Magenta Health Dictionary

These infections, also called mycoses (see MYCOSIS), are common and particularly affect the skin or mucosal membranes in, for example, the mouth, anus or vagina. Fungi consist of threadlike hyphae which form tangled masses or mycelia – common mould. In what is called dermatophyte (multicellular fungi) fungal infection of the hair, nails and SKIN, these hyphae invade the KERATIN. This is usually described as ‘RINGWORM’, although no worm is present and the infection does not necessarily occur in rings. PITYRIASIS versicolor and candidosis (monoliasis – see CANDIDA), called thrush when it occurs in the vulva, vagina and mouth, are caused by unicellular fungi which reproduce by budding and are called yeasts. Other fungi, such as ACTINOMYCOSIS, may cause deep systemic infection but this is uncommon, occurring mainly in patients with immunosuppressive disorders or those receiving prolonged treatment with ANTIBIOTICS.

Diagnosis and treatment Any person with isolated, itching, dry and scaling lesions of the skin with no obvious cause – for example, no history of eczema (see DERMATITIS) – should be suspected of having a fungal infection. Such lesions are usually asymmetrical. Skin scrapings or nail clippings should be sent for laboratory analysis. If the lesions have been treated with topical steroids they may appear untypical. Ultraviolet light ?ltered through glass (Wood’s light) will show up microsporum infections, which produce a green-blue ?uorescence.

Fungal infections used to be treated quite e?ectively with benzoic-acid compound ointment; it has now been superseded by new IMIDAZOLES preparations, such as CLOTRIMAZOLE, MICONAZOLE and terbina?ne creams. The POLYENES, NYSTATIN and AMPHOTERICIN B, are e?ective against yeast infections. If the skin is macerated it can be treated with magenta (Castellani’s) paint or dusting powder to dry it out.

Refractory fungal infection can be treated systematically provided that the diagnosis of the infection has been con?rmed. Terbina?ne, imidazoles and GRISEOFULVIN can all be taken by mouth and are e?ective for yeast infections. (Griseofulvin should not be taken in pregnancy or by people with liver failure or porphyria.) (See also FUNGUS; MICROBIOLOGY.)... fungal and yeast infections

Conditions of the tongue At rest, the TONGUE touches all the lower teeth and is slightly arched from side to side. It has a smooth surface with a groove in the middle and an even but de?nite edge. It is under voluntary control and the tip can be moved in all directions.

Ankyloglossia or tongue-tie is a rare disorder in which the frenum or band connecting the lower surface of the tongue to the ?oor of the mouth is so short or tight that the tongue cannot be protruded. Surgery can remedy the defect. It is easy to overdiagnose and is not a common cause of di?culty in feeding at birth or speech defects in infancy.

Gross enlargement of the tongue can make speech indistinct or make swallowing and even breathing di?cult. This is known as macroglossia and may be such that the tongue is constantly protruded from the mouth. The cause may be CONGENITAL, as in severe cases of DOWN’S (DOWN) SYNDROME, or it may occur as a result of ACROMEGALY or be due to abnormal deposits as in AMYLOIDOSIS.

A marked tremor of the tongue when protruded may be seen in various neurological diseases, but may be caused by alcoholism.

After a STROKE involving the motor nerve centre, the control of one side of the tongue musculature will be lost. This will result in the protruded tongue pointing to the side of the body which is paralysed. The sense of taste on one side of the tongue may also be lost in some diseases of the brain and facial nerve.

The presence of fur on the tongue may be obvious and distressing. This is due to thickening of the super?cial layers of the tongue which may appear like hairs which trap food debris and become discoloured. Furring is common during fever and as a result of mouth-breathing and smoking.

In some conditions the tongue may appear dry, red and raw (GLOSSITIS). An in?amed beefy tongue is characteristic of pellagra, a disease caused by de?ciency of NICOTINIC ACID in the diet. A magenta-coloured tongue may be seen when there is a lack of RIBOFLAVIN.

Ulcers of the tongue are similar to those elsewhere in the mouth. The most common are aphthous ulcers which are small, red and painful and last for about ten days. They are associated with stress, mild trauma (such as from jagged teeth), and occasionally with folic acid and vitamin B12 de?ciency. Ulcers of the tongue are sometimes found in patients with chronic bowel disease.... tongue, disorders of

(magenta) n. any one of a group of reddish to purplish dyes used in staining bacteria for microscopic observation and capable of killing various disease-causing microorganisms. Acid fuchsin (acid magenta) is a mixture of sulphonated fuchsins; basic fuchsin (basic magenta) and new (trimethyl) fuchsin are basic histological dyes (basic fuchsin is also an antifungal agent).... fuchsin

(PAS reaction) a test for the presence of glycoproteins, polysaccharides, certain mucopolysaccharides, glycolipids, and certain fatty acids in tissue sections. The tissue is treated with periodic acid, followed by *Schiff’s reagent. A positive reaction is the development of a red or magenta coloration.... periodic acid–schiff reaction