Ketone Health Dictionary

A condition in which an excessive amount of ketones (see KETONE) are produced by the body and these accumulate in the bloodstream. The affected person becomes drowsy, suffers a headache, breathes deeply, and may lapse into a COMA. The condition results from an unbalanced metabolism of fat, which may occur in DIABETES MELLITUS or starvation.... ketosis

Acetone is a volatile, colourless organic compound of the KETONE group produced by the partial oxidation of fatty acids. In some abnormal conditions, such as starvation, uncontrolled diabetes (see DIABETES MELLITUS) or prolonged vomiting, acetone and other ketones can accumulate in the blood. Acetone may then appear in the urine, along with beta-hydroxybutyric and aceotacic acids, presaging developing COMA.... acetone

The production of ketones (see KETONE) in the body; abnormal ketogenesis may result in KETOSIS.... ketogenesis

This contains such an excess of fats that acetone and other KETONE bodies appear in the urine. The diet is sometimes used in the treatment of EPILEPSY and chronic infections of the urinary tract by Escherichia coli; butter, cream, eggs and fat meat are allowed, whilst sugar, bread and other carbohydrates are cut out as far as possible.... ketogenic diet

Ruta chalepensis

Rutaceae

San: Gucchapatra;

Hin: Pismaram, Sadab, Satari;

Ben: Ermul;

Mal: Aruta, Nagatali;

Tam: Aruvadam, Arvada;

Kan: Sadabu, Nagadali; soppu, Simesdanu;

Tel: Sadapa, Aruda

Importance: Common rue or Garden rue also known as Herb of Grace due to its service in the Roman Catholic Church for sprinkling the holy water among the congregation, is an aromatic perennial herb. The plant is useful in vitiated conditions of kapha and vata, strangury, fever, flatulence, colic, amenorrhoea, epilepsy and hysteria. The oil acts as a stimulant for uterine and nervous systems. The fresh leaves are used for rheumatalgia. The juice obtained from the leaves is given to children for helminthic infections and is good for odontalgia and otalgia (Warrier et al, 1996). The dried leaves, powdered and combined with aromatics, are given as a remedy for dyspepsia and with the fresh leaves a tincture is made which is used as an external remedy in the first stages of paralysis (Nadkarni, 1998).

Distribution: The plant is a native of South Europe and it is found in subtropical countries. It is commonly cultivated in Indian gardens.

Botany: Ruta chalepensis Linn.syn. R. graveolens Linn. var. angustifolia Sensu Hook. f. belongs to the family Rutaceae. It is an aromatic perennial herb growing upto 75cm height. Leaves are compound, shortly petiolate with ultimate segments oblong or obovate-oblong. Flowers are yellow. Fruits are capsules and shortly pedicelled (Warrier et al, 1996).

Agrotechnology: The plant is suited to areas which are about 1000m above mean sea level and with moderate rainfall and sunlight. The plant can be propagated either by seeds or stem cuttings. Seeds are to be sown in seedbeds. Stem cuttings of length 20-25cm are to be planted in polybags for rooting. About 3-4 months old seedlings can be transplanted to pots and harvested when plants attain 6-8 months age. In highlands land is to be ploughed to a fine tilth, mixed with organic manure and seedlings are to be transplanted at a spacing of 45cm between plants. Irrigation is essential during summer months. Regular weeding is to be done. The plant is not attacked by any serious pests and diseases. Harvesting commences from sixth month onwards. The economic part is the whole plant and the oil extracted from it (Prasad et al, 1997).

Properties and activity: Roots contain coumarins-xanthyletin and (-)-byakangelicin. The alkaloids are rutacridone-epoxide, gravacridonol and its monomethyl ether, gravacridonchlorine, furacridone, 1-hydroxy-3-methoxy-N-methylacridone, iso-gravacridonechlorine, dictamine, r-fragarine and skimmianine. Skimmianine is also present in leaves and stem. Leaves and stem also contain graveolinine (1-methyl-2(3’,4’-methylenedioxyphenol)-4-methoxy- quinoline). Aerial parts give coumarins bergapten, xanthotoxin and psoralen. Coumarin- imperatin has also been reported from the plant. Herb contains alkaloids such as kokusagenine, rutamine(methylgraveoline) and graveoline(1-methyl-2(3’,4’- methylenedioxyphenyl)-4-quinoline). Tissue culture of the plant gives furacridone alkaloids-1-hydroxyrutacridone-epoxide, rutagravin and gravacridonol. Gravacridondiol and its glucoside have been obtained from the root tissue culture. The essential oil from leaves, stem and root yielded aliphatic ketones including 2-nonanone (10-35%), undecyl-2-acetate (0.5-15%), 2-nonyl acetate (trace-10%), nonylacetate, nonanol, 2-nonylpropionate, 2- nonylpropionate, 2-undecanol and its esters. The oil from roots gave pregeijerene also.

The plant is spasmolytic which is due to the presence of bergapten, xanthotoxin, the essential oil and a coumarin. It is also antispasmodic, emmenagogue, irritant, abortifacient and anti-bacterial. Leaf is analgesic, antirheumatic, antihysteric and anthelmintic (Husain et al, 1992).... garden rue

DC.

Family: Compositae; Asteraceae.

Habitat: Uttar Pradesh, Maharashtra, Karnataka, Tamil Nadu, Kerala.

Ayurvedic: Kukundara (var.).

Unani: Kakarondaa.

Folk: Nirmudi (Maharashtra).

Action: Juice of the herb— carminative. A warm infusion of leaves is given as a sudorific, while a cold infusion is considered diuretic and emmenagogue. The oil possesses significant antibacterial and antifungal properties. The oil also shows insecticidal activity.

The essential oil contains 95% ketones, the chief constituent of which are d-carvotanacetone and l-tetrahydro- carvone and an alcohol.

The plant contains a flavonol, cri- anthin (isolated from the flowers). It is identical to artemetin, isolated from Artemisia absinthium.... blumea eriantha

(Linn.) Spreng.

Family: Euphorbiaceae.

Habitat: Throughout India up to an altitude of 1,000 m, except in very dry regions.

Ayurvedic: Mahaaviraa, Asana (Asana is equated with Pterocarpus marsupium Roxb., the Indian Kino tree.)

Siddha/Tamil: Mulluvengai.

Folk: Gondani, Gondui, Khaajaa.

Action: Bark—astringent, used in the form of a liniment in rheumatism. Paste of the stem bark is applied to wounds.

The bark contains 16-40% tannin. Presence of a triterpene ketone in the bark is reported. The bark exhibited hypotensive properties in pharmacological trials. The extract of the bark significantly increased the mean survival time of mice infected intracere- brally with vaccinia virus. Ripe fruit pulp contains beta-sitosterol and gallic and ellagic acids.... bridelia retusa

Roxb.

Synonym: C. sikkimense King

Family: Burseraceae

Habitat: A large, deciduous tree distributed in West Ghats, Assam and Sikkim.

English: Black Dammar.

Ayurvedic: Raal Dhuup, Mand Dhuup.

Siddha/Tamil: Karunkungiliyam (gum).

Action: Resin—used for chronic cutaneous diseases, such as psoriasis, pityriasis; as a linament in rheumatic affections. Dammer Oil—used for rheumatism, asthma, venereal diseases.

Black dammer resin contains (+)- junenol, canarone and epikhusinal.

The plant contains a sesquiterpene ketone—canarone.

Canarium sikkimense King is known as Gogul Dhuup in Nepal.... canarium strictum

Spreng.

Synonym: Andropogon schoenan- thus Linn.

Family: Poaceae.

Habitat: Warmer parts of India, from Punjab to Bengal and in South India.

English: Camel-Hay.

Ayurvedic: Rohisha (var.).

Unani: Rusaa Ghaas, Izkhar.

Siddha/Tamil: Karpurapul, Rohisha- trna.

Action: Roots and rhizome— carminative, stimulant, diaphoretic, emmenagogue; used for fever, cold and genitourinary affections.

Fresh leaves yield an essential oil (yield 0.8%). It contains a series of methyl ketones, along with limonene 19.5, camphene 8.0%, and a group of oxygenated sesquiterpenes, the major being elemol 4.5%.

The fragrant oil is known as Rusa or Geranium Oil and is used as a substitute for rose oil. It exhibits stimulant, carminative, antispasmodic and diaphoretic properties. It is applied externally in rheumatism and neuralgia.... cymbopogon schoenanthus

Diabetes mellitus is a condition characterised by a raised concentration of glucose in the blood due to a de?ciency in the production and/or action of INSULIN, a pancreatic hormone made in special cells called the islet cells of Langerhans.

Insulin-dependent and non-insulindependent diabetes have a varied pathological pattern and are caused by the interaction of several genetic and environmental factors.

Insulin-dependent diabetes mellitus (IDDM) (juvenile-onset diabetes, type 1 diabetes) describes subjects with a severe de?ciency or absence of insulin production. Insulin therapy is essential to prevent KETOSIS – a disturbance of the body’s acid/base balance and an accumulation of ketones in the tissues. The onset is most commonly during childhood, but can occur at any age. Symptoms are acute and weight loss is common.

Non-insulin-dependent diabetes mellitus (NIDDM) (maturity-onset diabetes, type 2 diabetes) may be further sub-divided into obese and non-obese groups. This type usually occurs after the age of 40 years with an insidious onset. Subjects are often overweight and weight loss is uncommon. Ketosis rarely develops. Insulin production is reduced but not absent.

A new hormone has been identi?ed linking obesity to type 2 diabetes. Called resistin – because of its resistance to insulin – it was ?rst found in mice but has since been identi?ed in humans. Researchers in the United States believe that the hormone may, in part, explain how obesity predisposes people to diabetes. Their hypothesis is that a protein in the body’s fat cells triggers insulin resistance around the body. Other research suggests that type 2 diabetes may now be occurring in obese children; this could indicate that children should be eating a more-balanced diet and taking more exercise.

Diabetes associated with other conditions (a) Due to pancreatic disease – for example, chronic pancreatitis (see PANCREAS, DISORDERS OF); (b) secondary to drugs – for example, GLUCOCORTICOIDS (see PANCREAS, DISORDERS OF); (c) excess hormone production

– for example, growth hormone (ACROMEGALY); (d) insulin receptor abnormalities; (e) genetic syndromes (see GENETIC DISORDERS).

Gestational diabetes Diabetes occurring in pregnancy and resolving afterwards.

Aetiology Insulin-dependent diabetes occurs as a result of autoimmune destruction of beta cells within the PANCREAS. Genetic in?uences are important and individuals with certain HLA tissue types (HLA DR3 and HLA DR4) are more at risk; however, the risks associated with the HLA genes are small. If one parent has IDDM, the risk of a child developing IDDM by the age of 25 years is 1·5–2·5 per cent, and the risk of a sibling of an IDDM subject developing diabetes is about 3 per cent.

Non-insulin-dependent diabetes has no HLA association, but the genetic in?uences are much stronger. The risks of developing diabetes vary with di?erent races. Obesity, decreased exercise and ageing increase the risks of disease development. The risk of a sibling of a NIDDM subject developing NIDDM up to the age of 80 years is 30–40 per cent.

