Lupus Nephritis: From 1 Different Sources
a frequent and serious complication of systemic *lupus erythematosus (SLE). The 2002 WHO/ISN/RPS classification of lupus nephritis recognizes six classes: class I is the presence of mesangial deposits (see juxtaglomerular apparatus) seen on immunofluorescence and/or electron microscopy; class II is the presence of mesangial deposits and mesangial hypercellularity; class III is focal and segmental *glomerulonephritis; class IV is diffuse segmental or global nephritis; class V is *membranous nephropathy; and class VI is advanced sclerotic glomerulonephritis. Untreated, outcomes are poor in classes III and IV, but much improved with immunosuppressant treatment.
Inflation of the kidneys... nephritis
Auto-immune disease – antibody to DNA. Non-tubercula. Two kinds: (1) discoid lupus erythematosus (DLE) and (2) systemic lupus erythematosus (SLE). DLE occurs mostly in middle-aged women, but SLE in young women. Activity may be followed by period of remission. The condition may evolve into rheumatic disease.
Symptoms (SLE): Loss of appetite, fever. Weight loss, weakness. Thickened scaly red patches on face (butterfly rash). May invade scalp and cause loss of hair. Sunlight worsens. Anaemia. Joint pains. Enlarged spleen. Heart disorders. Kidney weakness, with protein in the urine. Symptoms worse on exposure to sunlight. Low white blood cell count. Many patients may also present with Raynaud’s phenomenon while some women with silicone breast implants may develop lupus.
Treatment. Anti-virals. Alteratives. Anti-inflammatories, anticoagulants. Alternatives. Teas: Lime flowers, Gotu Kola, Ginkgo, Aloe Vera, Boneset.
Decoctions: Burdock. Queen’s Delight. Helonias.
Tablets/capsules. Echinacea. Blue Flag root. Wild Yam. Ginkgo.
Formula. Dandelion 1; Black Haw 1; Wild Yam half; Poke root half. Dose: Liquid Extracts: one 5ml teaspoon. Tinctures: two 5ml teaspoons. Powders: 500mg (two 00 capsules or one-third teaspoon). Thrice daily.
Topical. Sunlight barrier creams: Aloe Vera, Comfrey. Horsetail poultice. Garlic ointment. Castor oil packs.
Diet. See: DIET – SKIN DISORDERS.
Supplements. Calcium pantothenate, Vitamin A, Vitamin E, Selenium.
Note: The disorder is frequently misdiagnosed as rheumatoid arthritis, multiple sclerosis or ME. Lupus antibodies have been linked with premature heart disease in women and transient strokes. ... lupus erythematosus
See separate dictionary entry.... systemic lupus erythematosus (sle)
See under LUPUS.... discoid lupus erythematosus (dle)
A form of arthritis associated with systemic lupus erythematosis in young girls. An auto-immune disease which may involve the heart, kidney, CNS or other systems.
Symptoms: Joint pains with feverishness, loss of weight, anaemia and red raised patches of skin on nose and face (butterfly rash). Swelling of the joints resembles rheumatoid arthritis. Chest and kidney disease possible. Personality changes with depression followed by mania and possible convulsions.
Treatment. Standard orthodox treatments: aspirin, steroids. Alternatives: Echinacea (rash), Valerian (mental confusion), Lobelia (chest pains), Parsley Piert (kidney function).
Tablets/capsules. Echinacea. Poke root. Dandelion. Valerian. Wild Yam. Prickly Ash bark.
Powders. Echinacea 2; Dandelion 1; Wild Yam half; Poke root quarter; Devil’s Claw half; Fennel half. Mix. Dose: 500mg (two 00 capsules or one-third teaspoon) thrice daily. In water or cup of Fenugreek tea. Tinctures. Dandelion 4; Valerian 1; Prickly Ash half; Poke root half; Peppermint quarter. Mix. Dose: 1 teaspoon thrice daily, in water or cup Fenugreek tea.
Tincture. Queen’s Delight BHP (1983) 1:5 in 45 per cent alcohol. Dose 1-4ml (15-60 drops).
Topical. Plantain Salvo. Castor oil. Oil Cajeput or Sassafras. Comfrey or Chickweed cream.
Diet. Young girls may require diet for anaemia.
Supplementation. Daily. Vitamins A, B6, B12, C, D. Dolomite (1500mg). Calcium Pantothenate (500mg). Iron: Men (10mg), women (18mg). ... arthritis, lupus
Sarcoidosis affecting the skin, in which purple, chilblain-like swellings appear on the nose, cheeks, or ears.... lupus pernio
See lupus erythematosus.... systemic lupus erythematosus
(DLE) see lupus erythematosus.... discoid lupus erythematosus
one of several autoantibodies that can cause *antiphospholipid antibody syndrome (APS). Despite the name, the antibody behaves as a coagulant, increasing the risk of thrombosis. It can be found in 50% of patients with APS.... lupus anticoagulant
a rare tuberculous infection of the skin – commonly the arm or hand – typified by warty lesions. It occurs in those who have been reinfected with tuberculosis.... lupus verrucosus
nephritis associated with infected indwelling shunts. The infection is usually with staphylococci (S. epidermidis) and patients present with anorexia, malaise, arthralgia, and low-grade fever. Purpura, anaemia, and hepatosplenomegaly may be found and urine analysis shows heavy proteinuria, often with a *nephrotic syndrome and haematuria. Treatment usually involves removal of the infected shunt as well as antibiotics.... shunt nephritis
disease of the *tubulointerstitium of the kidney. Acute interstitial nephritis (AIN) represents in many cases an allergic reaction to drugs (especially ampicillin, cephalexin, NSAIDs, allopurinol, and frusemide). AIN can also be associated with acute infections and autoimmune disease. Thirst and polyuria may be prominent, and renal function severely affected. In allergic cases, the use of steroids hastens recovery after the allergen has been removed. Chronic interstitial nephritis (CIN) is associated with progressive scarring of the tubulointerstitium, often with lymphocyte infiltration. Primary causes of CIN include gout, radiation nephropathy, sarcoidosis, *analgesic nephropathy, reflux nephropathy, chronic hypokalaemia and hypercalcaemia, and *Aristolochia-associated nephropathies. Management of CIN involves removal of the precipitating cause, where identified, and control of hypertension.... interstitial nephritis
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