Lupus anticoagulant Health Dictionary

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Lupus Anticoagulant: From 1 Different Sources

one of several autoantibodies that can cause *antiphospholipid antibody syndrome (APS). Despite the name, the antibody behaves as a coagulant, increasing the risk of thrombosis. It can be found in 50% of patients with APS.
Health Source: Oxford | Concise Colour Medical Dictionary
Author: Jonathan Law, Elizabeth Martin

Anticoagulant

Inhibiting the clotting of blood ... anticoagulant

Lupus Erythematosus

Auto-immune disease – antibody to DNA. Non-tubercula. Two kinds: (1) discoid lupus erythematosus (DLE) and (2) systemic lupus erythematosus (SLE). DLE occurs mostly in middle-aged women, but SLE in young women. Activity may be followed by period of remission. The condition may evolve into rheumatic disease.

Symptoms (SLE): Loss of appetite, fever. Weight loss, weakness. Thickened scaly red patches on face (butterfly rash). May invade scalp and cause loss of hair. Sunlight worsens. Anaemia. Joint pains. Enlarged spleen. Heart disorders. Kidney weakness, with protein in the urine. Symptoms worse on exposure to sunlight. Low white blood cell count. Many patients may also present with Raynaud’s phenomenon while some women with silicone breast implants may develop lupus.

Treatment. Anti-virals. Alteratives. Anti-inflammatories, anticoagulants. Alternatives. Teas: Lime flowers, Gotu Kola, Ginkgo, Aloe Vera, Boneset.

Decoctions: Burdock. Queen’s Delight. Helonias.

Tablets/capsules. Echinacea. Blue Flag root. Wild Yam. Ginkgo.

Formula. Dandelion 1; Black Haw 1; Wild Yam half; Poke root half. Dose: Liquid Extracts: one 5ml teaspoon. Tinctures: two 5ml teaspoons. Powders: 500mg (two 00 capsules or one-third teaspoon). Thrice daily.

Topical. Sunlight barrier creams: Aloe Vera, Comfrey. Horsetail poultice. Garlic ointment. Castor oil packs.

Diet. See: DIET – SKIN DISORDERS.

Supplements. Calcium pantothenate, Vitamin A, Vitamin E, Selenium.

Note: The disorder is frequently misdiagnosed as rheumatoid arthritis, multiple sclerosis or ME. Lupus antibodies have been linked with premature heart disease in women and transient strokes. ... lupus erythematosus

Lupus Vulgaris

Tubercula skin disease, with small apple-jelly yellow nodules progressing to ulceration. Distribution: face, neck and mucous surfaces of mouth and nose. Non-itching. Skin thickens and discolours. Nose may be eroded and deformed.

Treatment. Because of plastic surgery deformities are now seldom seen, yet herbalism may still have a case in the absence of conventional drugs.

Teas. Elecampane. Gotu Kola.

Red Clover compound.

Arthur Barker. Liquid Extract Echinacea 1oz; Liquid Extract Queen’s Delight half an ounce; Tincture Goldenseal 30 drops. Syr Senna 2oz. Distilled, or pure spring water to 8oz. Dose: 1 dessertspoon after meals.

Topical. Marshmallow and Slippery Elm poultices or ointment. Oil of Mullein. Aloe Vera. Castor oil packs. ... lupus vulgaris

Lupus

This is the Latin word for wolf, and a term applied to certain chronic skin diseases which can destroy skin, underlying cartilage and even bone to cause serious deformity if uncontrolled.

Lupus vulgaris is a form of TUBERCULOSIS of the skin. It typically begins in childhood and may spread slowly for decades if untreated. The face and neck are the usual sites. In untreated disease, large, well-demarcated areas may be affected with redness, scaling and thickening. If the affected skin is blanched by pressure, yellow-brown foci may be observed – the so-called apple-jelly nodules. The disease causes extensive scarring as it spreads and may destroy cartilage in its path – for example, on the nose or ear – causing gross deformity. The disease was common in the UK up to 50 years ago, but is now rare. It is treated with a combination of tuberculostatic drugs.

Lupus erythematosus is an autoimmune disease which can affect skin or internal organs.

Discoid lupus erythematosus (DLE) In this disease, only the skin is affected. Sharply de?ned red, scaly and eventually atrophic patches appear on the face, especially on the nose and cheeks. ALOPECIA with scarring is seen if the scalp is affected. The condition is aggravated by sunlight. Topical CORTICOSTEROIDS are helpful.... lupus

Systemic Lupus Erythematosus (sle)

See separate dictionary entry.... systemic lupus erythematosus (sle)

Anticoagulants

Anticoagulants are drugs which inhibit COAGULATION of the blood. They are used to prevent and treat abnormal clotting of the blood, to treat THROMBOSIS, and sometimes to prevent or treat STROKE or TRANSIENT ISCHAEMIC ATTACKS OR EPISODES (TIA, TIE). Anticoagulant drugs are also prescribed preventively in major surgery to stop abnormal clotting from occurring; HAEMODIALYSIS is another procedure during which these drugs are used. Anticoagulants are also prescribed to prevent thrombi (clots) forming on prosthetic heart valves after heart surgery.