Diet Many NIDDM diabetics may be treated with diet alone. For those subjects who are overweight, weight loss is important, although often unsuccessful. A diet high in complex carbohydrate, high in ?bre, low in fat and aiming towards ideal body weight is prescribed. Subjects taking insulin need to eat at regular intervals in relation to their insulin regime and missing meals may result in hypoglycaemia, a lowering of the amount of glucose in the blood, which if untreated can be fatal (see below).

Oral hypoglycaemics are used in the treatment of non-insulin-dependent diabetes in addition to diet, when diet alone fails to control blood-sugar levels. (a) SULPHONYLUREAS act mainly by increasing the production of insulin;

(b) BIGUANIDES, of which only metformin is available, may be used alone or in addition to sulphonylureas. Metformin’s main actions are to lower the production of glucose by the liver and improve its uptake in the peripheral tissues.

Complications The risks of complications increase with duration of disease.

Diabetic hypoglycaemia occurs when amounts of glucose in the blood become low. This may occur in subjects taking sulphonylureas or insulin. Symptoms usually develop when the glucose concentration falls below 2·5 mmol/l. They may, however, occur at higher concentrations in subjects with persistent hyperglycaemia – an excess of glucose – and at lower levels in subjects with persistent hypo-glycaemia. Symptoms include confusion, hunger and sweating, with coma developing if blood-sugar concentrations remain low. Re?ned sugar followed by complex carbohydrate will return the glucose concentration to normal. If the subject is unable to swallow, glucagon may be given intramuscularly or glucose intravenously, followed by oral carbohydrate, once the subject is able to swallow.

Although it has been shown that careful control of the patient’s metabolism prevents late complications in the small blood vessels, the risk of hypoglycaemia is increased and patients need to be well motivated to keep to their dietary and treatment regime. This regime is also very expensive. All risk factors for the patient’s cardiovascular system – not simply controlling hyperglycaemia – may need to be reduced if late complications to the cardiovascular system are to be avoided.

Diabetes is one of the world’s most serious health problems. Recent projections suggest that the disorder will affect nearly 240 million individuals worldwide by 2010 – double its prevalence in 1994. The incidence of insulin-dependent diabetes is rising in young children; they will be liable to develop late complications.

Although there are complications associated with diabetes, many subjects live normal lives and survive to an old age. People with diabetes or their relatives can obtain advice from Diabetes UK (www.diabetes.org.uk).

Increased risks are present of (a) heart disease, (b) peripheral vascular disease, and (c) cerebrovascular disease.

Diabetic eye disease (a) retinopathy, (b) cataract. Regular examination of the fundus enables any abnormalities developing to be detected and treatment given when appropriate to preserve eyesight.

Nephropathy Subjects with diabetes may develop kidney damage which can result in renal failure.

Neuropathy (a) Symmetrical sensory polyneuropathy; damage to the sensory nerves that commonly presents with tingling, numbness of pain in the feet or hands. (b) Asymmetrical motor diabetic neuropathy, presenting as progressive weakness and wasting of the proximal muscles of legs. (c) Mononeuropathy; individual motor or sensory nerves may be affected. (d) Autonomic neuropathy, which affects the autonomic nervous system, has many presentations including IMPOTENCE, diarrhoea or constipation and postural HYPOTENSION.

Skin lesions There are several skin disorders associated with diabetes, including: (a) necrobiosis lipoidica diabeticorum, characterised by one or more yellow atrophic lesions on the legs;

(b) ulcers, which most commonly occur on the feet due to peripheral vascular disease, neuropathy and infection. Foot care is very important.

Diabetic ketoacidosis occurs when there is insu?cient insulin present to prevent KETONE production. This may occur before the diagnosis of IDDM or when insu?cient insulin is being given. The presence of large amounts of ketones in the urine indicates excess ketone production and treatment should be sought immediately. Coma and death may result if the condition is left untreated.

Symptoms Thirst, POLYURIA, GLYCOSURIA, weight loss despite eating, and recurrent infections (e.g. BALANITIS and infections of the VULVA) are the main symptoms.

However, subjects with non-insulindependent diabetes may have the disease for several years without symptoms, and diagnosis is often made incidentally or when presenting with a complication of the disease.

Treatment of diabetes aims to prevent symptoms, restore carbohydrate metabolism to as near normal as possible, and to minimise complications. Concentration of glucose, fructosamine and glycated haemoglobin in the blood are used to give an indication of blood-glucose control.

Insulin-dependent diabetes requires insulin for treatment. Non-insulin-dependent diabetes may be treated with diet, oral HYPOGLYCAEMIC AGENTS or insulin.

Insulin All insulin is injected – mainly by syringe but sometimes by insulin pump – because it is inactivated by gastrointestinal enzymes. There are three main types of insulin preparation: (a) short action (approximately six hours), with rapid onset; (b) intermediate action (approximately 12 hours); (c) long action, with slow onset and lasting for up to 36 hours. Human, porcine and bovine preparations are available. Much of the insulin now used is prepared by genetic engineering techniques from micro-organisms. There are many regimens of insulin treatment involving di?erent combinations of insulin; regimens vary depending on the requirements of the patients, most of whom administer the insulin themselves. Carbohydrate intake, energy expenditure and the presence of infection are important determinants of insulin requirements on a day-to-day basis.

A new treatment for diabetes, pioneered in Canada and entering its preliminary clinical trials in the UK, is the transplantation of islet cells of Langerhans from a healthy person into a patient with the disorder. If the transplantation is successful, the transplanted cells start producing insulin, thus reducing or eliminating the requirement for regular insulin injections. If successful the trials would be a signi?cant advance in the treatment of diabetes.

Scientists in Israel have developed a drug, Dia Pep 277, which stops the body’s immune system from destroying pancratic ? cells as happens in insulin-dependent diabetes. The drug, given by injection, o?ers the possibility of preventing type 1 diabetes in healthy people at genetic risk of developing the disorder, and of checking its progression in affected individuals whose ? cells are already perishing. Trials of the drug are in progress.... diabetes mellitus

Holostemma ada-kodien

Asclepiadaceae

San: Jivanti;

Hin: Chirvel, Charivel;

Mal: Atapathiyan, Atapotiyan, Atakotiyan;

Tam: Palaikkirai;

Tel: Palagurugu; Mar: Dudurli, Shidodi;

Guj: Kharner, Khiravel

Importance: Holostemma is a twining shrub with large flowers. The roots of Holostemma are useful in ophthalmopathy, orchitis, cough, burning sensation, stomachalgia, constipation, fever and tridoshas. The leaves, flowers and fruits are eaten as vegetable. The root is also used in spermatorrhoea. It is used in preparations of Vidaryadiganam, Dhanwandharam thaila, Manasamithravatakam, Balarishta and Anuthaila. It is also useful in eye diseases and it imparts resistance to diseases.

Distribution: The plant occurs in tropical countries. In India, it is found in Himalayas, Dehradun, Konkan, Bombay, Deccan, Karnataka, Kerala and Tamilnadu. It grows over hedges and in open forests especially on the lower slopes of the hills. It is also distributed in Sri Lanka, Burma and W. China.

Botany: Holostemma ada-kodien Schult. syn. Holostemma annulare (Roxb.) K. Schum.

Holostemma rheedii Wall. belongs to the family Asclepiadaceae. It is a laticiferous twining shrub with large conspicuous flowers. Leaves are simple, opposite and cordate. Flowers are purple, arranged in axillary umbellate cymes. Fruits are thick follicles, 9 cm long, cylindrical and bluntly pointed. The roots are long upto 1 m or more, irregularly twisted, thick and cylindrical. When dry it is yellowish brown to brown black in colour with nearly smooth surface bearing white scars and small depressions. A mature root is about 1-2 cm thick when extracted for use (Warrier et al, 1995).

Agrotechnology: Holostemma prefers a tropical climate. The plant is propagated vegetatively by stem cuttings, but mainly by seeds. The seeds are collected from the plant in November-December before being dispersed. Seeds are cleaned, dried and stored for sowing. The stored seeds after soaking in water for 4-5 hours are sown in the seedbeds. About one month old seedlings are then planted in polybags of size 14x10cm which are filled with soil, sand and dried cowdung in 1:1:1 ratio, respectively. Polybags should be kept in shade and irrigated. About 1-1.5 month old seedlings are ready for transplanting. Pits of 30cm cube size are taken at 1-1.2m distance and filled with 10kg dried cowdung and sand. This is covered with surface soil and formed into a mound. Seedlings are transplanted on to the mounds from the polybags carefully. Regular irrigation is to be given till flowering. To aid in trailing, staking is given one month after planting. Flowering and fruiting occurs in November-December. Harvesting can be done at the end of second year when the vines start drying up. Harvesting is done by digging up the tubers. The tubers are cut into pieces of 10cm length and dried in sun before sale (Prasad et al, 1997).

Properties and activity: Holostemma tubers give -amyrin, lupeol and -sitosterol. Alanine, aspartic acid, glycine, serine, threonine and valine were detected chromatographically (Hussain et al, 1992). The root is antidiabetic, antigonorrhoeic, bechic, alterative, tonic, lactative, ophthalmic, emollient, stimulant, aphrodisiac, expectorant and galactagogue.

BLACH MUSALE Curculigo orchioides Amaryllidaceae

San: Musali;

Hin: Kalimusali, Mushali;

Ben: Talamuli;

Mal: Nilappana;

Guj: Musalikand

Tam: Nilapanai;

Tel: Nelatadi Kelangu;

Kan: Neladali

Importance: Musali is a small, geophilous herb, the tuberous rootstock of which is used as a rejuvenating and aphrodisiac drug. It cures morbid vata and pitta, improves complexion and is useful in general debility, deafness, cough, asthma, piles, skin diseases, impotence, jaundice, urinary disorders, leucorrhoea and menorrhagia (Nadkarni, 1954; Aiyer and Kolammal, 1963; Mooss, 1978). Rootstock is the officinal part and it enters into the Ayurvedic formulations like Vidaryadighrta, Vidaryadi lehya, Marmagulika, Musalyadi churna etc. The Pharmacognosy of C. orchioides has been discussed by Aiyer, Kolamma l (1963), Raghunathan, and Mitra (1982). A bibliographical study on C. orchioides has been done by Pandey et al (1983).

Distribution: The plant is found in all districts of India from near sea level to 2300m altitude, especially in rock crevices and laterite soil. It has been recorded to occur in the sub tropical Himalayas from Kumaon eastwards ascending to 1800m, the Khasia hills, Bengal, Asssam, Konkan, Kanara, the western peninsula and Madras extending south as far as a Cape Comerin. It is also distributed in Sri Lanka, Japan, Malaysia and Australia.

Botany: Curculigo orchioides Gaertn. syn. C. malabarica Wight, C. brevifolia Dryand, Hypoxis dulcis Stand belongs to the family Amaryllidaceae. Musali is a small herbaceous plant with cylindrical rootstock. Leaves are simple, sessile, crowded on the short stem with sheathing leaf bases. Flowers are bright yellow. Seeds are black, deeply grooved in wavy lines.

