n. a nodular form of glomerulosclerosis associated with diabetic nephropathy. See also diabetic glomerulosclerosis. [P. Kimmelstiel and C. Wilson (20th century), US physicians]
A rare, inherited disorder in which copper accumulates in the liver, resulting in conditions such as hepatitis and cirrhosis. Copper is slowly released into other body parts, damaging the brain, causing mild intellectual impairment, and leading to debilitating rigidity, tremor, and dementia. Symptoms usually appear in adolescence but can occur much earlier or later. Lifelong treatment with penicillamine is needed and, if begun soon enough, can sometimes produce some improvement. If the disease is discovered before the onset of symptoms, the drug may prevent them from developing.... wilson’s disease
Wilson’s disease, or hepatolenticular degeneration, is a familial disease in which there is an increased accumulation of COPPER in the liver, brain, and other tissues including the kidneys. Its main manifestation is the development of tremor and rigidity, with di?culty in speech. In many cases there is improvement following the administration of dimercaprol, penicillamine, or trientine dihydrochloride; these substances cause an increased excretion of copper.... wilson’s disease
an abnormality of small blood vessels (microscopically, an arteriovenous malformation), identified predominantly in the mucosal lining of the upper stomach, that may cause severe spontaneous haemorrhage. It can rarely be found in the duodenum, colon, jejunum, or oesophagus. If detected endoscopically, curative therapy is often possible, although the abnormality is often difficult to see at gastroscopy. Surgical exploration may be required if the bleeding is unresponsive to endoscopic treatment. [G. Dieulafoy (1839–1911), French physician]... dieulafoy’s lesion
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