The drugs are much more e?ective in the treatment and prevention of venous clotting – for example, deep vein thrombosis (DVT), see under VEINS, DISEASES OF – than in preventing thrombosis formation in arteries with their fast-?owing blood in which thrombi contain little ?brin (against which the anticoagulants work) and many PLATELETS.

The main anticoagulants now in use are the natural agent HEPARIN (a quick-acting variety and a low-molecular-weight long-acting type); synthetic oral anticoagulants such as WARFARIN and the less-often-used acenocoumarol and PHENINDIONE; and antiplatelet compounds such as ASPIRIN, clopidogrel dipyridamole and ticlopidines. Fondaparinux is an extract of heparin which can be given once daily by injection; ximelagatran, an inhibitor of thrombin, is being trialled as the ?rst new oral anticoagulant since heparin.

Patients taking anticoagulants need careful medical monitoring and they should carry an Anticoagulant Card with instructions about the use of whatever drug they may be receiving – essential information should the individual require treatment for other medical conditions as well as for thrombosis.... anticoagulants

Discoid Lupus Erythematosus (dle)

See under LUPUS.... discoid lupus erythematosus (dle)

Arthritis, Lupus

A form of arthritis associated with systemic lupus erythematosis in young girls. An auto-immune disease which may involve the heart, kidney, CNS or other systems.

Symptoms: Joint pains with feverishness, loss of weight, anaemia and red raised patches of skin on nose and face (butterfly rash). Swelling of the joints resembles rheumatoid arthritis. Chest and kidney disease possible. Personality changes with depression followed by mania and possible convulsions.

Treatment. Standard orthodox treatments: aspirin, steroids. Alternatives: Echinacea (rash), Valerian (mental confusion), Lobelia (chest pains), Parsley Piert (kidney function).

Tablets/capsules. Echinacea. Poke root. Dandelion. Valerian. Wild Yam. Prickly Ash bark.

Powders. Echinacea 2; Dandelion 1; Wild Yam half; Poke root quarter; Devil’s Claw half; Fennel half. Mix. Dose: 500mg (two 00 capsules or one-third teaspoon) thrice daily. In water or cup of Fenugreek tea. Tinctures. Dandelion 4; Valerian 1; Prickly Ash half; Poke root half; Peppermint quarter. Mix. Dose: 1 teaspoon thrice daily, in water or cup Fenugreek tea.

Tincture. Queen’s Delight BHP (1983) 1:5 in 45 per cent alcohol. Dose 1-4ml (15-60 drops).

Topical. Plantain Salvo. Castor oil. Oil Cajeput or Sassafras. Comfrey or Chickweed cream.

Diet. Young girls may require diet for anaemia.

Supplementation. Daily. Vitamins A, B6, B12, C, D. Dolomite (1500mg). Calcium Pantothenate (500mg). Iron: Men (10mg), women (18mg). ... arthritis, lupus

Anticoagulant Drugs

A group of drugs used to treat and prevent abnormal blood clotting, to treat thrombosis, and to prevent and treat stroke and transient ischaemic attack. Anticoagulant drugs are also given to prevent abnormal blood clotting after major surgery (especially heart-valve replacement) or during haemodialysis (see dialysis). The most common anticoagulants are heparin and the newer heparin-derived drugs, such as tinzaparin, all of which have to be given by injection, and warfarin, which is taken orally.

Excessive doses of anticoagulant drugs increase the risk of unwanted bleeding, and regular monitoring is needed.... anticoagulant drugs

Lupus Pernio

Sarcoidosis affecting the skin, in which purple, chilblain-like swellings appear on the nose, cheeks, or ears.... lupus pernio

Systemic Lupus Erythematosus

See lupus erythematosus.... systemic lupus erythematosus

Direct Oral Anticoagulant

(DOAC) a relatively recently introduced class of drugs that reduce coagulation of the blood by inhibition of one of the coagulation factors (Factor Xa). They may be used as an alternative to *warfarin in many (but not all) cases, their advantage being that regular blood tests are not required for dose adjustment. Examples include, apixaban, dabigatran, edoxaban, and rivaroxaban.... direct oral anticoagulant

Discoid Lupus Erythematosus

(DLE) see lupus erythematosus.... discoid lupus erythematosus

Lupus Nephritis

a frequent and serious complication of systemic *lupus erythematosus (SLE). The 2002 WHO/ISN/RPS classification of lupus nephritis recognizes six classes: class I is the presence of mesangial deposits (see juxtaglomerular apparatus) seen on immunofluorescence and/or electron microscopy; class II is the presence of mesangial deposits and mesangial hypercellularity; class III is focal and segmental *glomerulonephritis; class IV is diffuse segmental or global nephritis; class V is *membranous nephropathy; and class VI is advanced sclerotic glomerulonephritis. Untreated, outcomes are poor in classes III and IV, but much improved with immunosuppressant treatment.... lupus nephritis

Lupus Verrucosus

a rare tuberculous infection of the skin – commonly the arm or hand – typified by warty lesions. It occurs in those who have been reinfected with tuberculosis.... lupus verrucosus

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