A detailed description of the plant is as follows (Victoria, 1998). Rootstock is straight, cylindrical, tuberous, 5-22cm long, 0.5-0.8 cm thick, brownish surfaces marked with closely spaced prominent transverse wrinkles in the upper or basal half. It bears a few stout lateral roots of 5 or more cm long. Lateral roots are dull white in colour and spongy externally. The fresh cut surfaces of the rootstock has a starch white colour and mucilaginous. A few fibrous roots also occur. Leaves are sessile or short petiolate with sheathing bases, 15-45x1.2-2.5 cm size, linear or linear lanceolate, membranous, glabrouus or sparsely sofly hairy and plicate in bud. The leaf tips when contacts the soil, develops roots and produce adventitious buds. Inflorescence is axillary, scapose racemose, the scape very short and hidden among the bases of leaves underground, clavte, flattened with the pedicels, bracts and the ovary concealed in the leaf sheaths. The lower big flowers on the scape are mostly bisexual and the upper small ones staminate. Flowers are epigynous bright yellow, bisexual or unisxual with lanceolate, memb ranous bract.. Perianth gamophyllous, rotate & six lobed, locate at the top of a slender sterile long extension of the ovary by means of which the perianth is exposed above the ground. Perianth lobes similar, elliptic oblong 1.2-1.6 cm long, 0.2-0.3 cm broad, outer lobes hairy on the back, inner ones sparsely hairy along nerves. Stamens 6 in number, filamentous filiform, short 2mm long, adnate to the base of the perianth lobes, Anthers linear or linear lanceolate, basifixed and sagittate,.Ovary inferior, hidden among the leaves usually below the ground, tricarpellary syncarpous, lanceolate and trilocular with a fairly long slender beak or extension -the stipe. Ovules many in each cell attached by a distinct long funicle. Style short columnar, 2mm with a 3 lobed stigma. Lobes elongate, erect and appressed. Fruit is a capsule about 1.5-2cm long, 8mm broad, oblong, glabrescent with a slender beak and spongy septa. Seeds 1-many, oblong, black, shiny with crustaceous testa grooved deeply in wavy lines.

Properties and activity: Rao and Beri (1951) have identified glucose, mannose, xylose and glucuronic acid from the rootstock of C. orchioides. The rootstock is also reported to contain glycoside, polysaccharides (hemicellulose and other polysaccharides), starch, resin, tannin, mucilage, fat and calcium oxalate. The hexane extract contains an alkaloid-lycorine, sterols including -sitosterols and sapogenin identified as yuccagenin (Rao et al, 1978). The flavone glycoside from the rootstock has been identified as 5,7- dimethoxy glucopyranoside (Yadav et al, 1974; Sharma et al 1975). Mehta et al (1980) have isolated a number of fatty acids from C. orchioides root oil by GLC techniques. They are palmitic, oleic, linolenic linoleic, arachidic and behenic acid. Kubo et al (1983) isolated a new phenolic glycoside namely, curculigoside from the rhizomes and its structure has been elucidated as 5- hydroxy-2-0- -d-glucopyranosyl benzl 1,2,6-dimethoxy benzoate. Yamasaki et al (1994) developed HPLC method for estimating the curculigoside content in curculigo rhizome.

Two new aliphatic hydroxy ketone 27-hydroxy tricontan-6-one (M. P. 84-85o C) and 23- hydroxy tricontan-2-one (M. P. 109-110 o C) were isolated from the rhizome by Misra et al (1984). They also isolated 21-hydroxy tetracontan-20-one and 4-methyl heptade canoic acid from the root stock. Porwal et al (1988) have isolated and identified three new compounds from the rhizome as N- acetyl-N-hydroxy-2-carbamic acid methyl ester, 3-acetyl-5-carbomethoxy-2H-3,4,5,6-tetrahydro-1,2,3,5,6-oxatetrazine and N, N, N’, N’-tetra methyl succinamide. The rhizomes of C. orchioides yielded a new phenolic glycoside corchioside a, characterised as orcinol-3- -D-xylopyranosyl- (1 6)- -D-glucopyranoside and hentriacontanol (Garg et al, 1989).

A new aliphatic compound has been isolated from the rhizomes and characterised as 25- dihydroxy-33-methyl pentatricontan-one (Mehta et al, 1990). Misra et al (1990) isolated a new natural triterpene alcohol-Curculigol charactrised as 24-methy cycloart-7-en-3-beta-20-diol. A novel pentacyclic triterpene has been isolated from the rhizomes of C.orchioides and characterised as 31- methyl-3-oxo-20-ursen-28-oic acid (Metha and Gawarikar,1991). Xu and Xu (1992) and Xu et al (1992 a, b) have isolated 13 cycloartane type. Triterpene glycosides from C. orchioides rhizome and characterised them as curculigo saponin A-M.

The root stock are mucilaginous, sweet, cooling, bitter, emollient, diuretic, aphrodisiac, depurative, alternative, appetiser, carminative, viriligenic, antipyretic and tonic (Sivarajan and Indira, 1994; Warrier et al, 1994).

The uterine stimulant activity of the flavone glycoside extracted from C. orchioides has been studied by Dhawan and Saxena (1958), Sharma et al (1975) and Dhar et al (1979).

The plant extract of C. orchioides showed hypoglycaemic, spasmolytic and anticancer properties (Dhar et al,1968). Phagocytic activity (Kubo et al, 1983) and immunoadjuvant activity (Oru et al, 1982) of phenolic glycosides, curculigoside isolated from the rhizome of the plant have been reported. Porwal and Mehta (1985) discussed the medicinal importance of the plant and its use in indigenous system of medicine as a tonic. Sharma et al (1991) reported the influence of MAK an ayurvedic food supplement constituting C. orchioides against Dimethyl benz anthracene induced mammary tumours in rats. Samanta (1992) reported the modulation of male infertility by Ayurvedic drug, which constitutes C. orchioides. Immunostimulant activity of C. orchioides has been demonstrated by Saxena (1992). Immunological activites of curculigo saponin G were assayed in mice and the results showed that it promoted proliferation of spleen lymphocyctes very significantly and increased the weight of the thymus in vivo in mice (Xu et al,1992).

Pharmacological studies in China, on the alcoholic extract obtained from the plant showed several active effects such as adaptogenic, anti-inflammatory, anticonvulsant, sedative, androgenic and immunopromoting activities (Xu et al, 1992).

Curculigo orchioides is distributed widely throughout the country. The demand of the raw materials and derivatives of the plant for the indigenous drug industries are satisfied mainly from the wild source, depleting the natural population and thus the species have become extinct or endangered. Ansari (1993) have reported C. orchioides as a threatened plant from Madhulia forest of Garakhpur. Augustin and Souza (1995) also considered the plant as an endangered species. As the information on the cultivation of C.orchioides is scanty, it is very necessary to develop suitable agrotechniques for the domestication and large-scale cultivation of the plant.... holostemma

A rare condition (less than 0·2 per cent) of pregnancy, in which there is severe vomiting. If untreated it can result in severe dehydration, ketoacidosis (an excess of KETONE acids) and liver damage. More common in multiple pregnancy, it may recur in subsequent pregnancies.... hyperemesis gravidarum

Linn.

Synonym: C. domestica Valeton.

Family: Zingiberaceae.

Habitat: Cultivated all over India, particularly in West Bengal, Tamil Nadu and Maharashtra.

English: Turmeric.

Ayurvedic: Haridraa, Priyaka, Haridruma, Kshanda, Gauri, Kaanchani, Krimighna, Varavarni- ni, Yoshitapriyaa, Hattavilaasini, Naktaahvaa, Sharvari.

Unani: Zard Chob.

Action: Anti-inflammatory, cholagogue, hepatoprotective, blood-purifier, antioxidant, detoxi- fier and regenerator of liver tissue, antiasthmatic, anti-tumour, anticu- taneous, antiprotozoal, stomachic, carminative. Reduces high plasma cholesterol. Antiplatelet activity offers protection to heart and vessels. Also protects against DNA damage in lymphocytes.

Key application: In dyspeptic conditions. (German Commission E, ESCOP, WHO.) As antiinflammatory, stomachic. (Indian Herbal Pharmacopoeia.)

The rhizomes gave curcuminoids, the mixture known as curcumin, consisting of atleast four phenolic diaryl- heptanoids, including curcumin and monodesmethoxycurcumin; volatile oil (3-5%), containing about 60% of turmerones which are sesquiterpene ketones, and bitter principles, sugars, starch, resin.

Curcumin related phenolics possess antioxidant, anti-inflammatory, gastroprotective and hepatoprotective activities. The antioxidant activity of curcumin is comparable to standard antioxidants—vitamin C and E, BHA and BHT.

The volatile oil, also curcumin, exhibited anti-inflammatory activity in a variety of experimental models (the effects were comparable to those of cortisone and phenylbutazone). Used orally, curcumin prevents the release of inflammatory mediators. It depletes nerve endings of substance P, the neu- rotransmitter of pain receptors.

Curcumin's cholesterol-lowering actions include interfering with intestinal cholesterol uptake, increasing the conversion of cholesterol into bile acids and increasing the excretion of bile acids via its choleretic effects.

Curcuminoids prevent the increases in liver enzymes, SGOT and SGPT; this validates the use of turmeric as a he- patoprotective drug in liver disorders. Curlone, obtained from the dried rhizome, is used against hepatitis.

Turmeric and curcumin increase the mucin content of the stomach and exert gastroprotective effects against stress, alcohol, drug-induced ulcer formation. (Curcumin at doses of 100 mg/kg weight exhibited ulcerogenic activity in rats.)

The ethanolic extract of the rhizome exhibited blood sugar lowering activity in alloxan-induced diabetic rats.

Piperine (a constituent of black and long pepper) enhances absorption and bioavailability of curcumin.

Dosage: Cured rhizome—1-3 g powder. (API Vol. I.)... curcuma longa

Linn. Family: Cyperaceae.

Habitat: Native to Turkey; found in warm regions from Bengal to Sri Lanka in standing water of ponds and canals. Ayurvedic: Kronchaadana.

Action: Carminative, antiemetic (useful in vomiting of pregnancy), sedative (in dyspeptic disorders). The root contains a sesquiterpene ketone, articulone, which is identical to cyperone. Volatile oil contains sesquiterpene hydrocarbons and sesquiterpene alcohols, including cy- perenone.Cypress is a totally different herb. See Cupressus sempervirens.... cyperus articulatus

Benth. Derris indica (Lamk.) Bennet.

Synonym: Pongamia pinnata Pierre.

Family: Fabaceae.

Habitat: Native to the Western Ghats. Found all over India on the banks of rivers and streams.

English: Indian Beech. Pongamia oil tree.

Ayurvedic: Naktmaal, Guchpush- pak, Ghritpuur, Udkirya, Karanja.

Siddha/Tamil: Pungu.

Action: Used for skin diseases— eczema, scabies, leprosy, and for ulcers, tumours, piles, enlargement of spleen, vaginal and urinary discharges. Juice of root—used for closing fistulous sores and cleaning foul ulcers. Flowers— used in diabetes. Powder of seeds— used for whooping and irritating coughs of children. Seed oil—used in cutaneous affections, herpes and scabies.

The tree is rich in flavonoids and related compounds. These include simple flavones, furanoflavonoids, chro- menoflavones, chromenochalcones, coumarones, flavone glucosides, sterols, triterpenes and a modified pheny- lalanine dipeptide.

Synonym: D. trifoliate Lour.

