion. Follow with Chickweed ointment.
Chinese Herbalism. (1) Tea – Pan-chih-lien (Scutellaria barbarta), 2 liang. (2) Tea. Feng-wei ts’ao (Pteris multifida) 1 liang, and po-chi (water chestnut) 2 liang. (3) Concoction of suitable amount of ts’ang-erh ts’ao, for bathing affected area. (Barefoot Doctor’s Manual)
Diagnosis. Exploration of proctosigmoidoscope to confirm.
Diet. Special emphasis on yoghurt which is conducive to bowel health; orally and by enema. A vegan uncooked raw food diet has been shown to reduce the body’s production of toxins linked with colon cancer. A switch from conventional Western cooked diet to an uncooked vegan diet reduced harmful enzymes produced by gut bacteria. (Journal of Nutrition)
A substance has been found in fish oil believed to prevent cancer of the colon. Mackerel, herring and sardines are among fish with this ingredient. Bowel cancer and additives. See: CROHN’S DISEASE (Note).
Preventive care. All 55-year-olds with this predisposing condition should be screened by sigmoidoscopy. Regular faecal occult blood tests advised.
Regular exercise helps prevent development of bowel cancer. (Nottingham University researchers) Treatment by general medical practitioner or oncologist. ... cancer-colorectal
Symptoms (non-specific). Loss of appetite, anaemia, weight loss; pain in abdomen, especially stomach area. Vomit appears as coffee grounds. Occult blood (tarry stools).
Causes. Alcohol, smoking cigarettes, low intake of fruits and vegetables. Foods rich in salt and nitrites including bacon, pickles, ham and dried fish. (Cancer Researchers in Digestive Diseases and Sciences) Long term therapy with drugs that inhibit gastric acid secretion increase risk of stomach cancer.
Of possible value. Alternatives:– Tea. Mixture. Equal parts: Red Clover, Gotu Kola, Yarrow. Strong infusion (2 or more teaspoons to each cup boiling water; infuse 15 minutes. As many cups daily as tolerated.
Formula. Condurango 2; Bayberry 1; Liquorice 1; Goldenseal quarter. Mix. Dose: Powders: 750mg (three 00 capsules or half a teaspoon). Liquid extracts: 1 teaspoon. Tinctures: 1-2 teaspoons. Thrice daily in water or honey.
Traditional. Rosebay Willowherb. Star of Bethlehem.
Chinese green tea. Anti-cancer effects have been found in the use of Chinese green tea extracts. Clinical trials on the therapeutic effects against early stomach cancer were promising. (Chinese Journal Preventative Medicines 1990. 24 (2) 80-2)
Chinese Herbalism. Combination. Oldenlandia diffusa 2 liang; Roots of Lu (Phragmites communis) 1 liang; Blackened Ginger 1 ch’ien; Pan-chih-lien (Scutellaria barbarta 5 ch’ein; Chih-tzu (gardenia jasminoides) 3 ch’ien. One concoction/dose daily. Follow with roots of Bulrush tea.
William H. Cook, MD. “Mullein greatly relieves pain, and may be used with Wild Yam and a little Water- Pepper (Polygonum Hydropiper).” The addition of Water-Pepper (or Cayenne) ensures diffusive stimulation and increased arterial force. Burns Lingard, MNIMH. Inoperable cancer of the stomach. Prescribed: Liquid Extract Violet leaves and Red Clover, each 4 drachms; Liquid Extract Cactus grand., 2 drops. Dose every 4 hours. Woman lived 30 years after treatment attaining age of 70.
Arthur Barker, FNIMH. Mullein sometimes helpful for pain.
Wm Boericke MD. American Cranesbill.
George Burford MD. Goldenseal.
Maria Treben. “After returning from a prison camp in 1947 I had stomach cancer. Three doctors told me it was incurable. From sheer necessity I turned to Nature’s herbs and gathered Nettle, Yarrow, Dandelion and Plantain; the juice of which I took hourly. Already after several hours I felt better. In particular I was able to keep down a little food. This was my salvation.” (Health Through God’s Pharmacy – 1981) Essiac: Old Ontario Cancer Remedy. Sheila Snow explored the controversy surrounding the famous cancer formula ‘Essiac’. This was developed by Rene Caisse, a Canadian nurse born in Bracebridge, Ontario, in 1888. Rene noticed that an elderly patient had cured herself of breast cancer with an Indian herbal tea. She asked for the recipe and later modified it. Rene’s aunt, after using the remedy for 2 years, fully recovered from an inoperable stomach cancer with liver involvement, and other terminal patients began to improve.
Rene’s request to be given the opportunity to treat cancer patients in a larger way was turned down by Ottawa’s Department of Health and Welfare. She eventually handed over the recipe to the Resperin Corporation in 1977, for the sum of one dollar, from whom cancer patients may obtain the mixture if their doctors submit a written request. However, records have not been kept up.
In 1988 Dr Gary Glum, a chiropractor in Los Angeles, published a book called ‘Calling of an Angel’: the true story of Rene Caisse. He gives the formula, which consists of 11b of powdered Rumex acetosella
(Sorrel), 1 and a half pounds cut Arctium lappa (Burdock), 4oz powdered Ulmus fulva (Slippery Elm bark), and 1oz Rheum palmatum (Turkey Rhubarb). The dosage Rene recommended was one ounce of Essiac with two ounces of hot water every other day at bedtime; on an empty stomach, 2-3 hours after supper. The treatment should be continued for 32 days, then taken every 3 days. (Canadian Journal of Herbalism, July 1991 Vol XII, No. III)
Diet. See: DIET – CANCER. Slippery Elm gruel.
Note: Anyone over 40 who has recurrent indigestion for more than three weeks should visit his family doctor. Persistent pain and indigestion after eating can be a sign of gastric cancer and no-one over 40 should ignore the symptoms. A patient should be referred to hospital for examination by endoscope which allows the physician to see into the stomach.
Study. Evidence to support the belief that the high incidence of gastric cancer in Japan is due to excessive intake of salt.
Note: A substance found in fish oil has been shown experimentally to prevent cancer of the stomach. Mackerel, herring and sardines are among the fish with the ingredient.
Treatment by or in liaison with hospital oncologist or general medical practitioner. ... cancer – stomach and intestines
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