Leucocytosis Health Dictionary

Causes The direct cause is various BACTERIA. Sometimes the presence of foreign bodies, such as bullets or splinters, may produce an abscess, but these foreign bodies may remain buried in the tissues without causing any trouble provided that they are not contaminated by bacteria or other micro-organisms.

The micro-organisms most frequently found are staphylococci (see STAPHYLOCOCCUS), and, next to these, streptococci (see STREPTOCOCCUS) – though the latter cause more virulent abscesses. Other abscess-forming organisms are Pseudomonas pyocyanea and Escherichia coli, which live always in the bowels and under certain conditions wander into the surrounding tissues, producing abscesses.

The presence of micro-organisms is not suf?cient in itself to produce suppuration (see IMMUNITY; INFECTION); streptococci can often be found on the skin and in the skin glands of perfectly healthy individuals. Whether they will produce abscesses or not depends upon the virulence of the organism and the individual’s natural resistance.

When bacteria have gained access – for example, to a wound – they rapidly multiply, produce toxins, and cause local dilatation of the blood vessels, slowing of the bloodstream, and exudation of blood corpuscles and ?uid. The LEUCOCYTES, or white corpuscles of the blood, collect around the invaded area and destroy the bacteria either by consuming them (see PHAGOCYTOSIS) or by forming a toxin that kills them. If the body’s local defence mechanisms fail to do this, the abscess will spread and may in severe cases cause generalised infection or SEPTICAEMIA.

Symptoms The classic symptoms of in?ammation are redness, warmth, swelling, pain and fever. The neighbouring lymph nodes may be swollen and tender in an attempt to stop the bacteria spreading to other parts of the body. Infection also causes an increase in the number of leucocytes in the blood (see LEUCOCYTOSIS). Immediately the abscess is opened, or bursts, the pain disappears, the temperature falls rapidly to normal, and healing proceeds. If, however, the abscess discharges into an internal cavity such as the bowel or bladder, it may heal slowly or become chronic, resulting in the patient’s ill-health.

Treatment Most local infections of the skin respond to ANTIBIOTICS. If pus forms, the abscess should be surgically opened and drained.

Abscesses can occur in any tissue in the body, but the principles of treatment are broadly the same: use of an antibiotic and, where appropriate, surgery.... abscess

Habitat: Throughout India in shady wet places and near streams.

Action: Fruit and stem bark— astringent. Infusion of fruits—used as gargle in aphthae and sore throat. Fruit juice—used as application for wounds and ulcers. Oil of seeds— given in diarrhoea and dysentery Ether extract of fruit—antibacterial. Bark—astringent and styptic, used in menorrhagia, diarrhoea, dysentery and intermittent fevers.

Many snakes are non-venomous (e.g. pythons, garter snakes, king snakes, boa constrictors) but may still in?ict painful bites and cause local swelling. Most venomous snakes belong to the viper and cobra families and are common in Asia, Africa, Australia and South America. Victims of bites may experience various effects including swelling, PARALYSIS of the bitten area, blood-clotting defects, PALPITATION, respiratory di?culty, CONVULSIONS and other neurotoxic and cardiac effects. Victims should be treated as for SHOCK – that is, kept at rest, kept warm, and given oxygen if required but nothing by mouth. The bite site should be immobilised but a TOURNIQUET must not be used. All victims require prompt transfer to a medical facility. When appropriate and available, antivenoms should be administered as soon as possible.

Similar management is appropriate for bites and stings by spiders, scorpions, sea-snakes, venomous ?sh and other marine animals and insects.

Bites and stings in the UK The adder (Vipera berus) is the only venomous snake native to Britain; it is a timid animal that bites only when provoked. Fatal cases are rare, with only 14 deaths recorded in the UK since 1876, the last of these in 1975. Adder bites may result in marked swelling, weakness, collapse, shock, and in severe cases HYPOTENSION, non-speci?c changes in the electrocardiogram and peripheral leucocytosis. Victims of adder bites should be transferred to hospital even if asymptomatic, with the affected limb being immobilised and the bite site left alone. Local incisions, suction, tourniquets, ice packs or permanganate must not be used. Hospital management may include use of a speci?c antivenom, Zagreb®.

The weever ?sh is found in the coastal waters of the British Isles, Europe, the eastern Atlantic, and the Mediterranean Sea. It possesses venomous spines in its dorsal ?n. Stings and envenomation commonly occur when an individual treads on the ?sh. The victim may experience a localised but increasing pain over two hours. As the venom is heat-labile, immersion of the affected area in water at approximately 40 °C or as hot as can be tolerated for 30 minutes should ease the pain. Cold applications will worsen the discomfort. Simple ANALGESICS and ANTIHISTAMINE DRUGS may be given.