Family: Fabaceae.

Habitat: Costal forests of India and the Andamans.

Folk: Paan-lataa (Bengal), Kitani (Maharashtra).

Action: Stimulant, antispasmodic, counter-irritant. Bark—alterative in rheumatism. An oil prepared from the plant is used externally as an embrocation.

The roots contain dehydrorotenone, lupeol and a ketone. Bark contains 9.3% tannic acid. Stems contain tan- nic acid, hexoic, arachidic and stearic acids, ceryl alcohol, isomerides of cholesterol, potassium nitrate, gums and resins.... derris uliginosa

A condition that results from a lack of food for a long time. The person suffers weight loss and changes in the body’s METABOLISM, with production of potentially harmful chemicals called ketones (see KETONE) and ACETONE. Sometimes starvation may occur as a result of an eating disorder (see EATING DISORDERS – Anorexia nervosa). In cases of slow starvation, the vitality of the tissues is reduced and they become more liable to tuberculosis and other diseases. (See also FASTING.)... starvation

Basil Thyme. Calaminta ascendens Jord. French: Calament. German: Waldurze. Spanish: Calamento. Italian: Calamina. Dutch: Vold mynte. Part used: herb.

Constituents: volatile oil, ketones, terpenes.

Action: expectorant, diaphoretic.

Uses: upper airways obstruction, catarrh, bronchitis, colds.

Preparation. Tea: 1 teaspoon to each cup boiling water; infuse 10 minutes. Dose: Half-1 cup thrice daily. ... calamint

Pers.

Synonym: D. peregrina (Gaertn.) Gurke D. malabarica (Desr.) Kostel.

Family: Ebenaceae.

Habitat: Throughout India in shady wet places and near streams.

English: Gaub Persimmon, Riber Ebony

Ayurvedic: Tinduka, Tinduki, Sphu- urjaka, Kaalaskandha, Asitkaaraka. Nilasaara.

Unani: Tendu.

Siddha/Tamil: Tumbika, Kattatti.

Action: Fruit and stem bark— astringent. Infusion of fruits—used as gargle in aphthae and sore throat. Fruit juice—used as application for wounds and ulcers. Oil of seeds— given in diarrhoea and dysentery Ether extract of fruit—antibacterial. Bark—astringent and styptic, used in menorrhagia, diarrhoea, dysentery and intermittent fevers.

A paste is applied to boils and tumours. The ethyl acetate extract showed antistress and anti-ulcerogenic activity. It also prevented hepatotoxi- city and leucocytosis in experimental animals.

The bark contains betulinic acid, myricyl alcohol, triterpenoids and sa- ponin. The leaves gave beta-sitosterol, betulin and oleanolic acid. Fruit pulp and seeds contain lupeol, betulin, gallic acid, betulinic acid, hexacosane, hex- acosanol, sitosterol, beta-D-glucoside of sitosterol and a triterpene ketone.

Stem bark—antiprotozoal, antiviral, hypoglycaemic, semen-coagulant. Stems yielded nonadecan-7-ol-one.

Dosage: Bark—50-100 ml decoction. (CCRAS.)... diospyros embryopteris

Gaertin.

Family: Gramineae, Poaceae.

Habitat: Australia, North America; throughout the warmer parts of the world. In India, in wet plains and low hills and pasture grounds.

English: Crowfoot Grass, Crab Grass.

Ayurvedic: Nandimukha (var.).

Folk: Nandiaa (Orissa), Mahaar Naachni (Maharashtra), Thippa Ragi (Tamil Nadu).

Action: Used for biliary disorders. In Vietnamese traditional medicine, a decoction of the whole plant is used as stomachic, diuretic, febrifuge, and in sprains.

Aerial parts contain vitexin, 3-O- beta-D-glucopyranosyl-beta-sitosterol and its 6'-O-palmitoyl derivatives. of intoxication. Used for abdominal pains, nausea, bleeding nose. Fresh plants from Uttaranchal gave 0.4% essential oil having dehydroelsholtzia ketone 88.7% as the main constituent, followed by humulene 2.4% and caryophyllene 0.9% (the oil composition of the species which grow in Japan and Kashmir is different.)

Plant contains linarin, apigenin and 7-O-glucosides of apigenin and lute- olin.

The Japanese species, used for hangovers, gave compounds including tri- terpenoids, steroids and flavonoids.

Elsholtzia blenda Benth., synonym Perilla elata D. Don, is also equated with Ban-Tulasi. Major constituent of the essential oil is geranyl acetate. Other constituents are p-cymene, sa- binene, borneol, geraniol, linalyl acetate, fernesol, limonene, linalool, cit- ronellol, thymol and nerolidol.... eleusine indica

A food that has more energy-producing power, weight for weight, than any other. Animal fat is a mixture in varying proportions of stearic, palmitic, and oleic acids combined with glycerin. Butter contains about 80 per cent of fat; ordinary cream, 20 per cent; and rich cream 40 per cent – whilst olive oil is practically a pure form of fat. When taken to a large extent in the diet, fat requires to be combined with a certain proportion of either CARBOHYDRATE or PROTEIN in order that it may be completely consumed, otherwise harmful products, known as ketones, may form in the blood. Each gram of fat has an energy-producing equivalent of 9·3 Calories (see CALORIE).

Fats are divided into saturated fats – that is, animal fats and dairy produce; and unsaturated fats, which include vegetable oils from soya bean, maize and sun?ower, and marine oils from ?sh (e.g. cod-liver oil). (See also ADIPOSE TISSUE; LIPID; OBESITY.)

Body fat Most of the body’s fat is stored in ADIPOSE TISSUE which is mainly sited beneath the skin and around various internal organs. Some, however, is stored in liver, muscle and other cellular structures such as bone marrow (see BONE). Various methods can be used to estimate the body’s fat content but all are indirect and not very accurate, depending as they do on hard-to-measure di?erences in composition between fat and lean tissues. The average body fat of healthy young men and women is below 20 per cent and 25 per cent respectively of their body weight. In economically developed countries, middle-aged men and women usually undergo a steady increase in body fat. This is probably not a feature of ageing, however, since in developing nations, which have di?erent diets and greater levels of physical activity, increased age does not bring with it an increase in body fat. One widely used means to estimate whether a person has excess fat is to measure his or her skinfold thickness on the arms and torso. The distribution of fat can be a pointer to certain disorders: those adults, for example, who deposit their fat abdominally rather than on their hips – an android rather than a gynaecoid distribution – are particularly susceptible to disease of the CARDIOVASCULAR SYSTEM and to DIABETES MELLITUS.

Adipose tissue comprises fat deposited as a result of eating more food than is metabolised by exercise and the body’s basic energy needs. Surplus fat can in some circumstances be a useful energy store. For example, hibernating animals ‘burn o?’ the fat stored during the summer months and are much leaner when they wake up in the spring. Excessive quantities of adipose tissue result in OBESITY, an increasingly serious problem among all age groups, including children, in countries with developed economies.... fat

an organic acid produced in large amounts by the liver under metabolic conditions associated with a high rate of fatty acid oxidation (for example, in starvation). The acetoacetic acid thus formed is subsequently converted to acetone and excreted. See also ketone.... acetoacetic acid

(ketone body) see ketone.... acetone body

Linn.

Family: Euphorbiaceae.

Habitat: Native to Brazil; cultivated as an ornamental.

English: Tua-Tua.

Ayurvedic: Rakta-Vyaaghrairanda.

Siddha/Tamil: Stalai.

Folk: Laal Bagharenda.

Action: Leaf and seed—purgative. Leaf—antidermatosis. Bark— emmenagogue. Seed—emetic. Seed fatty oil—used in paralytic affections, also in skin diseases.

The leaves contain triterpenes, a tri- hydroxy ketone and corresponding diosphenol. The root contains the diterpenes, jatropholone A and jat- rophatrione. A tumour-inhibitor ma- crocyclic diterpene, jatrophone, has been isolated from roots.

The seeds contain phorbol derivatives, jatropholones A and B, hydroxy- jatrophone and hydroxyisojatrophone.

Hot water extract of the plant exhibits antimalarial activity against Plasmodium falciparum.... jatropha gossypifolia

n. a condition in which the acidity of body fluids and tissues is abnormally high. This arises because of a failure of the mechanisms responsible for maintaining a balance between acids and alkalis in the blood (see acid-base balance). In gaseous acidosis more than the normal amount of carbon dioxide is retained in the body, as in drowning. Patients with diabetes mellitus suffer from *diabetic ketoacidosis, in which sodium, potassium, and *ketone bodies are lost in the urine. See also lactic acidosis; renal tubular acidosis.... acidosis

n. an agent that prevents formation of *ketones in the body.... antiketogenic

n. the presence in the blood of *ketone bodies.... ketonaemia

(acetonuria) n. the presence in the urine of *ketone (acetone) bodies. This may occur in diabetes mellitus, starvation, or after persistent vomiting and results from the partial oxidation of fats. Ketone bodies may be detected by adding a few drops of 5% sodium nitroprusside solution and a solution of ammonia to the urine; the gradual development of a purplish-red colour indicates their presence.... ketonuria

n. the fluid excreted by the kidneys, which contains many of the body’s waste products. It is the major route by which the end-products of nitrogen metabolism – *urea, *uric acid, and *creatinine – are excreted. The other major constituent is sodium chloride. Over 100 other substances are usually present, but only in trace amounts. Analysis of urine (see urinalysis) is commonly used in the diagnosis of diseases (for example, there are high levels of urinary glucose in diabetes and of ketone bodies in ketonuria); immunological analysis of urine is the basis of most *pregnancy tests. See Appendix 3.... urine

Linn. var. saxatillis Palias.

Synonym: J. communis auct. non L.

Family: Pinaceae; Cupressaceae.

Habitat: Native to Europe and North America. Distributed in Western Himalayas from Kumaon westwards at 1,700-4,200 m.

English: Common Juniper.

Ayurvedic: Hapushaa, Havushaa, Haauber, Matsyagandha.

Unani: Abahal, Haauber, Hubb-ul- arar, Aarar.

Action: Berries—diuretic, urinary antiseptic, carminative, digestive, sudorific, anti-inflammatory, emmenagogue. Used for acute and chronic cystitis, renal suppression (scanty micturition), catarrh of the bladder, albuminuria, amenorrhoea, leucorrhoea. Aerial parts—abortifacient.

Key application: In dyspepsia. (German Commission E.) Juniper berry may increase glucose levels in diabetics. (ESCOP.) As a diuretic.

(The British Herbal Pharmacopoeia.)

The Ayurvedic Pharmacopoeia of India recommends the dried fruit in malabsorption syndrome.

Animal studies have shown an increase in urine excretion as well as a direct effect on sooth muscle contraction. (German Commission E, ESCOP.)Con- traindicated in kidney disease. (Sharon M. Herr.)

(In Kerala, Hapushaa and Mundi are considered to be synonyms; Syphaer- anthus indicus,Asteraceae, is used as Hapushaa.)

The major constituents of the volatile oil are alpha-pinene, sabinene and alpha-terpinene. Methanolic extract of the plant gave several labdane diter- penoids and diterpenes. The leaves contain the biflavones, cupressufla- vone, amentoflavone, hinokiflavone, isocryptomerin and sciadopitysin. The berries also contain condensed tannins. Seeds gave haemagglutinin.

Juniperus recurva Buch-Ham ex D. Don, syn. J. excelsa auct. non-Bieb. (temperate Himalaya from Kashmir to Bhutan) is known as Weeping Blue Juniper. J. macropoda Boiss. (the Himalaya from Nepal onwards) is known as Himalayan Indian Juniper. Both the species are used like J. communis var. saxatillis.

The berries gave a diterpene ketone, sugrol, beta-sitosterol glucoside and 10-nonacosanol.

Plant extract can be used in toothpastes and mouth-rinses to reduce dental plaque and bleeding.

Dosage: Dried fruit—2-6 g powder. (API, Vol. III.)... juniperus communis

H. B. & K.

Synonym: L. alba (Mill.) N.E.Br. L. javanica (Burm.f.) Spreng.

Family: Verbenaceae.

Habitat: Bihar and Orissa to Assam; Madhya Pradesh, Nilgiris and Anaimalais up to 900 m in wet places and river banks.

Folk: Basula (Madhya Pradesh), Naagaa-aiari (Orissa).

Action: Leaves—stomachic and nervine. Essential oil—fungitoxic.

The essential oil from leaves contains citral, neral and geranial. Diterpenes, d- and l-limonene, l-piperitone, geranial. Diterpenes, d-and l-limonene, l- piperitone, lippone, a saturated ketone, d-alpha-pinene, dl-dihydrocarvone, citral and camphor have been identified in different samples.... lippia geminata

Linn.

Family: Magnoliaceae.

Habitat: Native to North America; found in the Himalayas and the Nilgiri hills up to 2,100 m.

English: Bull Bay, Great Laurel Magnolia, Southern Magnolia.

Ayurvedic: Him-Champaa.

Action: Bark—anti-inflammatory, stimulant, diaphoretic. Wood— toxic. Plant is used against cold, headache and stomach-ache. Leaf extract—fungitoxic.

The leaves gave germacanolide lactones, a guaianolide (magnograndio- lide, melampomagnolide A and B); the wood, quaternary aporphine alkaloids; bark, cyclocolorenone; root bark, eudesmanolides; seeds, phenolic constituents.

The sesquiterpene ketone, cyclocol- orenone, also found in leaves, shows antifungal activity.

Magnolia pterocarpa Roxb., synonym M. sphenocarpa Roxb. (Vana- Champaa), Dhulichampaa) bark contains sesamin, eudesmin, fargesin, imperatorin, dimethyl-terephthalate and beta-sitosterol. Powdered bark is used for fevers and cough.... magnolia grandiflora

(L.) Dubard.

Synonym: Minusops Kauki L.

Family: Sapotaceae.

Habitat: A native of Malaya; occasionally grown in gardens, especially in North India, Andhra Pradesh and Kerala.

English: Kauki.

Ayurvedic: Khirni.

Siddha: Palai.

Action: Root and bark—astringent. Given in infantile diarrhoea. Seed— febrifuge, anthelmintic, antileprotic. Leaf—used as poultice for tumours.

Seeds contain about 16% of fatty oil and 1% saponin.

Manilkara hexandra (Roxb.) Du- bard, synonym Mimusops hexandra Roxb., found in central India and Dec- can Peninsula, and cultivated throughout the greater part of India, is also equated with Khirni.

All parts gave taraxerol, a triterpene ketone, alpha-and beta-amyrin, cin- namates, alpha-sipnasterol, beta-sitos- terol, its beta-D-glucoside, quercitol, quercetin and its dihydroderivatives, ursolic acid.

The bark contains 10% tannin.... manilkara kauki

DC.

Synonym: N. grandiflora DC.

Family: Valerianaceae.

Habitat: Alpine Himalayas, Kumaon, Sikkim and Bhutan.

English: Spikenard, Musk-root.

Ayurvedic: Maansi, Jataamaansi, Bhuutajataa, Tapaswini, Sulo- mashaa, Jatilaa, Naladaa.

Unani: Sumbul-e-Hindi, Sambul-ut- Teeb, Naardeen-e-Hindi, Baalchhar.

Siddha/Tamil: Sadamanchil.

Action: Used as a substitute for Valerian. Tranquilizer, sedative, hypotensive. Used for the treatment of epilepsy, hysteria, convulsive affections, palpitation of heart and in intestinal colic. A decoction of powdered roots is prescribed as a home remedy for high blood pressure. It is used in dysmenorrhoea for pain relief and smooth menstrual flow. It is used in hair oil for arresting hair loss and greying of hair.

The Ayurvedic Pharmacopoeia of India recommends dry rhizomes in obstinate skin diseases, erysipelas, disturbed mental state and insomnia.

The rhizome is rich in sesquiter- penoids. The crude drug gave an oil (yield 2.5% v/w), which contains d- nardostachone, valeranone and jata- mansone as the major ketonic sesqui- terpenes. The oil potentiated phenobarbital narcosis in rats, reduced brain serotonin content and decreased the conditioned avoidance performance in cats.

Jatamansone was shown to exert tranquilizing effect in mice and monkeys. In rabbits, jatamansone was found to impair biosynthesis of serotonin in the brain leading to a reduction in brain level of 5-hydroxytrypta- mine. The degradation of serotonin was unaffected. The mode of action of jatamansone was thus in variance with that of reserpine which has direct action on the cell to liberate serotonin.

On the other hand, the alcoholic extract of the roots of Indian Nard caused an overall increase in the levels of central monamines, 5-hydroxy indole acetic acid and the inhibitory amino acids, gamma-aminobutyric acid, norepinephrine, dopamine and serotonin in rat brain.

In a clinical trial on hyperkinetic children, jatamansone showed significant reduction in hyperactivity and improvement in restlessness and aggressiveness, almost at par with D- amphetamine.

The volatile oil was found to be less active than quinidine in several tests. It did not counteract digitalis induced ventricular arrhythmias.

Jatamansone semicarbazone, a sesquiterpene ketone, was found to possess antiestrogenic activity.

N. jatamansi is also used in place of Muraa (Selinum tenuifolium Wall. ex DC.)

Dosage: Root—2-3 g powder; 5-10 g for infusion; 50-100 ml infusion. (API, Vol. I; CCRAS.)... nardostachys jatamansi

(Linn.) Britton.

Family: Labiatae; Lamiacae.

Habitat: Throughout the Himalayas up to an altitude of about 3,500 m, and in the hills of Assam.

English: Perilla, Wild Coleus.

Folk: Bhanjeer, Ban-tulasi, Ban- jiraa, Bhasindi.

Action: Herb—sedative, antispasmodic, antiasthmatic, resolvent.

P. frutescens var. crispa is used in mixtures prescribed for cough and lung affections.

Several chemotypes of Perilla have been detected. The Indian type is rich in rosefuran. Other components are perillene, perilla ketone, beta-caryo- phyllene, phellandrene and a few ses- quiterpenoids. Aerial parts gave ethyl linolenate, linolenic acid and beta- sitosterol. The leaves also gave an an- thocyanin, perillanin. The leaves and flowering tops yield essential oils containing perilla ketone as major com- ponent—94% in leaf oils and 47% in inflorescence oils at fruiting stage.

Perillaldehyde, a major component of the plant extract, inhibits (moderately) a broad range of both bacteria and fungi. The MeOH extract of var. acuta Kudo is reported to prolong hexobarbital-induced sleep in mice. Dillapiol has been isolated as the active principle from the methanolic extract.... perilla frutescens

Bennett.

Family: Simaroubaceae.

Habitat: Garhwal, Himachal Pradesh and Kulu.

English: Quassia (substitute for P excelsa Lindtl).

Ayurvedic: Bhurangi, Nimbi. (Clerodendrum serratum and its related species represent Bhaargi or Bhaarangi.)

Folk: Nimatotaa.

Action: Wood—a non-astringent bitter tonic and stomachic, amoe- bicidal, anthelmintic (used as enema), insect repellent. Used as a supporting medicine for temporary relief in cirrhosis of liver.

Many indole alkaloids of beta-car- boline, canthin-6-one and beta-carbo- line dimer type, have been isolated from the wood. These are reported to increase the blood flow rate in the intestine and stomach of rabbit; also exhibited antiviral activity on Herpes simplex virus.

Nigaki lactone and methylnigaki- none, isolated from the wood, showed antigastric ulcer activity in rats. The extract of the wood is reported to prevent the secretion of gastric juice in a dose-dependent manner in rats. The extract also showed the same effects on rats having aspirin-induced gastric ulcer.

Family: Scrophulariaceae.

Habitat: The alpine Himalayas from Kashmir to Sikkim.

English: Picrorhiza.

Ayurvedic: Katukaa, Katurohini, Kattarohini, Katuki, Katukikaa, Krishnabhedaa, Kaandaruhaa, Matsyashakalaa, Chakraangi, Shat- parvaa, Arishta, Ashokarohinya, Shakuldaani.

Unani: Kutki, Kharbaq-e-Hindi.

Siddha/Tamil: Kaduguragini.

Action: Root—stomachic, antidiar- rhoeal, cholagogue, hepatoprotec- tive. Used in hepatitis, chronic dysentery, amoebiasis.

Key application: In jaundice, intermittent fever, dyspnoea and skin diseases. (The Ayurvedic Pharmacopoeia ofIndia.)

The roots yield a glycosidal bitter principle, kutkin, found to be a mixture of two iridoid glycosides, picro- side I and kutkoside. Also obtained were D-mannitol, kutkiol, kutkisterol and a ketone (identical with apocynin).

Kutkin exhibited hepatoprotective activity in CCl4-induced toxic rats.

Picroliv, a standardized fraction from the alcoholic extract of the root and rhizome, containing 55-60% of a mixture of picroside I and kutkoside (1:15) showed dose-dependent protective activity on isolated hepatocytes in vitro against thiocetamide-induced hepatic damage in rat and was found to be more potent than Silymarin, a known hepatoprotective agent. Pi- croliv is reported to show protective effect against rifampicin-induced hep- atotoxicity in rats. It also exerts hy- polipidaemic effect in normal, triton- treated and cholesterol-fed rats.

Kutkin, picroside I and kutkoside exhibit anti-inflammatory property.

The phenolic glycoside, androsin, isolated from the plant, prevents allergen and platelet activating factor- induced bronchial obstruction in guinea-pigs in vitro.

Cucurbitacin glycosides, isolated from the root, exhibit liver protective, tumour inhibitory and anti-inflammatory activity.

Dosage: Root—1-3 g; 3-6 g as purgative. (CCRAS.)... picrasma quassioides

Stapf.

Family: Rutaceae.

Habitat: Native to tropical America; cultivated in Indian gardens.

Family: Umbelliferae; Apiaceae.

Habitat: Native to the Mediterranean region; cultivated in Uttar Pradesh., Punjab, Assam and Orissa.

English: Anise, Aniseed.

Unani: Anisoon, Baadiyaan-roomi.

Action: Carminative, diuretic, anticholerin, antispasmodic, expectorant. Used for flatulence, dry coughs, whooping cough, bronchitis.

Key application: Internally in dyspeptic complaints; internally and externally in catarrhs of the respiratory tract. (German Commission E, ESCOP, WHO, The British Herbal Pharmacopoeia.)