Bees, wasps and hornets are insects of the order Hymenoptera and the females possess stinging apparatus at the end of the abdomen. Stings may cause local pain and swelling but rarely cause severe toxicity. Anaphylactic (see ANAPHYLAXIS) reactions can occur in sensitive individuals; these may be fatal. Deaths caused by upper-airway blockage as a result of stings in the mouth or neck regions are reported. In victims of stings, the stinger should be removed as quickly as possible by ?icking, scraping or pulling. The site should be cleaned. Antihistamines and cold applications may bring relief. For anaphylactic reactions ADRENALINE, by intramuscular injection, may be required.... bites and stings

Granulocytes Also known as polymorphonuclear leucocytes (‘polys’), these normally constitute 70 per cent of the white blood cells. They are divided into three groups according to the staining reactions of these granules: neutrophils, which stain with neutral dyes and constitute 65–70 per cent of all the white blood cells; eosinophils, which stain with acid dyes (e.g. eosin) and constitute 3–4 per cent of the total white blood cells; and basophils, which stain with basic dyes (e.g. methylene blue) and constitute about 0·5 per cent of the total white blood cells.

Lymphocytes constitute 25–30 per cent of the white blood cells. They have a clear, non-granular cytoplasm and a relatively large nucleus which is only slightly indented. They are divided into two groups: small lymphocytes, which are slightly larger than erythrocytes (about 8 micrometres in diameter); and large lymphocytes, which are about 12 micrometres in diameter.

Monocytes Motile phagocytic cells that circulate in the blood and migrate into the tissues, where they develop into various forms of MACROPHAGE such as tissue macrophages and KUPFFER CELLS.

Site of origin The granulocytes are formed in the red BONE MARROW. The lymphocytes are formed predominantly in LYMPHOID TISSUE. There is some controversy as to the site of origin of monocytes: some say they arise from lymphocytes, whilst others contend that they are derived from histiocytes – i.e. the RETICULO-ENDOTHELIAL SYSTEM.

Function The leucocytes constitute one of the most important of the defence mechanisms against infection. This applies particularly to the neutrophil leucocytes (see LEUCOCYTOSIS). (See also ABSCESS; BLOOD – Composition; INFLAMMATION; PHAGOCYTOSIS; WOUNDS.)... leucocytes

FAMILY: Amaryllidaceae or Liliaceae

SYNONYMS: Common garlic, allium, poor man’s treacle!

GENERAL DESCRIPTION: A strongly scented perennial herb up to 1.2 metres high with long, flat, firm leaves and whitish flowering stems. The bulb is made up of several cloves pressed together within a thin white skin.

DISTRIBUTION: It is said to have originated in south west Siberia and then spread to Europe and Central Asia. It is naturalized in North America and cultivated worldwide. Major oil-producing countries include Egypt, Bulgaria, France, China, Germany and Japan.

OTHER SPECIES: Closely related to the wild or wood garlic (A. ursinum) also known as ‘ramsons’. There are also many other wild species with similar but less pronounced properties.

HERBAL/FOLK TRADITION: It has been used for thousands of years for its medicinal virtues: for respiratory and urinary tract infections; digestive disorders and infestations; skin eruptions; heart disease, high blood pressure and arteriosclerosis, as well as epidemics and fever. It was used in the First World War for preventing gangrene and sepsis.

It has a high reputation in the East: in China it is used for diarrhoea, dysentery, tuberculosis, diphtheria, hepatitis, ringworm, typhoid and trachoma, among others. It is also held in high regard in the West: specific in the British Herbal Pharmacopoeia for chronic bronchitis. Its properties have been attested to by modern experimental and clinical research.

ACTIONS: Amoebicidal, anthelmintic, antibiotic, antimicrobial, antiseptic, antitoxic, antitumour, antiviral, bactericidal, carminative, cholagogue, hypocholesterolemic, depurative, diaphoretic, diuretic, expectorant, febrifuge, fungicidal, hypoglycaemic, hypotensive, insecticidal, larvicidal, promotes leucocytosis, stomachic, tonic.

EXTRACTION: Essential oil by steam distillation from the fresh crushed bulbs.

CHARACTERISTICS: A colourless to pale yellow mobile liquid with a strong, unpleasant, familiar garlic-like odour.

PRINCIPAL CONSTITUENTS: Allicin, allylpropyl disulphide, diallyl disulphide, diallyl trisulphide, citral, geraniol, linalol, phellandrene, among others.

SAFETY DATA: Generally non-toxic and non-irritant, although it has been known to irritate the stomach; may also cause sensitization in some individuals.

AROMATHERAPY/HOME: USE Due to its unpleasant and pervasive smell, the oil is not often used externally. However, the capsules may be taken internally according to the instructions on the label for respiratory and gastro-intestinal infections, urinary tract infections such as cystitis, heart and circulatory problems, and to fight infectious diseases in general.

OTHER USES: The oil is made into capsules and also included in many health food products mainly to help reduce high blood pressure and protect against heart disease. Extensively employed as a flavour ingredient in most major food categories, especially savouries.... garlic