The fruit gave volatile oil consisting mainly of trans-anethole (70-90%), with estragole, anise ketone, anisic acid, beta-caryophyllene, anisaldehyde, linalool. The fruit contained traces of furocoumarins; seeds gave benzoic acid, caffeic acid, containing protein and myristicin. Roots afforded sterols, coumarins and flavone glyco- sides. Aniseed has been demonstrated to increase the mucociliary transport in vitro and to significantly increase liver-regeneration in rats.

Aniseed is also used as a galacta- gogue. This property is thought due to the presence of polymers of anethole, dianethole and photoanethole.

Aqueous extract of roasted aniseed is reported to show cholinomimetic effect on rat blood pressure, rat jejunum and frog rectus abdominis preparations.

Alcoholic extract of aniseeds possesses antimicrobial and fungicidal activity.

Anethole has a structure similar to catecholamines including adrenaline, noradrenaline and dopamine and to the hallucinogenic compound myris- ticin as well. (Natural Medicines Comprehensive Database, 2007.)... pilocarpus microphyllus

Linn.

Family: Rutaceae.

Habitat: Native to Southern Europe and North Africa; cultivated in Indian gardens. (Most of the reports of the Garden Rue, cultivated in India, refer to this species and not to Ruta graveolens.)

Unani: Jangali Sudaab.

Siddha/Tamil: Arvada.

Action: Plant—antispasmodic, sudorific. Stimulates the nervous system; commonly used in decoction in convulsions and fever. Also used as a fumigant in infant catarrh.

The plant gave an essential oil which contains chiefly methyl heptyl ketone (while Ruta graveolens contains 8090% methyl nonyl ketone and methyl heptyl ketone in small amounts). Rutin is the most important active principle of the plant, responsible for its anti- inflammatory and tumour-inhibiting effect.... ruta chalepensis

A. Br.

Synonym: S. papilionacea (Burm. f.) Boiss.

Family: Scrophulariaceae.

Habitat: The arid regions of Gujarat and in Rajasthan.

Ayurvedic: Nepaal-Nimba.

Folk: Saannipaat (Maharashtra).

Action: Broken pieces of dried fruits, stems and leaves—used in enteric fever. Leaf—antidiabetic. Fruit, leaf, stem—diuretic.

An alkaloid, schweinfurthin, a hydrocarbon and an unsaturated ketone were reported from the leaves. Recently, two macrocylic alkaloids, 11- epi-ephedradine and schweinine, have been isolated from the whole plant, along with (-)-ephedradine A. Experimentally, 11-epi-ephedradine A was mutagenic to Salmonella typhimurium.... schweinfurthia sphaerocarpa

C. B. Clarke.

Family: Umbelliferae; Apiaceae.

Habitat: North-Western Himalayas from Kashmir to Kumaon at altitudes of 1,800-3,900 m.

Ayurvedic: Rochanaa-Tagara.

Folk: Peshaavari-Bhuutakeshi (Kashmir), Taggar (Garhwal).

Action: Roots—used as a nervine sedative. Oil—sedative, analgesic, hypotensive.

The roots gave coumarins, angelicin, oroselol, lomatin, selinidin, vaginidin, vaginol; a flavone derivative selinone; a sesquiterpene vaginatin.

The dry roots yield an essential oil containing alpha-pinene 45.5 limonene 25.3, camphene 5.7, beta-phellandrene 5.2, alpha-thujene 1.2, fenchyl alcohol 3.2, terpineol 3.8, and a ketone 2.6%. Beta-pinene and fenchone have also been reported.

The roots are sold in the drug markets of Jammu mixed with those of Seseli sibiricum. The roots are also used as a substitute for Nardostachys jata- mansi.... selinum vaginatum

Bunge.

Synonym: V. officinalis auct. non Linn.

Family: Valerianacea.

Habitat: Western Himalayas, Kashmir at Sonamarg at 2,4002,700 m.

English: Common Valerian.

Action: Rhizome and roots— sedative, hypotensive, cardiotonic; depressant on CNS, antispasmodic; used for hysteria, neurosis, nervousness, hypochondriasis.

The roots and rhizomes yielded alkaloids—dipyridylmethylketone, ac- tinidine, iso-valeramide and valerian- ine; sesquiterpene ketone-valeranone. Bornyl acetate is the major constituent of the root oil, 31.5%, whereas it is only 6.6% in leaf oil. Bornyl isovalerate is reported from the root oil.

Baalaka is a confusing synonym of Tagara. It should be equated with Pavo- nia odorata Willd. (Malvaceae).

Baalaka (syns: Ambu, Baala, Barhi- shtha, Hrivera, Jala, Kacha, Muurd- haja, Udichi, Udichya) is known as Sugandhabaalaa in Northern markets. In South India Coleus vettiveroides K. C. Jacob (Labiateae) is preferred as Baalaka. Delphinium brunonianum Royle (Ranunculaceae), with synonyms Kutila, Nata, Vakra, is also used as Tagara.

Valeriana leschenaultii DC. var. brunoniana C. B. Clarke.

Family: Valerianaceae.

Habitat: The temperate Himalayas from Kashmir to Bhutan at altitudes of 1,200-3,60 m and in the Khasi and Jaintia hills between 1,500 and 1,800 m.

Folk: Sugandhabaalaa, Tagger, Taggar-ganthodaa. Asaarun (Ku- maon).

Action: Used as V. jatamansi and V officinalis.

Valeriana hardwickii is known as Taggar-ganthodaa in Mumbai and Asaarun in Kumaon. In Unani medicine, Asaarun is equated with Asarum europaeum Linn. (Aristolochiaceae). It is known as Subul-e-barri, Naardin- barri and Persian Tagar; Wild Nard, Hazel Wort and Asarabacca in English. Though sedative and brain tonic, Asaarun should not be equated with Tagara.

Family: Valerianaceae.

Habitat: Karnakata and the Nilgiris.

Ayurvedic: Tagara (related species).

Folk: Sugandhabaalaa, Taggar, Baalaka.

Action: Used as a substitute for valerian.... valeriana dubia

Acorus calamus

Araceae

San: Vaca, Ugragandha, Bhadra;

Hin: Bacc, Gorbacc;

Ben: Bach; Mal:Vayampu;

Tam: Vasampu;

Kan: Bajai;

Tel: Vasa Vadaja

Importance: The sweet flag is an important medhya drug, capable of improving memory power and intellect. It is used in vitiated conditions of vata and kapha, stomatopathy, hoarseness, colic, flatulence, dyspepsia, helminthiasis, amenorrhoea, dismenorrhoea, nephropathy, calculi, strangury, cough, bronchitis, odontalgia, pectoralgia, hepatodynia, otalgia, inflammations, gout, epilepsy, delirium, amentia, convulsions, depression and other mental disorders, tumours, dysentery, hyperdipsia, haemorrhoids, intermittent fevers, skin diseases, numbness and general debility. It is reportedly useful in improving digestion, clearing speech and curing diarrhoea, dysentery, abdominal obstruction and colic. It is also useful in infantile fever, cough bronchitis and asthma. The drug is reported to cure hysteria, insanity and chronic rheumatic complaints. The rhizome is an ingredient of preparations like Vacaditaila, Ayaskrti, Kompancadi gulika, Valiya rasnadi kashaya, etc.

Distribution: The plant is a native of Europe. It is distributed throughout the tropics and subtropics, especially in India and Sri Lanka. It is found in marshes, wild or cultivated, ascending the Himalayas upto 1800m in Sikkim. It is plentiful in marshy tracts of Kashmir and Sirmoor, in Manipur and Naga Hills.

Botany: Acorus calamus Linn. belonging to the family Araceae is a semi -aquatic rhizomatous perennial herb. Rhizome is creeping, much branched, cylindrical or slightly compressed, light brown or pinkish brown externally, white and spongy within. Leaves are bright green, distichous, ensiform, base equitant, thickened in the middle and with wavy margins. Flowers are light brown and densely packed in sessile cylindric spadix. Fruits are oblong, turbinate berries with a pyramidal top. Seeds are few and pendant from the apex of the cells (Warrier et al, 1993).

Another species belonging to the genus Acorus is A. gramineus Soland, the roots of which are used in tonic, antiseptics and insecticidal preparations (Chopra et al, 1956).

Agrotechnology: Acorus is a hardy plant found growing from tropical to subtropical climates. It needs a good and well distributed rainfall throughout the year. It needs ample sunlight during the growth period as well as after harvest for drying the rhizomes. It may be cultivated in any good but fairly moist soil. It is usually grown in areas where paddy can be grown. It comes up well in clayey soils and light alluvial soils of river bank. The field is laid out and prepared exactly as for rice, irrigated sufficiently and after ploughing twice, watered heavily and again ploughed in the puddle. Sprouted rhizome pieces are used for planting and pressed into the mud at a depth of about 5cm at a spacing of 30x30cm. The rhizomes are planted in such a way that the plants in the second row comes in between the plants of the first row and not opposite to them. FYM is to be applied at 25t/ha. Fertilisers are applied at 25:50:60 kg N:P2O5:K2O/ha/yr. Whole of FYM and 1/3 of N, P2O5 and K2O are to be added in the field during March - April as a basal dose. The remaining 2/3 of nutrients is to be given in two equal split doses at 4 months and 8 months after planting. The field is to be regularly irrigated. About 5 cm of standing water is to be maintained in the field in the beginning. Later, it is to be increased to 10 cm as the plant grows. The field is to be regularly weeded. About 8 weedings are to be carried out in all. At each weeding the plants are pressed into the soil. The plant is attacked by mealy bugs. Both shoot and root mealy bugs can be controlled by spraying the shoot and drenching the roots of grown up plants with 10 ml Methyl parathion or 15ml Oxydemeton methyl or 20ml Quinalphos in 10 litres of water. The crop is ready for harvest at the end of first year. The field is to be dried partially so that sufficient moisture is left in the soil to facilitate deep digging. The leaves start turning yellow and dry, indicating maturity. The rhizome will be at a depth of 60cm and having about 30-60cm spread. Therefore, harvesting is to be done carefully. The rhizomes are to be cut into 5-7.5cm long pieces and all the fibrous roots are to be removed. Yield of rhizome is about 10t/ha (Farooqi et al, 1991).

Properties and Activity:Rhizomes, roots and leaves yield essential oil. The important constituents of the Indian oil are asarone and its -isomer. Other constituents are and -pinene, myrcene, camphene, p-cymene, camphor and linalool, sesquiterpenic ketones like asarone, calamone, calacone, acolamone, iso-acolamone, acoragermacrone, epishyobunone, shyobunone and iso- shyobunone. Alcohol present is preisocalamendiol. Sesquiterpene hydrocarbons like elemene, elemane and calarene are also present. Tricyclic sesquiterpenes present are caryophyllene, humulene, guaiene, S-guaizulene, arcurcumene, -cadinene, cadinane, calamenene, calacorene, dihydrocalacorene(calamenene), cadalene and selinene. Roots yield acoric acid as a main constituent in addition to choline. Plant also yields a flavone diglycoside- luteolin 6,8-C-diglucoside.

-asarone is the ma jor constituent of essential oil from rhizome (Dandiya et al, 1958,1959; Raquibuddoula, 1967).

Rhizome is insecticidal, pisicidal, spasmolytic, hypothermic, CNS active and analgesic. Essential oil is anticonvulsant. Rhizome is acrid, bitter, thermogenic, aromatic, intellect promoting, emetic, laxative, carminative, stomachic, anthelmintic, emmenagogue, diuretic, alexeteric, expectorant, anodyne, antispasmodic, aphrodisiac, antiinflammatory, sudorific, antipyretic, sialagogue, insecticidal, tranquillizer, sedative, analgesic, antithermic, antiasthmatic, hypotensive, respiratory depressant, aperitive and tonic.... sweet flag

Linn.

Synonym: V. malabarica Bl.

Family: Dipterocarpaceae.

Habitat: Peninsular India, from Kanara to Trivandrum and in Coorg.

English: White Damar, Indian Copal-Tree, Malabar Tallow tree, Piney Varnish-Tree.

Ayurvedic: Sarja, Sarjaka, Karsya, Sasyasumbara, Devdhuupa, Marich-patraka. Chhaagakar- na. Ajakarna and Shaala (related species) are also equated with V indica.

Unani: Raal.

Siddha/Tamil: Kungiliyam, Vellai Kundarakam.

Action: Resin—astringent, antibacterial, antidiarrhoeal, emmena- gogue. Used for chronic bronchitis, piles, skin eruptions, ringworm, scrofula, tubercular glands, ulcers, wounds, boils; urinary discharges; amenorrhoea; gonorrhoea and syphilis. Bark—antidysenteric. Oil and resin—antirheumatic. Resin enters into a number of antiseptic and anti-inflammatory ointments. Leaves—juice is applied to cure burns. Orally administered to prevent vomiting.

The Ayurvedic Pharmacopoeia ofIn- dia recommends the resinous exudate internally (1-2 g) in lipid disorders, anaemia, genitourinary diseases, diarrhoea and diseases due to vitiated blood; externally in gout, abscesses, skin diseases, burns, eruptions.

The bark contains polyphenols—dl- epi-catechin, levorotatory isomers of fisetinidol, fzelechin; and bergenin.

Resin is a complex mixture of several triterpene hydrocarbons, ketones, alcohols and acids, along with small amounts of sesquiterpenes. On distillation, the oleoresin gave an essential oil (76%), consisting of phenolic constituents and azulenes. The essential oil shows marked antibacterial activity against Gram-positive and Gramnegative micro-organism.

The leaves and roots contain berge- nin and hope phenol. The seed also contain bergenin. Hope phenol showed fungicidal activity. The plant exhibited anti-ulcerogenic activity in rats.

The fruit shell contains 25% tannins.

Dosage: Resinous exudate—1-2 g (API, Vol. IV.)... vateria indica

(Linn.) Nash.

Synonym: Andropogon muricatus Retz.

A. squarrosus Hook. f. (non L. f.).

Family: Gramineae; Poaceae.

Habitat: A perennial grass, cultivated chiefly in Rajasthan, Uttar Pradesh., Punjab and the West Coast.

English: Vetiver, Khas.

Ayurvedic: Ushira, Bahu-muulaka, Sugandhimuula, Jataamedaa, Indragupta, Nalada, Laamajjaka, Sevya, Samagandhaka, Jalavaasa, Virana, Aadhya.

Unani: Cuscus, Khas

Siddha: Vettiver, Vilamichaver.

Action: Root—infusion used as refrigerant, febrifuge, diaphoretic; stimulant, stomachic, antispasmod- ic, emmenagogue, astringent, blood purifier. Used in fevers, colic, flatulence, vomiting, spermatorrhoea and strangury. Root oil—used in obstinate vomiting, colic and flatulence.

The Ayurvedic Pharmacopoeia ofIn- dia recommend the root in dysuria.

Major constituents of North Indian laevorotatory oil, (obtained from wild roots) are antipodal terpenoids, while those of South Indian dextrorotatory oils (obtained from cultivated roots) are sesquiterpene ketones and alcohols.

The North India Khas oil contains large amounts of khusilal, other ses- quiterpenes include khusol, khusimol, khusitone, cadinene and laevojuneol. The South Indian Khas oil constituents are largely nootkatone, vestipiranes and substances of tricyclic zizaane structure. Khusilal is absent in typical dextrorotatory Khas oils.

The oils from other producing countries are found to be dextrorotatory similar to that from South India.

Dosage: Fibrous root—3-6 g for infusion. (API, Vol. III.)... vetiveria zizaniodes

(DKA) a metabolic state resulting from a profound lack of insulin, usually found only in type 1 *diabetes mellitus but sometimes arising in people of Afro-Caribbean ethnicity with type 2 diabetes. Inability to inhibit glucose production from the liver results in *hyperglycaemia, which can be extreme and lead to severe dehydration. The concurrent failure to suppress fatty-acid production from adipose tissue results in the excess conversion of fatty acids to ketones in the liver (*ketosis) and the development of a metabolic *acidosis, which can be severe. Patients often present with vomiting (from the ketosis), which contributes to the dehydration. The condition is treated as a medical emergency with intravenous fluid and insulin; patients should be monitored in high-dependency units.... diabetic ketoacidosis

Rosc.

Family: Zingiberaceae.

Habitat: Native to Southeast Asia; now cultivated mainly in Kerala, Andhra Pradesh, Uttar Pradesh, West Bengal, Maharashtra.

English: Ginger.

Ayurvedic: Fresh rhizome— Aardraka, Aadrikaa, Shrngibera, shrngavera, Katubhadra. Dried rhi- zome—Shunthi, Naagara, Naagaraa, Naagaraka, Aushadha, Mahaushad- ha, Vishvaa, Vishvabheshaja, Vishvaaushadha.

Unani: Fresh rhizome—Zanjabeel- e-Ratab, Al-Zanjabeel. Dried rhizome—zanjabeel, Zanjabeel-e- yaabis.

Siddha: Fresh rhizome—Inji, Allam, Lokottai. Dried rhizome— chukku, Sunthi.

Action: Rhizome—antiemetic, antiflatulent, hypocholesterolaemic, anti-inflammatory, antispasmodic, expectorant, circulatory stimulant, diaphoretic, increases bioavailabil- ity of prescription drugs. Used for irritable bowel and diarrhoea, colds and influenza. Showed encouraging results in migraine and cluster headache (J Ethnophar- macol, 1990, 29, 267-273; Aust J Med Herbalism, 1995, 7/3, 6978; Natural Medicines Comprehensive Database, 2007.) The Ayurvedic Pharmacopoeia of India recommends dried rhizomes in dyspepsia, loss of appetite, tympanitis, anaemia, rheumatism, cough and dyspnoea; fresh rhizomes in constipation, colic, oedema and throat infections.

Key application: For dyspepsia and prevention of motion sickness (German Commission E); vomiting of pregnancy, anorexia, bronchitis and rheumatic complaints (The British Herbal Compendium); as a post-operative antiemetic. (ESCOP).

The rhizome contains an essential oil containing monoterpenes, mainly geranial and neral; and sesquiterpenes, mainly beta-sesquiphellandrene, beta- bisabolene, ar-curcumene and alpha- zingiberene; pungent principles, consisting of gingerols, shogaols and related phenolic ketone derivatives. Other constituents include diarylheptenones, diterpenes, gingesulphonic acid and monoacyldigalactosyl glycerols.

Gingerol and shogaol have been shown to suppress gastric contractions. Both fresh and dried rhizomes suppress gastric secretion and reduce vomiting. Gingerol and shogaol have gained importance due to their sedative, anti-inflammatory, antipyretic, analgesic, hypotensive and hepatopro- tective activities.

Cardiotonic effects of ginger has been attributed to 6-and 8-shagaols and gingerols. (Antithrombotic effects remain unconfirmed.) Antimigraine effect is due to ginger's ability to decrease platelet aggregation. It also acts as a potent inhibitor of prostaglandins which enhance release of substance P from trigeminal fibers. (PDR, 2004.)

Indian ginger is considered only second to Jamaican in quality.

There are three main types of Indian ginger—Cochin ginger (light brown or yellowish grey; Calicut ginger from Malabar (orange or reddish brown, resembling African ginger) and Kolkata ginger (greyish brown to greyish blue).... zingiber officinale

Dryobalanops aromatica

FAMILY: Dipterocarpaceae

SYNONYMS: D. camphora, Borneo camphor, East Indian camphor, Baros camphor, Sumatra camphor, Malayan camphor.

GENERAL DESCRIPTION: The camphora tree grows to a great height, a majestic tree often over 25 metres high, with a thick trunk up to 2 metres in diameter. Borneol is a natural exudation found beneath the bark in crevices and fissures of some mature trees (about 1 per cent); young trees produce only a clear yellow liquid known as ‘liquid camphor’.

DISTRIBUTION: Native to Borneo and Sumatra.

OTHER SPECIES: To be distinguished from the Japanese or Formosa type of camphor, more commonly used in Europe, which is relatively toxic. See also Botanical Classification section.

HERBAL/FOLK TRADITION: Borneol has long been regarded as a panacea by many Eastern civilizations, especially in ancient Persia, India and China. It was used as a powerful remedy against plague and other infectious diseases, stomach and bowel complaints. In China it was also used for embalming purposes. ‘It is mentioned by Marco Polo in the thirteenth century and Camoens in 1571 who called it the “balsam of disease”.’. It is valued for ceremonial purposes in the east generally, and in China particularly for funeral rites. Its odour repels insects and ants, and it is therefore highly regarded as timber for the construction of buildings.

ACTIONS: Mildly analgesic, antidepressant, antiseptic, antispasmodic, antiviral, carminative, rubefacient, stimulant of the adrenal cortex, tonic (cardiac and general).

EXTRACTION: The borneol is collected from the tree trunk in its crude crystalline form (the natives test each tree first by making incisions in the trunk to detect its presence). The so-called ‘oil of borneol’ is extracted by steam distillation of the wood.

CHARACTERISTICS: Watery white to viscous black oil depending upon the amount of camphor which it contains, with a distinctive, sassafras-like, camphoraceous odour.

PRINCIPAL CONSTITUENTS: The crude is made up of mainly cl-borneol which is an alcohol, not a ketone (like Japanese camphor). The oil contains approx. 35 per cent terpenes: pinene, camphene, dipentene; 10 per cent alcohols: d-borneol, terpineol; 20 per cent sesquiterpenes, and 35 per cent resin.

SAFETY DATA: Non-toxic, non-sensitizing, dermal irritant in concentration.

AROMATHERAPY/HOME: USE

Skin Care: Cuts, bruises, insect repellent,

Circulation Muscles And Joints: Debility, poor circulation, rheumatism, sprains.

Respiratory System: Bronchitis, coughs.

Immune System: Colds, fever, ‘flu and other infectious diseases.

Nervous System: Nervous exhaustion, stress-related conditions, neuralgia.

OTHER USES: It is used to scent soap in the East but is still relatively unknown in the West in pharmaceutical and perfumery work. In China and Japan it is used for making varnish and ink; also asa dilutant for artists’ colours. Mainly used for ritual purposes in the East.... borneol

Carphephorus odoratissimus

FAMILY: Asteraceae (Compositae)

SYNONYMS: Trilisa odoratissima, Liatris odoratissima, Frasera speciosa, hound’s tongue, deer’s tongue, Carolina vanilla, vanilla leaf, wild vanilla, vanilla trilisa, whart’s tongue, liatrix (oleoresin or absolute).

GENERAL DESCRIPTION: A herbaceous perennial plant distinguished by a naked receptacle and feathery pappus, with large, fleshy, dark green leaves, clasped at the base. When fresh, the leaves have little odour but when dried they acquire a vanilla-like odour, largely due to the coumarin that can be seen in crystals on the upper sides of the leaves.

DISTRIBUTION: Native to eastern USA; gathered on the savannah land between North Carolina and Florida.

OTHER SPECIES: There are several species of deertongue native to America, for example blazing star or prairie pine (Liatris squarrosa), and gayfeather (L. spicata). Not to be confused with the common vanilla (Vanilla planifolia) or with the European hound’s tongue (Cynoglossum officinale), all of which have been used in herbal medicine.

HERBAL/FOLK TRADITION: The roots have been used for their diuretic effects, and applied locally for sore throats and gonorrhoea. It has also been used as a tonic in treating malaria. In folklore the plant is associated with contraception and sterility in women.

ACTIONS: Antiseptic, demulcent, diaphoretic, diuretic, febrifuge, stimulant, tonic.

EXTRACTION: Oleoresin by solvent extraction from the dried leaves.

CHARACTERISTICS: A dark green, heavy, viscous liquid with a rich, herbaceous, new-mown hay scent. It blends well with oakmoss, labdanum, lavandin, frankincense, clove, patchouli and oriental-type fragrances.

PRINCIPAL CONSTITUENTS: Mainly coumarin (1.6 per cent), with dihydrotoumarin and terpenes, aldehydes and ketones.

SAFETY DATA: ‘Coumarin has toxic properties including liver injury and haemorrhages.’. (There is also the possibility of dermal irritation and phototoxicity due to the lactones present.)

AROMATHERAPY/HOME: USE None.

OTHER USES: The oleoresin is used as a fixative and fragrance component in soaps, detergents and perfumery work. Used for flavouring tobacco and; also employed for the isolation of coumarin.... deertongue

Pilocarpus jaborandi

FAMILY: Rutaceae

SYNONYMS: Pernambuco jaborandi, P. pennatifolius, iaborandi, jamborandi, arrudo do mato, arruda brava, jamguaraddi, juarandi.

GENERAL DESCRIPTION: A woody shrub up to 2 metres high with a smooth, greyish bark, large brownish-green leathery leaves containing big oil glands and reddish-purple flowers.

DISTRIBUTION: Native to Brazil; other species are found in Paraguay, Cuba, the West Indies and Central America.

OTHER SPECIES: There are many members of the Rutaceae and Piperaceae family known simply as jaborandi, such as Piper jaborandi. Others include maranham jaborandi (P. microphyllus), ceara jaborandi (P. trachylophus) and aracti jaborandi (P. spicatus).There is consequently some confusion about the exact botanical source of the oil.

HERBAL/FOLK TRADITION: Jaborandi induces salivation and most gland secretions; it was also used at one time to promote hair growth. ‘Useful in psoriasis, prurigo, deafness ... chronic catarrh, tonsillitis and particularly dropsy.’ .

ACTIONS: Antiseptic, diaphoretic, emmenagogue, galactagogue, stimulant (nerve).

EXTRACTION: Essential oil by steam distillation from the dried leaflets.

CHARACTERISTICS: An orange or yellow liquid with a sweet-herbaceous fruity odour.

PRINCIPAL CONSTITUENTS: Pilocarpine is the main active constituent; also isopilocarpine, pilocarpidine, methyl nonyl ketone, dipentene and other hydrocarbons.

SAFETY DATA: Oral toxin, skin irritant, abortifacient.

AROMATHERAPY/HOME: USE None.

OTHER USES: Various hypodermic solutions are prepared from pilocarpine: the crude oil is rarely used. Little used in perfumery or flavour work due to toxicity.... jaborandi

Citrus aurantium var. amara

FAMILY: Rutaceae

SYNONYMS: C. vulgaris, C. bigaradia, Seville orange, sour orange bigarade (oil).

GENERAL DESCRIPTION: An evergreen tree up to 10 metres high with dark green, glossy, oval leaves, paler beneath, with long but not very sharp spines. It has a smooth greyish trunk and branches, and very fragrant white flowers. The fruits are smaller and darker than the sweet orange. It is well known for its resistance to disease and is often used as root stock for other citrus trees, including the sweet orange.

DISTRIBUTION: Native to the Far East, especially India and China, but has become well adapted to the Mediterranean climate. It also grows abundantly in the USA (California), Israel and South America. Main producers of the oil include Spain, Guinea, the West Indies, Italy, Brazil and the USA.

OTHER SPECIES: There are numerous different species according to location – oils from Spain and Guinea are said to be of superior quality.

HERBAL/FOLK TRADITION: ‘Oranges and lemons strengthen the heart, are good for diminishing the coagubility of the blood, and are beneficial for palpitation, scurvy, jaundice, bleedings, heartburn, relaxed throat, etc. They are powerfully anti-scorbutic, either internally or externally applied.’. The dried bitter orange peel is used as a tonic and carminative in treating dyspepsia.

In Chinese medicine the dried bitter orange and occasionally its peel are used in treating prolapse of the uterus and of the anus, diarrhoea, and blood in the faeces. Ingestion of large amounts of orange peel in children, however, has been reported to cause toxic effects.

ACTIONS: Anti-inflammatory, antiseptic, astringent, bactericidal, carminative, choleretic, fungicidal, sedative (mild), stomachic, tonic.

EXTRACTION: An essential oil by cold expression (hand or machine pressing) from the outer peel of the almost ripe fruit. (A terpeneless oil is also produced.) The leaves are used for the production of petitgrain oil; the blossom for neroli oil.

CHARACTERISTICS: A dark yellow or brownish-yellow mobile liquid with a fresh, dry, almost floral odour with a rich, sweet undertone.

PRINCIPAL CONSTITUENTS: Over 90 per cent monoterpenes: mainly limonene, myrcene, camphene, pinene, ocimene, cymene, and small amounts of alcohols, aldehydes and ketones.

SAFETY DATA: Phototoxic; otherwise generally non-toxic, non-irritant and non sensitizing. Limonene has been reported to cause contact dermatitis in some individuals.

AROMATHERAPY/HOME: USE See sweet orange.

OTHER USES: Used in certain stomachic, laxative and carminative preparations. Employed as a fragrance component in soaps, detergents, cosmetics, colognes and perfumes. Extensively used as a flavouring material, especially in liqueurs and soft drinks. Also utilized as a starting material for the isolation of naturallimonene.... orange, bitter

Ruta graveolens

FAMILY: Rutaceae

SYNONYMS: Garden rue, herb-of-grace, herbygrass.

GENERAL DESCRIPTION: An ornamental, shrubby herb with tough, woody branches, small, smooth, bluish-green leaves and greeny yellow flowers. The whole plant has a strong, aromatic, bitter or acrid scent.

DISTRIBUTION: Native to the Mediterranean region; found growing wild extensively in Spain, Morocco, Corsica, Sardinia and Algeria. It is cultivated mainly in France and Spain for its oil; also in Italy and Yugoslavia.

OTHER SPECIES: There are several different types of rue, such as the summer rue (R. montana), winter rue (R.chalepensis) and Sardinian rue (R. angustifolia), which are also used to produce essential oils.

HERBAL/FOLK TRADITION: A favoured remedy of the ancients, especially as an antidote to poison. It was seen as a magic herb by many cultures and as a protection against evil. It was also used for nervous afflictions. ‘It helps disorders in the head, nerves and womb, convulsions and hysteric fits, the colic, weakness of the stomach and bowels; it resists poison and cures venomous bites.’.

ACTIONS: Antitoxic, antitussive, antiseptic, antispasmodic, diuretic, emmenagogue, insecticidal, nervine, rubefacient, stimulant, tonic, vermifuge.

EXTRACTION: Essential oil by steam distillation from the fresh herb.

CHARACTERISTICS: A yellow or orange viscous mass which generally solidifies at room temperature, with a sharp, herbaceous-fruity acrid odour. The winter rue oil does not solidify at room temperature.

PRINCIPAL CONSTITUENTS: Mainly methyl nonyl ketone (90 per cent in summer rue oil).

SAFETY DATA: Oral toxin (due to main constituent). Skin and mucous membrane irritant. Abortifacient. ‘Rue oil should never be used in perfumery or flavour work.’ .

AROMATHERAPY/HOME: USE None. ‘Should not be used at all in aromatherapy.’.

OTHER USES: Employed as a source of methyl nonyl ketone.... rue

Curcuma longa

FAMILY: Zingiberaceae

SYNONYMS: C. domestica, Amomoum curcuma, curcuma, Indian saffron, Indian yellow root, curmuma (oil).

GENERAL DESCRIPTION: A perennial tropical herb up to 1 metre high, with a thick rhizome root, deep orange inside, lanceolate root leaves tapering at each end, and dull yellow flowers.

DISTRIBUTION: Native to southern Asia; extensively cultivated in India, China, Indonesia, Jamaica and Haiti. The oil is mainly distilled in India, China and Japan. Some roots are imported to Europe and the USA for distillation.

OTHER SPECIES: Closely related to the common ginger (Zingiber officinale). Not to be confused with the Indian turmeric or American yellow root (Hydrastis canadensis).

HERBAL/FOLK TRADITION: A common household spice, especially for curry powder. It is high in minerals and vitamins, especially vitamin C. It is also used extensively as a local home medicine.

In Chinese herbalism it is used for bruises, sores, ringworm, toothache, chest pains, colic and menstrual problems, usually in combination with remedies. It was once used as a cure for jaundice.

ACTIONS: Analgesic, anti-arthritic, anti inflammatory, anti-oxidant, bactericidal, cholagogue, digestive, diuretic, hypotensive, insecticidal, laxative, rubefacient, stimulant.

EXTRACTION: Essential oil by steam distillation from the ‘cured’ rhizome – boiled, cleaned and sun-dried. (An oleoresin, absolute and concrete are also produced by solvent extraction.)

CHARACTERISTICS: A yellowy-orange liquid with a faint blue fluorescence and a fresh spicy woody odour. It blends well with cananga, labdanum, elecampane, ginger, orris, cassie, clary sage and mimosa.

PRINCIPAL CONSTITUENTS: Mainly tumerone (60 per cent), with ar-tumerone, atlantones, zingiberene, cineol, borneol, sabinene and phellandrene, among others.

SAFETY DATA: The ketone ‘tumerone’ is moderately toxic and irritant in high concentration. Possible sensitization problems. ‘The essential oil of turmeric must be used in moderation and with care for a fairly limited period.’.

AROMATHERAPY/HOME: USE

Circulation muscles and joints: Arthritis, muscular aches and pains, rheumatism.

Digestive system: Anorexia, sluggish digestion, liver congestion.

OTHER USES: Employed in perfumery work, for oriental and fantasy-type fragrances. The oleoresin is used as a flavour ingredient in some foods, mainly curries, meat products and condiments.... turmeric